Dpul007023.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila pullipes
Gene Symbol
FOXL2
Assembly
GCA_035043795.1
Location
JAWNMT010000551.1:169646-171370[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.8e-35 3.1e-32 110.4 0.0 2 87 135 217 134 218 0.96

Sequence Information

Coding Sequence
ATGATGATGGCCAACACAGAAAACTTGTCCCCAACGCGACCCTCCACACCCTCAAACTCAAGCATAGCTGGTCAGCACCAGGAGGAGCAAAAGCCGCTTTTCGCCAGCGTGCACTACCCGCTCggaggcggcagcagcagcagcagcaatgccaaTACCAATAGTCCGGTAGTGTCACGTCAGATGGCCCTCGAGCAGTACCGGCTGCAGCTGTATAATTATGCGCTGAACATCGAGCGACTTCGGTGTCCGCAATATGGAACGGGTAGCTCGCTGCTACCCAGCTGGTTGCAGCCGTCGGCGACCTATGGAGCCGTACACTCCACCGGCAATCGCTTGGCAACCCTCTCAACGATCTCCCTGTTTCCGCAGACACAGCGTATCTTCCAGCCGGAGGAGCCGAAGCCACAGCACAGCTATATCGGCCTCATTGCGATGGCAATACTTAGTTCGAGTGAATTGAAGCTGGTGTTATCCGATATCTATCAGTACATACTCGATAACTATCCGTACTTTCGCAGTCGCGGCCCTGGCTGGCGCAACTCCATACGTCACAACTTGTCGCTCAATGATTGCTTCATCAAATCGGGCCGCAGTGCGAACGGCAAGGGACACTATTGGGCAATTCACCCGGCGAATATGGATGACTTCCGCAAGGGCGATTTTCGGCGTCGGAAAGCACAGCGCAAGGTGCGCAAGCATATGGGTCTGTCGGTGGACGATGCCAGCACAGATTCGCCGAGTCCGCCACCCCTCGATTTAACCACCCCACCTCCGGTAGTGCCACAGGCTCTCAACTATCcctatcatcatcatcatcatcatcagcagcagcagcagcagcagcagcatgagcagcagcagcgtcagcattATATCGGGCAGTTCTTTGGCAGGGGCATCATTGGCGCACAGCCACGATTGgattatcagcagcagctgcagcagcagcagcagctgcatgcaCAGCATCCACAACAGCATCCACAACAGCATCCACAACAGTATCCACAACATCCACAGCACATTTCGTACATCAATTccacgacgacgacaacaattgCGAATCTTTATTCGCAGACGCGCAAAAGGCAATTTGATGTTGCCTCGCTGCTGGCGCCCGATGTGCAAATTGTGGACATTGTGGCAGATGATGGGCAGGttgccacacagacacagcacACGCTCATCACCAAGGTGCAGGTGAAGAAGCAACAAATGATGCTACTCGAACAGCATCCACCACcgagcaataacaataataataataatcccGCTCTCGATGTGGATGCCGAGGCGGAAATTGATGTCGAGGATTGCGAAGAGGAGCAAATTGCAGCCGGTACACCCGGTACTACAACGGGTGCTGCTGTGCCCGCATACCTCAGCGACGTGGAACTGGAGGAGAGGGATCCACACAATTACTCACCAGTGTTGGGCAGCTCAAACGATTCCAACTCGCTCGAGGAGTGCCCGCTAAACACTGCCGGTACGGCTGCTGACACCCTACTGACACCCGCTGCCGTTCACCCGTTGCCCATTTCGTATGTGGAACTTAATGGCGTCGATCCGCAGATACTCAGTCGTTATTATGGCAGCTATATGGCAGCTGCAGCGAGGCGAGCCAGCCTCGAGGTAGCTGCGAGAGCCCAATCGAAGACGACCATGTTGGTTGCCGCGCCCCCGCCGGCTATATCAACAGAACTGTTACctaataaatcataa
Protein Sequence
MMMANTENLSPTRPSTPSNSSIAGQHQEEQKPLFASVHYPLGGGSSSSSNANTNSPVVSRQMALEQYRLQLYNYALNIERLRCPQYGTGSSLLPSWLQPSATYGAVHSTGNRLATLSTISLFPQTQRIFQPEEPKPQHSYIGLIAMAILSSSELKLVLSDIYQYILDNYPYFRSRGPGWRNSIRHNLSLNDCFIKSGRSANGKGHYWAIHPANMDDFRKGDFRRRKAQRKVRKHMGLSVDDASTDSPSPPPLDLTTPPPVVPQALNYPYHHHHHHQQQQQQQQHEQQQRQHYIGQFFGRGIIGAQPRLDYQQQLQQQQQLHAQHPQQHPQQHPQQYPQHPQHISYINSTTTTTIANLYSQTRKRQFDVASLLAPDVQIVDIVADDGQVATQTQHTLITKVQVKKQQMMLLEQHPPPSNNNNNNNPALDVDAEAEIDVEDCEEEQIAAGTPGTTTGAAVPAYLSDVELEERDPHNYSPVLGSSNDSNSLEECPLNTAGTAADTLLTPAAVHPLPISYVELNGVDPQILSRYYGSYMAAAARRASLEVAARAQSKTTMLVAAPPPAISTELLPNKS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00499399; iTF_00497962; iTF_00576874; iTF_00542251; iTF_00501614; iTF_00552846; iTF_00564464; iTF_00595761; iTF_00518254; iTF_00576156; iTF_00557024; iTF_00570208; iTF_00485670; iTF_00516804; iTF_00513270; iTF_00616010;
90% Identity
iTF_00485670;
80% Identity
-