Basic Information

Insect: Drosophila niveifrons
Gene Symbol: zfh1
Assembly: GCA_035046325.1
Location: JAWNOC010000046.1:4963498-4967915[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.8e-05 0.0018 18.5 1.0 1 23 147 169 147 169 0.97

2 15 0.00087 0.057 13.8 1.2 3 23 177 197 175 197 0.94

3 15 9.5e-05 0.0062 16.9 0.1 1 23 361 383 361 383 0.98

4 15 0.0038 0.25 11.8 2.3 1 23 389 411 389 411 0.98

5 15 3.3e-05 0.0021 18.3 2.3 1 23 442 465 442 465 0.95

6 15 2.7e-05 0.0017 18.6 0.3 1 23 496 518 496 518 0.96

7 15 0.011 0.74 10.3 1.3 1 23 524 547 524 547 0.97

8 15 0.028 1.8 9.1 0.4 3 19 556 572 555 573 0.95

9 15 0.00017 0.011 16.1 5.6 1 23 582 604 582 604 0.97

10 15 0.062 4 8.0 1.2 3 23 611 631 609 631 0.96

11 15 9.7e-06 0.00063 20.0 1.0 1 23 640 662 640 662 0.98

12 15 0.0011 0.071 13.5 0.1 3 23 670 690 668 690 0.97

13 15 5.9e-05 0.0038 17.5 0.5 1 23 696 718 696 719 0.95

14 15 0.076 4.9 7.7 1.4 1 23 729 751 729 751 0.97

15 15 0.0031 0.2 12.1 0.1 1 23 1294 1316 1294 1316 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.8e-05	0.0018	18.5	1.0	1	23	147	169	147	169	0.97
2	15	0.00087	0.057	13.8	1.2	3	23	177	197	175	197	0.94
3	15	9.5e-05	0.0062	16.9	0.1	1	23	361	383	361	383	0.98
4	15	0.0038	0.25	11.8	2.3	1	23	389	411	389	411	0.98
5	15	3.3e-05	0.0021	18.3	2.3	1	23	442	465	442	465	0.95
6	15	2.7e-05	0.0017	18.6	0.3	1	23	496	518	496	518	0.96
7	15	0.011	0.74	10.3	1.3	1	23	524	547	524	547	0.97
8	15	0.028	1.8	9.1	0.4	3	19	556	572	555	573	0.95
9	15	0.00017	0.011	16.1	5.6	1	23	582	604	582	604	0.97
10	15	0.062	4	8.0	1.2	3	23	611	631	609	631	0.96
11	15	9.7e-06	0.00063	20.0	1.0	1	23	640	662	640	662	0.98
12	15	0.0011	0.071	13.5	0.1	3	23	670	690	668	690	0.97
13	15	5.9e-05	0.0038	17.5	0.5	1	23	696	718	696	719	0.95
14	15	0.076	4.9	7.7	1.4	1	23	729	751	729	751	0.97
15	15	0.0031	0.2	12.1	0.1	1	23	1294	1316	1294	1316	0.97

Sequence Information

Coding Sequence: ATGAACAGTCAGGATTATGGCGGCATCCAATGGATACAACAGCACTCCGAATCATCGGATCTGCTGGAAAACGGCGCCAACGAAAATGAGGTGACTGCAGCCGCCGCCTATTTGGTCAATGGCAATGCCACCGACGAGGATCTCGATCATATGGCGGCCGAAAATCTCATTTTTATGGCACGCGATGGCCAGCTAAGCGAGATCATTGCCGCCAATGAAGCCGGCGGTGGCACAGTTTTGATCACAGACAGCGGCGTCGCCTATGCAGAATcgtttgatgatgatgctcaAGTGGTCACCGAGGAAATCATCACTGATGATTGGGTGCAACACCAAGGCGCCGAGCGCGTGGAAATCGCTGCCGAGCAAATTGCGGGCAATGCCAACGCGTTGGAGCTGCTGGATATGGAGCAGGACGAGTATACGGCATTGCGTCCCTATCCCTGTGATTTCTGTAGTCGACGCTTTCGCAAAAAGGCCAGTCTCAATAATCACATGCTTGCCCATCAAACGGATCGCCCGCATCTCTGTAAATTGTGCGGAGCGCGCTTCTCGCGTCGTGCCGAGCTTATCAGCCACTTTAAAGCACACGCCGAGGCGCAGGATGCAGCTGATGCGGAggctgcggcggcggcagctgcagcaattaaatttgagccacagcagcagcatcagcggcAAATTGTTGATCATTTCTATGAGCAAGAGTGGCCCATGTATCCTGAACAGGAGCAggaacaagagcagcaacagcagcagcaacacattCAGGACACCGAGCAACTAACGGTGGTGCAGCAGGCCAGCTATGCGGAGCCAGTGGCGGCGCCAACAGCGGCACGAGGACGCATCAGCCGTCTCAAGCCCAAGGAGGAGAGCACACAGTATATTGTACTTGCGGAGAAGCAAGCGGCAGCGGATGAACTGCAACAGTTCATGGAGCAATTGCCCGCAGATCTGGacaatgccacaacaacaacaacaacagcagcagcagcagctgtagaATCCGCAGCCACATCGGATAATCTACAGGTGTCTGAAGCGTCACGTTTCCCAGTGCTGGACGAGAGCAAACCCTTTGTTTGCCAGCAATGTGGCTTGGCGTTTGCGCGCGAAAAGGCGCTTGTCTCACACATCAAGAATCATCGCGTGGATTCGCCTTTCGAGTGTAATCAGTGCCAGGAGATGTTCTGGGACACGCACAGTTTGCAGGAGCATCAGAAGACGCATCAGTTTGAGGAGAGCAACTCGGAATATGATCCCGCCTCGGCAGGCGATGATAGCGCCAGTGAATCGGAACCCGAGCAGCTTTATGGTGATTTCTACTGCACAGAATGCGGCATTTCGTTTCATCGCCAGGATCTGTTGCGACGTCATGCCAAGCAGCAACATGCCACCGAGGGTAGCGCAGATGCTGAGGGCGACGGCGAcgttggcgatggcgatggtgatgttgatgttgagaATACCAAAGATGCGATGCATAGTTGTCCGACATGCAACAAATCATTTGCTCGCGCCTTGGAGCTGCGCGCTCACGTCGAGATTCATGCACGTTTCCCGCCATTCAAATGTGTCTTGTGTGGCATCAGTTTCTATGAGGAACAGGCCATCAAACGTCACTTGCACACGCGTCATCCACACGAACTGAAACCCAATTCGTGTGTGCTGTGTGGCAAAGAGTGTCGCGATCGCAAAGCGTTGATCAAACATGCCTGGGATCATTCGCGTGAGAAATGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCGCGCCTGAAGCGACACATGGCCTCGCATCGCGACAAATCCGTCATCTGCGAGGTGTGCCATGAGGAATTCCCCGACGGACGCACGCTCTCCAATCACCGACATTCGCATAGCACAACGTCGCCGGGAAAACTCTTTCCCTGCCACGAGTGCGGCAAAACATTCGGTTCACGCAGCTCCCAGCAGATTCATGTGCGCATTCACACGGGCGAACGTCCGTACGGATGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTTTGCGCAAACACGAACGCATTCACACCGGCGAGAAGCCTTACGCCTGCTCCGTGTGTCCACGGGCCTTCAATCAACGTGTCGTGCTGCGCGAGCACATACGCTCGCATCACTCGGGATTGGATGCGGTGCGGGGCACGTATCATTGCACCGTCTGCACTGCGGATCTGTCCTCCTCCAATGAGCTGATCCATCATCTCATTCAGCACAGCGACACAAACACCGCCAAGCAACGACAGCCAATTACTGGTCCTCGCAAATACAAGCGAAGGAGGAAACTGCAACCGCATGAGATTGCGCACATGCGGGCAGAGAACAAGGATGAAGGCGATGAGTATGCCAGCGACATGGATCTCGGTGAGCTGGACGTGGAAAACGTGGACGATTTCTTCGATGGCGCCGATGCAGCGCCCAGCAAAAAGGAGAAACGCAAACGTAATGCTGTTGGCCAAACAAATCCAGCGGCCAATGGtgtcaacaacaatgcaacaacgCCAGCTAAATCTGGTAATCAAGAGCGTGGCGGCTGGGATGATAAATTCCTACAGGCCaatagcaatggcaatgccggAGGCAGCAACGCTGCAAACGATGATGCGTTTAAGAGCATCTTTCAAATCGATTCGATGGTTATGGTCAATGACACTACATTGCAGCCGATCAGCACATCCAGCAGTGGTGGtgcggctgctgcagttgcgtCCAAGACGCGTCGTAGTGCCAAGCAAACGCcacaaacacagcagcagacgtcgagcaacaacaagtccggagcagcaacagcgtccGGCGAATCAAGTACAACGGTATCTTCGAGCACTcgcagcagccgcaaaaaGACTGCCAAGTCCAACAAAGCCACAAgcgcaacaacggcagcagctgctgcaagcAGTTCGCGTCCACGCATGATCCATACGGAGAAGACCCGAGTGCCGCAAGAGAATGCGACTAAAAAGTCGACGCGAAGTCGTTCGTATGTGACGCGCACAAATGCCAGCGAAACCAgtagcaaccagcagcagcagctgggtGGTCTGGTCAAGTCGAGTGGCGTCGCCAGTTCGTGCATTGTGGATGACTATGAGATAATATCGCCCGCCACCCAGCCACCGAATCAGATCAGCTCGAGTCCGCTGCACATTAAGCAGGAACAGGAGCAGCatcagcaccaacagcagcgcGGGTCGCTCATGTACGATGACACACATCTGCTAATCGAAACGGCGCTGTTGCGCGAGAAGACCTACGAGAAGTTCAATCCCAGCATTGTCAATGATCTCGAGGAGATATTGCGCAGTCCCCTGAAGCATGATCGCAATGCGCGGCTGCGTTTCACCAGCGAATCGTCGACAACGCCACAGTTTCTGCCCGAAGAGGAGCAGAATCTGATTAAAATCGAACCAACGTCGCCGGATCTCCGTGAGATGGTCGAGAGTCAACAGCGGGTTAGCTCCTCTGGACATGGCGGCACACccacatcatcatcgtcagcgGCGCGTACTTCACGCCATCTGCGACAATTAACTGCCAACTCGAGTTCCCGCACTGCCACAAAacgtggcagcagcagtaaagcTGGATCCACGTCGAGTGCCAAGAAATCcgcatcatcctcatcgtcatcgtcgtcgtctgtgGCCGTTAGCAAAGCCAACAGCTCGTACCTCAGTTATGGCGTTGATTCCTACCATGTGAGTGTGGCTGGCAATGCCAGCTCTTCGGATGTCAGCTCCGGTTTCTTTTCCATCTCCGAAGTGGTCTCCGCTGCCGATGCCGCCGATGCAGCTGCCAAGGCAGCAGCCGCCAATAAACCGGAGCGTCGTGCCCGTTGCTATGAGTGCGAAATGTGTTCGGCCAACTTTCCGGATCGAGCTCAGCTGCTAGAGCATGTGCATATACACATCTGA
Protein Sequence: MNSQDYGGIQWIQQHSESSDLLENGANENEVTAAAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEAGGGTVLITDSGVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNANALELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQTDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAAAAIKFEPQQQHQRQIVDHFYEQEWPMYPEQEQEQEQQQQQQHIQDTEQLTVVQQASYAEPVAAPTAARGRISRLKPKEESTQYIVLAEKQAAADELQQFMEQLPADLDNATTTTTTAAAAAVESAATSDNLQVSEASRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDTHSLQEHQKTHQFEESNSEYDPASAGDDSASESEPEQLYGDFYCTECGISFHRQDLLRRHAKQQHATEGSADAEGDGDVGDGDGDVDVENTKDAMHSCPTCNKSFARALELRAHVEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVICEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCTADLSSSNELIHHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDEGDEYASDMDLGELDVENVDDFFDGADAAPSKKEKRKRNAVGQTNPAANGVNNNATTPAKSGNQERGGWDDKFLQANSNGNAGGSNAANDDAFKSIFQIDSMVMVNDTTLQPISTSSSGGAAAAVASKTRRSAKQTPQTQQQTSSNNKSGAATASGESSTTVSSSTRSSRKKTAKSNKATSATTAAAAASSSRPRMIHTEKTRVPQENATKKSTRSRSYVTRTNASETSSNQQQQLGGLVKSSGVASSCIVDDYEIISPATQPPNQISSSPLHIKQEQEQHQHQQQRGSLMYDDTHLLIETALLREKTYEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSSSGHGGTPTSSSSAARTSRHLRQLTANSSSRTATKRGSSSKAGSTSSAKKSASSSSSSSSSVAVSKANSSYLSYGVDSYHVSVAGNASSSDVSSGFFSISEVVSAADAADAAAKAAAANKPERRARCYECEMCSANFPDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579414;
90% Identity: iTF_00472486; iTF_00553837;
80% Identity: -