Dnik002511.1
Basic Information
- Insect
- Drosophila nikananu
- Gene Symbol
- run
- Assembly
- GCA_008042635.1
- Location
- VNJV01014935.1:21991-38296[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4 2.4e+04 -9.1 8.8 56 78 55 77 42 85 0.70 2 2 1.3e-72 7.6e-69 229.7 0.1 4 129 107 232 104 232 0.98
Sequence Information
- Coding Sequence
- ATGCACATTTCTGCTGAGGTCAGTTCGACCACCTCAAATCAAatacagcagcaacatcagacgcagcagcagcagcagcatcagcaaacAACAACGACCGCAACGAAGCGACGCAATGCtgagtcctcctcctcctcctccaacaacaacaacaataccagtacaaccaacaacaataacaacaacagcactacgatcaacaacaataataacacgaataacaataacaataataacaataacaatgttAAAACAAAGCCCGTGGACACGAGTCCGTATCTGACGCCGGAGAATCTCATCGAGCGCACCGTCGACGTCCTGCTCGCCGAACATCCTGGCGAGCTGGTCAAGACGGGATCACCTCATGTGGTCTGCACCACCTTGCCCACGCACTGGCGTTCAAACAAGACCCTTCCGATCGCCTTCAAGGTCCTGGCCTTGGGCGAGGTCATGGACGGCACCATAGTGACCATTCGGGCCGGAAACGATGAGAACTTTTGCGGTGAACTAAGGAACTGCACAGCCGTAATGAAGAACCAGGTGGCCAAGTTCAACGATCTGCGATTTGTGGGCAGAAGTGGAAGGGGGAAGAGCTTCACCCTGACGATTGTCATCTCGACGAACCCCATCCAGATAGCGACATACACGAAGGCCATCAAGGTGACCGTCGACGGACCGAGGGAGCCCCGCTCGAAGGTCCGCCACCAGGGCTTCCATCCGTTCGCATTTGGGCCACAGCGCTTTGGACCGGATCCACTTATGGCCGGATTGCCCTTCAAGTTGCCAGGTAAGCGGAGCAGGTGA
- Protein Sequence
- MHISAEVSSTTSNQIQQQHQTQQQQQHQQTTTTATKRRNAESSSSSSNNNNNTSTTNNNNNNSTTINNNNNTNNNNNNNNNNVKTKPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGKRSR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00617413;
- 90% Identity
- iTF_00489154; iTF_00477796; iTF_00612589; iTF_00606095; iTF_00525668; iTF_00540868; iTF_00617413; iTF_00479950;
- 80% Identity
- -