Dpro007569.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila prostipennis
Gene Symbol
ken
Assembly
GCA_037075205.1
Location
JBAMCJ010002431.1:8201771-8203605[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.6e-22 1.4e-19 70.5 0.1 7 104 23 119 18 124 0.91

Sequence Information

Coding Sequence
ATGTTGATGTTGCAATACAGCAAACATGGCGAGTGCATACTCAAAGAAATCGGAGCCGCCTTCAGAGGGGAGCACCCTGCGGACCTGACCATAGTATGCGAGAACAAAGTGAAGCTGCATGCCCACAAGTTGGTCCTGGCGGCAGCCAGTCCGCTGATAAGGAACCTGCTGGAGGACACCCACTTGAGCGACTGCTCGACCACCGTGTACTTTCCCGACGTGAATGCCACCTACTTCAAGTTCCTGCTGGACTTTCTGTACTCCGGTCAGACGTGCATCACCTCGCGGGATGTGAACTACCTGCAcgacctgctgctgctgctgcagatcAAGTCGGACAGCTGGAAGACCACCGATTCCGCCTATCTGAGCAGCAAGTGCGGCGGTCTGCGGGATCGGTCGGACAGGCGAAAGCAGCAGTACACTAGCCCGCAGAATGTGGAGCCTGATCAGACGCTAAAGTACGAGGTGGACAGCGTGGATGAGTCGCGCAACGCGGCCGACTTCTCGTCCGCCTTCAACTCCGGCGACAATTGCGAGAGTGCGCCCGAGTGCGAGCGAAGTGGCGGCGGCGGGCCCAacaaggaggaggacgaggacgactgCACCCACAAGGACAATAAGAGCGACAAAGACACGGACGAAATTGTAAATCTCTCGAATGCCCCGCCCAGCGGaaccagcggcagcaacagcaacatcagcaccagcagcaaccaCCAGcatcagcaccaccaccaccacaaccacaataacaacaataataataacaacaacaacagcagctcaGCTATAAATCCCGTCAACCTTTCACTCGACCTTCGGACAAAGAACGAGAACTCGGCGGGCAGAACCCTGGGCTCCGGATCCGAACACAGTGGCATCGATTTGGCCGTGACAGCGAGCGAGAGCACGAAGCGCAAGGGCCTGTTCTTCGATTCGCACAAGGACGTGATGAAGCCGCTGTCGGATGGCTCGGATATCAACAGCTCGCCGGAGAACTACGTGGTTACGCCGCACCGGAAGCGGCGACCCGGATTCCACAACACGCAGAGCGACAACCAGCCGTTCACCTCGTATCCACACAGTCTGCTGGAGGAACTGCGCCTGGCCAAGTCGACGACATCGCCCATTTCGGGCTTCGGATCGGAGAAGAACATGCTGGCGCACTTGGAGGACGGAGCCCTCAACGGGGACACCCTGACGCCGGACAGGAAGCATTTGCTGGAGGCGCAGCGCAATCGAGCCCAGAGCCCCGAGATGCCGATGCACCTGGGCCCCCAGTTCGTGTACCAGTGGCAGTCCAACCAGAACGCAGCCATGTCCGCAATGCCCAACCTGCAGTCGCGACTCTCTAGTCTGTCGCACATCAGCCTCAATCTGGACCATCCGGAGGGGCGCAGTGGGTCGGCCTCGGGATCCGGATCGAATCTGGGCGGCAGCAACACGCACGCCTCCTCGGTGCGGGAGTATCGATGCGAGTACTGTGGCAAACAGTTTGGCATGTCCTGGAACCTCAAGACCCATCTGCGTGTTCACACGGGCGAAAAGCCGTTCGCCTGCCGCCTGTGCGTGGCCATGTTCAAGCAGAAGGCCCACCTGCTGAAGCACCTGTGCTCCGTGCATCGAAACGTCATCACCACCACCAACGGGGCGGACACGGAGAATCGATACAGCTGTTGCTTCTGCTCCATGTGTTTCGAATCGGTCCAGGAGCTCGTCCGCCACCTATCCGGCCACCACAACAACCTGCTGCTGACCAAGAATCTGCGCGAATAG
Protein Sequence
MLMLQYSKHGECILKEIGAAFRGEHPADLTIVCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLLLLLQIKSDSWKTTDSAYLSSKCGGLRDRSDRRKQQYTSPQNVEPDQTLKYEVDSVDESRNAADFSSAFNSGDNCESAPECERSGGGGPNKEEDEDDCTHKDNKSDKDTDEIVNLSNAPPSGTSGSNSNISTSSNHQHQHHHHHNHNNNNNNNNNNSSSAINPVNLSLDLRTKNENSAGRTLGSGSEHSGIDLAVTASESTKRKGLFFDSHKDVMKPLSDGSDINSSPENYVVTPHRKRRPGFHNTQSDNQPFTSYPHSLLEELRLAKSTTSPISGFGSEKNMLAHLEDGALNGDTLTPDRKHLLEAQRNRAQSPEMPMHLGPQFVYQWQSNQNAAMSAMPNLQSRLSSLSHISLNLDHPEGRSGSASGSGSNLGGSNTHASSVREYRCEYCGKQFGMSWNLKTHLRVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVRHLSGHHNNLLLTKNLRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00581636; iTF_00601153; iTF_00514986; iTF_00601387; iTF_00515223; iTF_00474598; iTF_00564274; iTF_00474836; iTF_00564020; iTF_00574920; iTF_00580841; iTF_00581135; iTF_00480953; iTF_00481179; iTF_00575197; iTF_00536140; iTF_00536389; iTF_00484528; iTF_00484739; iTF_00471994; iTF_00471729; iTF_00517819; iTF_00518070; iTF_00603453; iTF_00603694; iTF_00611678; iTF_00611442; iTF_00487392; iTF_00487624; iTF_00548162; iTF_00550340; iTF_00536867; iTF_00527400; iTF_00533411; iTF_00489700; iTF_00485480; iTF_00533192; iTF_00527667; iTF_00485241; iTF_00489470; iTF_00483073; iTF_00515684; iTF_00580294; iTF_00580068; iTF_00615656; iTF_00619240; iTF_00566410; iTF_00566183; iTF_00591786; iTF_00504781; iTF_00531983; iTF_00531754; iTF_00477424; iTF_00480496; iTF_00480261; iTF_00604944; iTF_00602692; iTF_00569777; iTF_00570021; iTF_00613811; iTF_00613584; iTF_00541396; iTF_00541168; iTF_00526198; iTF_00525960; iTF_00607862; iTF_00609494; iTF_00609259; iTF_00606680; iTF_00606417; iTF_00594874; iTF_00594641; iTF_00491835; iTF_00491606; iTF_00476252; iTF_00476019; iTF_00481629; iTF_00572221; iTF_00571992; iTF_00561855; iTF_00562075; iTF_00524736; iTF_00524504; iTF_00592480; iTF_00596746; iTF_00605928; iTF_00605670; iTF_00494476; iTF_00494723; iTF_00612908; iTF_00613124; iTF_00539053; iTF_00539275; iTF_00588238; iTF_00588481; iTF_00488112; iTF_00488334; iTF_00594162; iTF_00593931; iTF_00512339; iTF_00512098; iTF_00614995; iTF_00539749; iTF_00504308; iTF_00546056; iTF_00504082; iTF_00507701; iTF_00507938; iTF_00505495; iTF_00529656; iTF_00529895; iTF_00490172; iTF_00490402; iTF_00478111; iTF_00478338; iTF_00486912; iTF_00486656; iTF_00565472; iTF_00565703;
90% Identity
iTF_00572221;
80% Identity
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