Dpse010177.1
Basic Information
- Insect
- Drosophila pseudotakahashii
- Gene Symbol
- E2f1
- Assembly
- GCA_035046095.1
- Location
- JAWNOE010000159.1:1537369-1542434[+]
Transcription Factor Domain
- TF Family
- E2F
- Domain
- E2F_TDP domain
- PFAM
- PF02319
- TF Group
- Helix-turn-helix
- Description
- This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 1.7e-31 9.7e-28 96.0 0.1 2 64 263 325 262 326 0.98 2 2 0.61 3.4e+03 -1.8 0.0 17 39 571 599 559 600 0.78
Sequence Information
- Coding Sequence
- ATGTCCAAGTTCTTTGTGAATGTTGCTcctatcaacaacaacaacaacaacagcagcggcagcaacaactccACCAGCAACACCCAGcgacaccagcaacagcacTATGGCGCGGGCGGGGCAACTGGCCACACGATGGTGGCCCGCAGACTTAACTACGATCAgctcggcggcggcggcggcaccaccaacattaacaacaacaatattgTGATCAAGAACGAGGCCCTCGATCTAGACTACGAACACGGTCTGAGCAACAGCGACAgtaacagcaacagcaatagcaacagcaacagcggcgTGGCAGCCCATCTGCGGGATCATGTCTATATCAGTCTGGACAAGGGGCACGTCGGGACGGGGACGGGGGCAGTGGCAACAGCAACGGCGGGCCACtcgcaacagcaactgcagcagcagcaccaccaaaATCAGCAGCACCGCAAGACGGCCGGCAAGTCCAACGATATCACAAATTATTACAAGGTCAAACGCCGGCCACACGCCGTCACCGACGAGATCCACCCGAAAAAGCAGGCCAAGCAGAGCGCCCACCACCAGACGGTTGGGTACCAGAAGCATGTGGCCAGCAGCACGCCCCAACAGCTGCGACACAGCCACCTTCAGCAGCTTCACCATGCGACGAATGCCGAGCTGGACGAGGATGTGGTGGAGCGAGTGGCCAAGCCGGCTTCGCATCACCCATTCGCACTGTCGACGCCCCAGCAACAGTTGGCCGCTTCGGTGGCCAGCAGTTCTGCGAGCGGGGATCGCAATCGGGCGGACACCTCGCTGGGAATACTGACCAAAAAGTTTGTGGACCTGCTGCAGGAGTCACCGGATGGCGTCGTGGATCTGAACGAGGCCTCCAACCGGTTGCATGTTCAGAAGCGACGCATCTACGACATCACCAATGTCCTTGAAGGCATCAATATCGTGGAGAAGAAGTCGAAGAATAACATCCAGTGGCGCTGCGGACAGTCGATGGTCAGTCAGGAGCGATCGCGGCGCATCGAGGCGGAGTCGGAACGACTGGAGCAGTTCGAGAACGAGCTGAACATGGCCCTGGTCCAGATGCGCGGCAATCTGGCCGAGATCTCGCAGGAAGTGGAGAACTCCGGCGGCATGGCCTACGTCACGCAGAACGACCTGCTCAACGTGGATCTCTTCAAAGATCAGATCGTTATCGTTATCAAGGCGCCGCCAGAGGCCAAGCTTGTGCTGCCCAACACAAAATTGCCGCGCGAGATTTACGTGAAGGCGGAGAACAGCGGGGAGATCAACGTCTTCCTTTGCCATGACACCTCGCCGGAGAATTCGCCGATTGCGGCGGGCGCCGGCTACGTTGGAGCACCAGGAGCCGGATGCGTTCGAACGGCCACCTCCACCCGACTGCATCCGCTGACCAACCAGCGCCTGAACGATCCGCTCTTCAACAATATCGATGCCCTGAGCACCAAGGGATTAGTTCCCACGCCCTACCGCTCGGCCCGTAACCTCAGCAAATCGATCGAGGAAGCCGCCAAGCAGTCCCAGCCTGAATATAATAACATTTGTGATATTGCGATGGCCCAGCATCATAATCtgaaccagcagcagcagcagcagcaacagttgctgCAGCAGCCGGAGGAGGACGATGTGGACACGGAGCTGAGTCAGCTGGTGCCGACACTGACGAATCCGGTGGTCCGCAGCCATCagttccagcagcagcaccagcagacCTCCATCCAGGAGCTGTTTAGCAGCTTAACAGAATCCTCGCCCCCAACGCCCACCAAGCGTCGTCGGGcggcagcagccgcagcaatTGCCGCAGGCagcgcaacagcagcaaccacTACGCTTAATAGTCATAACAACAACACCAATAACACCAACAGCAACCACAGCAATCATAGCaaccacagcaacagcaactccCAACCACCCACAATAGGCTACGGCAGCAGTCAGCGACGCAGCGATGTGCCCATGTATAATTGTGCAATGGAAGACGCAACCACAACATCtgtagcagcagcagttgcagcaacAGGAACAGGAACATCGCgcgcggcagcagcaacacaatCGTCGGCGATAAGCTCGCTTCAAATGCAATTCGCTGCCGTGGcggacagcaacaacagcagcagcaacgatGACGGCGGCTATGGCAGCATTGCTGGCGCTGGCGCCAACGCTGATCCCCATCAGCCGTTCAGCCATGGCCGCCACAGCCTGCCGCCCAGCGTGGCCGACTGCGATGCcaatagcaacagcagcaacgtAACGCTTCAGGGCCTCGATGCGCTCTTCAACGACATTGGCTCGGACTacTTCAGCAACGACATTGCCTTTGTGTCCATCAATCCGCCGGACGACAATGACTATCCGTATGCGCTGAACGCGAACGAGGGCATCGATCGGCTGTTCGACTTTGGTTCGGACGCCTATGGACCCTAA
- Protein Sequence
- MSKFFVNVAPINNNNNNSSGSNNSTSNTQRHQQQHYGAGGATGHTMVARRLNYDQLGGGGGTTNINNNNIVIKNEALDLDYEHGLSNSDSNSNSNSNSNSGVAAHLRDHVYISLDKGHVGTGTGAVATATAGHSQQQLQQQHHQNQQHRKTAGKSNDITNYYKVKRRPHAVTDEIHPKKQAKQSAHHQTVGYQKHVASSTPQQLRHSHLQQLHHATNAELDEDVVERVAKPASHHPFALSTPQQQLAASVASSSASGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIYDITNVLEGINIVEKKSKNNIQWRCGQSMVSQERSRRIEAESERLEQFENELNMALVQMRGNLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVLPNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAAGAGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDALSTKGLVPTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMAQHHNLNQQQQQQQQLLQQPEEDDVDTELSQLVPTLTNPVVRSHQFQQQHQQTSIQELFSSLTESSPPTPTKRRRAAAAAAIAAGSATAATTTLNSHNNNTNNTNSNHSNHSNHSNSNSQPPTIGYGSSQRRSDVPMYNCAMEDATTTSVAAAVAATGTGTSRAAAATQSSAISSLQMQFAAVADSNNSSSNDDGGYGSIAGAGANADPHQPFSHGRHSLPPSVADCDANSNSSNVTLQGLDALFNDIGSDYFSNDIAFVSINPPDDNDYPYALNANEGIDRLFDFGSDAYGP
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00602374; iTF_00536556; iTF_00542934; iTF_00505193; iTF_00578316; iTF_00547854; iTF_00604627; iTF_00604628; iTF_00607603; iTF_00504476; iTF_00596445; iTF_00592182; iTF_00539450; iTF_00618944; iTF_00591492;
- 90% Identity
- iTF_00536556;
- 80% Identity
- -