Basic Information

Insect: Drosophila novamexicana
Gene Symbol: L
Assembly: GCA_003285875.3
Location: NW:2535994-2544969[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 17 9.5e-06 0.00051 19.9 2.9 1 23 168 190 168 190 0.98

2 17 0.33 17 5.6 6.2 1 23 196 218 196 218 0.97

3 17 1.6e-07 8.4e-06 25.5 3.2 1 23 224 246 224 246 0.99

4 17 1.2e-05 0.00062 19.6 0.4 1 23 252 274 252 274 0.99

5 17 0.011 0.59 10.2 0.1 2 23 347 371 346 371 0.92

6 17 0.00071 0.038 14.0 0.2 2 23 399 421 398 421 0.95

7 17 0.026 1.4 9.1 0.7 1 23 492 514 492 514 0.97

8 17 0.0072 0.38 10.8 0.1 2 23 522 543 521 543 0.91

9 17 0.00061 0.032 14.2 0.1 1 23 551 575 551 575 0.94

10 17 6.3 3.4e+02 1.6 1.6 2 23 611 633 610 633 0.94

11 17 0.0024 0.13 12.4 1.1 1 23 687 710 687 710 0.97

12 17 0.006 0.32 11.1 1.6 2 23 882 904 881 904 0.96

13 17 0.11 5.7 7.1 0.1 1 23 910 932 910 932 0.92

14 17 0.52 27 5.0 0.4 2 23 940 961 939 961 0.93

15 17 0.69 37 4.6 0.5 2 23 1063 1084 1063 1084 0.94

16 17 0.029 1.6 8.9 0.0 1 23 1094 1116 1094 1116 0.96

17 17 0.00021 0.011 15.7 1.2 1 23 1121 1143 1121 1143 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	17	9.5e-06	0.00051	19.9	2.9	1	23	168	190	168	190	0.98
2	17	0.33	17	5.6	6.2	1	23	196	218	196	218	0.97
3	17	1.6e-07	8.4e-06	25.5	3.2	1	23	224	246	224	246	0.99
4	17	1.2e-05	0.00062	19.6	0.4	1	23	252	274	252	274	0.99
5	17	0.011	0.59	10.2	0.1	2	23	347	371	346	371	0.92
6	17	0.00071	0.038	14.0	0.2	2	23	399	421	398	421	0.95
7	17	0.026	1.4	9.1	0.7	1	23	492	514	492	514	0.97
8	17	0.0072	0.38	10.8	0.1	2	23	522	543	521	543	0.91
9	17	0.00061	0.032	14.2	0.1	1	23	551	575	551	575	0.94
10	17	6.3	3.4e+02	1.6	1.6	2	23	611	633	610	633	0.94
11	17	0.0024	0.13	12.4	1.1	1	23	687	710	687	710	0.97
12	17	0.006	0.32	11.1	1.6	2	23	882	904	881	904	0.96
13	17	0.11	5.7	7.1	0.1	1	23	910	932	910	932	0.92
14	17	0.52	27	5.0	0.4	2	23	940	961	939	961	0.93
15	17	0.69	37	4.6	0.5	2	23	1063	1084	1063	1084	0.94
16	17	0.029	1.6	8.9	0.0	1	23	1094	1116	1094	1116	0.96
17	17	0.00021	0.011	15.7	1.2	1	23	1121	1143	1121	1143	0.97

Sequence Information

Coding Sequence: ATGATGGCTTTAAAGATGTTGTATCGCGGTCCCAGTTCGCGTTTGgagaatttaattgaaaagatTCAAGCCACCAAGGAGATTACAAATAACGACATGTACAGCACGCACACCTCCTCCAGCTACTCGCCGAGCATCTCGGACGGCACATTGACGCCCAATtcgcagcagcatcagccaCAATTGGCGACAGCTGCCGCGGCACACACATTGGAAGCCCCCAGCGGCGAGGAGTCTAAGGCGAATGGCGAAGCTGTTGCCGCACAAtcggagctggagcagcaggaacaggagGCAGCCAGACCCAAGCGACCTGCACAtttgcatcatcatcatcatcatcattatcatcatcagcaggCGCTGAAAATTGCGAACAAGCTGCGTAAAATCAATAAGGATGCCAAACTGGCAGCTGGTGGCACAGGACCAGGACACGGAACAGCCGCCAAGTTTGATAAGTTGACAGGCGAGGGCATTAAAAGTCGAGGCGACGGCTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGTCTCGGCTACTTGAAGCATCACGTGCAGaGTCATGCCGAGCATTTGCCTTTCAAGTGCGAATATTGCGCCAAGCTCTTCAAGCACAAACGTTCCCGAGATCGTCATAAGAAGCTCCATACCAACGAGAGGAACTACAAGTGTCCGCATTGCGAGGCTGCTTTCTCGAGAAGCGATCATTTGAAGATTCACATGAAAACGCACGACATCCAGAAGCCCTTCCAATGCAGCATGTGCAATCGTGGCTACAACACGGCCGCCGCTTTGACCTCGCACATGCAGAAGCACAAGAAGAATGCCGCCATCCTGGCAGCTGGCGGCAATCCCAATGCCCTCAACTATAGCCCCAGATCGACGGGGTCCGCTTCCATTTCGAGCAATGGCAGCCTGCACAAGCGTCGCTATGCGCTGGCCCTCGCCTCCGACAGCAGTCCCAGTCGCTTGGACTTTCCCAAACGCTCTCGGGCGCATGTCCCGACCACGCCCACGCCGACACCGCTGCTGCGCTGCAGCTACTGCCCGAAGGTGACGGAATTCAGCAGCCTGGAGCAGCTGAATGCGCATCTGCAGAGCGCACACGAGCAGCGAGAGACGCGCAGCTCGACCGCCACGGCAGGCGGGGAGGCTGGAGAGGCTGTGCAGGCGAATGGCTTCCAGTTGAGCTGCGAATACTGCACGATGAAATTTGCGAATATCGCTGCGCTGTTTCAGCACATGCGGGCCACACACTTGGATAGGCTGAGCAGTCCAAACTCCTATTACGAGCACTTCAATCGCCTGGCCACGGCGGGCACATTTAGTCCCAGGCTGGCGCTGGAGCTGCCCAAGATCAAGCAGGACCTGGCCAGTCCACAGCCGCAAGCTGTCGAAAAGCCGGAACAGGAGCTGCCCACAGATCTAAGCAGCAATAAGCGTCGCCCGTTGACGCCGCCGGGCGTCTTCTTTTGTAATCAATGCAATGCCGGCTTGCCGGACTTCGAGAGTTTCCGGAATCATCTGAAGACGCACATAGCCGAGGGCATGCAGCTGATCTGTCCACACTGCGGCCTGAGCTTGCCCGAGCAGAGCGAATACGAACGGCACGTGGTTGCCCatttcttgatcagcagctCCGAGTTCAactgcagcgccagctgcgGAAAATCCTATGCCAAGGccgaggagctgcagcagcatttgctCAGCGAGCACGTGCTCACGATGCTCAAGTGCGCCCTCTGCTCGGAGCTGTGCGAGAATCGGATGTCCATGCAACTGCATCTCGCCTGCGCGCACAGCCAGGAGTCGAAGTTGTTGCGCTGCAGCGCCTGCCTGGAGCTATTTCGCAGCGACACGGACTTCCATGTGCATGTCAAGACGCGCCATCAGCTGGATCGTGGATCGGCAAATGGTGCTGCCgcggccgctgccgctgctgcggctgccgtcTCCGCGCCCGCCAATCCGCTGCAGTGCATGTTCTGTCGCGCCGTTTGCGCCTCGGAGCTGGAAATGCATTTCCATTTGGCTGCGCATGCGCGACAATTCCGCTGTCCCAGCTGCCCGGAAACATTCCATGTGGAATTTCTGCTCGATCGCCACATGCAGAGCCAGCATGGCGGAGGCGTCAAGGATAAGGAGCCCGGCTCCAATATGGGCAGCCTCTATGTAAAtgcgctgctgccgcccctggcagctgctgccgctgccgccgccgtggcgaccaacaacaacaacaacaacaacagcaacctgCACATCGACTACAATGTGGCCTTCAAGGGCCTGTTCGGCGGCACGCCCAGCCCAGCGCAGGCGAACAGCAAATTCTATAGTCCACTGCAGGTGGACACCAGCGCGCTGAAGCCACAGCAAACGCCGCATCCGGCTCTAATGTACGGCCTGAGCCAGCGCTATCTGATGGAAATGTATGCGGCCAAGGCCACATCGCCGGCAGCCAGTGCACCCGAGCTGCCGGCTGCCAGCAGCcaagcaacagccacagcgtCCAGCGCAGGCGGGAGTAGCAGCTACAGCTGCGGCATGTGCGAGCGGCAGGATTTGCGCAGCGAAGCGGAGCTGCATTCGCATCGCAAGCTGGCGCATAATCTCAAGACGGGCGTCAGCCTGAGATGCGCCTATTGCTCCGGCAATTACAAGTCGCGCGCCGAGCTGGAGCAGCACATGAAGAGCTGTCACAATTCGAGCGGCAAACACAAGTGTCTCATCTGCGACGAGATATTTCCCTCGCCCGCCATACTCGCCGAGCACAAGCTGCAGCACAGCAAGGTGGGCCAGTCCGGAAAGTGCGCCCACTGtggccagcagctggagcatGTGGCCGCCTTTCGGGCACATCTCGGTGAGCATGGCAATGACGGGCACCTGCCCATGGCCTGCATCTGTTGCCGGCAGACATTGCACTCGGAATTCGAGCTCAGCTTGCATGCCAAATTCCACACCAAATCGCCGGGCAGCGGCAGTCTGCAAGAGCCGGTCTGTGCTCTGTGCCTGGAACCATTGCCGGGTGCAGCGGGTGAGACGGCCAAGCTGTGCGAGAAATGCTGTCGCAAGCATAATCTCAATGGCAAGCGCAAGGAGTCAACGGCGGCGGCTCCTCCTCCGCCCCCTGCTGCTCCCCCTGCCACGGCAAGCACAGCCTATCTGGAGAATCGCTGTAATCTGTGCAAAATGATACTGCCGCACGCCCAGAAACTGCAGGAGCATCTCGTCGAGCACACCTTTGCAGGCACCGAGCAGCGCGGCTTCAATTGCTACATCTGCTCCGCGGTCTTCACGGCGCCCGCTGGCCTCTTGACCCACATAGCCGAGCATGGCGCGCGACCCTATGACTGCAATCTGTGTCCGGAGAAATTTTACTTTCGCGCCGAACTCGAGCATCATCAGCGCGCTCACGAGCTGCGACCGCCACCACCAACAGCAGGAGCTGCGCGTGGAGCACAGCCCAAACAGGAGACGCACAGCTCCACGACCAGCTCACCCCAGGCGCCCAGTCCCAGTCATGTCAAGCAGGAGCTGTACGAGTCGGAAACGGCCAACTCGCCCAATGCTGAGCAGCCCCatcaggaggaggaggaataTATCGAAGTGGAACAAGTTCCGCAAGAGACGCTGCGCTCCGGCGAGCTGCTCAGCACCGAGcgctccagcagcagcgcctga
Protein Sequence: MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTLTPNSQQHQPQLATAAAAHTLEAPSGEESKANGEAVAAQSELEQQEQEAARPKRPAHLHHHHHHHYHHQQALKIANKLRKINKDAKLAAGGTGPGHGTAAKFDKLTGEGIKSRGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASISSNGSLHKRRYALALASDSSPSRLDFPKRSRAHVPTTPTPTPLLRCSYCPKVTEFSSLEQLNAHLQSAHEQRETRSSTATAGGEAGEAVQANGFQLSCEYCTMKFANIAALFQHMRATHLDRLSSPNSYYEHFNRLATAGTFSPRLALELPKIKQDLASPQPQAVEKPEQELPTDLSSNKRRPLTPPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQLICPHCGLSLPEQSEYERHVVAHFLISSSEFNCSASCGKSYAKAEELQQHLLSEHVLTMLKCALCSELCENRMSMQLHLACAHSQESKLLRCSACLELFRSDTDFHVHVKTRHQLDRGSANGAAAAAAAAAAAVSAPANPLQCMFCRAVCASELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGGVKDKEPGSNMGSLYVNALLPPLAAAAAAAAVATNNNNNNNSNLHIDYNVAFKGLFGGTPSPAQANSKFYSPLQVDTSALKPQQTPHPALMYGLSQRYLMEMYAAKATSPAASAPELPAASSQATATASSAGGSSSYSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCSGNYKSRAELEQHMKSCHNSSGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCAHCGQQLEHVAAFRAHLGEHGNDGHLPMACICCRQTLHSEFELSLHAKFHTKSPGSGSLQEPVCALCLEPLPGAAGETAKLCEKCCRKHNLNGKRKESTAAAPPPPPAAPPATASTAYLENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPAGLLTHIAEHGARPYDCNLCPEKFYFRAELEHHQRAHELRPPPPTAGAARGAQPKQETHSSTTSSPQAPSPSHVKQELYESETANSPNAEQPHQEEEEYIEVEQVPQETLRSGELLSTERSSSSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538445;
90% Identity: iTF_00526768;
80% Identity: -