Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.21 2.2e+02 2.1 0.1 6 15 11 20 4 24 0.65

2 3 0.86 9.2e+02 0.1 2.5 51 64 148 161 146 165 0.80

3 3 8.6e-12 9.2e-09 35.3 13.8 6 70 188 251 183 251 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.21	2.2e+02	2.1	0.1	6	15	11	20	4	24	0.65
2	3	0.86	9.2e+02	0.1	2.5	51	64	148	161	146	165	0.80
3	3	8.6e-12	9.2e-09	35.3	13.8	6	70	188	251	183	251	0.93

Coding Sequence: ATGTCCAGATCTCCGAAAGATGCGGATTACATGCGCTGTATGCATTGCCAGAAAGTGATCCGCGTCTCCCGCTGCGACCCCACATGCCTGCTGCGCCACGTCGAGCAGGATCATCCAAGTAAGTGCACAGTGCCCAGCAAGAAGAGCGCGCAGTGCAGCAAGAAGAGCAAAGATCTGAATTCGTCGGTTATGTCACAAATATCAGAGAAAATGGAGGAATTTTGCGAGAAGAACAGGAAGAAGTGCAAGCCGGCCTTATCCGAAGACCAATCCAGCGGGAAGATCAAGAGGATGCACATGCTGGCCGCCCAGCACGGAATCAGCGAGGAACGCCTTTCGGAGATCAGCAGAAAGACGGGCCTATCCGAGGCCCAGATGGCCGATAAGGCGGAGGCATATATGGCCAAGAAAAAGAGTTCCCACAGCGGCAAAGGGTCTGGTGGTTGCGAGAAGAAGGATAACGCCTGTCCGACCTGCCAGTGTGGCTCGGAAAAGGAGGCGGCAAACCGAAAGCAGTCCTATAGGCTCTCCATCAAGCGTTGGGTGCCGGCCGAGGGCTGCCTCTACTGCCCGTGTTGCGGCTGCCGTCGCCGTCCCCTGATCAAGGCCGCCTCAGAGCTCGTGACCACCAGGTGCTGCGCCACCTGTATTTTGGTTTGCTGGCCGTTGCGCCTTCTGCCCTGCCTGGTCTCGTCAGATAACCGGGAATATTTGTACTGCTCCAAATGCAGTGCCTTCCTCGGGATTTACGAGCGAGAGAAACGCTGCGTAAGGCCCAGCAAGGAGTTCTTGACCTGTTGCAACTCCGTGACGCCTCCGGCTACGCCGAAGTAG
Protein Sequence: MSRSPKDADYMRCMHCQKVIRVSRCDPTCLLRHVEQDHPSKCTVPSKKSAQCSKKSKDLNSSVMSQISEKMEEFCEKNRKKCKPALSEDQSSGKIKRMHMLAAQHGISEERLSEISRKTGLSEAQMADKAEAYMAKKKSSHSGKGSGGCEKKDNACPTCQCGSEKEAANRKQSYRLSIKRWVPAEGCLYCPCCGCRRRPLIKAASELVTTRCCATCILVCWPLRLLPCLVSSDNREYLYCSKCSAFLGIYEREKRCVRPSKEFLTCCNSVTPPATPK

Sequence clustering based on sequence similarity using MMseqs2