Dpic003173.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila picticornis
Gene Symbol
ftz-f1
Assembly
GCA_035043845.1
Location
JAWNMR010000122.1:24044471-24058823[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 2 1.6e+04 -12.4 29.4 40 160 25 159 4 172 0.44
2 4 0.6 4.9e+03 -3.6 15.1 37 113 87 164 77 200 0.53
3 4 1.5e-19 1.3e-15 57.7 0.3 1 78 333 409 333 439 0.75
4 4 2.5e-72 2e-68 231.6 1.3 157 408 532 776 494 778 0.91

Sequence Information

Coding Sequence
ATGTTATTAGAAATGGATCAACAACAGGCGACTGTACAGTTTATATCGTCGCTGAATCTGTCGCCGTTTAGCATGCAACTCGAACAACAGCAGCCCGCGAGTCCGGCGCACAGCAACACTAACAACgctagcagcaacaacaacaacaacaacagcagtagcagcagtaacaacaacaacaacaacagcaataatagcaacaacaataacaacgataACGATACAAATGCATTGAGCAATTCCGATAACGATTACAGTGCATACACGCTGCAACTGGGcagtcatcagcagcagcagcaacactcacatcacacacatcaccagcagcagcagcaacaacagcagcaacagcagcagcattaccaacagcaacaacaacagaatatTGCCAACAATGCGAATGCAGCGGCGAACCAATTCAATGCTTCCTCCTATtcgtatatatacaatttcgATTCACAGTACATATTCCCGACAGGCTATCAGGAAACGAACTCATCCCATTCGCAGCAAAGTGCAAATGGAGCTGGCAATgccgcagcagctggcaactcTGGCCAGCTCTTAaacggtggcagcagcagctcgacaGGTAATGGTTACATGCTGTTGCCACCAGGCGCTAGTGGAACCtcagccgctgccgctgcccatATGTCCGGCAATGTGGGCGGCAATCCGGCCGCGAGCGTAAGTGGAACTGCTGCCGGCGGTGGTCATCATGGCGGCACCAGCGCCACTTCTGGCGGTGGCGAAGCAATCGATTTTAAGCATCTGTTCGAGGAGCTGTGCCCCGTTTGCGGGGACAAGGTGAGCGGCTATCACTACGGCCTGCTCACTTGTGAGTCCTGCAAGGGCTTCTTCAAGCGCACcgttcaaaacaaaaaggtcTACACTTGCGTGGCGGAGCGCTCCTGTCACATCGACAAGACGCAGCGCAAACGTTGTCCATATTGTCGATTCCAAAAGTGCCTGGAGGTGGGCATGAAACTAGAGGCGGTTCGAGCCGACCGGATGCGTGGCGGTCGCAATAAATTTGGACCCATGTACAAACGGGATCGGGCGCGAAAACTGCAAGTGATGCGTCAGCGGCAACTGGCGCTGCAGGCGTTGCGCAGTTCGATGGGCACGGACATAAAGCCGACGCCTCTCTCGCCGGGCTATCAGCAAGCATAtccaaatatgaatattaagcAAGAAATTCAAATACCTCAGgtaTCCTCACTCACACAATCGCCAGATTCATCACCCAGCCCCATTGCTATTGCCTTGGGTCAGGTGAATGCGAGCGGGGGCGGTGTGATAGCCACGCCGATCAATgccggcaacggcaatggtGGCTCCTCacttggcaatggcaacagcaacaccaacaacaacaacggcagcaacggcaCAGGCAGCGGAagcggaggaggagggggtGGTGGAGGAGGCACCAATGctggtggcaacaacaacgtcacCGATGGCCTGCAACGCAAtggaaacagcagcaatagcaacagcaacagcagctgccacgaAATCGGCACTGGATCTCTACAGAACTCAGCCGAAGCGAAATTGTGCTTCGATTCTGGCACACACCCATCGAGCACAGCCGACGCGCTTATTGAGCCACTGAGggTCTCGCCAATGATACGCGAGTTTGTGCAATCGATCGATGATCGGGAATGGCAAACGCAACTTTTTGCGCTACTGCAGAAGCAGACGTACAATCAAGTTGAAGTGGATCTCTTTGAGTTAATGTGCAAAGTGCTTGATCAGAATCTATTCTCACAAGTGGATTGGGCAAGAAACACCGTCTTCTTTAAGGATTTAAAGGTTGACGATCAGATGAAGCTGCTTCAGCATTCTTGGTCCGATATGCTCGTGCTGGATCATTTGCATCATCGCATTCACAACGGTCTGCCCGATGAGACTCAGCTGAATAACGGTCAGGTCTTCAATTTGATGAGTCTTGGTCTGCTGGGTGTGCCACAGCTTGGTGACTATTTCAACGAACTGCAGAATAAGCTGCAGGAATTGAAGTTCGATATGGGCGACTATGTTTGCATGAAATTCCTAATACTGCTAAATCCAGATGTGCGAGGCATTGTGAACAAGAAGACCGTCTTGGAGGGACATGAGAATGTTCAGGCCGCTTTGCTGGATTACACACTGACATGTTATCCCTCAGTTAATGACAAATTCAGGAGGCTACTGAACATTCTTCCGGAAATTCACGCAATGGCCGCACGGGGCGAGGAACACCTCTACTCAAAGCATTGTGCTGGCAGTGCGCCCACACAGACGCTGCTCATGGAGATGTTGCATGCAAAGCGGAAAGTGTAA
Protein Sequence
MLLEMDQQQATVQFISSLNLSPFSMQLEQQQPASPAHSNTNNASSNNNNNNSSSSSNNNNNNSNNSNNNNNDNDTNALSNSDNDYSAYTLQLGSHQQQQQHSHHTHHQQQQQQQQQQQQHYQQQQQQNIANNANAAANQFNASSYSYIYNFDSQYIFPTGYQETNSSHSQQSANGAGNAAAAGNSGQLLNGGSSSSTGNGYMLLPPGASGTSAAAAAHMSGNVGGNPAASVSGTAAGGGHHGGTSATSGGGEAIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRSSMGTDIKPTPLSPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASGGGVIATPINAGNGNGGSSLGNGNSNTNNNNGSNGTGSGSGGGGGGGGGTNAGGNNNVTDGLQRNGNSSNSNSNSSCHEIGTGSLQNSAEAKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQELKFDMGDYVCMKFLILLNPDVRGIVNKKTVLEGHENVQAALLDYTLTCYPSVNDKFRRLLNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00485910;
90% Identity
iTF_00553087;
80% Identity
iTF_00576399;