Basic Information

Insect: Drosophila repleta
Gene Symbol: lz
Assembly: GCA_018903745.1
Location: JAEIGN010000204.1:17924-37973[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 8.7e-71 3.3e-67 223.7 0.0 5 129 9 133 5 133 0.98

2 2 1.4 5.2e+03 -3.2 0.0 26 60 157 192 154 200 0.69

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	8.7e-71	3.3e-67	223.7	0.0	5	129	9	133	5	133	0.98
2	2	1.4	5.2e+03	-3.2	0.0	26	60	157	192	154	200	0.69

Sequence Information

Coding Sequence: ATGGAAAGATTTGTGCTTGAGCGACAACAGGAATATCCCGGTGAATTGGTGCGTACCAGCAATCCGTACTTCCTGTGCTCTGCCCTGCCCTCCCACTGGCGCTCGAATAAAACTCTGCCGCTGGCCTTTAAAGTCGTCGCCCTGGCGGACGTCGGCGATGGCACCTATGTGACCATCCGGGCGGGCAACGACGAGAATTGCTGTGCCGAGCTCCGCAACTACACAGCCCAGATGAAGAACGGCGTGGCCAAGTTCAATGATCTGCGCTTCGTGGGACGCAGCGGACGAGGAAAGAGCTTTACGCTAACAATTACCGTTGCAACGAGCCCGCCACAAGTTGCCACCTATGCCAAAGCCATCAAAGTGACCGTTGACGGTCCCAGGGAGCCGCGCTCCAAGACAAGTCCGCCCGGCGGTCCTCAATATCGTGCCCTCGGCCTGGGCCAGCGACCATTCATCGACGGTTTCCCAAAAACGTTTCACGAGCTGGAAACGCTGCGACACTCGGCAAAGGTGGCGGCTGCCACAACGGCAGCGGCGGCTGCTGCGGTGTCGGTTGCATCGGCTGGCAACGCGCTGACCACAAACGCGAGCATTGCCCAGCAATTGGGTAGCAATTACTCATCGTCAAATAGTACAATAAATTCGGATTGCCAGGGCTACAAGCCTAATGCGCCACAAATTCAAGAGACCGATCTGATAGGTGCAGCTGAATGGACAGGCTCTGCCAGCTCCGGTGCTAACGTCGCCTATCCGGTGGGCGTCGGGGTGGGTGTGCCCTATCATCACGCCCATCACAGTCACACCCACTCGCACTCGCATTCGCACTCGCACTCGCATAGCCACACGGCGCACCACCACCACGCGCACCACCTGCAGCATCAGGTAGCTCTGCCGCCACCGCCGCCCCCGCCGGCAGCTGCACCCGTCCCGGTGCCAGTGGCCACGGCGTCGGCCATGAACCACTATAGCAGCGCCATGAGCGGCTACGATACAACCACGCTGGACGCGGCCAACTACCACATATCCACGGTGCTTCCCGAGATGCACGGCTTCTCCGCCGATCCTTATCAGACGGCCGCTGCCGGCGGTTACTGCGGCACCAGCTCCAAGTCGGACCTAGAGACACTCAACGCCAGCTACGGAGCGACGCCCTCGGCCTACAACAATGCGGCGGCCTGGTCCAACGGGTACAATAATTACCAGTACGGGAGTTGTTCGGCGACGGCGGCTCAGTACGGCGGAGCCGGTGGGCACGCTACGGCCCCGCCGCCTCCGGTCGTGCTATATCCACAGCTCTACTCCACGGTCAACCAAAACCAGATACATCTGCACTTGCACAGCAGCGAAAAGCTGGAACAGTACCTGGCCACGGACCAACAGCTGACCATCAGCTCTCTGGCCAGCAATCGCTCCAGCATCGAGATCGGCCTGGGCGCCGGCCTCAGTGGCGGCGTTTCGCTGGGCGAGCAGGACCAGCAGGCAGCCGTTGCTATTGCCGAGCAGGCAGCCGAGGGCGCCACCCAGAACAACTATCATTTGCATCATCATCACCACCAGCAACATCAGCAGCAGCAGCACGAGGCGCAGCGCCAGCTGGAGGCGCAGCACCAGCAACACCAGCAGCATCCTAACGATGTTAGCAACGAGGCGGCACGCGAAGAGGATGTCGGCGACATGACGCAAGTCTGGCGTCCCTATTGA
Protein Sequence: MERFVLERQQEYPGELVRTSNPYFLCSALPSHWRSNKTLPLAFKVVALADVGDGTYVTIRAGNDENCCAELRNYTAQMKNGVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPPGGPQYRALGLGQRPFIDGFPKTFHELETLRHSAKVAAATTAAAAAAVSVASAGNALTTNASIAQQLGSNYSSSNSTINSDCQGYKPNAPQIQETDLIGAAEWTGSASSGANVAYPVGVGVGVPYHHAHHSHTHSHSHSHSHSHSHTAHHHHAHHLQHQVALPPPPPPPAAAPVPVPVATASAMNHYSSAMSGYDTTTLDAANYHISTVLPEMHGFSADPYQTAAAGGYCGTSSKSDLETLNASYGATPSAYNNAAAWSNGYNNYQYGSCSATAAQYGGAGGHATAPPPPVVLYPQLYSTVNQNQIHLHLHSSEKLEQYLATDQQLTISSLASNRSSIEIGLGAGLSGGVSLGEQDQQAAVAIAEQAAEGATQNNYHLHHHHHQQHQQQQHEAQRQLEAQHQQHQQHPNDVSNEAAREEDVGDMTQVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582041;
90% Identity: iTF_00505886;
80% Identity: -