g16170.t3


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila pseudoobscura
Gene Symbol
tfap2e
Assembly
GCA_009870125.2
Location
CM020872.1:56186012-56189323[-]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.2e-82 2.8e-78 262.5 0.2 1 196 175 368 175 369 0.99

Sequence Information

Coding Sequence
ATGCATCATCAATCACTTCAGTCCGATTTTCAGCCTCCGTATTTTCCGCCGCCGTTCCACCATTCCACGCAAAGCCCTCCTCAGCAACAGAATCACGGTGCCCTCGAATACCTGGGCACGGATCCGTATGGTCAGCCTTTGTCATCGTTACACCACGCCCCCCTCCATCACTACAATCAGTTGGCGGGCCTGAGGTCGACGCAAGATCAACTTGGGATTCACAGAACCCACAGAGAGGCGGAGCTGCAAGGACATGTTtCCCAGCTGGCTCATGGATTTCCGTACACAGATAGAAGAGGCGACTACAGCAGTGCAATATCGGCAGGAGCAGCGCATGGAACCCGAATCGGCCATGAACATGACTCCCTGGCCCTGCATCAAGCGCTGCAAAATGCTGTCGACGATGTGCAAGCACCTGCCATAGATGACAACGTAGCCTTCATGTCAGACCTTCCACTAATAAAAAGCATGAAAAGCGGTAAAGATGCAGGGAACATTGGTTCTGGTTCCCCCAGTGAGGTATTCTGTGCAGTTCCTGGTCGCCTTAGTCTCCTATCGAGCACGTCGAAATATAAGGTCACCATTGCGGAAGTGCAGCGAAGACTGTCGCCACCCGAATGTTTAAACGCCTCCTTGTTGGGCGGAGTTCTTCGAAGGGCCAAGAGTAAGAACGGCGGGCGTTTGCTAAGGGAGAAGCTTGAGAAGATCGGCTTGAACCTACCCGCGGGAAGGCGAAAAGCGGCTAATGTGACGTTGCTAACGTCTTTGGTGGAGGGAGAAGCAACCCACTTGGCCAAGGACTTTCACTTTGTTTGCGAGACGGAATTCCCGGCTAGGCAGTTGGCGGAGTACATTGTACGTCATCAAACGGAGCCAAATGATTCATATCGACGAAAAGAGCTCATCCTTCATTCCCAGCAGATTACAAAAGAGTTAATGCAGATCTTAAGCCAAGATCGGACTACTCATTTTGGAACAAGATCACAGCACTTGTTGGAGCCGTCGATGCAGCGTCATTTAACACACTTTTCACTAATTACGCACGGGTTTGGATCACCCGCAATAATGGCCGTTCTGCATGCTTTCCAGACATTTTTGAATGAATCATTAAACTATTTAGAAAAGCTATATCCTTCGAATGGAGGTGGCATGGTGTCGTCATCATTGGACAAAAGTAAAATggacaacgaaaaaaaatga
Protein Sequence
MHHQSLQSDFQPPYFPPPFHHSTQSPPQQQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQLGIHRTHREAELQGHVSQLAHGFPYTDRRGDYSSAISAGAAHGTRIGHEHDSLALHQALQNAVDDVQAPAIDDNVAFMSDLPLIKSMKSGKDAGNIGSGSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPNDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKMDNEKK*