Dbuz016817.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila buzzatii
Gene Symbol
sd
Assembly
GCA_035045845.1
Location
JAWNOS010000596.1:16387784-16409166[+]

Transcription Factor Domain

TF Family
TEA
Domain
TEA domain
PFAM
PF01285
TF Group
Helix-turn-helix
Description
The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 7.8e-31 8.1e-27 93.5 0.1 2 66 161 227 160 229 0.96
2 2 2 2.1e+04 -11.1 9.1 32 44 460 472 436 488 0.46

Sequence Information

Coding Sequence
atgaacacacacacgcacacacacgcacatgtcGAGGCTGGCATTTCAAGTGGGGTGACTGATCCTGCtgcagcagtagtagcaggCATAACACCACCAACAACATCACTaacaacaccaccaccaccagcagcagcagcaccaccaacaacaactccaCCACCATCGCCATCACCATCGCCATCACCATCGGCAACAACGCCAGCAAAGCGTCTCGCACAGCTGTTCCTAATTTATTTGAAGAGCGACTCAGATAACGGCTCCAAATTGGCGCCGTTCTCCAAGCACTTGGATTCCCTAGAGGAATTTAAGACCCTGTCCGTTGGACCCGGCACCATACCATCTCCGTGGCCACCAGTGAATGCCGGTCCTCCTGGTCCCCTGGGATCGGCAGACACAAATGGCAGCATGGTGGACAGTAAAAACTTGGATGTTGGCGATATGAGCGATGACGAAAAAGATTTATCATCTGCTGATGCCGAAGGTGTCTGGAGTCCGGACATTGAGCAAAGCTTTCAAGAGGCACTGTCAATATATCCACCATGTGGACGCAGAAAGATTATATTATCCGATGAGGGTAAAATGTATGGGCGCAACGAGCTAATCGCGCGTTACATCAAACTGCGCACGGGCAAGACGAGAACCCGTAAGCAAGTCAGCTCCCATATCCAAGTGCTCGCCAGACGGAAACTTCGTGAAATTCAAGCCAAAATCAAAGTCGAACCAAATGGTGTCTCCTTGCATTTACTCAATGAGAAAGAGCAAACCCTGCAGGCCATGAGCTCAATGACCAGTTCACAGATTGTCTCCGCTCAGGCGGCCAATAATCTAGCCTTGGCCGCCTCGGCGCTGACGGCGGGCGTGCATCAGCATTCGAAGCATTTGCCGCAGCCCGCCCACCATCAGCATCCGCACCATCATCCGCACCTGCACCACCATCATCCGCACCTGCACCACCATCATCCGCACCACCATCATCAGGTGGGCGTGgcggcggctgcagctgctgccgctgctgctgctgctgcggcggctgccgttgccgttgcacaGCCACCGACGACTGGTGGTGCtagtggtgctggtggtgctggtagTTCTAGTGGTGCTAGTggtgttactgctgctgctggtgttggtggtgcAAGCACATCCAGCACCATTGCCGTGCCGCCGccattgtcgtcgtcgtcgtcgccatCGCCACGACTACAACACCACCATCACCACCACCACCTTCACCACCAAGCCCACCATTCCCATCACAATATGCCGCACCACACGCATAGCCATATGCATccacatcatcagcaacatgCGGCGGCCGTTGCAGCAGTTTACCacctacagcagcagcagcaacagcagcagcaacagcagcaccaacacctgcaacaacaacaacagcagcagcaccatcagcagcaacaacaacaacagcagcagcaacagcagcactcAAGTGGTGCAACAACAGGTGCATTGTCACCATCTGTGGCCGAGCCACCGCTGCCACctccgccaccgccgccgccattGCACCATCCGCCGTTGTATCCGGGCCAATTTTGGCAACCCGGTCTGCAGCCGAGCACATCGCAAGATTTTTATGATTACAGCATCAAGCCGTTCGCCCAGCCGCCCTACACGCCCGGCAAGCCATCGACGGCGGTGTCTGGCGAAATCGAGGCTGGTATTCCGCCCGCACAATTGCCATGGGAGGGACGCGCGATTGCCACACAGAAATTCCGCTTGCTAGAGTTTACGGCCTTCATGGAAATCCAAAGAGATGAAATCTATCACCGACATCTATTCGTACAACTGGGCGGCAAGCCATCCTTCTCCGATCCGCTGCTTGAGACTGTTGACATACGacaaatatttgacaaatttCCGGAGAAATCCGGCGGTCTCAAAGAGCTTTACGAGCAGGGTCCACAGAATGCGTTCTACCTGGTTAAATGTTGGGCGGATCTCAACACGGATGTGACGACGGGCAGCGAAACGGGTGATTTCTATGGCGTAACCAGCCAATATGAAAGCAATGAGAACATTGAGCTTGTCTGTTCGACAATTGTCTGCTCGTTTGGCAAACAGGTTGTGGAGAAGGTGGAGCACGAGTATTCCCGTCTGGAGCACAATCGCTACGTGTATAGGATTCAGCGTTCGCCGATGTGCGAATACATGATCAATTTCATACAGAAGCTGAAGAACCTACCTGAACGCTACATGATGAACAGTGTGCTCGAGAACTTTACAATATTGCAAgTAATGCGAGCGCAAGAAACGAAAGAGACACTGCTATGCATAGCGTATGTGTTTGAGGTGGCGGCGCAGAATAGCGGCACCACGCATCATATCTATCGCCTTATAAAGGAATAG
Protein Sequence
MNTHTHTHAHVEAGISSGVTDPAAAVVAGITPPTTSLTTPPPPAAAAPPTTTPPPSPSPSPSPSATTPAKRLAQLFLIYLKSDSDNGSKLAPFSKHLDSLEEFKTLSVGPGTIPSPWPPVNAGPPGPLGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVEPNGVSLHLLNEKEQTLQAMSSMTSSQIVSAQAANNLALAASALTAGVHQHSKHLPQPAHHQHPHHHPHLHHHHPHLHHHHPHHHHQVGVAAAAAAAAAAAAAAAAVAVAQPPTTGGASGAGGAGSSSGASGVTAAAGVGGASTSSTIAVPPPLSSSSSPSPRLQHHHHHHHLHHQAHHSHHNMPHHTHSHMHPHHQQHAAAVAAVYHLQQQQQQQQQQQHQHLQQQQQQQHHQQQQQQQQQQQQHSSGATTGALSPSVAEPPLPPPPPPPPLHHPPLYPGQFWQPGLQPSTSQDFYDYSIKPFAQPPYTPGKPSTAVSGEIEAGIPPAQLPWEGRAIATQKFRLLEFTAFMEIQRDEIYHRHLFVQLGGKPSFSDPLLETVDIRQIFDKFPEKSGGLKELYEQGPQNAFYLVKCWADLNTDVTTGSETGDFYGVTSQYESNENIELVCSTIVCSFGKQVVEKVEHEYSRLEHNRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRAQETKETLLCIAYVFEVAAQNSGTTHHIYRLIKE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00566752;
90% Identity
iTF_00544450; iTF_00545197; iTF_00540326; iTF_00476583; iTF_00532331; iTF_00502482; iTF_00568211; iTF_00516216; iTF_00473020; iTF_00573278; iTF_00572557; iTF_00509776; iTF_00599540; iTF_00559448;
80% Identity
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