Dezo004917.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila ezoana
Gene Symbol
lz
Assembly
GCA_035045725.1
Location
JAWNOU010000044.1:12154126-12172224[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 8.3e-71 5.5e-67 223.4 0.0 5 129 107 231 103 231 0.98
2 2 0.62 4.1e+03 -2.5 0.0 24 60 253 290 250 299 0.74

Sequence Information

Coding Sequence
ATGGTCACATCGTCGGCATCGCCAACGGGAACGGGCTGGTCAGCGCCTGCCGATTATAAGAGCGCCAACACGGCTGGCGCAGCTGCCTCGGCGGTGGCTGCGGTCATGTGCGAGGTGATACCATCGAGCAGTGCCAGTGTTGGCAGCAGCTCGCCAACAGGTGGCGCCAGCAATGGTACTGCCAATAGTGCACACAGTggtagcaacaaaaacaacaacaacaacaataacaacaacagtcgcaacaacaataacaacaacagcaacaatgcagTGCATCAGGATCTGTTGTGGATGGAAAGATTTGTGCTCGAAAGACAGCAGGAATATCCAGGAGAATTGGTGCGTACGAGCAATCCGTACTTCCTGTGCTCGGCTCTGCCCTCTCACTGGCGGTCAAATAAAACGCTACCGTTGGCCTTTAAAGTCGTCGCCCTGGCGGACGTCGGCGATGGCACCTATGTGACGATCCGGGCGGGGAATGACGAGAACTGCTGCGCCGAGCTGCGAAACTATACCGCCCAGATGAAGAACGGCGTGGCCAAGTTTAACGATCTACGCTTCGTGGGACGCAGTGGTCGGGGAAAAAGCTTTACGCTGACAATTACCGTTGCAACAAGCCCGCCACAAGTGGCCACCTATGCCAAAGCCATCAAAGTGACCGTCGACGGTCCAAGGGAACCGCGCTCCAAGACGAGTCCACCCGGCGGTCCCCAATACCGAGCACTCGGCCTCGGCCAGCGACCATTCATTGATAGTTTCCCCAAAACTTTTCACGAACTGGAAACGCTGCGTCGCTCCGCGAAGGTTGCGGCAGCcacgacggcggcggcggctgctgcggtgTCGGTTGCATCGGCGGGCAACACGCTGACCACAAACGCTAGTATTGCCCAGCAATTGGGTAGCAATTACTCATCGTCAAATAGTACAATAAATTCGGATTGCCAGGGCTACAAGCCTAATGCGCCACAAATTCAAGAAACCGATCTGATAGGTGCCGCTGAATGGACAGGCTCGGCCAGCTCCGGTGCTAATATCGCCTACCCAGTGGGCGTTGGTGTGGGTGTACCCTATCATCATGCGCACCACAGCCACACccactcgcactcacacagCCACTCGGCGCATCACCACCACGCTCACCACTTGCAACACCAAGTGGCGTtgccgccaccaccaccgccgccagcCGCAGCGCCGGTGCCGGTGCCGGTAGCCACCGCATCGGCCATGAATCACTACAGCAGCGCTATGGGAGGCTATGATACAACGACGCTGGACGCGGGCAATTATCATATATCCTCGGTGCTTCCCGATATGCATGGATTTTCCGCCGATCCGTATCAGACGGCCGCTGCAAGCGGCTATTGCGGTACCAGCACCAAGTCAGATCTGGAATCAATTAACGCCAGCTATGGCGCAACGCCCGCTGCCTACAATAATCCAGCGGCCTGGTCCAATGGTTATAACAACTATCAGTACGGCAGCTGTTCGGCGACGGCAGCACAATACGGCGGAGCTGGTGCACATGCAACGGCACCTCCGCCGCCGGTGGTTCTGTATCCACAGCTTTACTCGACTGTTAACCAGAACCAGATACATCTGCATCTTCACAGCAGCGAGAAGCTGGAACAGTACCTGGCCACAGACCAGCAATTGACTATCAGCTCACTGGCCAGCAATCGTTCTAGCATAGAGATCGGATTGGGAACTGGCGTCtgtggcggcggcgggggtAGCAGCGTAAGCGGGGGTGTCGCCCTGGgcgagcaggagcagcaggcagcagtgTCAATTGCCGAGCACGCAGCGGAAGGTGCCTCCCAGAACTATCACTTGCATCACCATCACCATCACCACGAgacgcagcggcagctggaggcacaacagcagcatcagagCGACGTTAGCAACGAGGCGGCACGGGAAGAGGATGTTGGCGATATGACGCAAGTCTGGCGTCCCTATTGA
Protein Sequence
MVTSSASPTGTGWSAPADYKSANTAGAAASAVAAVMCEVIPSSSASVGSSSPTGGASNGTANSAHSGSNKNNNNNNNNNSRNNNNNNSNNAVHQDLLWMERFVLERQQEYPGELVRTSNPYFLCSALPSHWRSNKTLPLAFKVVALADVGDGTYVTIRAGNDENCCAELRNYTAQMKNGVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPPGGPQYRALGLGQRPFIDSFPKTFHELETLRRSAKVAAATTAAAAAAVSVASAGNTLTTNASIAQQLGSNYSSSNSTINSDCQGYKPNAPQIQETDLIGAAEWTGSASSGANIAYPVGVGVGVPYHHAHHSHTHSHSHSHSAHHHHAHHLQHQVALPPPPPPPAAAPVPVPVATASAMNHYSSAMGGYDTTTLDAGNYHISSVLPDMHGFSADPYQTAAASGYCGTSTKSDLESINASYGATPAAYNNPAAWSNGYNNYQYGSCSATAAQYGGAGAHATAPPPPVVLYPQLYSTVNQNQIHLHLHSSEKLEQYLATDQQLTISSLASNRSSIEIGLGTGVCGGGGGSSVSGGVALGEQEQQAAVSIAEHAAEGASQNYHLHHHHHHHETQRQLEAQQQHQSDVSNEAAREEDVGDMTQVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00538009;
90% Identity
iTF_00616684; iTF_00534360; iTF_00530730; iTF_00512493; iTF_00526354; iTF_00586456; iTF_00490558;
80% Identity
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