Dnov012339.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila novamexicana
Gene Symbol
pax6
Assembly
GCA_003285875.3
Location
NW:4258349-4268929[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6e-35 8.5e-32 109.2 0.0 23 125 142 239 135 239 0.95

Sequence Information

Coding Sequence
ATGGCTACAACAGCGCCAACGGCAGCCCCCACAAGGACCTCCAGCAAAAGCACTGCGGCCTATTCAACAGTCACGCCCACTTGCACCGCCAGCGTTACAGTTATGCCCAGTGTCGGCATTCCGCCGGGCCTGCCCGTGGGCATGGCAGCGGTGCCCATGCCGCCACATCTGCCGCTGCTGGGCGGCCTGGACAGCGCGGCCGGCAAGGCCATTGCAACGGGCAGCGGCGCCGCACAGCcgacggcaacaacaagtcCCAGCTTGGCGGCCGTCTCGCCCACGCCCACAGCGCTTACGCACAGCCACTGCCCGTCCACATCGATGCTAGCCGCCGGCTCACCACCAGCTCCCACGTTGGCCCTCTTGGCCCCTCAGGGCAAcgcagcgacggcggcggccACAAATCTCAGCGCTCTGGCCTCCCAGCATCGGCTACTGGAACTGTCACGCTTTGGCCTGCGGGGCTACGATCTGGCCCAACATATGCTCTCCCAACAGGGCGCAGTATCCAAGCTGCTGGGCACACTGCGCCCGCCCGGGCTTATTGGCGGCTCAAAACCGAAGGTGGCCACGCCGACAGTTGTCTCCAAGATCGAGCAGTACAAACGCGAAAATCCAACGATATTCGCGTGGGAAATACGCGAGAGACTGATTAGCGAAGGTGTCTGCACGAATGCCACTGCCCCCTCGGTGAGCAGCATCAATCGCATCCTGCGCAACCGCGCCGCCGAGCGTGCCGCGGCGGAGTTTGCGCGCGCCGCCAGCTATGGCTATGCTTTACATCCAACGCATCCGCATCCACATCCCTATACGAGTTTTCCCACCTGGCCGGCCACGTTGCCGGGCCACCATCCGCTTTGGGGCGCTGTGCCGCTACCCGCCAGCAGCGCTTtgcccggcagcagcagctacaacagcgACGGCAGCTCCAATCcgaataccaacaacaacagcaccagcgccggcggcggcagcagcgcggGCAGTGGACGCCTATCCCTGCCGGCACTATCACCGGGGTCGGGCAGCCGGGACAGTCGTTCGCCGGATGTGGATGCCAACCGCATGATAGATATTGAAGGCGAGGGCAGCGATTCGGAGGACAGTGACCAGCCCAAGTTTCGGCGGAATCGCACAACGTTCAGTGCCGAGCAGCTGGATGAGCTGGAGAAGGAGTTCGAGAAGTCGCACTATCCCTGCGTGGGCACGCGCGAGAAGCTAGCGGCGCGCACGGCGCTGAGCGAGGCGCGGGTGCAGGTTTGGTTTTCCAACAGACGAGCGAAATGGCGGCGCCATCAACGGGTCAATCAGCTGAAGCAGCGCGACTCGGCCTCGACATCGCCTCAGCCCGCGGCTGCCTTGGGtccacagcagcaggagcagagcACGGCTGCAGCGGCAGTCTCCAGTCTGCAGTATGCTACCCGTTCCAGCGTCTACCACACGACACTGGCGGGCGAGGGCAACACCTCCACCCccatcagcatcagcaccaGCATAAGCCCTACGGCCCCAGGCCGCGAtccagcgacagcaacagcgccGCCGCCTGCCTCACTCACAGCATCAGTTCCATTATTAATGGGCGGTGAGCATAGCGCCTTTCGTGCCGCCCTGCCcgccgcatccgcatccgcctCCGCGTCGGCGGCCGCCTTCGCCCTGAACTTTGCCCGGCAGTACCTCTGGCGGCATATGGCGGCGCCGCAGAAGGAGCCCCGATCGGAGCTGGATGAGGAGATCAATGTGGATGCGGAGACGGAAACGGAGTCGGAGGCTAATTAA
Protein Sequence
MATTAPTAAPTRTSSKSTAAYSTVTPTCTASVTVMPSVGIPPGLPVGMAAVPMPPHLPLLGGLDSAAGKAIATGSGAAQPTATTSPSLAAVSPTPTALTHSHCPSTSMLAAGSPPAPTLALLAPQGNAATAAATNLSALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERAAAEFARAASYGYALHPTHPHPHPYTSFPTWPATLPGHHPLWGAVPLPASSALPGSSSYNSDGSSNPNTNNNSTSAGGGSSAGSGRLSLPALSPGSGSRDSRSPDVDANRMIDIEGEGSDSEDSDQPKFRRNRTTFSAEQLDELEKEFEKSHYPCVGTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNQLKQRDSASTSPQPAAALGPQQQEQSTAAAAVSSLQYATRSSVYHTTLAGEGNTSTPISISTSISPTAPGRDPATATAPPPASLTASVPLLMGGEHSAFRAALPAASASASASAAAFALNFARQYLWRHMAAPQKEPRSELDEEINVDAETETESEAN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00475047;
90% Identity
iTF_00563009; iTF_00475047; iTF_00475170; iTF_00534413; iTF_00534530; iTF_00505941; iTF_00506060; iTF_00490614; iTF_00490729; iTF_00530903; iTF_00530787; iTF_00526527; iTF_00526408; iTF_00616735; iTF_00616851;
80% Identity
iTF_00563009;