Basic Information

Insect: Drosophila repleta
Gene Symbol: -
Assembly: GCA_018903745.1
Location: JAEIGN010000204.1:150076-154566[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.5e-15 5.7e-12 44.9 0.1 7 74 386 449 381 451 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.5e-15	5.7e-12	44.9	0.1	7	74	386	449	381	451	0.87

Sequence Information

Coding Sequence: ATGAGTTCGCCAGACGACGCCTTGGAAAAAGGCAGGAACATCTATGGTTCAATGAAGCAGACAGGGGCCTCCCCGACATCGAGTGGTGATTATATGCCCGGCAACGACAACTCCAATCATTCGACTGGCTTGAACAAGTCCACTGACAACATCAACGGCCATGGACCGCGAGACAAACAACTAAAAAAGCAGAATTCATTCGAAATGGAATCTGATGTCTCACAACAGACAGTGCAGCTAGATGGCGAGCAGAATGCTGAGAACGAAAACGTTCGCAAGGCCAAAAAGCGTAAGGCCAAGAAGAGCAAAAGACGCGGCTCGAAGGAGGTAGCCTTAATGGGCTGGAACGGTGCCTTTCCCAATCTCTCATCCACCCACAGTTTGGAGAGTAATTCGGATGCTGAGCAGCAGCAGCTGCCCACTGACCTAAAGGCAATCTATGCCACTGGGCTGAGCGTGTTTCCCAGAGAGGACAAGGAGCAGGGGCCGCCGCTGTCATCACCGTCTTCTGATTCTACTTCCCTTTCGCCAGTTTCCCAACAAAAAACGCCTACAACAGCGACAACAGCAGCTTTCACAATTACAACAAATTCGACTACCCCAAGTCCAAAGTCTACGCAGACAACCAACAACAACCTCGACAACAACGACAACAATTCAGCGTCAATGTCACTTGCTACACGTTTTCCACGCTCAGAATCATCATCAGAGCCAGAGTCAGAATCAGAATCACAAGCTGATCTAGCCAAGCAGAAGAAAAAGCGTGCAAAGAAGAGATCATCCGGTGCCGCTGCTGATATTGATAACGTGGGCTTGGTCGCTGGCGAAGAGTCGAATGCCTCATCTAGCTCCAAAAGCGGTGGAAAACGTAACCTCTCCAAAAAAGAAATATTTGATAAGCAGGAGAATGAGTCAAAACGCTCCAAGTCTTCTGATAAGGATTGGACCTGTAGCTTGCGCACGCGCTCCAAGTCTTTCCATTATCCGGATCCGGATCTACCACAACGTACAACGCGTGCACGCAGCGTTTGTGCTGCCACTTTTCGTAATCAAGTCGAGAAGTCGATTGAAGCAATCGCAGCCAGCCAGGATGCTAAGACTCTGGCTCGCCGTCGTTCGGCCGCTGCAGTCAAGCTTCCTGTAACTGATGAATATTATTGCTTGCCGTTCAAGTATGGCTGGAAACGTGAGTTGGTGCTGCGCAGCAACTCATCCACGTCGCGTCAACGTGGCGACATCATTTTTATATCGCCAGGAGGGAAGAAGCTACGTTCCCGCGAGGATATCATTCCTTTGCTCAAGGGCGAGTTGACTATAGATCATTTCTGCTTTCAACGACAGATGCAGCAGGTCGGTGAGCAGTATGAGACGATGCGTCAGGCTCAGCCTGCCCCGTTCCGCCGCAAATCGGCAGCAGCAGCCAAACAACTGGCGGCAGCCAATAATAATACCCAGCAACTACAGCCAGTAGTTGCACCCGTGTCTGGCAAACGTGTGCCTAAGCCGAAGGTTCCCAAAGGCGCCAGTCCTCCACCAGAGGGTTGGACCTCGACGATGGCCGTGAAGGGCAATGCTCGCGTATTGGCAGCTAGCAATGGTAACAACAGCGTTGGGAGTGGCTCTGGTTCTGGCAGTAACGCACGCAAACGAAGCAGCAACCAGTCAAAACAACCAACTAAGACTGTTTCGGAACAGGCAACTGCGCAAGTTAACGTGCACCTCACCTCTGTTGAAAACAACATGATGATCTGTGTGTATTGCTTGAAGCAGATCACTGGGAATCAGCAGGCTTTTCCGGTGGGCACAGCCCAAGTCAACAGCTACATCTGCATGCAATGCGTTAAACCTAAATCAGCCAGTTTGCAGCTGGCAGCAAAAGGACTCACAGCAGGACATCTACAGGCACAGGCGAATGGTGTTAAGAAGCAAGATATAATTGATGAGAATGTAAACGCAAATACCAAATCTGCCTCTGATGCGGGCAAGACTTCGCTGTGTGATCTAAATATTAATGGTAATAGTAATGGCAATGGAGCCTTGCTAGAAATCGGTGGAGAGATTGAACTTCCAGGCGCATTGCCACCCGACCAGTTGCTCAGCGATGATACACCTCCAAGACGTGCTGGTAACAAGATCACGCCCAAGCCGATGGAGGTTGTTGTAATTAATGGTCGCAAAGCTCTGGCCATTGCTGGCGAGCCGCCGCGCCCTCGTTTACAAGTCATACCACGAGAGCCAGATTTGGAGACTTATGAAAAACATTTTCTTAGACGTAACAAGGCCAAGGAGAAGCGTCAAAATTTTGTTGAGTGCGTTTCAACTGGCAATTTAAGTATCCAAGTGATGTCAGCCGTTATTAAGACTATGGATATGCACGACCGTGTACGTATGTCACAGGTGTGCAAGACTTGGGCTATGATTGCCCGTGATCGTAGCGTGTGGCGCACGTTGAAGCTGCGCGACACACACATTACCAAATGGTTGTTCCTTTTGCGTGATATGGCGCGTTATCGCACCTACGAACTGGATATGATGGGCGTTATAATGGATGATCCCAAAATGCGCATGGAGGGAGATTTGCGCGTGTTGAAGTCTCTTCGTGTACTGCGCACTGATCCATCCGATGCGGAGTTCATTCAGACGGTTATTAAGCGCATACCGCGTTTACATGAGCTGCGCACAACCTGCACCAGCCGTGTACTTAATTTGACTAATGTGGACAAGATGGTGGAAATGCGCGTGCTGCGCATACGTATGTTAGAGCCCAAGGCTGGCATTGTCTCGCTGCAGCCGCTGCAAAATCTGGAACTATTGCGGGAGCTTAGCTTGCGCGGCATTAACAATATGGGTCAGTTGGAATTATTGCAACTGAAGGGATTACAACAGCTCGAAACACTTGTGCTGGGCTCTTGCCGTGGCATGAAAGTTTCGGTGTTCGGCAACCAAGTACTACCCAGTCTAAGCCGTCTTCGCAATCTGCGCCTTGAGAATCACCATAGCAATCGCTCGTTTAACATCAATGAGATAATGACTGGCCTCGCCGGCGGCGGTGTGAATCGTGTGGAGCTCATAAATGTCAACGTGGATGAAGATCTCAGTCGTCAGTTGGGCGCATGTGCATCGGTGCAGGAACTGCTGCTGATGCCAAATTTCCACAACAATACGGCTTACATGATGTATTACATTATGCAGGCCATCAATGAAAACAGCGAGCAGCTCAAAGTATTTCGTTTGGGTCTGACATTTGAGCTGCTGAGTGTCACTCGCGCCCTGGCCATAAATCAAGAAAAGGATTGCATTCCGGTAGCATTGCCCATACCTGGCGTGCCAGACAACGATATACTTAACGAGTCCGACGAGCCAATCGCTTATTTGCCGGTCGATCGCCTCGAGTCCATCCTACACCATATGATGCCGCAGGCCTGGCTGACAGTCGCCAAGGTCTCCCAGAGCGAAACCACCAATCTTAAATTCCTTCCGGCTTTACCGACTGACGGGGCCGGAATATCACAACTTAAATAA
Protein Sequence: MSSPDDALEKGRNIYGSMKQTGASPTSSGDYMPGNDNSNHSTGLNKSTDNINGHGPRDKQLKKQNSFEMESDVSQQTVQLDGEQNAENENVRKAKKRKAKKSKRRGSKEVALMGWNGAFPNLSSTHSLESNSDAEQQQLPTDLKAIYATGLSVFPREDKEQGPPLSSPSSDSTSLSPVSQQKTPTTATTAAFTITTNSTTPSPKSTQTTNNNLDNNDNNSASMSLATRFPRSESSSEPESESESQADLAKQKKKRAKKRSSGAAADIDNVGLVAGEESNASSSSKSGGKRNLSKKEIFDKQENESKRSKSSDKDWTCSLRTRSKSFHYPDPDLPQRTTRARSVCAATFRNQVEKSIEAIAASQDAKTLARRRSAAAVKLPVTDEYYCLPFKYGWKRELVLRSNSSTSRQRGDIIFISPGGKKLRSREDIIPLLKGELTIDHFCFQRQMQQVGEQYETMRQAQPAPFRRKSAAAAKQLAAANNNTQQLQPVVAPVSGKRVPKPKVPKGASPPPEGWTSTMAVKGNARVLAASNGNNSVGSGSGSGSNARKRSSNQSKQPTKTVSEQATAQVNVHLTSVENNMMICVYCLKQITGNQQAFPVGTAQVNSYICMQCVKPKSASLQLAAKGLTAGHLQAQANGVKKQDIIDENVNANTKSASDAGKTSLCDLNINGNSNGNGALLEIGGEIELPGALPPDQLLSDDTPPRRAGNKITPKPMEVVVINGRKALAIAGEPPRPRLQVIPREPDLETYEKHFLRRNKAKEKRQNFVECVSTGNLSIQVMSAVIKTMDMHDRVRMSQVCKTWAMIARDRSVWRTLKLRDTHITKWLFLLRDMARYRTYELDMMGVIMDDPKMRMEGDLRVLKSLRVLRTDPSDAEFIQTVIKRIPRLHELRTTCTSRVLNLTNVDKMVEMRVLRIRMLEPKAGIVSLQPLQNLELLRELSLRGINNMGQLELLQLKGLQQLETLVLGSCRGMKVSVFGNQVLPSLSRLRNLRLENHHSNRSFNINEIMTGLAGGGVNRVELINVNVDEDLSRQLGACASVQELLLMPNFHNNTAYMMYYIMQAINENSEQLKVFRLGLTFELLSVTRALAINQEKDCIPVALPIPGVPDNDILNESDEPIAYLPVDRLESILHHMMPQAWLTVAKVSQSETTNLKFLPALPTDGAGISQLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00559481;
90% Identity: iTF_00568244;
80% Identity: -