Basic Information

Insect: Drosophila nasuta
Gene Symbol: zfh1
Assembly: GCA_017165715.1
Location: Scf:39578-45448[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.3e-05 0.0014 18.5 1.0 1 23 147 169 147 169 0.97

2 15 0.0005 0.031 14.3 1.2 3 23 177 197 175 197 0.94

3 15 7.7e-05 0.0048 16.9 0.1 1 23 359 381 359 381 0.98

4 15 0.0031 0.19 11.8 2.3 1 23 387 409 387 409 0.98

5 15 2.7e-05 0.0017 18.3 2.3 1 23 440 463 440 463 0.95

6 15 9.1e-05 0.0057 16.7 1.0 1 23 490 512 490 512 0.95

7 15 0.0092 0.58 10.3 1.3 1 23 518 541 518 541 0.97

8 15 0.022 1.4 9.1 0.4 3 19 550 566 549 567 0.95

9 15 0.00013 0.0084 16.1 5.6 1 23 576 598 576 598 0.97

10 15 0.05 3.1 8.0 1.2 3 23 605 625 603 625 0.96

11 15 7.8e-06 0.00049 20.0 1.0 1 23 634 656 634 656 0.98

12 15 0.00088 0.056 13.5 0.1 3 23 664 684 662 684 0.97

13 15 4.7e-05 0.003 17.5 0.5 1 23 690 712 690 713 0.95

14 15 0.023 1.4 9.1 0.5 1 23 723 745 723 745 0.97

15 15 0.0025 0.16 12.1 0.1 1 23 1279 1301 1279 1301 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.3e-05	0.0014	18.5	1.0	1	23	147	169	147	169	0.97
2	15	0.0005	0.031	14.3	1.2	3	23	177	197	175	197	0.94
3	15	7.7e-05	0.0048	16.9	0.1	1	23	359	381	359	381	0.98
4	15	0.0031	0.19	11.8	2.3	1	23	387	409	387	409	0.98
5	15	2.7e-05	0.0017	18.3	2.3	1	23	440	463	440	463	0.95
6	15	9.1e-05	0.0057	16.7	1.0	1	23	490	512	490	512	0.95
7	15	0.0092	0.58	10.3	1.3	1	23	518	541	518	541	0.97
8	15	0.022	1.4	9.1	0.4	3	19	550	566	549	567	0.95
9	15	0.00013	0.0084	16.1	5.6	1	23	576	598	576	598	0.97
10	15	0.05	3.1	8.0	1.2	3	23	605	625	603	625	0.96
11	15	7.8e-06	0.00049	20.0	1.0	1	23	634	656	634	656	0.98
12	15	0.00088	0.056	13.5	0.1	3	23	664	684	662	684	0.97
13	15	4.7e-05	0.003	17.5	0.5	1	23	690	712	690	713	0.95
14	15	0.023	1.4	9.1	0.5	1	23	723	745	723	745	0.97
15	15	0.0025	0.16	12.1	0.1	1	23	1279	1301	1279	1301	0.97

Sequence Information

Coding Sequence: ATGAACAGTCAGGATTATGGCGGCATCCAATGGATACAACAGCACTCCGAATCATCGGATCTGCTGGAAAACGGCGCCAACGAAAATGAGGTGACTGCAGCCGCCGCCTATTTGGTCAATGGCAATGCCACCGACGAGGATCTCGATCATATGGCGGCTGAGAATCTCATCTTTATGGCACGCGACGGCCAGTTAAGCGAGATCATTGCCGCCAATGAAGCTGGCGGTGGAACAGTTTTGATCACAGACAGCGGCGTCGCCTATGCAGAATCCTTTGATGATGATGCTCAAGTGGTCACCGAGGAGATCATCACTGATGATTGGGTGCAACACCAAGGCGCCGAGCGCGTGGAAATCGCTGCGGAGCAAATTGCGGGCAATGCCAACGCGTTGGAGCTGCTGGATATGGAGCAGGACGAGTATACGGCGTTGCGCCCATATCCCTGTGATTTCTGCAGTCGGCGTTTTCGCAAAAAGGCCAGTCTTAATAATCACATGCTTGCCCATCAAACGGATCGCCCGCATCTCTGTAAATTGTGTGGAGCACGCTTCTCGCGCCGTGCTGAGCTAATCAACCACTTTAAAGCACACGCCGAGGCCCAGGATGCAGCTGATGCGGAGGCTGCATCGGCGGCAGCGGCAGCGATTAAATTTGAACCACAGCAACAGCAGCGGCAAATTGTTGATCATTTCTATGAGCAAGAGTGGCCCATGTATCCCGAGCAGGAACAGGAGCAAGAGCAACAACAGCAGCAGCAGCAACACATTCAGGACACCGAGCAACTAACGGTGGTGCAGCAGGCCAGCTATGCGGAGCCAGTGGCGGCGCCAACAGCGGTACGAGGACGCATCAGCCGTCTCAAGCCCAAGGAGGAGAGCACACAGTATATTGTACTTGCAGAGAAGCAGGCGGCAGCTGATGAACTGCAGCAGTTTATGGAACAGTTGCCCGCGGATCTGGACAATACCACAACAACAACAGCAGCAGCAGTCGCCATAGAATCCCCAGCCACAACAGATAATCAACAGGCGTCTGAAGCTTCGCGTTTCCCAGTGCTGGACGAGAGCAAACCATTTGTTTGCCAGCAATGTGGCTTGGCGTTTGCGCGCGAAAAGGCGCTTGTGTCACACATTAAGAATCATCGCGTGGATTCGCCTTTCGAGTGCAATCAGTGCCAGGAAATGTTCTGGGACACGCACAGTTTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAATATGATCCCGCCTCGGCAGGCGAAGATAGCGCCAGCGAATCGGAAGCCGAACAGCTTTATGGTGATTTCTATTGCACAGAATGCGGCATTTCGTTTCATCGCCAGGATCTGTTGCGACGTCATGCCAAACAGCAGCACGCCACAGAGGGCAGTGCAGATGCTGAGGGCGAGGGCGACGTCGGCGATGGCGATGCCGAGAATACCAAAGATGCGACGCATTGTTGTGACACATGCGGCAAATCATTTGCTCGTGCCTTGGAGCTGCGTGCTCACGCCGAGATTCATGCACGTTTTCCGCCTTTCAAATGCGTCTTGTGTGGCATCAGTTTCTATGAGGAACAGGCCATCAAACGTCACTTGCACACGCGTCATCCACACGAACTGAAGCCCAACTCGTGTGTGCTCTGTGGTAAAGAGTGTCGCGATCGCAAAGCGTTGATCAAACATGCCTGGGACCATTCGCGTGAAAAATGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCACGCCTGAAGCGACACATGGCCTCGCATCGTGATAAATCCGTCATTTGCGAGGTGTGCCACGAGGAATTCCCCGACGGACGCACACTTTCCAATCACCGACATTCGCATAGCACAACGTCGCCGGGCAAACTCTTTCCCTGCCACGAGTGCGGCAAAACTTTCGGTTCGCGCAGCTCCCAGCAGATTCATGTGCGCATTCACACGGGCGAACGTCCGTACGGGTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACCTTGCGCAAGCACGAACGCATTCACACCGGTGAAAAGCCTTACGCCTGCTCCGTGTGCCCACGGGCCTTCAATCAGCGTGTCGTTCTGCGCGAGCACATACGCTCGCATCATTCGGGACTCGATGCAGTGCGGGGCACTTATTATTGCACCGTCTGCACTGCGGATCTGTCCTCTTCCAATGAGCTTATCCATCATCTCATTCAGCACAGCGACACAAATACCGCCAAGCAACGACAGCCAATCACTGGTCCCCGCAAATACAAGCGACGAAGGAAACTGCAACCGCATGAAATTGCGCACATGCGGGCAGAGAACAAGGATGGCGATGAGTATGCCAGCGACATGGATCTCGGTGAACTGGACATGGAAAACGTGGACGATTTCTTCGATGGCGCCCATGCAGCGCCCAGCAAAAAGGAGAAACGCAAACGCAATGCTGCTGGCCAAACAAAGCCAGCGGCCAATGGAGTTAATAACAATGCAACGACACCAGCTAAATCCGGTAATCAAGAGCGTGGTTGGGACGATAAATTCCTACAGGCCAATAGCAATGGCAATGCCGGAGGCAGCAACGCTGCAAACGATGACGCTTTTAAGAGCATCTTTCAAATCGATTCGATGGTTATGGTCAATGACACCACACTGCAGCCGATCAGCACATCCAGCAGTGGTGCTGCAGTTGCGTCAAAGACGCGTCGCAGTGCCAAGCAAACGCCACAAACACAGCAGCAGACACCGAACAACAAGTCGGGAGCAACAGCGACCAACGAGTCAAGTACGACGGTATCTTCGAGCACTCGCAGCAGCCGCAAAAAAACTGCCAAATCCAGCAAAGCGACAAGCGCAGCGACGGCAGCAGCTGCTGCAAGCAGTTCTCGTCCACGCATGATCCATACGGAAAAGACCCGAGTGCCGCAAGAGAATGCGACAAAGAAGTCGACGCGAGGTCGTTCGTATGTGACGCGGACAAATGCCAGCGAAACCAGCAGCAGCCAGCAGCTGGGTGGTCTGGTCAAGTCGAGTGGCGTCGCCAGTTCGTGCATTGTGGATGACTATGAGATTATATCGCCCGCCACCCAGCCACCGAATCAGATCAGCTCAAGTCCGCTGCACATTAAGCAGGAACAGGAGCAGCATCAGCACCAACAGCAGCGCGGGTCGCTCATGTACGATGACACACATCTGCTGATCGATACGGCGCTGTTGCGCGAGAAGACCTACGAGAAGTTCAATCCCAGCATTGTCAATGATCTCGAGGAGATATTGCGCAGTCCGCTGAAGCATGATCGCAATGCGAGGCTTCGTTTCACCAGCGAATCGTCGACAACGCCACAGTTTCTGCCCGAAGAGGAGCAGAATCTGATTAAAATCGAACCAACGTCACCGGATCTGCGTGAAATGGTCGAGAGCCAGCAGCGTGTTAGCTCCGCTGGACATGGCGGCACACCCACATCGTCATCATCGGCGGCGCGTACTTCACGCCATCTGCGACAATTAACTGCCAACTCGAGTTCACGAACTGCCGCAAAACGTGGCAGCAACAGTAAAGCTGGATCCACGTCGAGTGCCAAGAAATCCGCATCATCCTCATCGTCATCGTCATCGTCTGTGGCCGTCAGCAAAGCCAACAACTCGTACCTCAGCTATGGCGTTGATTCCTACCATGTGAGTGTGGCTGGCAATGCCAGCTCTTCGGATGTCAGTTCTGGTTTCTTTTCCATCTCTGAAGTGGTCTCCGCTGCCGATGCCGCCGATGCAGCTGCCAAGGCAGCAGCCGCCAATAAACCGGAGCGTCGCGCCCGTTGCTATGAGTGCGAGATGTGTTCAGCCAACTTTCCGGATCGAGCTCAGTTGCTGGAGCATGTGCATATACACATCTGA
Protein Sequence: MNSQDYGGIQWIQQHSESSDLLENGANENEVTAAAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEAGGGTVLITDSGVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNANALELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQTDRPHLCKLCGARFSRRAELINHFKAHAEAQDAADAEAASAAAAAIKFEPQQQQRQIVDHFYEQEWPMYPEQEQEQEQQQQQQQHIQDTEQLTVVQQASYAEPVAAPTAVRGRISRLKPKEESTQYIVLAEKQAAADELQQFMEQLPADLDNTTTTTAAAVAIESPATTDNQQASEASRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDTHSLQEHQKTHQFEESNSEYDPASAGEDSASESEAEQLYGDFYCTECGISFHRQDLLRRHAKQQHATEGSADAEGEGDVGDGDAENTKDATHCCDTCGKSFARALELRAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVICEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYYCTVCTADLSSSNELIHHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDGDEYASDMDLGELDMENVDDFFDGAHAAPSKKEKRKRNAAGQTKPAANGVNNNATTPAKSGNQERGWDDKFLQANSNGNAGGSNAANDDAFKSIFQIDSMVMVNDTTLQPISTSSSGAAVASKTRRSAKQTPQTQQQTPNNKSGATATNESSTTVSSSTRSSRKKTAKSSKATSAATAAAAASSSRPRMIHTEKTRVPQENATKKSTRGRSYVTRTNASETSSSQQLGGLVKSSGVASSCIVDDYEIISPATQPPNQISSSPLHIKQEQEQHQHQQQRGSLMYDDTHLLIDTALLREKTYEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSSAGHGGTPTSSSSAARTSRHLRQLTANSSSRTAAKRGSNSKAGSTSSAKKSASSSSSSSSSVAVSKANNSYLSYGVDSYHVSVAGNASSSDVSSGFFSISEVVSAADAADAAAKAAAANKPERRARCYECEMCSANFPDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579414;
90% Identity: iTF_00562600;
80% Identity: -