Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.6 3.3e+03 -1.7 1.6 6 12 11 17 7 27 0.56

2 3 6.6 8.2e+03 -3.0 0.1 11 22 129 140 123 144 0.69

3 3 3.6e-14 4.5e-11 42.7 9.9 4 70 154 220 151 220 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.6	3.3e+03	-1.7	1.6	6	12	11	17	7	27	0.56
2	3	6.6	8.2e+03	-3.0	0.1	11	22	129	140	123	144	0.69
3	3	3.6e-14	4.5e-11	42.7	9.9	4	70	154	220	151	220	0.96

Coding Sequence: ATGTCCCAGCCCATGACACCACCGGCCGATATGCAGTGTCTTCGGTGTCTCCATTGCATGAAGGTGATACGCTGCTCCCGCTACGACACCAGCGCCCTGGTGCGCCACATCGAGCAGGATCACCCGGAAATCTTCGCAGGAGCCAACGAGAAGGTCAAGAATCTGCACAAGCTGGCCGCTGCCCACGGGATCAGCGAGGAGCGTCTCTCGAAGATCAGCAAAATGACGGGTCTCTCAGAGTCCCAGATGGCCGACGAAGCGGAAAAATACATGGCCAAGAAGAAGAGCTCTGCACGGAGTGGTAGCTCCGGCGATGGAGATCCCCTGAACAAAGAACCCTCGACTGCAAGCTCCCCCAATAAGAAGTCCCCAGATCGCTGTCCATGTCCCGTGGAAAAGACGACCGAGATTCGGAGGAAGCGTTATAGGGCCTCCATCGAGCGATGGGCTCCGGCGGAGGGTTCCATCTTTTGTCCTTGCTGCGGCTCCAGCAACCGTCCGCTGATTAAGAGCTCTTCGGAGCTGAGTGGGTCCACCGGCTGCTGTGCATCCTGCGTGGTTGCCTGCTGGCCTCTGTGCTTCCTGCCCTGTTTGCTGTCGCCGGAGAACCGAGAGTACCTGTACTGCTCCAACTGCCGCACCTTCCTGGGCATCTACGATCGGGATAATAATTGCATTAAGCCCAGCAGGGAGTTTGTGTCCTGCGGCAAGTCGGCCACGCCCCCACCGGAACCGCCCCTCCAGCAGCCCTCTGATAAAGGTTTTAAGAACTTTTAG
Protein Sequence: MSQPMTPPADMQCLRCLHCMKVIRCSRYDTSALVRHIEQDHPEIFAGANEKVKNLHKLAAAHGISEERLSKISKMTGLSESQMADEAEKYMAKKKSSARSGSSGDGDPLNKEPSTASSPNKKSPDRCPCPVEKTTEIRRKRYRASIERWAPAEGSIFCPCCGSSNRPLIKSSSELSGSTGCCASCVVACWPLCFLPCLLSPENREYLYCSNCRTFLGIYDRDNNCIKPSREFVSCGKSATPPPEPPLQQPSDKGFKNF

Sequence clustering based on sequence similarity using MMseqs2