Dpla009129.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila planitibia
Gene Symbol
gsb-n
Assembly
GCA_035043785.1
Location
JAWNMS010000053.1:8255825-8272972[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.2e-20 3.2e-17 62.5 0.2 1 38 20 57 20 57 0.97
2 2 5.7e-31 8.4e-28 96.7 0.2 59 125 57 120 56 120 0.99

Sequence Information

Coding Sequence
ATGGATATGTCCAGCGCCAACTCATTGCGACCGCTTTTCGCCGGTTATCCCTTTCAAGGTCAGGGACGCGTCAATCAGCTCGGGGGAGTCTTCATCAATGGTCGCCCGCTGCCCAATCACATTCGTTTGAAAATCGTCGAAATGGCGGCCAGCGGGGTGAGGCCATGCGAGACGGGCTCGATACGGCCGGGCGTGATTGGTGGCAGCAAACCGAAGGTGACATCGCCGGAGATCGAAGGCCGGATCGATGAGTTGCGCAAAGAGAATCCGGGCATATTCAGCTGGGAGATACGCGAGAAACTGATCAAGGAGGGCTTTGCGGATCCACCGTCAACATCATCGATCAGTCGTCTGCTGAGGGGCAACGATCGCAGCAGCGAGGATGGACGCAAGGATTATACGATCCATGGCATACTGGGCGGCCGCGATTCGGACATCAGTGATACGGAATCGGAGCCGGGCATTCCATTGAAGCGCAAACAGCGTCGCTCCCGCACCACATTCACCGCCGAGCAGCTGGAGGCGCTGGAGCGTGCCTTTGCCCGCACCCAGTATCCGGATGTCTATACCAGGGAGGAGCTGGCACAGACCACCAGCTTGACGGAGGCACGCATCCAGGTGTGGTTCTCCAATCGACGTGCCCGTCTTCGCAAACACTCGGGTGGCTCCGGTTCCGGTCTGTCGCCCATGAATGGCAGTGGTCCCGGAATGCCTACTGGCCTTGGTGTTGGCGGCAGTGGTGCGGCTGCGCCACTTGGCTTTGGGCCCCTCGGCGTGGGTTCGATGGCGGGCTATAGTCCCGCCGCCGGCACCACGGCCAGTGGTTCGGCGGGCATGAGCGATGGATcccatcaccatcatcatcacaccACCACCGCCCATGCACCCAGCTCTCacagcgctgctgcagcggcagctgcagctcatcATCACACCCAAATGGGTGGCTACGATCTTGTGCAGAGTGCGGCAGCGCAACACGGCTTCCCGGGTGGATTTGCGCAACACGGACACTTTCCCAGCCAGAACTACTATCATCAAGACTACTCAAAACTGAGCATCGACGACTTCTCGAAGCTAACCGCGGACAGTGTATCAAAGATCTCGCCCTCGTTGCATCTGAGCGATAATTATGCCAAGTTGGAGTCACCGTCGAACTGGTCGCAGGCCGCCTATCATCTCAACCAGTCAGCGGTGGCGGCGGCCAATTACAATGCGGCAGCCGCTCACCATGCGGTCGCCCAGCATCAGTTGACCACGGATTATGCAACGGCTGCCGCAGCCCATGGGAATGTGGTGCCCAGTGCCTACAATCACCCACTGCCCGCCCAGGGACAGGCGGCCAAATACTGGTCATGA
Protein Sequence
MDMSSANSLRPLFAGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCETGSIRPGVIGGSKPKVTSPEIEGRIDELRKENPGIFSWEIREKLIKEGFADPPSTSSISRLLRGNDRSSEDGRKDYTIHGILGGRDSDISDTESEPGIPLKRKQRRSRTTFTAEQLEALERAFARTQYPDVYTREELAQTTSLTEARIQVWFSNRRARLRKHSGGSGSGLSPMNGSGPGMPTGLGVGGSGAAAPLGFGPLGVGSMAGYSPAAGTTASGSAGMSDGSHHHHHHTTTAHAPSSHSAAAAAAAAHHHTQMGGYDLVQSAAAQHGFPGGFAQHGHFPSQNYYHQDYSKLSIDDFSKLTADSVSKISPSLHLSDNYAKLESPSNWSQAAYHLNQSAVAAANYNAAAAHHAVAQHQLTTDYATAAAAHGNVVPSAYNHPLPAQGQAAKYWS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00901334;
90% Identity
iTF_00576908; iTF_00557059; iTF_00499433; iTF_00499532; iTF_00497997; iTF_00542285; iTF_00518287; iTF_00498098; iTF_00542386; iTF_00518388; iTF_00595796; iTF_00595893; iTF_00557152; iTF_00570242; iTF_00498820; iTF_00570343; iTF_00616044; iTF_00616145; iTF_00498714; iTF_00496547; iTF_00573892; iTF_00558503; iTF_00521194; iTF_00573997; iTF_00558610; iTF_00521300; iTF_00496438; iTF_00598726; iTF_00598830; iTF_00564497; iTF_00564598; iTF_01327111; iTF_01321035; iTF_01321137; iTF_01327734; iTF_01327835; iTF_01327005; iTF_01321864; iTF_01321765; iTF_01320415; iTF_01320312; iTF_00516938; iTF_00516838; iTF_00543690; iTF_00543588; iTF_01325610; iTF_01325507; iTF_00514125; iTF_00514024; iTF_00485807; iTF_00485706; iTF_00501750; iTF_00501649; iTF_00593047; iTF_00592938; iTF_01324057; iTF_01323956; iTF_00582906; iTF_00582805; iTF_01323323; iTF_01323221; iTF_00552252; iTF_00552149; iTF_00576188; iTF_00576291; iTF_00513406; iTF_00513305; iTF_01322590; iTF_01322485; iTF_01326239; iTF_01326339; iTF_00482180; iTF_00619684; iTF_00522117; iTF_00609831; iTF_00548648; iTF_00607016; iTF_00524969; iTF_00494954; iTF_00566635; iTF_00497228; iTF_00560205; iTF_00619789; iTF_00511118; iTF_00548751; iTF_00525073; iTF_00527891; iTF_00566739; iTF_00597203; iTF_00495060; iTF_00497332; iTF_00511220; iTF_00535158; iTF_00535257; iTF_00482075; iTF_00527995; iTF_00560091; iTF_00522012; iTF_00597309; iTF_00609725; iTF_00606910;
80% Identity
iTF_00576908;