Dpic004278.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila picticornis
Gene Symbol
su(Hw)
Assembly
GCA_035043845.1
Location
JAWNMR010000362.1:1019851-1024122[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00069 0.042 14.2 2.2 1 20 249 268 249 270 0.94
2 12 2.8e-06 0.00018 21.7 0.4 3 23 321 342 319 342 0.93
3 12 0.0097 0.6 10.6 0.1 1 23 348 370 348 370 0.97
4 12 7.7e-07 4.8e-05 23.5 2.5 1 21 377 397 377 398 0.95
5 12 3.3e-06 0.00021 21.5 0.6 2 23 410 431 409 431 0.96
6 12 0.00011 0.0066 16.7 5.3 1 23 442 464 442 464 0.99
7 12 8.3e-05 0.0051 17.1 0.9 1 23 470 492 470 492 0.97
8 12 1.9e-05 0.0012 19.1 0.7 1 23 498 520 498 520 0.99
9 12 1.5e-06 9.4e-05 22.5 3.0 1 23 526 548 526 548 0.98
10 12 2.9e-05 0.0018 18.5 1.3 1 23 552 574 552 574 0.97
11 12 5.7e-05 0.0035 17.6 0.1 1 20 582 601 582 606 0.93
12 12 3.3e-05 0.002 18.3 0.3 3 23 626 647 624 647 0.96

Sequence Information

Coding Sequence
ATGGCTGTGAATAGTCAGACGCTAACGCCATCGTATACGTGCCTGCAATCGTGCTGTGAACTATCACTTCCAATGAGCGCGAGAAAGGACGCCTCCGAGGCGAACTCCCTCAGCTCCAGCAGCGATGGCGGCGGCAACGTAATCAAAATCTTGGACGTTGAGAAAATAGCATCAGCCAAGGATAAACGTCCTGGCACCCGCATGAAACTGCTCAACGATGTGACAGCGGCTAAGTCAAAAATCTCTGCACGCGTCAAGCAAGAGAAACGCACCAGCATCAAAATACTCAACAACGATGATTCAGCGAACAGTCCCAAAGGCAGCAGCGATAGGCGCTCCGCTAGCAAAGCAGCGACTGCAACAGCTGGCGTCAAAATCTTAAATGAGAAACGCATTGCGCCACCCTCGACGCCCGTGGAGACGGCCAAAATTAAGACATCGCCCggtaaaaagaagaaaatggaTCACTATGTGCTGCAGGCCATCAAGAGTGAGAACAGTAAATTGGACAATACGACGGCCAGCAGCGTGGAGATTGAGGATGATGACGATACCATTGATTTTATACTCGCCGACGACGATGTCGAGTTGGGTGCCGCCAAGGAGAACGACGATGAGTTCGTTGTTTCCGGTGTGGaggaagacgacgacgacgatgacgatgaggatgagggcACCGCTGAAGGCACTAGTACAACGAATCGCAATGCCGGCAACAACAGTGAACTCAAGGAGATTATGGAGCATGTGTGCGGCAAGTGCTACAAGACATTCCGGCGCGTCAAAAGCCTGAAGAAGCACTTGGAATTCTGCCGCTATGACAGTGGGTATCATCTGCGCAAAGCGGACATGCTCAACAATCTGGAAAAGATCGAAAAGGATGCAGTGGTCATGGAGAAGAAGGAcatctgcttctgctgcagcgAGAGTTACGACACCTTCCACCTGGGCCACATCAATTGCCCTGACTGTCCCAAGTCGTTTAAGACACAGACCAGCTACGAGCGTCACATCTTTATCACTCACTCCGAGTGCAATGATTATCCATGCTCCATATGCAATGCGAAATTGCGCAGCGCCGCCTTACTCAAACTGCACgaacagcagcatcaattgCGCGGCAAACCCTTCGCCTGTAAGATTTGTGGCAAGGACTTTACGCGCTCGTACCACCTGAAGCGCCACCAGAAGTATTCGTCGTGCTCGGCCAACGAAAATGATACCATGAGCTGCAAGGTCTGCGATCGCGTCTTCTATCGCCTCGACAATCTGCGCGCCCATCTCAAACAGCATTTGGGCACCCAGGTGGTCAAGAAGCCCGAGTACATGTGTCATGTGTGCAAGAATTGCTTCTACAGTCTGTCGACGCTCAACATTCACATACGCACTCACACTGGAGAGAAGCCCTTCGATTGCGATCTGTGCGACAAGAAGTTTTCCGCCTTGGTGGCGCTTAAGAAGCATCGACGCTATCACACCGGCGAGAAACCCTACACCTGTTCAGTGTGCAGTCAATCTTTTGCCGTCAAGGAGGTGCTCAATCGCCACATGAAACGGCATACGGGCGAGCGTCCACATAAATGCAACGAGTGCGGCAAGAGCTTCATTCAGGCCACACAGCTGCGCACGCATTCCAAGACGCATCTGCGTCCCTACCCCTGCTCCAAGTGCTCAGAAAAGTTCAAGACAGAGAAACAACTCGAGCGTCACGTTAAGGAGCATTCGCGGCAGAAGCGTCGCTCCTTTCCCTGCACGGAATGTCCCCGAAGTTTCCGGACTAGCGCGTTGCTGCAGGAGCATGTTGATGCTGGCGATCACTCACCTGATAAGCAGGTGAGGGCCAAGCGCTCGGCCAAGGCGATCGAGCGCACCGATTGCGCCATCTGCGACAAGAACTTCGACAGCACCGATACGCTGAGGAATCACATTCGCAGCGTGCACGAGTGCGATCCGGATGACATTTTTGGCACGGAGCCACCGCCCGCAAAGCGACGGACTAAGAAGACCGTCCAATTTGTGGCACCGATAGAGCAGGACGAGGCCGACGACGAAGACGCTGAGCAGGAGGAAAGGGAAGATGTGCCGGCTGCCAACACATCGGCGGGTTCGCTTATCTCCAGCCAAACGGATGGCAACGGGGTTGTGGTGCGCGAGTTTCTGGTGGATGAGGGCGACGGCAGCGCCCAGACAATTGTCCTCGAAAATGAGGTGTACACCATATTGCCCTTGGAGGGTGCCGCCTCCGGTGCAACCGAAGCGAAATCAGCTGAGGGCGATGTCAAGGCCGAATCCAAGGAGAAGCAGAAACAGGCAGTGTCGCCAGTGGTTAAGAAGGAGCAACGGAAATCATTGGCGGCCAGTCTGGCTGCTGCCATAGCGGATAATCAGGATGAGCCATTGAGCGAAGATGATTTCAGTGGCGAGGTGCTCACCGAAGAGGATTTAAAGCTAAAGGAGAACATAGCCAAGCTAATTGATATGCTCGTCGATCCGCAGACACTCAAGAAATACGGCTGGCCGAACAGCACCGAGGAGTCGGTGCTCTGCAAGGTCATCGAGAACTGTGGCCACGATTTGGACAAGGGTGGCGAGAACTATGCCGAATTGGATTACGGCAGTCGCATGCGTGAATATTGCAAGCTCCTCTTCACGGTGGTCATACACAATGACTCGATTAAGTCGCTGCTCAACAATTTTCCCATCGACGATGTCATTGAGTATGTGCTGGGCGATGAGGATCAAGAACAGGAGCAGGACCCGGACATGGAAAAGGACAAGGAAAAGGGCAAAGACAAGGAGACTGAGCAATCAGACACGAACACTAGGCCGGATGCCGTTGAAACCGATGCCTAA
Protein Sequence
MAVNSQTLTPSYTCLQSCCELSLPMSARKDASEANSLSSSSDGGGNVIKILDVEKIASAKDKRPGTRMKLLNDVTAAKSKISARVKQEKRTSIKILNNDDSANSPKGSSDRRSASKAATATAGVKILNEKRIAPPSTPVETAKIKTSPGKKKKMDHYVLQAIKSENSKLDNTTASSVEIEDDDDTIDFILADDDVELGAAKENDDEFVVSGVEEDDDDDDDEDEGTAEGTSTTNRNAGNNSELKEIMEHVCGKCYKTFRRVKSLKKHLEFCRYDSGYHLRKADMLNNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSECNDYPCSICNAKLRSAALLKLHEQQHQLRGKPFACKICGKDFTRSYHLKRHQKYSSCSANENDTMSCKVCDRVFYRLDNLRAHLKQHLGTQVVKKPEYMCHVCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYTCSVCSQSFAVKEVLNRHMKRHTGERPHKCNECGKSFIQATQLRTHSKTHLRPYPCSKCSEKFKTEKQLERHVKEHSRQKRRSFPCTECPRSFRTSALLQEHVDAGDHSPDKQVRAKRSAKAIERTDCAICDKNFDSTDTLRNHIRSVHECDPDDIFGTEPPPAKRRTKKTVQFVAPIEQDEADDEDAEQEEREDVPAANTSAGSLISSQTDGNGVVVREFLVDEGDGSAQTIVLENEVYTILPLEGAASGATEAKSAEGDVKAESKEKQKQAVSPVVKKEQRKSLAASLAAAIADNQDEPLSEDDFSGEVLTEEDLKLKENIAKLIDMLVDPQTLKKYGWPNSTEESVLCKVIENCGHDLDKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQEQEQDPDMEKDKEKGKDKETEQSDTNTRPDAVETDA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01325058;
90% Identity
iTF_00511421;
80% Identity
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