Basic Information

Insect: Drosophila paulistorum
Gene Symbol: -
Assembly: GCA_018152135.1
Location: JAECXG010000821.1:14124777-14129898[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.7e-14 6.6e-11 41.8 0.0 3 73 563 628 561 631 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.7e-14	6.6e-11	41.8	0.0	3	73	563	628	561	631	0.89

Sequence Information

Coding Sequence: ATGTGTGTGTGTGTACGCAAGCGAGCTTTATGCAGAAAAAAAAACAAACATTTTTTTCACCGTTACCGCGTTCGATTTCAAACTTTTGATGAAACAAGAAGGGCAGGTGTCTCATGTTGCTTAACTGTTTTCCATTGTTTGTTTTCTAGAGAGAGCAATATGAGCTCAGCGGATGATGATATTCCTGGTACGTCGTCGTCGGCGGCTGCTGCCAAAGCGACCGACTATGCCAAGAAACACAAACGTTCGAAGTCTCGCCTAAGTAAATCCTCAAAATTTCCCTCACCGGATAGGAAGCACAGTCTATTCCATCATCGTAGTCCGGCCAGTCTACGGGATCGCGTCTTGCTGGCCAATGCCAATGCTGTGGAACGGGCCTTGTCGGTATCCACTGGAGATTTGAGCGATAGCACTACTACCACTAGCAGCAGTAGCGGTAGCACCACTACCTCCGGCGGCTCCTCCAGCAGCAGCAGCGGATCGTCCTCGCCCACACCGTACAGTGATCCTAAACCTGGTGCCATACGAAAACCGAAGAAAAAGAAGACCAAAAAGTCCAAGGATCGTCGCAATTCGAGAGATTCAGTTTTAATTGGATTTTCGGGAAGCTTTCCAAATTTATCCTCAACCCAAAGCATCGATTCGGAATCGGAGAGACAGCCGTCTCCAGGCGATCTCAGGTCAATCGGTGCCAGCGGCCTAGGCATTTTTCCACCAGAACGTTATGAGACAGAGCTGGCGGAACAGCAGCAAAAGCATTTAGACTCTCCATCCGCATCCTCAACAATCTCTGATCCACATTCAACACCAACAGCCATGCAACAGCCAATGTCAATCCCTACACCAATCCCAGCATCCCCATCAGATGAGCAAGCGACTCTAACAACAGAAACAACAGCAACATCAAGTTGCATAAATCTGATATCGACAACTAAGATCACTCCAAGTGCGATTGCATATTCCTCGGCTAAAGTAGAGGAACCAGAACCAAAACCAGAACCTAAACCAGAACTAGAAGACCAAACTGATCTACCACCCAACAGTGAACCAGACAAAGAGCAACACAAGGAAAATGTTATTCCAAAGACGGAAATGGGAGAGCTTATGGAGGAAGCGACACCACGAGACGATCATGAGATCGATAAAGATGGTTTACGTATACGTAAACGTGGTGCTGCTGTTGGCATGGTCCAGAGGGCAGAGGGGGAAGGCAACGGAGATGTTGGTGTCCACGATGAACCGGAACAGGACAAGCAGCATTTACAAGCCAAGCGTACTAAAATGTCAATATTGCCATCAAGACGTGGACGCTCCAAATCATTCAGTGTCGCGAGTAACACAAAACGAGATGCGGATGCGACCAGACAACGATCTCTGAGTGAGGCAAATTTGTCATTAATAGACAATGTTAATTTTGTGCATGAACCACAGAAAGTGGAGCAGGAACAACAAGTAGTGCACAAGGAGGAGAAGCAGGGGGCGGAGGAGGAGGAGCAGCAACAACAGGACCAAGAGAAAAAACCCCTCATCGCCCAAGTAGATATAAGTGCAGATGAACCACACGCACCACCCAGTGGTTTGCTTCTGTCGAAAACCAAGGAGGAAGAGACGTCGGCCACCGTTAAAAGGTCGGAGCGACTGTCGGCCCAGCAGACGCGTCGTCCGCCGACACCGAAATTGAAGCCAACCGATGAACACTATCGCCTTCCTTTTGCCCATGGCTGGAAACGTGAACTGGTCTTGCCCAGCAGCGATACCCATCGACGGTCTGGCGATGTGTTCTTCATCTCGCCCGAGGGTCGCAAGTTTCGGTCACGTGAAGACATTATACCCCAACTCAAGGGCGATCTGACAATTGATCACTTTTGCTTTCAACGCGTATCGCAAGAGGTGGGTCCAGAGTTTGAGCTAGTGCGTCGTGCTGTGCCAGTCAGTGCGAGGTCGCAGCCCAGTTTCTTCTCATCCACGCCGGCAGTGTCCGGTAAACGGGTGCCCAAGCCAAAGGTACCCAAGGGGGCTAGTCCACCGCCTGAAGGATGGACACCCACCATGGCCGTTAAAGGCAATGCCCGAGCAATAGCGGCGGCGTCGTCCACCAATGGATCGAATAGTTCAAGTGTGGCCCATTCTCAATCCGGAGCCATTAGTGTAAGCTCTTCGCGCAAGCGTAGTGCGCAAACATCCAGCAAGCACACATCAGCGAAACAACAACCATCTCCACCAGCAGCAACAGCAGCACCATTAAAGCTTCCTACGCAGAGTCAGAGTCAGGATTCTTCATTTGATAACGACGCCGACAACGAGGCTGAGGTGGAAGATGAAGATGGCAGTGGCGCTAGTATACTCGAGATTAGCGAACAAATGGAACAACCGGGACAATTGCCTCCTGCCCAATTGCTTAGTGATAACGTTCTAAGTCCAGACACGCCTCGCTGGCAGGAGATTGTGGTCATTGGTGGCCGTAAAGCAATTTCAATTCTGGACAATCCGCCAAGGATTTCAACTCGTCGTTCCTCTCCCGTAGTTTCCCAAGCGGTAATAGATGGCTGGAATAGTAAATACGAACAGTTCTATAACAAGCGCATAGCAGGACCCAAGAAATTAAATCAGAATGCATTATTGGAGAGTTTGGGCAATGCTCATAATGGCTGTCAAGTCCTAATGGGCATTATGAAAACTATGACCCTAAAGGAACGTGCCAATATGTCACATGTGTGCAAGACCTGGGCCATGATCAGTCGGGATAGAAGTGTCTGGAAATCGGTCACTCTAAAGGATACTTATATTAGTAATTGGATTATTTGCATGCGAGAGTTGGCTCGTCATCGCACTAGGGATTTGGACATGATGGGCATGATATTGGCCAAGCCAGAATTACGATTGACCGGTGATTTGCGTACATTAAAATCTCTGAGAGTGTTACGCACAGATCCCAGTGATGCGGAGTTTTTGCATTTGGTATTTAAGCATCTAACGCAGCTACTGGAACTGCGTTCCATTTGCACCAGTGATTCGCTCAATCTGTCGAATCTGGAGTCAATGCGTGGACTGAAGGTACTGCGACTGCATATGATTGATCCCACAGCAAAAATCAATTCATTGGGCACGCTGGGCCAGCTGACCAACTTGACCGAGCTGTGTGTGCGAGGAGCTACAAATCTGGATGAAATGGAGATTGGTCAGCTGAAGGCATTGACCAAACTGGAGACTCTGGTGTTGGGATCGTGCTTAGATGTGGATCGGGTGCAATTGGGCCAAGAGGTATTGCCAGCTCTTACGAATCTTCGACACTTTCGCTTAGAGAACGAGCACAAGCTCATGGATGTATTTCCCATACACGACATAATGCAGGGCTTGGCTGCTGCCGGTCAGGTCAAACGTTTGGAATTGGTCAATGTGGATGTGGATGAGGATTTCGGGCATCTAATGGCCAAATGCAAAAACTTGGAGGAACTCCTGTTGATGCCCAAATGTATGCATAATACAGCCAATATGACCAATGCTGTGATGCAAGCTGTCAGCGATAATGCTGATCAGTTAAGGGTTCTTCGGATGGGCCTCGCGGCTCAGCTACTGAGTGCCACGAATTATCTGTGCAAGGGCAAAGATGTGGTGCCAGTGCGTCGACCCGTTCCAGGCATTCCTGCCAATGATCACTTGAACTTCTGCTCCGACGATTGCTTTGAAACTGATCATGGCCAGTGTGTGGCATATTTACCAATGGAACGTCTCGAATCTATTCTGCATCACATGATGCCGCAGGCCTGGCTAAGTGTGGCCAAAATAGCCATGCGTGACACAACAAAGCTTCAGTTCCTGAAACGGCTAGATGTCGGCAAATCGATGACCCGGGAACGGCAGCAGCAGCAGCTGAATCAAGATCAGATGCTGAAAGAACCAAAACAAACAGCTCCTTGA
Protein Sequence: MCVCVRKRALCRKKNKHFFHRYRVRFQTFDETRRAGVSCCLTVFHCLFSRESNMSSADDDIPGTSSSAAAAKATDYAKKHKRSKSRLSKSSKFPSPDRKHSLFHHRSPASLRDRVLLANANAVERALSVSTGDLSDSTTTTSSSSGSTTTSGGSSSSSSGSSSPTPYSDPKPGAIRKPKKKKTKKSKDRRNSRDSVLIGFSGSFPNLSSTQSIDSESERQPSPGDLRSIGASGLGIFPPERYETELAEQQQKHLDSPSASSTISDPHSTPTAMQQPMSIPTPIPASPSDEQATLTTETTATSSCINLISTTKITPSAIAYSSAKVEEPEPKPEPKPELEDQTDLPPNSEPDKEQHKENVIPKTEMGELMEEATPRDDHEIDKDGLRIRKRGAAVGMVQRAEGEGNGDVGVHDEPEQDKQHLQAKRTKMSILPSRRGRSKSFSVASNTKRDADATRQRSLSEANLSLIDNVNFVHEPQKVEQEQQVVHKEEKQGAEEEEQQQQDQEKKPLIAQVDISADEPHAPPSGLLLSKTKEEETSATVKRSERLSAQQTRRPPTPKLKPTDEHYRLPFAHGWKRELVLPSSDTHRRSGDVFFISPEGRKFRSREDIIPQLKGDLTIDHFCFQRVSQEVGPEFELVRRAVPVSARSQPSFFSSTPAVSGKRVPKPKVPKGASPPPEGWTPTMAVKGNARAIAAASSTNGSNSSSVAHSQSGAISVSSSRKRSAQTSSKHTSAKQQPSPPAATAAPLKLPTQSQSQDSSFDNDADNEAEVEDEDGSGASILEISEQMEQPGQLPPAQLLSDNVLSPDTPRWQEIVVIGGRKAISILDNPPRISTRRSSPVVSQAVIDGWNSKYEQFYNKRIAGPKKLNQNALLESLGNAHNGCQVLMGIMKTMTLKERANMSHVCKTWAMISRDRSVWKSVTLKDTYISNWIICMRELARHRTRDLDMMGMILAKPELRLTGDLRTLKSLRVLRTDPSDAEFLHLVFKHLTQLLELRSICTSDSLNLSNLESMRGLKVLRLHMIDPTAKINSLGTLGQLTNLTELCVRGATNLDEMEIGQLKALTKLETLVLGSCLDVDRVQLGQEVLPALTNLRHFRLENEHKLMDVFPIHDIMQGLAAAGQVKRLELVNVDVDEDFGHLMAKCKNLEELLLMPKCMHNTANMTNAVMQAVSDNADQLRVLRMGLAAQLLSATNYLCKGKDVVPVRRPVPGIPANDHLNFCSDDCFETDHGQCVAYLPMERLESILHHMMPQAWLSVAKIAMRDTTKLQFLKRLDVGKSMTRERQQQQLNQDQMLKEPKQTAP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00503267; iTF_00612072; iTF_00618409; iTF_00523695;
90% Identity: iTF_00618409;
80% Identity: -