Dobs004449.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila obscura
Gene Symbol
hang
Assembly
GCA_018151105.1
Location
NW:418449-435997[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.26 16 5.9 1.0 3 23 214 235 213 235 0.93
2 17 0.16 10 6.5 2.7 3 22 343 362 341 362 0.89
3 17 0.00056 0.034 14.3 3.3 1 22 462 483 462 485 0.90
4 17 0.064 3.9 7.8 0.1 2 21 497 516 496 517 0.93
5 17 0.00065 0.04 14.1 0.2 2 23 658 680 657 680 0.95
6 17 0.0019 0.11 12.7 0.1 1 23 688 711 688 711 0.96
7 17 0.00024 0.015 15.5 0.2 2 23 797 818 796 818 0.97
8 17 0.00027 0.016 15.3 2.9 2 23 927 949 926 949 0.97
9 17 0.021 1.3 9.3 0.2 2 23 958 980 957 980 0.95
10 17 0.0019 0.11 12.7 0.2 1 23 993 1016 993 1016 0.97
11 17 0.00012 0.0071 16.4 1.1 1 23 1102 1124 1102 1124 0.99
12 17 0.0018 0.11 12.7 0.9 1 23 1132 1155 1132 1155 0.96
13 17 0.32 20 5.6 0.5 2 19 1163 1180 1162 1181 0.92
14 17 3e-05 0.0018 18.3 1.4 3 23 1276 1296 1275 1296 0.98
15 17 0.00064 0.039 14.1 0.2 1 23 1331 1353 1331 1353 0.97
16 17 5.7e-05 0.0035 17.4 0.6 2 23 1447 1469 1446 1469 0.93
17 17 0.0041 0.25 11.6 0.5 3 23 1525 1545 1525 1545 0.98

Sequence Information

Coding Sequence
ATGAAACACTCCGCTCCCTCTAGTAAATGGAAAAGAAGGATAACGCCACAAGATCGGCTGTCACTGCAGATCTGTCACGCCTGCATCAGCTACTTGAACTCGTGGCAGAGCTTTAAGAATCGCTCGGTTAGCGCACAGACCAAACAGCGCCAGTGGCTGGAGGCCAACAAGAGCAAGCTGCTCAGCTATTTGGACTTGAACAGTGCCGAGAATGGAGGAggtcatcagcagcagcagcagcatcaccaccaccaacagaaccagtcacagtcacagcagCATCATTCGGAGAATGAGATCGATTTGGAGAAGCCATCGGCCGCCCAAATATTGGACGGCATACCCTCGCTGAAGAAACGCAAATCCCTAACAGTCTATCCACTGCCCGCAATTCCCATCAAGGATGAGCCCATTGACACAGATGATGATTATCAAATGAAATCGTTGGACGAATCCGATGACATGGTCGATCCCACAATGTTCCTAGAACGCTCCGAGCACGAGGGCGATGTACCACTTATGACCTCCGACTATGATTATACGGCGCAGCATGGTGTGAATGCAGAAACAGCGGCCGCCTCGCTGCCGCCCAATGCTGTGGCTAATGTGGCCGCCGCCGGGGACTCAAAGGTGGCCAGCTGCCGGGCATGCAGTCTCCAGTTTTCGACGCGTGCCAATGCCCGACGCCATGAGCGAAATTTGCACCCAAATCTATTCCAATTGTCGACAGACTCGCCCAACAATACGCCCATCACAAAGCCCACACCGGCACTGGCGGCTGCATTGGAGATACAGCGTGCCGCTGCGGAGGCGGCCACCGAGGAGGCCAGCAAAGCTGCCGGCGCTGCCGGGGGTAATATATCGACCCAAAAGTATCGTCAGGTGGTGATGAATGCCTTCATCAAATGCGAGGGTGGGGGCTTCAACTATGACAATCCGGAGCAATATCAGCTGCTGCTCACCCGCGACAAGGTGGAGTTTATCGAGCAAAATTATGAATTCCTTGAGCAGTACCAGACGATGACATGCCGCTGCTGCGACAAATACTTTAGTACGTACAAGAACTTTATGGCGCATGTGCGTAAAAAGTATCCGCTGTTGCCGCGTAATCTCTGCTTCAACTGCCTCAAGATGAACGAATCGAAGGCGCTGTTCATTTCACATCTCAAGAAGCGCAACTGCATCAATCTGTATCGTGTGCTGAACGCCCTGCGCGGCAAGCAGCCAAACTTTCATCCCACATCATCGGACCTGGGTGCATTCGGTGGCGAGACGACGACCCAAATCAGTCCCACTGTCgttgtgccgctgctgctcgaTAACAGCTCGAGCGGCGAACGGCCGGAGAAGCTGCGCGCCAAGGAGCTGCTGGTGAATAAGCTTTACGAGTGCAAACTCTGCCCCAAGGGCTTCCGCACCAAGCACGAGTTTCGCACCCATGTGTACGACAAGCATGCGGATGTGCAGCGCAAGGACAACAATTCGATACAGTGCAGCTTCTGTGGCCTGGACTTTGCCGATCCCGTGGACAGGCGACGCCACTACAACAATATGGACTGCATTGTCCGGCTACGCTGCATGACGTGCGACGCCAAGGTGGAGACGCATCAGCGTTTCCTCGATCATGTCTATCAGGATCATTTGGGAGGTATAAGCAGCGATAATGCCTCCACTGTCAGTGGAATGGGCGGAGGTGGCGGtggtaggagcagcagcagtattgAGAACTCACCTGGCAAGCGGAGTCTACTGGGTGCCCTTGGAATTGGAGTTAGCTCCCCCGCCGATGAGTCACGCAGCGgcagtgcagcagcggcagcagcagcagcacccaatCAAACCTCAACGCCAAAGCCCATATCgggaggaggtggtggtggtggtgtggcgGCGTCTTGCACAACACCTGGCTCCCTAAATCGTGACGCCGGTGGTGCACCAAAATCGCAGTATTTCTCACGAATGCCACAGGTATGCCCcatctgtggccagcagtacaacaactacaacaacgtTCTGCGTCACATGGAATCGAAGCATCCAAACAAACTGCCGGAGACATACAAATGCGTGCGTTGCGGCCTGGGCTATCCAAGAATCTCGTATCTGCGGGAGCACATGATCAATGTGCATGGCGTCGACAAGAATCGACATTCCGGTGGCTTTGAATACATTGTGAATGCGGATGCCGTCAAGCTGGCCGATGGCAGTACACCGAATGTATCCACAGGTCGTTACGACTATGTGATGAAGGATCTGATGTCAATAACAAATGGTGGGACACTCGAtgatgacgaggaggagaccgGCAGCATGGCCAAGAAGATACGCCTCGACgatagcagcaacaacagcagtcTGGTGGGTGGCGTGGCCAGCCAGCAAAAGGAATGCCCCATCTGCAATGCCCTGTTCAGCAACAATATTGGCCTGTCCAATCACATGCGCTCACATTACACGGCCTCGAATTCGGTGAATGCCGCTCTGGTGGCGGCCAATCGCATGACACCCAAATCGCTGACCATAACCGCCGCCCCAGCCACAGAGACGGTCACATCATCGGCAGCCTCCatggatgtggatgatgatgatgagggtATGCTGGCGCTCGAAACAGGAAAGCTGATGGCCAGCGTCAGTGGTGTTAGAGGTGGTGCTGCTTCTAGTTCGgctactgctgttgctgtgcccCCTGCCATGGTTAATCAGACGCCTCAGGAGCAGGCCGTATTCCGTCGTAGCCTTGATCAGGCGGCGGATCGTCGCTTTCGCCGGATGCGCTGCCGCATCTGTCAGCGGCGTTTTAGCTCAAAGAAATCGTACCGCTATCACATGCTGACCGACCATCAAGTGCAGAATGTGCAGTTCATCAAATGCAAGCTGTGCAATGCCGAGTTTGCCTACGAGAAGGGTCTGAAGGTGCATCTGTTCAAGGTGCACGGACGTGCGATCAAGGATGAGATGATTGTGAAGCAGTTTGAGTGCGATGTCTGTTCGATTGTCTACAGctcggagctggagctgaagcagcACAAGAGGAGTGTCCATAAGCTAACGTCCGTGTCGGTGTCTGCATCTGCCTCGGCATCGGCTtcggcctctgcctctgcatcCACATCCTCGAAAatcaatgatgatgatttaaTGATCATGGAGGAGATTGGTGGCAATAGAAGCcgtcaccatcaccatcatcatcagcagcaccaccacagcAAGTCGTCTGGCGACTTGGCCGATCAGTCCATCATTTCCGCTGTgggtgccacagccactgccgccACAACGACGCCGCTGTACTGGTACCAATGCAAATACTGTCCCTCCAACTttaacacaaacaaaaagctgGCCATCCACATCAACTCGCACGATGAGTTCGACTCGAATGATTATTCGTGCAAGGACTGCGGCAATGTCTATAGCGGCCGCAAGAGTCTATGGGTTCATCGCTACAAAAAGCATCCGCAGGTGCCCGACCCCATCGAGTGCACGCTGTGCCGCAAGGTGTTCTTTGACCATCAGATGCTGGACAATCATACGCCAACCTGCAACCGCAAACCGATTACCTCCACGGGGGCGCATCAACAGGAGCTGCTTACGCAGACAAATTCATCGCAGGGTCGGGCCGTATTCCGGCACAAGACTGGCGACGATGATGACGAGGAAgacgtgcagcagcagcagccgcagcaccgtcatcagcagcagcgtaaCCATCAGGAGGATGCTGGTGATGGAGGAGCAGCCgtatcagcaacaacaacaacagcagcagccacatctAGTGGCAGTACCAAGAAGCTGCGCACACCGGAGGTGGCATGTACAATTTGTGGTGCCCGTTTCACCGATCAGGAGCACTTTAGCAAGCACATACAGAAGCATGAACAGGATCTATATGTGGACAATCCGTTGGCGGCGATGTTCGATGATGGGCCAGCGGATGCGGCCCAATTTAAGGTGGAGGGCCAGAACGAGAATGGGGAATATGCGTGCGATATGTGTACAAAGACATTCCCCCAAGTGATTGCACTCAAAGTGCATCGCAAGTGGCATTTCAGAGGTGATAGCAAGCAGAACCACATCGACAGCGAAACGACGAatatcatcaacaacaacaacaacaattcgGTGAACAACTCCACATCGATGCTACGGGAGCTGCATGCAGTGGGTCTGACGCccaaccaacaacagcaacagcagcagcagagccaacaACAGAACTCCACGTCCACGccgaacagcaacagcaacaacaacagcagcagcaggagcaacaacaacaacaacagcagcagcaggagcaaatCAATGAAACGGAAACGTGAATTGAAATGCGAATACTGCCCCTCGACCttcatcagcaacaacaacctgCGACGACATATGTATGAGCTGCATAAGCATGAAGTGAGTAGCCTGCCAGCACCGCCAGTGATTGTGGTTGATGAGCCACTGAGCTGTCGACGTTGCGGCAATCTGAAATTCGAGACAAAGGAACTGTGGATCGAACACAAGCTGGCCGATGCGAAGGTGGTGCGACCGTTTTGTCCCTTCCAATGGGGCTGTGATATGTGCGGCGAGTACTTGTCGCGCAAGGAGAAGCTCATGAATCACATCAATAATCATTTGAAGGAGGATGTCATTGTACCAGTCGCCACACAATCGGCCATCGACAGAGAACGGGCATCATCAGGTGCATCGTCAGCATCCGAGGCAACAACATCCAAAGCATCCGGATTGGTTGAGCCGCCACCCAGCGCCGCCGCAGCGTTGCAAAAGAAAACGGAAGAGAATGGTGGACTGGATACAGCGGAGGcgacggcggcagcggcagaggcagaggcggtGAAGGCAGAGGAAGATGATAGCGAAATGGAGGACGGGGACAGCTCAGACGCTGATGAAGAAAGCTCCGGCACAGGGGatgaggacgacgacgacactgAAGACGATGATGAAGAAGATGAGCTGCAGGATGAGGACGACGATGAAGATGAGGGCGAAGATGAAGAGGGTGTGCCCCCACCAACACCTGCCACACAATTGTTGCAGCCGCAACACAAGCATGCCAATAATAttgacaatgatgatgatctCGTCGAGGAAGTGAACAGCTCCGATGATGAGGAGCCAGAGGATGGAGGTGAAGTCGGGAGCGAAAGTCAAAGCGATgaggacgatgacgatgaagaagacgacgacgacgacgacgatgaagaagacgaagacgacgagGAGACGGAGGaggtagaggcagaggcacagggcTCGTCACAGCCCCTTATGAATGGCAAGTCTGAAAAGCATCAAACCACGCCCCAACAGCAAAGGGATGAGATATTGCCCAGCTCCGACGAGGACAACGAAGATCAGGATGGCCATCCAATGGCCATTGAAGACATTATTGAAGAAGAATTTGATGAAGACGATGATGTGGAGGAGGTGTATGATGAGCAGAATGTCGATGGGGGGGCCACATCGTCGGCATCTTCATCAGAGAGCGAATCAACATCCACGACCACATCCAATTCGCATTCAACTGGAGCTTCTCCAGTCTCACATCAAAAGCCATTTTCTCAATGGTCCAAAAATCTCTGCCTCACAAGCAACAAGCAATGCAACAGCAgtagcaccagcaacagcaacggcaacggtaACGACGACGGccacggcagcggcagcggcgacgACTGTTCCCAGCAGTTGTAA
Protein Sequence
MKHSAPSSKWKRRITPQDRLSLQICHACISYLNSWQSFKNRSVSAQTKQRQWLEANKSKLLSYLDLNSAENGGGHQQQQQHHHHQQNQSQSQQHHSENEIDLEKPSAAQILDGIPSLKKRKSLTVYPLPAIPIKDEPIDTDDDYQMKSLDESDDMVDPTMFLERSEHEGDVPLMTSDYDYTAQHGVNAETAAASLPPNAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPNNTPITKPTPALAAALEIQRAAAEAATEEASKAAGAAGGNISTQKYRQVVMNAFIKCEGGGFNYDNPEQYQLLLTRDKVEFIEQNYEFLEQYQTMTCRCCDKYFSTYKNFMAHVRKKYPLLPRNLCFNCLKMNESKALFISHLKKRNCINLYRVLNALRGKQPNFHPTSSDLGAFGGETTTQISPTVVVPLLLDNSSSGERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKVETHQRFLDHVYQDHLGGISSDNASTVSGMGGGGGGRSSSSIENSPGKRSLLGALGIGVSSPADESRSGSAAAAAAAAPNQTSTPKPISGGGGGGGVAASCTTPGSLNRDAGGAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVSTGRYDYVMKDLMSITNGGTLDDDEEETGSMAKKIRLDDSSNNSSLVGGVASQQKECPICNALFSNNIGLSNHMRSHYTASNSVNAALVAANRMTPKSLTITAAPATETVTSSAASMDVDDDDEGMLALETGKLMASVSGVRGGAASSSATAVAVPPAMVNQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGRAIKDEMIVKQFECDVCSIVYSSELELKQHKRSVHKLTSVSVSASASASASASASASTSSKINDDDLMIMEEIGGNRSRHHHHHHQQHHHSKSSGDLADQSIISAVGATATAATTTPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPDPIECTLCRKVFFDHQMLDNHTPTCNRKPITSTGAHQQELLTQTNSSQGRAVFRHKTGDDDDEEDVQQQQPQHRHQQQRNHQEDAGDGGAAVSATTTTAAATSSGSTKKLRTPEVACTICGARFTDQEHFSKHIQKHEQDLYVDNPLAAMFDDGPADAAQFKVEGQNENGEYACDMCTKTFPQVIALKVHRKWHFRGDSKQNHIDSETTNIINNNNNNSVNNSTSMLRELHAVGLTPNQQQQQQQQSQQQNSTSTPNSNSNNNSSSRSNNNNNSSSRSKSMKRKRELKCEYCPSTFISNNNLRRHMYELHKHEVSSLPAPPVIVVDEPLSCRRCGNLKFETKELWIEHKLADAKVVRPFCPFQWGCDMCGEYLSRKEKLMNHINNHLKEDVIVPVATQSAIDRERASSGASSASEATTSKASGLVEPPPSAAAALQKKTEENGGLDTAEATAAAAEAEAVKAEEDDSEMEDGDSSDADEESSGTGDEDDDDTEDDDEEDELQDEDDDEDEGEDEEGVPPPTPATQLLQPQHKHANNIDNDDDLVEEVNSSDDEEPEDGGEVGSESQSDEDDDDEEDDDDDDDEEDEDDEETEEVEAEAQGSSQPLMNGKSEKHQTTPQQQRDEILPSSDEDNEDQDGHPMAIEDIIEEEFDEDDDVEEVYDEQNVDGGATSSASSSESESTSTTTSNSHSTGASPVSHQKPFSQWSKNLCLTSNKQCNSSSTSNSNGNGNDDGHGSGSGDDCSQQL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00480993;
90% Identity
-
80% Identity
-