Dpse009229.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila pseudotalamancana
Gene Symbol
gsb-n
Assembly
GCA_037075185.1
Location
JBAMCK010000671.1:835094-850688[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.9e-72 1.7e-68 228.2 0.7 1 125 20 141 20 141 0.99

Sequence Information

Coding Sequence
ATGGATATGTCCAGCGCCAACTCCTTGCGACCGTTATTTGCCGGATATCCTTTTCAAGGACAGGGACGCGTCAATCAGCTCGGCGGCGTCTTCATCAATGGTCGCCCGCTGCCCAATCACATCCGCCTGAAAATCGTGGAAATGGCGGCCAGCGGAGTGAGGCCGTGCGTGATATCGCGGCAGCTGCGGGTCTCACATGGCTGTGTGTCGAAGATACTGAATCGCTACCAGGAGACGGGCTCGATCAGGCCGGGCGTGATTGGCGGCTCCAAGCCGAAGGTGACTTCGCCGGAGATCGAGGGACGGATCGATGAGCTGCGCAAGGAGAATCCCGGCATATTCAGCTGGGAGATACGCGAGAAGCTGATCAAGGAGGGCTTTGCGGATCCACCATCGACTTCATCGATCAGTCGACTGCTGAGGGGAAACGATCGCAGCAGCGAAGACGGACGCAAGGACTATACGATCCATGGCATACTGGGCGGCCGGGATTCGGACATCAGCGACACAGAATCGGAGCCGGGAATTCCGCTGAAGCGCAAGCAGAGACGCTCCCGCACCACATTCACCGCCGAGCAGCTGGAGGCTCTCGAGCGGGCCTTCGCCCGGACCCAGTACCCGGATGTCTACACCAGGGAGGAGCTCGCCCAGACCACCAGCTTGACTGAGGCGCGCATCCAGGTGTGGTTCTCCAATCGTCGAGCTCGCCTGCGCAAGCATTCTGGCGGCTCGGGCTCCGGCCTGTCGCCCATGAATGGCAGCGGTGcaggcgtgggcgtgggcgtgagCGTAGGCGTCGCCGCCAGTGGTGCCGCTGCACCACTTGGCTTTGGTCCCCTGGGCGTGGGCTCCATGGCGGGCTACAGTCCGGCAGCGGGCACCACAGCCAGCGGAGCCACAGGCATGTCCGACACCTCCCACCTGCACCACAGCACCGCCCATGCGCCCAGCTCGCACAGCGCAGCGGCCGCCGCGGCGGCGGCCCATCATCACACGCAGATGGGTGGCTACGACCTGGTCCAGAGCGCGGCACAGCACGGCTTCCCGGGCGGCTTTGCGCAGCATGGACACTTCGGTGGTCAGAACTACTATCATCAAGACTACTCCAAGCTGACCATCGACGACTTCTCCAAGCTGACCGCAGACAGTGTATCAAAGATCTCGCCCTCGCTGCATCTGAATGACAACTACGCAAAACTGGAGTCGCCCTCCAATTGGTCGCAGGCCGCCTACCATCTCAACCAatcggcggtggcggcggccaATTACAACGCGGCGGCCGCCCACCACGCCGTCGCCCAGCATCAGTTAACGGATTATGCCGCGGTCCACGGCAATGTAGCCGCTGCTTACCAACATCCATTGCCAGCCCAGGGTCAGACGGCCAAATACTGGTCATGA
Protein Sequence
MDMSSANSLRPLFAGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEIEGRIDELRKENPGIFSWEIREKLIKEGFADPPSTSSISRLLRGNDRSSEDGRKDYTIHGILGGRDSDISDTESEPGIPLKRKQRRSRTTFTAEQLEALERAFARTQYPDVYTREELAQTTSLTEARIQVWFSNRRARLRKHSGGSGSGLSPMNGSGAGVGVGVSVGVAASGAAAPLGFGPLGVGSMAGYSPAAGTTASGATGMSDTSHLHHSTAHAPSSHSAAAAAAAAHHHTQMGGYDLVQSAAQHGFPGGFAQHGHFGGQNYYHQDYSKLTIDDFSKLTADSVSKISPSLHLNDNYAKLESPSNWSQAAYHLNQSAVAAANYNAAAAHHAVAQHQLTDYAAVHGNVAAAYQHPLPAQGQTAKYWS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00901334;
90% Identity
iTF_00582114; iTF_00505954; iTF_00490628; iTF_00490725; iTF_00575527; iTF_00506056; iTF_00534425; iTF_00534526; iTF_00575422; iTF_00530210; iTF_00530113; iTF_00520483; iTF_00520577; iTF_00610501; iTF_00610595; iTF_00832101; iTF_00832002; iTF_00502374; iTF_00502469; iTF_00544321; iTF_00554241; iTF_00572449; iTF_00509763; iTF_00479428; iTF_00546596; iTF_00568198; iTF_00509671; iTF_00599527; iTF_00546505; iTF_00599433; iTF_00479338; iTF_00516202; iTF_00568106; iTF_00516107; iTF_00551435; iTF_00551532; iTF_00559436; iTF_00559343; iTF_00573167; iTF_00473008; iTF_00472913; iTF_00573265; iTF_00544437; iTF_00549398; iTF_00549495; iTF_00540216; iTF_00519769; iTF_00519865; iTF_00540313; iTF_00476474; iTF_00554330; iTF_00476571; iTF_00532222; iTF_00532318; iTF_00586526; iTF_00572544; iTF_00586624; iTF_01555977; iTF_01556070; iTF_00478666; iTF_00478565; iTF_00541706; iTF_00541614; iTF_00567383; iTF_00567482; iTF_00550765; iTF_00522802; iTF_00512568; iTF_00522904; iTF_00512665; iTF_00550843; iTF_00616749; iTF_00563023; iTF_00530800; iTF_00616848; iTF_00563122; iTF_00530899; iTF_00475061; iTF_00526422; iTF_00526524; iTF_00475165; iTF_00508270; iTF_00508167; iTF_00585135; iTF_00585038; iTF_00804240; iTF_00804333; iTF_00598097; iTF_00597997; iTF_01549428; iTF_01549520; iTF_00510485; iTF_00510381; iTF_00562325; iTF_00562418; iTF_00568822; iTF_00470713; iTF_00568922; iTF_00470813; iTF_00901334; iTF_00901446; iTF_00472215; iTF_00472309; iTF_00589400; iTF_00589494; iTF_00495802; iTF_00495702; iTF_00493499; iTF_00493591; iTF_00508955; iTF_00509047; iTF_00595099; iTF_00595194; iTF_00608284; iTF_00608386; iTF_00538173; iTF_00538075; iTF_00583517; iTF_00583624; iTF_00492798; iTF_00492905;
80% Identity
iTF_00582114;