Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 5.6 6.7e+03 -2.3 0.0 11 28 31 48 20 51 0.70

2 2 1.8e-40 2.2e-37 127.5 0.1 1 87 137 222 137 223 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	5.6	6.7e+03	-2.3	0.0	11	28	31	48	20	51	0.70
2	2	1.8e-40	2.2e-37	127.5	0.1	1	87	137	222	137	223	0.97

Coding Sequence: ATGgtgaaaagtgaaatggaATTCAAGAGCAACTTCTCCATCGATGCCATTTTGGCCAAGAAACCCCAAGTgaaccatcagcagcagcacgttGTGGTGGGCATAAAGCAGGAGCCCAgtcatcatcttcatcttcagcAGCTGCCTCACCACCAGTACGTGCATCCCTACTCCAACTCGGATGGCGAGCTGTCCGCCTCGGAGGACTTCGACACTCCCAGCCGGACCAGCACGCCCATGAGCAGTGCCGCCGAAAGTCTGTCCTCGCAGAACAACGACAAGCTGGATGTGGAGTTCGACGACGATCTGGATGATCAGCTGGAGGAGGACCAGGAGAGCGCCGAAGAGGAGGGCAATCCCAGCAAGAAGCAGAAGACAAGctcagcctcctcctccgcttcGGACACCAAGAAGCCGCCCTACAGCTACAATGCCCTCATCATGATGGCCATCCAGGACAGCCCCGAACAGCGGCTGACCCTCAACGGGATCTATCAGTACCTCATCAACCGCTTCCCGTACTTCAAGGCCAACAAGCGCGGCTGGCAGAACTCCATCCGCCACAATCTCAGCCTCAACAAGTGCTTCACCAAGATTCCGCGCAGCTACGATGATCCCGGCAAGGGCAACTACTGGATCCTGGACCCCTCGGCCGAGGAGGTCTTCATTGGCGAGACCACCGGCAAGTTGAGGCGCAAGAATCCCGGCGCCAGCCGCACTCGCCTCGCCGCCTACCGTCAGGCCATCTTCTCGCCCATGgcgggcggcggtggctccCCCTACGGAGCTCCTGCTCCCGGCTATGGTTATCCCGGAGTTCCCTTCGGCGGAGCCgcggctgccgccgccgccgctgctgcggctgccgcTCTCTATCAGCGCATGAATCCCGCCGCCTATCAGGCAGCCTACCAGCAGATGCATCATCAGTACCAGGCACCTCCCCAGCATCCAGCCGCCGCCCAGCTGCAGGGTTATCCGCCGCATCTCAACTCCGCCGAACTCTTCCAGCGGATGCAGTTCTTCGGCAAGTTCCCCGCCAGCTAA
Protein Sequence: MVKSEMEFKSNFSIDAILAKKPQVNHQQQHVVVGIKQEPSHHLHLQQLPHHQYVHPYSNSDGELSASEDFDTPSRTSTPMSSAAESLSSQNNDKLDVEFDDDLDDQLEEDQESAEEEGNPSKKQKTSSASSSASDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRKNPGASRTRLAAYRQAIFSPMAGGGGSPYGAPAPGYGYPGVPFGGAAAAAAAAAAAAALYQRMNPAAYQAAYQQMHHQYQAPPQHPAAAQLQGYPPHLNSAELFQRMQFFGKFPAS

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00525696;
90% Identity: iTF_00612618; iTF_00524225; iTF_00613315; iTF_00484943; iTF_00527112; iTF_00532914; iTF_00489182; iTF_00488521; iTF_00594350; iTF_00491318; iTF_00593656; iTF_00477824; iTF_00540896; iTF_00617440; iTF_00492029; iTF_00489887;
80% Identity: -