Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 5 2.2e+04 -11.3 10.5 57 72 72 87 56 96 0.57

2 2 1.8e-72 7.8e-69 229.5 0.1 4 129 120 245 117 245 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	5	2.2e+04	-11.3	10.5	57	72	72	87	56	96	0.57
2	2	1.8e-72	7.8e-69	229.5	0.1	4	129	120	245	117	245	0.98

Coding Sequence: ATGCACATTTCTGCTGAGGTCAGTTCGACCACCTCAAATCAAatacagcagcaacatcagacgcagcagcagcaacagcagcagcagcagcaacagcagcaacatcagcaaacAACAACGACCGCAACGAAGCGACGCAATGCTgagtcctcctcctcctcctccaacaataacaacaacaacaacaataataccAGCACCACCAATAACAACactagcaacaacaacaacaacagcactacgatcaacaataataacaatacgaataataataataataacaatgtTAAAACAAAGCCCGTGGACACAAGTCCCTATCTGACACCGGAGAATCTCATCGAGCGCACCGTCGATGTCCTGCTTGCCGAACATCCTGGCGAGCTGGTCAAGACGGGATCACCTCATGTGGTCTGCACCACCTTGCCCACGCACTGGCGCTCAAACAAGACCCTGCCGATCGCCTTCAAGGTCCTGGCCTTGGGCGAGGTCATGGATGGCACCATAGTGACCATTCGGGCTGGAAACGATGAGAACTTTTGCGGTGAATTAAGGAACTGTACGGCGGTGATGAAGAACCAGGTGGCCAAGTTCAATGATCTGCGATTTGTGGGCAGAAGCGGAAGGGGCAAGAGCTTCACCCTGACGATTGTCATCTCGACGAATCCCATCCAGATAGCGACCTACACGAAGGCCATCAAGGTGACCGTGGATGGACCAAGGGAACCCCGCTCGAAGGTCCGCCACCAGGGCTTCCATCCGTTCGCATTTGGGCCACAGCGCTTTGGACCGGATCCACTTATGGCCGGATTGCCCTTCAAGTTGCCAGGTAAGCGGAGCCGGTGA
Protein Sequence: MHISAEVSSTTSNQIQQQHQTQQQQQQQQQQQQQHQQTTTTATKRRNAESSSSSSNNNNNNNNNTSTTNNNTSNNNNNSTTINNNNNTNNNNNNNVKTKPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGKRSR

Sequence clustering based on sequence similarity using MMseqs2