Dnov011377.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila novamexicana
Gene Symbol
BAZ2B
Assembly
GCA_003285875.3
Location
NW:3867024-3893674[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 9.1e-13 2.3e-09 36.3 0.0 5 75 999 1069 995 1071 0.91

Sequence Information

Coding Sequence
atgaacaaaaatgcCGGCGATGGCAGCGGCAATGATGGCAAAAACTCAAACAATCACGGCAAGGGCGGCTCCGGCGGGGGTGGCGGCGCAGGGGCAGGCGGGCCCCACGATCCCACCGGACTATTAGACGCTGCGTCGCTGTTTGCTTATTGGGGCCGAGATCCCACTggagctgcagccgcagctgcttCAAATCCGCTCTTCAACTCGCAGTtcaatgctgccgctgccgccggctTGGGCCTATTACCAAATGCTGCGGGCGCAGCGGCTGCCAATGACCGTTACTCATCAATggccgcagcagcggcggcagctgcaggcGCCCACCATCACCAGAACACAATGGCCGTCGCGGCCTCCCAGGCCGCCAGCCTGGCAGGTCTGCATCCAGCAAGCTGGTGGTCCATGGCTCAGTTGGCCGCACAGGATTACTTTAGCCGTCTGCAGGCCTCCGGTCTGTCGCCGTTTCCCCATCCTGATCTGGCAGCTGCCTTTGGGCCCGCCGCCATGGCCATGGGTGGCGCCGGCACGGGCTCAGGTGCGGGAGCAGCGGGCGGCGCGGGCATGGTCGGAGTAGGTGGTGGAGGTGGCGCcgcgggcggcggcggcagcggctccaGCAGCAAGTCGAACAAGTCGCGCAAGGAGAAACGCGccgcccaacagcagcagcagcaacaacaacagcaacagcagcagcagaatctGGCCAACAGCCTGAACgccgcggcggcagcagcagctgcagcagcagccaacaaTCCCGCCGCGGCCTTGGCCAGCATGCACGGCTTCGGACTGCCGGGCACTAGCATGCCGCCTTCCGGCAGCAGCGCCTCCATCTCGACAAGCAGCGCGGGCCACGGCGGCTACAAGAGCACTGCCAGCGCGTATGGCAAACCCTCGACAATgaccagcagcggcagcagcaacagtattGCGAGCAATCCTGGCTCTGCCTACGATCCGGTCACCCTGCACAAGGAGCTGCTGGCCATGCAGGCCGTCGCAGCGGCCGCCTCCGGCTCCGGCGTGGGCGGCATGTCGGGTCTCGGCAGTGGGGGCGGCTCGAACAGTTCCTCTGGCAAGAAATCTAGCGGAGCTGGTGGTGGCTCATCGCTGCATGCTCACGGTCTGTCCAATCTGGCCATGAGCCTAGGCGCAGGCGGCAGCGGTGGTGGCGGCAGTGGAAGTGGCATCATGTCCAGCAGCAAGACGTCGACCAACGTCAGCTCAAGCTCGAGCGGCGGCGCCTCGCTGGGTGGCATGCACCCGAGCATGGCCATGTCGCCGCATGCAAGCATCTCTGGCAGTGGCATGGGCAGCTCTGGCAAGGATCGGGATCGCGACAAGAACAATCCGTCGCTCAATGCCCTCAACTCGCTCTCACAATTCGGCGCACTCGGCATGACGCCCCAGCAGAGCGTGCAGGCGGCCATGAATGCGTTTGCGGCGAGCAGCGGAGCCGCAGCCAGCGCCACGGTCACCTCTGCGGCACATctgtcacagcagcagcagcaacagcaggtgGCCAGCACAACGATGGCCGGCAGCGGGAACAAAGGCAGCGCCAAGGACTACATGAGCAATGCGGCCATGATGAGCAGcggcagcgagcATCCGTCACTGCTGGGTGTGAGACTGCCGCCGGATACGGAGATTATCAAGTACACGTCCTCCATCGTGGGCCCCAAGATACCCGGTAGTACTTCACGCGGTCGCAAGAAGACCATATCCGAAacagaacaacagcaacaacagtccacacagaaacaacaacaacaacaacaccaagcagaacaacagcaacaacaacaacaccttacacaacaacaacagcagcagcagaaggatttagaaagcacaacaaatgcaattaccTCTCTGCTTGCATTTCCAGGGCTCAGTCCGTCGAAGCGCGCCAGACTCGAAATGGAGTACGCGGCAATGGCGGCagcggcacagcagcagcagcatctgcacGGCATGCTGGGCGCCGCCGGAATGCCCATGGGTCTGGGCATGAGTCCCATGGAGCAGCTAAGTGGCGTCTCCAAGGCGGCTATTTCcgcatcgtcgtcgtcgtcgacggtGACCAGCACTGCTGGCTCCACAGCCGGGCACAGCCAGagccacagtcacagccaGAATGCGTCCAACGATCGGGTGGAGGTCATCAAGTTGCCGCCGACCATTACCTCGAACGGCGCGTACAATCTGTCCAACAAGGGTTGCGGCAAGGAGTTGCACGACCTGACCACCGACCCGTCGCTGGCCTCTGGTGTTAATCTCAGCTTGAAGTCGAGTGCTTTGCCCGCCAGCGGTGCCATTGGCTCCGCCTCCAATCCCATCACCATAGACGACTTTGATGCTCCACTGAATCTGTCCATGAAACCCTCGGACAAAAATAGTTCAAACAGCATgaacacagcagcagcaggagcatcGTCTGCCGCCTCTTCAGCGGCCTCTTCGGCGCTGGGCAATCTGGCCAGCGATTATCAGGCGCagggcagcggcggcagcggttCAAACAGCTTGCAGAGTCTGAGCTCTATAACCGCTGCCTTGGGCGGCACCGGTGGCATGCCGGGCGGATCCATTTCTGGCAGCGGTAGTGGAGCAGGCGGTGCTTCGCCTTCGCCGGCACAGGGCAGCATGCCAGCTGCATCGGGTACGTCTAgctccggctctggctctgggtCTGGCTCCTCGACATATAAGGAGGGACGACCGCGCAACTTGGGCCGTGGCGTGTCCAAGCCCAAGAAGAACACGGTGGCCTCGCTGCTGGCGCAGTCACGCGCCGTCGGATTGAAACCCATGTTGGCCACGCAGCAGTTGCTCCAACAGGGCGCGGACATTGAAAAGATACGCTTGGCGCTGAGTGAGGCTAACGCACACATGGAAACGTCAACGGACTCGGAGAGCGTCGCCGCCGAGAGCGGCCTTTCGGAGTCGGAGAGCGAGGATGCCAACATACTGAATGTGGCGGAGCTGCGTGTGCCCCTAGAACTCGGCTGGAAGCGGGATACAGTCATACGCGGCTTAACCAAGCAGGGTCAGATCCGTGGCGAGGTCACCTACTACGCCCCGGGCAGCACCCTGCCCTTGAAGACCATTGGCCAAGTGTTTGCTCTCTTGGAGCAGCAGCCATCGAGTCTGACGCGCGAGAACTTCAGTTTCTCGGCGCGTGCCATTGTGGGCTCGTTCCTGCAGCCTGCGCCACCGCCCTATGCCAACGATGGCGAGTACATACGGATGACGGACGAGGATGTGGCCAAGCGGCTGGAGGATCTGAAAGTATTTACGCGCCAGACGCTCAACGTGGAGCAGCGCATTGAGAtcgccaagcagcagcaggcgatgCGTGACGCCAAGAAACAGCAGAAGGAGGAGCTGGCACGCAACAAGGAGAAGGCGCGCCAAGAGAAGAATGCcaagctggagcagcagcgcaAGGAGAAGGAACTCAAGAACCAGCAGGCCATTGAGGAGCGCAAAAAGCGTCAGGAAGAACTGGATCGCCTCAAGCAGGAGGAGTTGCTCAAGAAGCAGCAGGAGAAAGAGAAGCGACGTCAGGAAGCTATTCTAGCTAAAGAACAGGAACTGCAGAAGCAAAAGGAGCTACTGCTGGCTGCCGAAATGGAGCGCGAACGTCGTCGCCAGCACATGAACTTGATCAGGATGCTCGAGCTGCGGCGCAAATTCGAAGAACGCGAAAAGAAGAAGCACCAGCTGGTGCTGGATCGCTTGATTCTGCGCGAGCGTCGCATGGCTGAGCGCAAGCGGGACGCGGAGATACTGCAGCTAATACGCAAGCCCAGCGAGGATTCAGAGCTGCCGCAGGAGCTGAACGTTCCGGAACTGGAGCGCATCGCTGGCAATCGGTTGCCTGGACAGGCGATGGCCGATTTGCTGATGGTGTTCGAGTTCCTGCACAACTTTGGCGAGACACTGGGCTTCGACATGGAGTCGCTGCCGTCACTGCAGAACCTTCACGATGCGCTCATCAGCGACAGCAATGCGGACGCCGAGGAGGAGCTGCTTTCGGTGATGACGCACCTGCTGGTCTGTGCCATCGAGGATCCGGGTGTGCCCAATCCTGGCCGGCACACCACGCTGCTGGGCCAGTCGCTGCGCAACGCGGACATTACTAACTCGAACGTGTCCGAGATCCTGCGCATCTACCTGTACGCCACCGCCACCGGCGAGATTCGCCAGATGCACGGCATCACTGTGGACAGGGAGCGCGAGCGACGCGTGCCCGACCACCACCAACTGGACGCGGATACGGCCACGCACTCGGCCAAGAACCATGAGTACTACAAGCTGCTGCACGAGAACGACACCTGGAAGCTCTCGCACGCGCTCAAGGATCGGCCCTTCGTGGCACTCAATCCGACGCGCAAGGCACAGATGCTGGCGCACCTGTGCAACGACCTGCTGATGAACAAGGCGGTGCTGCGCCAGATTGACGGCAGCCTCGAGACCTGCGCCCAGATGCGCAAGGAGAAGTACATGACTGACATGAAGGTGCGCAAGTACAAGGCCTTGCACCAGCGCAAGGCTCGCATCGAGGCCTACGAGAAGGCGCAGGCGGAACGTGAAGCGGCCATGCAAGCGCTCCTGGCCCAACAGAAGCTCGACGCCGAGCGCGAACGCGAACGTCTCGCCAAGCAGGCGGAGGCCGAAGCGGAGGCAGAGGCCAACAAGCAGGCAACGACCGAGTCGCCGGCTGAAGGAACTGCTGCAGCAGAGGCAACTGCTGGCGCCGAATGCAACAGCGAGGACAAAAGTCAGGAGGAGAAAACCaggcaggagcagcagcagcagactcCAGACACGGAACAACCACAGCCCATGGAACTGGATGGCGATGCTCCAGTGCTGATCGCCAGCAGCGGCGACCAAGTAGCGCCGCTCTCCGTCGCGCCTATGTCCGAGGTGAGCCCCTCGAagcagctggccaagctgGAGGAGTATCAGCAAAACGGCGGAacggcagcaggagcaacacCTGCGGCTGATGTCGGGATGACGGCGCTGCTTCAGGCGAAGAAGAGCGGCGCACGCAACTCCATCAATGAGGATGGGCACTCGCAGAGCCACGACGTTAGCATCATTGAGGATGACCTGTCCGATTTGGACTCGGAGATAACCAACGTTGAGGAGGACGAGGACAATCGCCTGAGTGCCGACGAGCTGCAAAAGAAGCTAGACAAGATTGTGCGCGCCTCGCTCAACTGCAAGGAGGCGCTCGAGAAGAGCACCAATCAGCTGCGGGCTGCCTGCTTTGGCCAGGATCGTTTCTGGCGACGCTACTGGAAGCTGCCAAAGGCTGGCGGCATTTTCATCGAGGCTCTGGAATCGGCCCAGAACGACATTTGCGGTTACCACGAGGCACTGGAGGCCATGGacgagcagctgcaacagcagacGCAGCAGGAGACGCCCAGCGACACACAGAATGTGGCAGTAGATGGCATCGAACAGCATGAACAGCCCGCACAGCTGCCGGACGCAAGTGtccctgcagcagcagcagcaacagcagcagagcaaaTGGAGGTCGATGAACCGACGGAACTGGATAGTGTCAAAGCGCAGCAGGCGAATCACCAGCCAGAGAACGAGAACCAGAACGATGAGgaggacgatgacgatgacgatgatgtgACGGAGATCAACAAAGTGGAGCCGGAAATTGTGGACCTTggcgacgatgatgatgaggtGTTGCCCACCGTTGTGAAGGCCACAGAGCCTGTCGTGGCCAGGCCAGAGATTAAGGTCAAGTCGGAGATGGAGCTAATGGGACCGCCGCCCACGGTAATCTCCACGAAAACCGACTTTGAGGCCGAGATCAAGATACCCACCATTCCGGGTCTAATCCCAACtctcagcaacagcaacaacaacaataataacaataacaataacaataataacaacaacggaggcgtcggcagcagcaacggcaactgtgATAAGGTGGAGGCAATGAGTCAGGAGGATCTAAAGAAGGAGGACGACTGCATCATTGTGTCGACAACGCAGATTGGCGAGGACGCTGCGCCCAAATGGTTCTCGATTGTTAAGCGCGAGGTGCCGCTGGTCAGCGAGCTGCCGGCGGAGGAGGGTGGCGTGGTGGCCACGGAACTGCAGCTCAGCTATGCCAGTTACCAGCACTGCAgtgcacagctgcagctgcagggcCATCCGTGGGATCTGATAAACAACATGCAGTACTACAGCATACCCATGGAGGAGTGCAAGGTGGATCCGACGAAGTTCAGTCAGGAGTGCATCTTCACGCTGTCGGGACTGGACGAGAAGCAGATGCAGGCCAAGCTGGATGAGTACGAACAGGCCAAGTTAACGGTGTCAAAAAACGGTCTGGCGTCTCCTCATCGTGGCCAGCCAACCgatgaggagcagcagcagcagctactaaAGCTGTCCAAGTCCAAATCCGAGCCGGAAGCGTTTTTTCGTTTGCGCGCTGATGCCGCACCGGACACGGGCGGCGGGAACGGCGAATCTCTGGACCTGAAGCCCAAGATTGAACTGCGTCTGGACGAAGCCCTGTCCCAGGCGTACTACCACAACATAGCGAACATGTCGCTGAGCAGCGTGCAGACCTATATACCGATAGACATTCCGTTGCCGCTGTCGATGACGCCGGACGAGCACCGGCTGCTGGAGCAGGTGAAGCTGGCCGGCTTCCCGGAGAAGGTGCACGGCGTCTATGTGCCGCGCAGGCAGCGCTACGGCTGGTGGCAGCTGGACGACGAGCAAAagctgcgccagctgctgaAAACGTTGAATCCGTCGGGACTGCGCGAGCGCGAGCTGCAGGAGAATCTGACGCGCTTCCTCGGACTCGAACAGCCGCTGGGCGTCAACTATCAGCTGAAGCTGAACGAGGCCCAGGTCGAACTGGTCGAGTACATGATGCCGGATCGACCCGGCGACTGGAACCCCAAGGTGGCCAGGCGAGTGGAGTTGGCACTTTTGGAGCAGCTCGAATCGCTGGAAGATAAAATTGCCAGCGCCTCGATGCAGCTAAAGAACTGGCAACTGCCCACGCGCAGCGACAATGACATCAATCTGGGCGAGCAGGAGGAGATGAGCGAGGCGGACTTTGTGAGCATCATACCCATGATTAGGGAGCGCATCATCGATCTGGAGGCGAATATCGAGCGACGCTATCTGAAGCCGCCGCTTGGCTCTCAGACCGGCGACGCCCACCTGGCCGTCATCGCCCAGAACCAGCAGACCTCCACGCAGACGCAGAACTCCGCCTCGGCGGCGGCGTATCTGCtgcagatgcagcagcagcagcaacagctgatgGCCCAGCAGCAGACCCAACAGCCCGGCAACAACCTGAACGCCTCCGTCTTTAACGAGCGCGCCATGGCCTtggccgcagctgctgcggcagctgctcccAGCACCAGCGTCGCGTCCACATCGTGCGAGGCGGTTGTGCCGGCAGCCGGAACCCTGGAGCCCTGCTCCGGCGCCGCATCGCCGGCCAGCaactgcgacagcgacaagGACGAGAAGGTGGAGAATATACCCAAGGGCCTGGTGCAATGGCGAGATGCCGTCGCTCGATCCCATACCACCGCCCAGCTGGCCATGGCCCTGTATGTGCTGGAGTCCTGCGTGGCATGGGACAAAAGCATCATGAAGGCGtatgcaacgccCGCAAAGAACAACAAGTCCAACAAGAAGAAAGGCAGCGCCAAAAAGCAGGCTACgccaaagaagaagcagcagcaacaacaagaacagagCGCCTCAAAGCAAAAACAGTCCAAAAAGGACAAGGACAAGGAGAAGAAACAGTCAAGCAAAGCAACACCGAAGAAATCAAAGCAAAGGGAAAATGCTAAAGAGACGCCACCTGCCGCAAAAAATCCTTCGAtgaccataaaaataaatttgaaagccTTGGCGCAAAACGGATGCGACCAGAACTCAAACTCGAACTCAAACTCGAACTCTGACTCCGATTCGAACTCGGACACTGACTGCAATTCGTATTCGAACGGCAAACGCAAACGACAAGGACGACGTTCAGGCACTACTACAAACTCTTGCAAATATTCAAACTCCTTACAGAATTGCCAGTTCTGCACCTCGGGCGAGAACGAGGACAAGCTGCTGCTCTGCGATGGCTGCGACAAGGGTTACCACACCTACTGCTTCAAGCCCAAAATGGACAACATACCCGATGGCGACTGGTATTGCTATGAGTGCGTCAATAAGGCGACCAACGAGCGCAAGTGCATCGTCTGCGGCGGGCATCGGCCCTCGCCTGTCGGCAAGATGATCTACTGTGATCTGTGTCCGCGCGCCTATCACGCCGACTGCTACATTCCGCCGCTGTTGAAGGTGCCGCGCGGCAAGTGGTACTGCCACGGCTGCATCACCCGCGCCCCGCCACCCAAGAAGAGGAgcgccgccagcagcggcagcagcagcagcaagtcgCGACGGGATCGCGATGCCAGCACCGCGGCAAAGCGACGCGGCAGCGACAAACATCAGCTGTTGGCCTCGGCCGGCAGCATGGAGCAGCTGTGTCCCATCGATccacaccagcagcagcaacagcaacaacaacaactgcagcagcagcagcagcaaatgctgctgcatGGCTCACAGCAGTCGCTCAACTCGTCGCACGACGAGTCCATGACATCCCTGCCAGCGCCGCTTAGTCCGGCGCATTCGATTGCCTCGGCCACGTACGATGAGCAGCATCACAATAACTCGATTGACGGCAGCCGTTTCCAGGCGCAtctcggcaacaacaacggagGCGTGCAGCTGGAGGAGAGCGGCTCCTTTGCGGCTGGCTACGCAGCGCCGAGCAACTTTGGCGTGGTGTCTGTGCCGCAGGCGATGCAGTTTGCGGCCATGTCGCCGCGTGAGGTGACGCCCACGCGCACCCCTACGCCCACGCCGACGTCCACGCCCGTGGCGGCACCAACACCACCACCgccagcgctgccagcgccgCTGCAGCCACCGACGCCGAACGTAACGGCGCCTATTCTGATGCAGGCATCGCCAACGGCACTGCTGAACGTTGCCTGTCAGTCGcctccgcagcagcagctgatggcCATGCCGTCGCCGAGGACATGCACTCCGACGCCGCcgggtgctggtggtgctggagCTGGGACGCAAATGTCGCCGCCGCCCATTAACATACACGCCATACAGGAGGCCAAGGAGAAGCTGAAGCAGGAGAAGAAGGAGAAGCATGCCACCAAGAAGCTGATCAAGGAGCTGGCCGTCTGCAAGACGCTACTGGGCGAAATGGAGCTTCATGAGGATTCGTGGCCATTTCTGTTGCCTGTGAACACCAAACAGTTTCCCACATATCGCAAAATCATTAAAGCGCCCATGGATCTGTCCACAATCAAGAAGAAACTGCAGGATTTGAGCTACAAGTGCCGCGAGGACTTTTGCGTGGATGTGCGGCAAATCTTTGACAACTGCGAGATGTTCAACGAGGATGATTCGCCCGTGGGCAAGGCTGGGCATGGCATGCGCAAGTTCTTCGAGTCACGTTGGACTGAGCTCACCGACAAGCACTCCTGA
Protein Sequence
MNKNAGDGSGNDGKNSNNHGKGGSGGGGGAGAGGPHDPTGLLDAASLFAYWGRDPTGAAAAAASNPLFNSQFNAAAAAGLGLLPNAAGAAAANDRYSSMAAAAAAAAGAHHHQNTMAVAASQAASLAGLHPASWWSMAQLAAQDYFSRLQASGLSPFPHPDLAAAFGPAAMAMGGAGTGSGAGAAGGAGMVGVGGGGGAAGGGGSGSSSKSNKSRKEKRAAQQQQQQQQQQQQQQNLANSLNAAAAAAAAAAANNPAAALASMHGFGLPGTSMPPSGSSASISTSSAGHGGYKSTASAYGKPSTMTSSGSSNSIASNPGSAYDPVTLHKELLAMQAVAAAASGSGVGGMSGLGSGGGSNSSSGKKSSGAGGGSSLHAHGLSNLAMSLGAGGSGGGGSGSGIMSSSKTSTNVSSSSSGGASLGGMHPSMAMSPHASISGSGMGSSGKDRDRDKNNPSLNALNSLSQFGALGMTPQQSVQAAMNAFAASSGAAASATVTSAAHLSQQQQQQQVASTTMAGSGNKGSAKDYMSNAAMMSSGSEHPSLLGVRLPPDTEIIKYTSSIVGPKIPGSTSRGRKKTISETEQQQQQSTQKQQQQQHQAEQQQQQQHLTQQQQQQQKDLESTTNAITSLLAFPGLSPSKRARLEMEYAAMAAAAQQQQHLHGMLGAAGMPMGLGMSPMEQLSGVSKAAISASSSSSTVTSTAGSTAGHSQSHSHSQNASNDRVEVIKLPPTITSNGAYNLSNKGCGKELHDLTTDPSLASGVNLSLKSSALPASGAIGSASNPITIDDFDAPLNLSMKPSDKNSSNSMNTAAAGASSAASSAASSALGNLASDYQAQGSGGSGSNSLQSLSSITAALGGTGGMPGGSISGSGSGAGGASPSPAQGSMPAASGTSSSGSGSGSGSSTYKEGRPRNLGRGVSKPKKNTVASLLAQSRAVGLKPMLATQQLLQQGADIEKIRLALSEANAHMETSTDSESVAAESGLSESESEDANILNVAELRVPLELGWKRDTVIRGLTKQGQIRGEVTYYAPGSTLPLKTIGQVFALLEQQPSSLTRENFSFSARAIVGSFLQPAPPPYANDGEYIRMTDEDVAKRLEDLKVFTRQTLNVEQRIEIAKQQQAMRDAKKQQKEELARNKEKARQEKNAKLEQQRKEKELKNQQAIEERKKRQEELDRLKQEELLKKQQEKEKRRQEAILAKEQELQKQKELLLAAEMERERRRQHMNLIRMLELRRKFEEREKKKHQLVLDRLILRERRMAERKRDAEILQLIRKPSEDSELPQELNVPELERIAGNRLPGQAMADLLMVFEFLHNFGETLGFDMESLPSLQNLHDALISDSNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTTLLGQSLRNADITNSNVSEILRIYLYATATGEIRQMHGITVDRERERRVPDHHQLDADTATHSAKNHEYYKLLHENDTWKLSHALKDRPFVALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDMKVRKYKALHQRKARIEAYEKAQAEREAAMQALLAQQKLDAERERERLAKQAEAEAEAEANKQATTESPAEGTAAAEATAGAECNSEDKSQEEKTRQEQQQQTPDTEQPQPMELDGDAPVLIASSGDQVAPLSVAPMSEVSPSKQLAKLEEYQQNGGTAAGATPAADVGMTALLQAKKSGARNSINEDGHSQSHDVSIIEDDLSDLDSEITNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKSTNQLRAACFGQDRFWRRYWKLPKAGGIFIEALESAQNDICGYHEALEAMDEQLQQQTQQETPSDTQNVAVDGIEQHEQPAQLPDASVPAAAAATAAEQMEVDEPTELDSVKAQQANHQPENENQNDEEDDDDDDDVTEINKVEPEIVDLGDDDDEVLPTVVKATEPVVARPEIKVKSEMELMGPPPTVISTKTDFEAEIKIPTIPGLIPTLSNSNNNNNNNNNNNNNNNGGVGSSNGNCDKVEAMSQEDLKKEDDCIIVSTTQIGEDAAPKWFSIVKREVPLVSELPAEEGGVVATELQLSYASYQHCSAQLQLQGHPWDLINNMQYYSIPMEECKVDPTKFSQECIFTLSGLDEKQMQAKLDEYEQAKLTVSKNGLASPHRGQPTDEEQQQQLLKLSKSKSEPEAFFRLRADAAPDTGGGNGESLDLKPKIELRLDEALSQAYYHNIANMSLSSVQTYIPIDIPLPLSMTPDEHRLLEQVKLAGFPEKVHGVYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLTRFLGLEQPLGVNYQLKLNEAQVELVEYMMPDRPGDWNPKVARRVELALLEQLESLEDKIASASMQLKNWQLPTRSDNDINLGEQEEMSEADFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVIAQNQQTSTQTQNSASAAAYLLQMQQQQQQLMAQQQTQQPGNNLNASVFNERAMALAAAAAAAAPSTSVASTSCEAVVPAAGTLEPCSGAASPASNCDSDKDEKVENIPKGLVQWRDAVARSHTTAQLAMALYVLESCVAWDKSIMKAYATPAKNNKSNKKKGSAKKQATPKKKQQQQQEQSASKQKQSKKDKDKEKKQSSKATPKKSKQRENAKETPPAAKNPSMTIKINLKALAQNGCDQNSNSNSNSNSDSDSNSDTDCNSYSNGKRKRQGRRSGTTTNSCKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCYECVNKATNERKCIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGCITRAPPPKKRSAASSGSSSSKSRRDRDASTAAKRRGSDKHQLLASAGSMEQLCPIDPHQQQQQQQQQLQQQQQQMLLHGSQQSLNSSHDESMTSLPAPLSPAHSIASATYDEQHHNNSIDGSRFQAHLGNNNGGVQLEESGSFAAGYAAPSNFGVVSVPQAMQFAAMSPREVTPTRTPTPTPTSTPVAAPTPPPPALPAPLQPPTPNVTAPILMQASPTALLNVACQSPPQQQLMAMPSPRTCTPTPPGAGGAGAGTQMSPPPINIHAIQEAKEKLKQEKKEKHATKKLIKELAVCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKAPMDLSTIKKKLQDLSYKCREDFCVDVRQIFDNCEMFNEDDSPVGKAGHGMRKFFESRWTELTDKHS