Basic Information

Gene Symbol
su(Hw)
Assembly
GCA_951394115.2
Location
OX596005.2:18588155-18591225[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00066 0.065 14.3 2.2 1 20 231 250 231 252 0.94
2 12 2.7e-06 0.00027 21.7 0.4 3 23 303 324 301 324 0.93
3 12 0.012 1.2 10.3 0.1 1 23 330 352 330 352 0.95
4 12 7.4e-07 7.3e-05 23.5 2.5 1 21 359 379 359 380 0.95
5 12 6.1e-06 0.0006 20.7 1.0 2 23 392 413 391 413 0.96
6 12 0.0001 0.01 16.8 5.3 1 23 424 446 424 446 0.99
7 12 8e-05 0.0079 17.1 0.9 1 23 452 474 452 474 0.97
8 12 6.1e-06 0.0006 20.7 0.8 1 23 480 502 480 502 0.99
9 12 4.5e-07 4.4e-05 24.2 2.1 1 23 508 530 508 530 0.98
10 12 0.00031 0.031 15.3 1.7 1 23 534 556 534 556 0.96
11 12 0.0005 0.049 14.6 0.1 3 20 566 583 564 588 0.92
12 12 8.9e-05 0.0087 17.0 0.3 3 23 608 629 606 629 0.96

Sequence Information

Coding Sequence
ATGAGCACCAATAAGGAGGGCAAAATGACTGATGTCCCTAAGGCGACCGTTGTCTCCGCCTCTGCTCCCGTTTCCGTCGCCGTCCCCGCCTCCAGGGGCAATGATGAAAGTGTCGTCAAATTACTGGACACTGGCAAGGAGAAGCGACCCAGTACTCGCATGAAACTGCTCAATGATGCGGCAGCCAAAGGCGGAAGCAAGTCCACATCCGTGTCCACGCCCCGTGTGAAGCAGGAGAAGCGCACAAGCATCAAAATACTGAACAATGATGAGGCCACAAGCACTCCCAAAGGCGACAGACGTTCCACAACAAAAACTGTAAGCCCCACCGCAAGTGTCAAGATACTGAACGAGAAGCGCACTGCGGTGGTTGCCTCTCCGGTGGAAACGACCAAGATCAAGACATCGCcgagcaaaaagaagaaaatggaTCACTATGTACTGCAGGCCATTAAAAGCGAAAGCAGCAAGGCGGACAATACCACCAGCATTGTGATCGAGGATGAGGATACTATTGACTTTATACTTGCCGAGAACGATGACATTGAGTTGGGAGCAGCCAAGGCAAATGACGATGAGTTTGTTGTCTCTGGCGTTGAGGAAGATGACGACGATGAGGACGATGTATTGGGTGAGGACAGTCCAAGCCGCAAGAGTGGCAACAATAGCGACCTCAAGGAAATGGTGGAGCACGTGTGCGGCAAGTGCTATAAGACATTCCGACGTGTTAAGAGCCTCAAGAAGCACTTGGAATTCTGTCGCTATGACAGTGGTTATCATCTGCGCAAGGCGGACATGCTCAAGAATCTGGATAAGATCGAGAAGGATGCTGTGGTCATGGAGAAGAAAGACATCTGCTTCTGCTGCAGCGAGAGCTACGACACTTTTCATCTTGGCCACATCAATTGTCCAGACTGTCCAAAGTCGTTCAAGACACAGACCAGCTATGAGCGTCACATCTTCATCACTCACGCCGAGCTCAATGATTATCCCTGCTCCATTTGCAATGCGAAGCTACGCAGCTCTGCCCTGTTGAAGTTGCATGAGGAACAGCATCAGTCGCGTGGCAAGCCATTCGCATGCAAGATTTGTGGCAAGGACTTTACTCGCTCCTACCATCTGAAGCGCCATCAGAAGTACTCGTCGTGCTCGGCCAACGAAAATGATACCATGAGCTGCAAGGTGTGCGATCGTGTCTTCTATCGCCTGGACAATTTGCGGTCTCATCTCAAGCAGCACCTGGGCACTCAGGTGGTAAAGAAGCCGGAATACATGTGCCATGTGTGCAAGAATTGCTTCTACAGTCTCTCTACGCTCAACATTCACATACGTACTCACACTGGTGAGAAACCATTCGACTGCGATCTGTGTGACAAGAAGTTCTCCGCCTTGGTGGCACTCAAGAAGCATCGTCGTTATCATACGGGCGAGAAACCCTACACTTGCACAGTGTGCAATCAATCGTTTGCTGTCAAAGAGGTTCTAAATCGCCACATGAAGCGACACACTGGCGAGCGTCCACACAAGTGTCCCGAGTGCGGCAAGAGCTTCATCCAAGCGACACAGCTACGTACGCATTCCAAGACGCATCTGCGTCCCTTTCCCTGCTCCTCGTGCCCCCAAAAGTTTAAGACAGAGAAACAACTTGAGCGCCACTTTAAGGAGCATACACGTCAGAAGCGTCTCGGCTTTGGTTGCATGGATTGTCCACGTAGTTTCCGCACCAGCGCACTCCTTAAAGAGCACATTGATGCAGGCGATCATTCCCCTGTGAAACCAACCCGAGCCAAGCGCACTGCCAAGATGATCGAGCGCACGGACTGCGCTATCTGTGACAAGAACTTTGATAGCACTGAAACCCTGCGAAATCATATACGCAACGTGCACGAATGCGATCCGGATGATATCTTTGGCACTGGGCCACCCGCCAAACGTAAAGCTAAAAAGACCATTGTTGTGGAGGAGGAAGTGGAAGATGAGGCggaggaggatgaggaggTGGAGGAGGATGTGGCACCAGCAAACACATCGGCAGGTTCGCTCATCTCCAGCAAAACCGATGGCAATGGCGTTGTGGTGCGTGAGTTCCTGGTGGATGAGGGAGATGGAAGTGCGCAGACCATTATGCTAGAGAATGAAGTCTACACCATTTTGCCTTTGGAAGGAGCCAACGCTACCGAGGCGCCATCTGTAAGTGAGGTCAAGTCAGATACTAAGGAGAAGCAGTCCCCGGTTGTCTCGCCGGTGGTCAAGAAAGAGCAGCGCAAATCCCTAGCTGCCAGCTTGGCAGCTGCCATTGCTGATAATCTGGAGGAGCCATCCAGCGAGGACGAGTTCACCGGCGAGGTGCTCACCGAAGCGGATCTGAAGCTCAAGGAGAACATTGGGAAGTTAATCGACATGCTCGTCGATCCGCAAACACTTAAGAAATACGATTGGCCAAACAGCTCCGAGGAAACTGTACTGTGCAAGGTCATTGAGAACTGTGGCCACGATTTGGCCAAGGGAGGAGAGAGCTATGCCGAGTTGGATTACGGCAGCCGCATGCGTGAATATGTCAAGCTCCTGTTCACAGTTGTCATTCACAATGATTCGATCAAGGCGCTGCTAAATAACTTCCCAATTGACGAGGTTATCGAGTATGTGCTGGGTGATGAAGATCAGGACGATGACCTGTTAATGGACGAAGATAAGGAGCCAGAAAAGTCCGAAAAGGAAACCAGACTGGATGCCGTTGAAGCTGAGGCTTGA
Protein Sequence
MSTNKEGKMTDVPKATVVSASAPVSVAVPASRGNDESVVKLLDTGKEKRPSTRMKLLNDAAAKGGSKSTSVSTPRVKQEKRTSIKILNNDEATSTPKGDRRSTTKTVSPTASVKILNEKRTAVVASPVETTKIKTSPSKKKKMDHYVLQAIKSESSKADNTTSIVIEDEDTIDFILAENDDIELGAAKANDDEFVVSGVEEDDDDEDDVLGEDSPSRKSGNNSDLKEMVEHVCGKCYKTFRRVKSLKKHLEFCRYDSGYHLRKADMLKNLDKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHAELNDYPCSICNAKLRSSALLKLHEEQHQSRGKPFACKICGKDFTRSYHLKRHQKYSSCSANENDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHVCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYTCTVCNQSFAVKEVLNRHMKRHTGERPHKCPECGKSFIQATQLRTHSKTHLRPFPCSSCPQKFKTEKQLERHFKEHTRQKRLGFGCMDCPRSFRTSALLKEHIDAGDHSPVKPTRAKRTAKMIERTDCAICDKNFDSTETLRNHIRNVHECDPDDIFGTGPPAKRKAKKTIVVEEEVEDEAEEDEEVEEDVAPANTSAGSLISSKTDGNGVVVREFLVDEGDGSAQTIMLENEVYTILPLEGANATEAPSVSEVKSDTKEKQSPVVSPVVKKEQRKSLAASLAAAIADNLEEPSSEDEFTGEVLTEADLKLKENIGKLIDMLVDPQTLKKYDWPNSSEETVLCKVIENCGHDLAKGGESYAELDYGSRMREYVKLLFTVVIHNDSIKALLNNFPIDEVIEYVLGDEDQDDDLLMDEDKEPEKSEKETRLDAVEAEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00569117;
90% Identity
iTF_00510679;
80% Identity
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