Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 8.5e-40 1.1e-36 125.3 0.1 2 88 38 123 37 123 0.97

2 2 8.2 1.1e+04 -2.9 0.1 27 46 172 181 155 188 0.56

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	8.5e-40	1.1e-36	125.3	0.1	2	88	38	123	37	123	0.97
2	2	8.2	1.1e+04	-2.9	0.1	27	46	172	181	155	188	0.56

Coding Sequence: ATGCACTCTACTTTATTAACGAAAACGTCGACGCCAGAAGAATCTATGGAGGGAAAATTATATACGGACAAAGACAAAGTTACCGAAGATGTCTCAAATACGCTGAAAGCTAAGCCACCCTACAGCTACGTTGCCTTGATAGCAATGGCCATACAGAACTCAACAATGAAGAGAGCcacattaaatgaaatatacaattttattgcatTGAAGTTCCCGTATTTTGAGCAAAATAAGAAGGGTTGGCAAAACTCGATACGTCACAATCTGAGTTTAAATGAATGCTTTATCAAAGTGCCCAGGGAGGGAGCGGGTGATAGAAAGGGGAATTATTGGACCCTAGATGTGCATTACGAGGATATGTTCGAGAACGGCAATTATCGAAGAAGACGTCGCATGAAACGGCCATATCGGAATATCAGTCAGTTTTCCAGTTCACACGCTTTAACCGATACATTCAagtcaaaaacaacaacaacaacaacaacaacattgcatCAAATACCGAGCCAAGCCATTTACCAGTACAATTCCAGCTCCCAATGGATGGCTGCACAAACATCTCATATTAATGCGTACACTTCTAGAATGAATAACTCCAAAAGCTGCATgATGTATTCACCACAAACGAATTTGGTAGCTGGCAATAATTATGGCAACAAACTTAACTTGGaTTTTGTACACGAAAACATCCCTATTGATTGCTCCAAAATATTTGATGGTCATGCAGTTGCTTCTTGGGAAGCAGAAGCATATTATCAATCAATCAAAAGAGAGGGTCCATTTGAGTTATCCACAAGTATAACCAACTACCAAAACTCATATttatcacaacaacaacaataa
Protein Sequence: MHSTLLTKTSTPEESMEGKLYTDKDKVTEDVSNTLKAKPPYSYVALIAMAIQNSTMKRATLNEIYNFIALKFPYFEQNKKGWQNSIRHNLSLNECFIKVPREGAGDRKGNYWTLDVHYEDMFENGNYRRRRRMKRPYRNISQFSSSHALTDTFKSKTTTTTTTTLHQIPSQAIYQYNSSSQWMAAQTSHINAYTSRMNNSKSCMMYSPQTNLVAGNNYGNKLNLDFVHENIPIDCSKIFDGHAVASWEAEAYYQSIKREGPFELSTSITNYQNSYLSQQQQ

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00613993; iTF_00595049; iTF_00506666; iTF_00533608; iTF_00522768; iTF_00585770; iTF_00568779; iTF_00470667; iTF_00478522; iTF_00557710; iTF_00608246; iTF_00583482; iTF_00518964; iTF_00610453; iTF_00579094; iTF_00584987;
90% Identity: iTF_00522768;
80% Identity: -