Dpar005237.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila paracracens
Gene Symbol
sd
Assembly
GCA_035044025.1
Location
JAWNMN010000357.1:7642003-7653914[-]

Transcription Factor Domain

TF Family
TEA
Domain
TEA domain
PFAM
PF01285
TF Group
Helix-turn-helix
Description
The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 8.9e-31 5.1e-27 93.9 0.1 2 66 68 134 67 136 0.96

Sequence Information

Coding Sequence
ATGCATATCAACACCCGGACACCCGGTCGTGTTTGTTGGGCAGTCGGACCCGGCACCATACCATCTCCGTGGCCACCAGTGAATGCCGGTCCTCCTGGTCCCCTGGGATCGGCAGACACAAATGGCAGCATGGTGGACAGTAAAAACTTGGATGTTGGCGACATGAGCGATGACGAAAAGGATTTATCATCCGCCGATGCCGAGGGTGTCTGGAGTCCGGACATTGAGCAAAGCTTTCAAGAGGCACTGTCAATATATCCACCATGTGGACGCAGAAAGATTATATTATCAGACGAGGGTAAAATGTATGGCCGCAACGAGTTAATTGCGCGCTACATCAAATTGCGCACGGGCAAGACGAGAACCCGTAAACAAGTGAGCTCCCACATTCAGGTGCTCGCCAGACGGAAACTGCGTGAAATCcaagcaaaaatcaaagtcGAACCCAATGGTGTCTCCTTGCATTTACTCAATGAGAAAGAGCAGACCCTACAGGCCATGAGCTCAATGACCAGCTCACAAATTGTCTCCGCACAGGCGGCCAATAATCTTGCCCTGGCCGCTTCGGCGCTGACGGCGGGCGTGCACCATTCGAAGCATCTTTCGCATTCCGCCCACAATCAGCATCCACAGCACCACCACCCACACCACccacaccaccaacaccaccaccatcatacgcaccaccaccaccatcaggTGGGTGTTgccgcagccgccgccgccgcagctgcagctgctgctgctgccgctgccggtGCTGTACAGTCGccggcagcagctgttgctgctattacTGGGTCTGGTGTGGCGTCCAACTCCGTTGCAGCAGTATCCACATCGTTGTCTCCACGACACCACAACCACCACGCCCATGCCCACGTCCACGCCCACCATTCCCATCACAATTTGCCGCACCACATGCATCCACACCATCACCAACATGCGGCGGCCGTTGCAGCAGTTTAtcacctacaacaacaacaacaacaacaacatcagctgcAACTTCAACAACCAAATGAGGCAACAACAGGTGCGGTATCACCAACATCTGTCGCTGATGGGGCACAATCACTACCGCCGCCGTTGCACCATCCGCCGTTGTATCCGGGCCAATTTTGGCAACCCGGACTGCAGCCGAGCACATCGCAAGATTTCTATGATTACAGCATCAAGCCGTTCGCCCAGCCGCCCTACACACCCGGCAAACCCTCGACGGCGGTGTCCGGCGAGATCGAGGCTGGTATTCCGCCCGCTCAATTGCCATGGGAGGGACGAGCCATTGCAACGCAGAAATTCCGCTTGCTTGAGTTTACGGCCTTCATGGAAATCCAAAGAGATGAAATCTATCACCGACATCTATTCGTGCAGCTGGGTGGCAAGCCATCCTTTTCCGATCCGCTACTAGAGACTGTTGATATTcgacaaatatttgacaaatttcCGGAGAAATCCGGCGGTCTCAAAGAGCTCTACGAGCAAGGTCCACAGAATGCGTTCTACCTTGTTAAATGTTGGGCGGATCTCAACACGGACGTAACGACCGGCAGTGAAACAGGCGATTTCTATGGCGTAACAAGCCAATACGAAAGCAATGAGAACATTGAGCTCGTCTGCTCGACAATCGTTTGCTCGTTTGGCAAACAGGTTGTGGAAAAGGTGGAGCACGAGTACTCGCGGCTGGAGAACAATCGCTACGTTTATCGCATTCAGCGCTCGCCCATGTGCGAGTACATGATCAATTTCATACAGAAGCTGAAGAACTTACCTGAACGCTACATGATGAACAGTGTGCTCGAGAACTTTACAATACTGCAAgTAATGCGAGCGCAAGAGACGAAAGAGACACTGCTATGCATAGCGTACGTGTTTGAGGTGGCGGCACAGAATAGCGGCACCACGCACCACATCTATCGCCTTATAAAGGAATAG
Protein Sequence
MHINTRTPGRVCWAVGPGTIPSPWPPVNAGPPGPLGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVEPNGVSLHLLNEKEQTLQAMSSMTSSQIVSAQAANNLALAASALTAGVHHSKHLSHSAHNQHPQHHHPHHPHHQHHHHHTHHHHHQVGVAAAAAAAAAAAAAAAAGAVQSPAAAVAAITGSGVASNSVAAVSTSLSPRHHNHHAHAHVHAHHSHHNLPHHMHPHHHQHAAAVAAVYHLQQQQQQQHQLQLQQPNEATTGAVSPTSVADGAQSLPPPLHHPPLYPGQFWQPGLQPSTSQDFYDYSIKPFAQPPYTPGKPSTAVSGEIEAGIPPAQLPWEGRAIATQKFRLLEFTAFMEIQRDEIYHRHLFVQLGGKPSFSDPLLETVDIRQIFDKFPEKSGGLKELYEQGPQNAFYLVKCWADLNTDVTTGSETGDFYGVTSQYESNENIELVCSTIVCSFGKQVVEKVEHEYSRLENNRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRAQETKETLLCIAYVFEVAAQNSGTTHHIYRLIKE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00495073; iTF_00497345; iTF_00560995; iTF_00519878; iTF_00528007; iTF_00495817; iTF_00513418; iTF_00496558; iTF_00568211; iTF_01325622; iTF_00516951; iTF_00508283; iTF_00616860; iTF_00560221; iTF_00518400; iTF_00544450; iTF_00564610; iTF_00501763; iTF_00549508; iTF_00552996; iTF_00593060; iTF_00522917; iTF_00506820; iTF_00563861; iTF_00512678; iTF_00540326; iTF_00582918; iTF_01324070; iTF_00476583; iTF_00552263; iTF_00567495; iTF_00526536; iTF_00582216; iTF_01327848; iTF_00597321; iTF_01323337; iTF_00532331; iTF_00538187; iTF_01322604; iTF_00545197; iTF_00572557; iTF_00516216; iTF_00573278; iTF_00576303; iTF_00498832; iTF_00509776; iTF_00530224; iTF_00482193; iTF_00546609; iTF_01326353; iTF_01320428; iTF_00490738; iTF_00502482; iTF_00522130; iTF_00547315; iTF_00901459; iTF_00599540; iTF_00493603; iTF_00607028; iTF_00570355; iTF_00609844; iTF_01327124; iTF_00492917; iTF_00506069; iTF_00543702; iTF_01324855; iTF_00559448; iTF_00551545; iTF_00574010; iTF_00619802; iTF_00485819; iTF_00548763; iTF_00473020; iTF_00525085; iTF_00616157; iTF_00542398; iTF_00558622; iTF_00498111; iTF_00521312; iTF_00530912;
90% Identity
iTF_00570355; iTF_00521312; iTF_00597321; iTF_00496558; iTF_00574010; iTF_00560221; iTF_00495073; iTF_00564610; iTF_00501763; iTF_00582918; iTF_00548763; iTF_00552263; iTF_00498832; iTF_00513418; iTF_00576303; iTF_00498111; iTF_00518400; iTF_00522130; iTF_00607028; iTF_00543702; iTF_00497345; iTF_00593060; iTF_00528007; iTF_00482193; iTF_00609844; iTF_00542398; iTF_00558622; iTF_00619802; iTF_00485819; iTF_00525085; iTF_00616157;
80% Identity
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