Basic Information

Insect: Drosophila paracracens
Gene Symbol: ey_2
Assembly: GCA_035044025.1
Location: JAWNMN010000223.1:627535-646456[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.7e-72 2.6e-69 230.8 0.9 2 125 104 227 103 227 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.7e-72	2.6e-69	230.8	0.9	2	125	104	227	103	227	0.99

Sequence Information

Coding Sequence: ATGTTTACACTTCAACCGACTCCGGCCACAATTGGCAGCGTTCCGTGGTCCGCCGGAGCCCTCATCGAACGGCTGCCGACCTTGGAGGATATGAACCATAAGGACAATGTGCTTGCTATGAGAAATTTGCCGTGCTTGGGCGGCATTGGCGGCATGGGCGGCaaagcggcggcagcggcggcggcagcagcagccgcaacaacagctgcaatgGATGCCGCCGCGGATGTGACAGCAGCGCCACAGCCACCACACTCTACATCATCGTACTTTACCACAACCTACTACCACCTCACCGATGATGAATGTCACAGTGGGGTAAACCAACTGGGAGGTGTCTTCGTTGGGGGAAGACCCCTACCGGATTCAACTCGCCAGAAAATTGTTGAGCTGGCTCATTCCGGCGCTCGACCCTGTGATATTTCCCGGATTCTTCAAGTTTCCAATGGATGTGTTAGCAAAATTTTAGGCAGatattaTGAAACGGGAAGCATTCGACCACGTGCGATTGGAGGATCGAAGCCACGAGTGGCGACTGCTGAAGTCGTTAGTAAAATCTCTCAATATAAACGGGAATGTCCGAGCATATTTGCCTGGGAGATTCGGGATAGATTGCTGCAGGAAAATGTGTGCACAAATGACAACATACCGAGTGTATCGTCAATAAATCGCGTGCTGCGCAATTTGGCCGCCCAAAAGGAGCAGCAAAGCAGCGTCGGCTCCGCAAGCAGTTCCAACTCGAATCCCGGAGCAAACTCAAAGGCGACTGGGAGCGGTTCGGCTGCCGGTACCGTCACCGGGAGTGCTAATGGGAATAATATTGGGAGCAGCAACGGAACGGGGCCTGGCAACTCTGGGAATGATCTAATACAGACGGCAACGCCGTTGAACTCCTCGGAAAGTGGAGGAGCGAGCAACTCGGGCGAGGGGAGTGAACAGGAGTCGATCTATGAAAAGTTGCGTCTGCTAAACACGCAACATGTTGCGGCATTGGATGTGGCAACTGCCCCGCAAACGATGACGAGTAGTCACTTTAGTCCACATACCATCCACGCCCATTgtcatcaccagcagcagcagcagcaacaacaacaacaacagcagcaacaacaacaacaacaacagcagcagcaacaacaacatcagcaacaacaacaacagcaacaaagttgGCCGCCTCGTCATTATTCGACGGGTTCTTGGTATGCAGCACCTTTAAATGGTAGCAGCAATGATATCTCTGCCTCGTCTGGAGTTTTATCTGTGGCTGGGTATGGCAACACTGGCGCCGCTTCGGCTCCGGCGCCAGGTCATCCGTTGACGCCGCCCACGGATCTCATCAATATAGGTGGACCGAGCGTGAATCTGGGCAACTGTACCATTGCATCCGATGATGTGATGCTCAAGAAGGAGCTGGATGGTCATCAATCAGACGAAACGGGATCTGGCGAGGGAGATAACTCGAATGGAGGTGCCTCCAACATTGGCACAAGCGAAGACGATCAAGCCCGATTAATACTGAAGAGAAAACTGCAAAGGAATCGAACATCATTCACAAATGAACAGATTGACAGTCTAGAAAAAGAGTTTGAGAGAACCCATTATCCCGATGTGTTTGCACGCGAAAGATTGGCGGGGAAAATAGGATTGCCGGAGGCGAGGATACAAGTCTGGTTTTCCAATCGACGTGCCAAATGGCGACGTGAGGAAAAATTACGCAATCAGCGGCGAACACCAAATTCCACGGGCACAAATGGCACTTCCTCATCCACCTCGGCCACAACCTCGATGACGGAGAGTCCCAACAGTCTGGGTGGGGGCTGCTCCACGCACCTTGTCGGCTCAACTGGCAGTGGTCTGAATGGATTGGCTTCGCCCAATCCCATTGGGCCGGGAAGTGGAGCAAGTGAAGCTGGCGAGGCACAGATACGATCCATTGGCGTCACCCGATTGACTGATGAGGTGGGCAACGCCTGCTCGCCGGGTCTGGGCATAGGAGCggagcatcatcatcagcagcagcggcatccgcatccgcatcaggTGCCGCCGCAGCATCAGCCGCATccgcagcatcagcatcatcatcacatGGCGCATCATACGCTGGTGCCATCGATTTCACCGCGTCTCAACTTCAACAGTGGCTTCAGCGCCATGTATTCAAATATGCATCACAATGCAATCTCGATTGGTGATGGTTACGGCTCCGTTTCAACGATGCCCAGCTTCAGTCATGCCAGCGTTGGTGGCTCGCCAAttgcgcaacagcagcgcgATCTCAGTCCACCCACAATGTACCCGTGCCACATGCCACCGTTACGCCCGCCGCCCATTATAGGGCCCCATCAgttggtgggcgtggcaagtgTGGCTGCCGAGAGCGttgcgagcagcagcagtcctAGCCTGGCAACAGCTGGCAATGCAAcaagtggcaacaataacagcaacaataataatgccaCAAGTGGCTATGAAGCATTGTCTGCCTATGGCTTGCCCCCGCCACCGCCCCTGCCGCAGTCGGAGtcgcagtcagcagcagcagcgaatgcTGCCTCATGCCACCAGCATGGCAGCACCAACACAATGGAGCTGCCACGCCAGTCCAGCTGCAGTCCcagccatcatcatcaaatgGGCTTTGGCAGCGAATCCATTGCCACCACAGCAATGCCATCCTATGCCCACATGAGCTATAAttatgctgcagcagcggcggcaagcAGTGTGGCGCCATCTGTCGGTAGCGCCAATGCCACACACGGCACCACCAAACAACAATTCTTCGCTTCCTGCTTCTACTCGCCGTGGGTGTAA
Protein Sequence: MFTLQPTPATIGSVPWSAGALIERLPTLEDMNHKDNVLAMRNLPCLGGIGGMGGKAAAAAAAAAAATTAAMDAAADVTAAPQPPHSTSSYFTTTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSSVGSASSSNSNPGANSKATGSGSAAGTVTGSANGNNIGSSNGTGPGNSGNDLIQTATPLNSSESGGASNSGEGSEQESIYEKLRLLNTQHVAALDVATAPQTMTSSHFSPHTIHAHCHHQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQQSWPPRHYSTGSWYAAPLNGSSNDISASSGVLSVAGYGNTGAASAPAPGHPLTPPTDLINIGGPSVNLGNCTIASDDVMLKKELDGHQSDETGSGEGDNSNGGASNIGTSEDDQARLILKRKLQRNRTSFTNEQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGTNGTSSSTSATTSMTESPNSLGGGCSTHLVGSTGSGLNGLASPNPIGPGSGASEAGEAQIRSIGVTRLTDEVGNACSPGLGIGAEHHHQQQRHPHPHQVPPQHQPHPQHQHHHHMAHHTLVPSISPRLNFNSGFSAMYSNMHHNAISIGDGYGSVSTMPSFSHASVGGSPIAQQQRDLSPPTMYPCHMPPLRPPPIIGPHQLVGVASVAAESVASSSSPSLATAGNATSGNNNSNNNNATSGYEALSAYGLPPPPPLPQSESQSAAAANAASCHQHGSTNTMELPRQSSCSPSHHHQMGFGSESIATTAMPSYAHMSYNYAAAAAASSVAPSVGSANATHGTTKQQFFASCFYSPWV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00498095;
90% Identity: iTF_00566627; iTF_00619786; iTF_00527886; iTF_00527992; iTF_00619680; iTF_00548748; iTF_00548642; iTF_00525070; iTF_00524964; iTF_00558606; iTF_00558499; iTF_00521296; iTF_00521190; iTF_00495057; iTF_00494949; iTF_00497329; iTF_00497221; iTF_00593043; iTF_00592933; iTF_00482070; iTF_00482177; iTF_00522007; iTF_00522115; iTF_00560087; iTF_00560202; iTF_00606904; iTF_00607013; iTF_00609720; iTF_00609828; iTF_00597305; iTF_00597198; iTF_00496543; iTF_00496432; iTF_00573887; iTF_00573993;
80% Identity: iTF_00566627;