Basic Information

Gene Symbol
RREB1
Assembly
GCA_035043635.1
Location
JAWNMV010000302.1:2435902-2442596[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.037 2.6 8.7 0.8 1 21 257 277 257 279 0.93
2 13 0.00034 0.024 15.1 0.2 1 23 289 311 289 311 0.98
3 13 8.3e-05 0.0058 17.1 7.3 1 23 317 339 317 339 0.98
4 13 0.79 55 4.6 2.4 2 19 581 598 581 601 0.93
5 13 0.037 2.6 8.7 0.1 1 23 766 788 766 788 0.97
6 13 1.3e-05 0.00088 19.6 0.7 1 23 798 820 798 820 0.99
7 13 0.00085 0.059 13.9 2.0 1 23 826 849 826 849 0.97
8 13 0.003 0.21 12.1 2.0 1 23 1128 1151 1128 1151 0.95
9 13 8.9e-05 0.0062 17.0 0.3 2 23 1498 1519 1497 1519 0.97
10 13 0.15 10 6.8 6.3 1 23 1525 1548 1525 1548 0.97
11 13 4.6 3.2e+02 2.1 3.6 1 23 1683 1706 1683 1706 0.79
12 13 0.0086 0.6 10.7 0.5 3 23 1764 1784 1762 1784 0.96
13 13 0.0014 0.096 13.2 4.8 1 23 1790 1812 1790 1812 0.99

Sequence Information

Coding Sequence
ATGCTGGccacacaacagcaacaacaacacacagcaacaactgttgctgctgcaacaacaacaacaacagcagcagcagcagcagcaacaacagttgcacaCAGCAGCGATGCCAGCGACATGGATCGCCAGCGTCGCGATTCAACCACCTCAGAATCCTCCCTGGAGCATCTCGACTTGGGACGCACACCAAAGaagctcagcagcagcagcggagCGCCGCAGCCGACGTCAACGCCGCACGAgacagcagcgacaacgacagcgacagcgacgtcgcgCAAGCGTAAGctgcgacagcagcagcatcagcaacatttGTTCTCCGATGACGatgagcagcagttgcagctgcagcagcagcaacagcagcaacaacatcaattggATCCGTCAGCGCAGCGACCGCGTCACAAGCAGCGACGCAGCGCCAACGCTGCAGCCAGCGCCAGCATTGTCGTCGATTACAGCGCCAGCGGCGACGCCAGTTCGCTGCGTAAAAAGTTTCGACTGAAtcgcagcagcggcagcggcgtcAACGGCGAACTCTCTGAATCGGGCTTTGTGGATGGCAGCGCTCATAGCGGTTATTTGCTCAGCAGCAGCGCCGGCAGCAGCGCAcagtcagcgtcagcgtcggcagcggcagcagccgcAGTTGCAGCGCAGCAGGCGTCAGCGTCGAGCAGCTCGGGCGGCTCGTCACCGCAAGGCTTGTGCCTGTCGAGCGCCGAATCGGGAATTGGCGCCGGCGACGAGCACATGAAATATCTGTGCCCCATCTGCGAGGTCGTCTCGGCCACGCCCCACGAGTTCACCAATCACATCCGTTGCCACAACTATGCCAACGGCGACACGGAGAACTTCACCTGCCGCATCTGCTCAAAGGTGTTGTCGTCGGCCTCGTCGCTGGACAGACACGTGTTGGTGCACACTGGCGAGCGACCGTTCAACTGCCGTTATTGCCACTTGACATTCACAACGAACGGCAACATGCATCGTCACATGCGAACACACAAGCAACATCAGGCACAGGCACagacacagcagcaacagtcgcaatcgcagtcgcagcaacaacaggcacagcaacaacattcgcactcacagcagcaacagttgcagtcacagtcgcagcaacagcgacgacagcaacatgcggcagcaacaaatgcCACACTGGCGGCAGGTGGAAGATCCGAGAGTTATGAAAGTGATGCGAGTTGCTCGACGGATGTGTCCAGTGCACAAagtcacagcagcaacagcagcagcagcaatcactccagcaacaacagcaacagcaacaacaacaacaacaacaacaataacaacaataacaataataaaatcagcaacaacaacaccattgAGGAGAAAgaacagcaacatgttgctgccacaatgTGTGGCAAGCAGCGACGccataaaatcaatataaacaacaacaatattatgGACAAAGAGCAAGAAGAGCAGCAGGCGGCGGAGGATGACTTAGACAATGAGAATGGCTCCGATGCGGAGAGCgcgcaggaggaggaggatgtgGCACAATTGATAACCTCCACGCCCGATGTGGCAACACTGCTCGCCTCCTCCGGCGGCACAACGCCGAGTCAATCGCCGGCACCGCCAATGATGCTGCTCCTGAATTGTCCCGCCTGTGAGGCGGATGATTTCGAATCGCTGCCAGCGCTGTGGCAACACTTGGATGCCCGGCATGCGGATATACCCGCCAAGTGCAGGGAGTGCGAGGTAATCTTCGCCAGCCATCGCCAGTTGCAGACGCACAATTGTCGTGGCTTGAATGGGCTGCAAATGTTGCCGCTACTCGCCGCTAGCTCAAGTCCCAAGCACGAAatcgaggaggaggatgatgagcagcagcagcgagagATGGATGAGGAGGAGCCGGAGCTGGAGggggaggaggatgaggagcagcagcagcagcagcagcagcaacaaaatcaagTGCGCGAACAAACCGAACGCGATGATTTCTTTCAGCAGCTGTATCACAAGGGCAAATCCAACATTGCCGCACCGCTGCCCTCGCCGATCAAACACGAACCCAGCACGGAACGCGGCGATAGTCGTCAGGATTTGGCCGATATCCAGAGCATACTCAACATGACCAGCTCCAGCTGCACCTCCAGCTTTCTGCGCAACTTTGAGCAGTCGGTGAACACGCCCTGCTCCAGCCAGTACAGCCTCGATGGCCGCGATGGCGACGAGGAGGCGCAGGACGCGTTCACCAGTGAATTCCGACGCATGAAGCTGCGCGGCGAGTTCCCCTGCAAGTTGTGCGTCGCGGTGTTTCCCAATCTGCGCGCCCTCAAGGGCCACAATCGGGTGCACCTGGCGGCGGTGGGGGCGGCGGGTCCGTTCCGGTGCAACATGTGTCCGTACGCCGTCTGCGACAAGGCGGCGCTGGTGCGGCACATGCGCACGCACAACGGGGATCGGCCGTATGAGTGCGCCGTCTGCAATTACGCGTTCACCACCAAGGCCAACTGTGAGCGGCATTTGCGCAATCGGCACAGCAAGACGAGTCGCGAGGACGTGAAACGCGCCATTGTCTATCATCCGGCGGAGGATGCCAGCTGTGATGAGTCCAAGTCCGGGCAGAGATTGAACGACTCGGAGCTGGGCGAGCTGAGTTATCGCTCCATGTCGCCAACTGTGGAGCCGGCATCGCAATTGAAGCACATGTTGCTGGCGgaaacggcagcaacagcaacagttgctgtcacacccgcaacagcaactgttgccgtCAAGTGTGCGCCCTCTAAGATTCAAGTCAAGAGCTTGGATCAGCTGGTGGATAAACCATTGGCGCCTGCTTTGGATCTCAGCATGGATGTGTTGGATCTTAGCAAAAAGGAGCGGCCACAGGAATTGctacaggagcagcagcagcagcagcagcagcagcagcagcgggagcagcagcagcagcgggagCAAAGAGAACGTGAATTGCTGCTgtgtcagcaacaacagcaacaacagcagcagcagcagcagcaactttttGGCGCTGGCGATGCTGCCACTCAGTACATGCAACAGCTGTTCCGCAATCTCATGTTCCAGCAATCGCCGGCATTTCCATTCTTCAGCTTTAtgccaccaacagcagcagcagctgctgagaAAACCAACTCGGCAACACCAACTGTCATgccaacaacggcagcaacagctgctgttacGCCAGCAAATGGCGCCGCTTTGGGTCTGCCAATGCCGCTGCCCAATGTGGGCGGCGTGGGCGTGCCCGTGCCCGCGGGCGGACCCGTCAAGATGGTCATCAAAAATGGCGTGCTGatgccaaagcaaaagcagcgtCGCTACCGCACCGAACGTCCCTTCGCCTGTGAGCATTGCTCGGCCCGATTCACGCTGCGCTCCAACATGGAGCGTCATGtgaagcagcagcatccgCAGTTCTATGCCCAGCGTCAGCGCAGTGGACACCATGTGATGCGCGGACGCGCTGCATCCtcaaatgcagcagcagcagcagctgctgctgccgccgccgccgccgccgctgctgccgctgcggcAGCAATGTCGAATCTgagccagcagcaacatggtCATCATGCGCATCATGCACACATCTCGGATCAGGTGAAATATGCGATATTGGCGCAGCAGTTGAAGGCGCGCAAGGATACGGATTTGTTGCAACAGGCACTGGCACATGGCTCGAGCAGTGTGGCCGGCAATCCTCTCCAGCATTTTGGCTACAAGCAATATGGcagcaatgccaatggcaatgctCATAGCTCCAGCAATGGACATCATGCCGCtcatgataatgatgatgagccCAAGTTGATCATCGATGAGGATGATGAGCTGGAGGAGGAGCTCGATGAGGAGCtgctggaggaggaggaggaggaggaggatgagctggatgaggagcagcaggaggaggagcagcagcaggaggagcagcgGCGGGAGGAGGAGCAACAGCCACCGCGCACTTCAACGCCCATTGAGGCGGCCAAAAAGGTGGCGGAAACGATCTTGGAGCAGGCCATCAAAGCGGGCAAAGCCACAGACTTTGAGTCCAAAAAGTTGGTCactccaacaacaactgccacgcccacgcccactccGACGCCCACTGCCACCACAATGAAAACAATGATTGCCCAGGCCGAATCCGTAGCCAAATCCCTTAAAGAGGTCGCCAGCTCGCCGTTTAAAGATGAATCTCAGGATCTGGTGCCGGTTTCCAAGCTGGTGGACAATGCCACCAGCAATCAGGTGTCCTTCAATAGCTACTTTCGGCCCAGCGATGTGGCCAATCACATGGAGCAGTCCGATGAGGAGGGACTCGTCGCCTCCGGCAGTGCCAGCGAGAGCAACAATTCCGGCACCGAGGAcgtcaccagcagcagcagcagcagcaatgagCCCAAAAAGAAATCCGCCTACAGTTTGGCGCCCAATCGCGTCAGTTGTCCGTACTGCCAGCGCATGTTCCCCTGGAGCAGCAGCCTGAGGCGTCACATCCTGACGCACACGGGTCAGAAGCCATTCAAGTGCTCCCATTGCCCCTTGCTGTTCACCACGAAGAGCAACTGCGATCGCCATTTGTTGCGGAAGCACGGCAATGTGGAGAGTGCGATGAGTGTCTATGTGCCCACGGAGGATGTGAGCGAACCGATACCGGTGCCCAAATCGGTGGAGGAGATTGAGCTGGAGGAGCAGCGACGACGCAAGGCGGAGCAGCTGGAAAGGGAGcgggagagggaaagggagcgggagcgggagcgggaaaGGGAGCAGGAAAGGGAACTGGAGCGGGAGAGGGAGCGGGAaagggaacgggaacgggcgCGAGAACTGGAGcgagaacagcagcagcaacagctcatcCAGCAATTGGCTGCAGCCGCACAAATGGTTGCCGCCTCCGTAACCGCATCCGCTTCCGCCTCAGCCGCCTCCGCCGTCGCTTCGCCAACTGCCAGCGGCAGTCCAGGGGAATCGCAGGGCAGCGATTTGCCCTATAAATGCCATCTGTGCGAATACTCGTTCGGCGAGCGTCTGCAGTGCTTGGAGCACATCAAACAGCAGCATGCACACGAGTTTGCATTGCTGTTGGCCAAAGGTGCCATCGAAACGGAggagcaacagctgccagCACCAGCaggaccaacaacaacagttgcctcCGATGAGGATTCCGGTCATGCCGCACGCGCCACGAATGTCGTCAAATATCCGGACTATAGCAATCGCAAAGTGATTTGCGCTTTCTGCGTGCGTCGCTTCTGGTCCACGGAGGATCTGCGGCGTCACATGCGCACGCACTCCGGCGAACGGCCGTTCCAGTGCGAGATCTGTCTGAGGAAGTTCACGCTGAAGCACAGCATGTTGCGGCACATGAAGAAGCACAGTGGACGCAGTCACAATGGCGATTTGGCTGGTCAATCCGATTGCTCCGATGATGAGcagtctgccacgcctcccagCACGCCCACGCCCATGATAATGCCGCaagcgaacaacaacaacaacaataacaacacttgtcacaataacaacaacaacacaaacaacaacaacaacagcagcagcaaacaaagcTTACGTCTGCCGAAATTGCATGAATTGTTGGACAAGGCGAACGAATGGCGCGTGAGTCGTTCATGCGAACATAAGGAAAACATTGCTGAATCTGCCACAGCATCGGCAgcaagtgcaacagcagcagcggcggcagctgccgTGGCCGTGGCAAGTGGCGATCTAATTGGCAATTTGCTTGGCATAAGTGATCAAGGTATACTTAATAAGCTACTTTCCTCCGCCGACGAGGCAGCTAAGCTACTAGGCGTtgacaaataa
Protein Sequence
MLATQQQQQHTATTVAAATTTTTAAAAAATTVAHSSDASDMDRQRRDSTTSESSLEHLDLGRTPKKLSSSSGAPQPTSTPHETAATTTATATSRKRKLRQQQHQQHLFSDDDEQQLQLQQQQQQQQHQLDPSAQRPRHKQRRSANAAASASIVVDYSASGDASSLRKKFRLNRSSGSGVNGELSESGFVDGSAHSGYLLSSSAGSSAQSASASAAAAAAVAAQQASASSSSGGSSPQGLCLSSAESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQAQAQTQQQQSQSQSQQQQAQQQHSHSQQQQLQSQSQQQRRQQHAAATNATLAAGGRSESYESDASCSTDVSSAQSHSSNSSSSNHSSNNSNSNNNNNNNNNNNNNNKISNNNTIEEKEQQHVAATMCGKQRRHKININNNNIMDKEQEEQQAAEDDLDNENGSDAESAQEEEDVAQLITSTPDVATLLASSGGTTPSQSPAPPMMLLLNCPACEADDFESLPALWQHLDARHADIPAKCRECEVIFASHRQLQTHNCRGLNGLQMLPLLAASSSPKHEIEEEDDEQQQREMDEEEPELEGEEDEEQQQQQQQQQNQVREQTERDDFFQQLYHKGKSNIAAPLPSPIKHEPSTERGDSRQDLADIQSILNMTSSSCTSSFLRNFEQSVNTPCSSQYSLDGRDGDEEAQDAFTSEFRRMKLRGEFPCKLCVAVFPNLRALKGHNRVHLAAVGAAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHSKTSREDVKRAIVYHPAEDASCDESKSGQRLNDSELGELSYRSMSPTVEPASQLKHMLLAETAATATVAVTPATATVAVKCAPSKIQVKSLDQLVDKPLAPALDLSMDVLDLSKKERPQELLQEQQQQQQQQQQREQQQQREQRERELLLCQQQQQQQQQQQQQLFGAGDAATQYMQQLFRNLMFQQSPAFPFFSFMPPTAAAAAEKTNSATPTVMPTTAATAAVTPANGAALGLPMPLPNVGGVGVPVPAGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRAASSNAAAAAAAAAAAAAAAAAAAAAMSNLSQQQHGHHAHHAHISDQVKYAILAQQLKARKDTDLLQQALAHGSSSVAGNPLQHFGYKQYGSNANGNAHSSSNGHHAAHDNDDEPKLIIDEDDELEEELDEELLEEEEEEEDELDEEQQEEEQQQEEQRREEEQQPPRTSTPIEAAKKVAETILEQAIKAGKATDFESKKLVTPTTTATPTPTPTPTATTMKTMIAQAESVAKSLKEVASSPFKDESQDLVPVSKLVDNATSNQVSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSSSNEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRKAEQLEREREREREREREREREQERELERERERERERERARELEREQQQQQLIQQLAAAAQMVAASVTASASASAASAVASPTASGSPGESQGSDLPYKCHLCEYSFGERLQCLEHIKQQHAHEFALLLAKGAIETEEQQLPAPAGPTTTVASDEDSGHAARATNVVKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRSHNGDLAGQSDCSDDEQSATPPSTPTPMIMPQANNNNNNNNTCHNNNNNTNNNNNSSSKQSLRLPKLHELLDKANEWRVSRSCEHKENIAESATASAASATAAAAAAAVAVASGDLIGNLLGISDQGILNKLLSSADEAAKLLGVDK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00608648;
90% Identity
-
80% Identity
-