Basic Information

Insect: Drosophila nigromelanica
Gene Symbol: zfh1
Assembly: GCA_004149445.1
Location: SCDR01000117.1:50991-55114[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.4e-05 0.0028 18.5 1.0 1 23 150 172 150 172 0.97

2 15 0.003 0.36 11.9 1.2 3 23 180 200 178 200 0.94

3 15 7.9e-05 0.0095 16.9 0.1 1 23 367 389 367 389 0.98

4 15 0.00027 0.033 15.2 0.9 1 23 395 417 395 417 0.98

5 15 3e-05 0.0036 18.2 2.2 1 23 448 471 448 471 0.95

6 15 9e-05 0.011 16.7 0.8 1 23 491 513 491 513 0.96

7 15 0.0016 0.19 12.8 0.4 1 23 519 542 519 542 0.98

8 15 0.023 2.8 9.1 0.4 3 19 551 567 550 568 0.95

9 15 0.00014 0.016 16.1 5.6 1 23 577 599 577 599 0.97

10 15 0.036 4.3 8.5 1.2 2 23 605 626 604 626 0.96

11 15 8e-06 0.00096 20.0 1.0 1 23 635 657 635 657 0.98

12 15 0.00091 0.11 13.6 0.1 3 23 665 685 663 685 0.97

13 15 0.00013 0.015 16.2 0.9 1 23 691 713 691 714 0.95

14 15 0.045 5.4 8.2 0.4 1 23 724 746 724 746 0.97

15 15 0.00042 0.05 14.6 0.5 1 23 1272 1294 1272 1294 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.4e-05	0.0028	18.5	1.0	1	23	150	172	150	172	0.97
2	15	0.003	0.36	11.9	1.2	3	23	180	200	178	200	0.94
3	15	7.9e-05	0.0095	16.9	0.1	1	23	367	389	367	389	0.98
4	15	0.00027	0.033	15.2	0.9	1	23	395	417	395	417	0.98
5	15	3e-05	0.0036	18.2	2.2	1	23	448	471	448	471	0.95
6	15	9e-05	0.011	16.7	0.8	1	23	491	513	491	513	0.96
7	15	0.0016	0.19	12.8	0.4	1	23	519	542	519	542	0.98
8	15	0.023	2.8	9.1	0.4	3	19	551	567	550	568	0.95
9	15	0.00014	0.016	16.1	5.6	1	23	577	599	577	599	0.97
10	15	0.036	4.3	8.5	1.2	2	23	605	626	604	626	0.96
11	15	8e-06	0.00096	20.0	1.0	1	23	635	657	635	657	0.98
12	15	0.00091	0.11	13.6	0.1	3	23	665	685	663	685	0.97
13	15	0.00013	0.015	16.2	0.9	1	23	691	713	691	714	0.95
14	15	0.045	5.4	8.2	0.4	1	23	724	746	724	746	0.97
15	15	0.00042	0.05	14.6	0.5	1	23	1272	1294	1272	1294	0.98

Sequence Information

Coding Sequence: ATGAACAACCAGGAATATGGCGGCATCCAGTGGATACAACAGCACGCCTCGGCGGTTGACTCCGAGACGGATATACTGGAAAGCGGCGCCGCCGACGGCGAGGTGACCGCCGCCTATCTGGTGAACGGGAATGCCACCGACGAGGATCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCGCGCGACGGCCAGCTGAGCGAGATCATTGCAGCCAACGAAACGAGCGGTGGCACCGTGTTTATTAGGGACAACGGCACCGTTGCTTACGCCGAGTCCTTCGACGATGACGCCCAAGTGGTCACCGAGGAGATTATCACCGATGACTGGGTGCAGCATCAAGGCGCAGAGCGCGTGGAAATCGCGGCCGAGCAAATTGCGGGCAACAACAGCTCGCAGGAGCTGCTGGACATGGAGCAAGATGAGTACACGGCGCTGCGCCCGTATCCCTGTGACTTCTGCAGCCGGCGCTTTCGCAAGAAGGCCAGCCTCAACAACCACATGTTGGCGCACCAAAACGATCGTCCGCATTTATGCAAACTGTGCGGCGGACGTTTTTCGCGGCGCGCCGAGCTGATTAGCCACTTCAAGGCGCACGCTGACGCACAGGTGGCGGCGGATGCCGaggccgcagcagctgcagcagcggctgcaattaaattcgagccgcagcagcagcaacgacaaatCGATGATCATTTCTACGAACAATGGCCGCTTTATCAGGACCAGGACCAAGACCAGGatcaggagcaggagcaggagcaggaagaGGACCAGGTGCAGTCACATGCGCAGGCACAGCAACtggtgcagcagcaccaaacTGTGCCCCAGGCCAGCTATCCAGCGGTCAGCGCTGTGGCAGCGCCAACAGCCGCACGCGGTCGCATTAGCCGCCTCAAGCCCAAGGAGGAGAGCACCCAGTACATTATGATTGCCGAGAAGCAGGCGGCATCTGAGGTCGATAATATGCCCCAGTACATGGACTGTGAagagctgccgctggcgggCAGCACATCGATCGGGGAAAGCGGCCAAGTCGCTGATACAGCGCAGCCGCTGCGCTTTCCGGTGCTGGACGAGAGCAAGCCCTTCGTGTGCCAGCAGTGCGGCTTGGCATTTGCGCGCGAGAAGGCGCTTGTCTCACACATCAAGAATCATCGCGTGGACTCGCCCTTCGAATGTAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGCCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAAAGCAACTCGGAGTATGATCCGGCATCGGCGGGCGAGGATAGCGCCAGCGAATCGGAACCGGATCAGCTATACGGCGACTTCTACTGCAGCGAGTGCGGCATTTCATTTCACAGGCAGGACCTGCTGCGCCGCcatgccaagcagcagcacaagGATGCGGAGGGCGGCGACCATGCAGAAGCTGGCGAAAATGCCAAAGATGCGCCACACAGTTGTCACACGTGCGGCAAAGCTTTTCCCAGTGCACTGGAGCTGAATACCCATGTCGAGATTCATGCCCGTTTCCCGCCCTTCAAATGCGTCCTGTGCGGTGTTAGCTTCTACGAGGAGGAGGCTATCAAGCGGCATTTAAAGACGCGCCATCCCCACGAGCTGAAGCCCAACTCCTGCGTGCTGTGCGGCAAGGAGTGCCGGGATCGTAAGGCGCTGATCAAGCACGCCTGGGACCATTCGCGCGAGAAGTGCCATTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCGCGACTGAAGCGGCACATGGCCTCCCATCGCGACAAGTCGGTGGTGTGCGAGGTGTGCCACGAGGAGTTCCCCGATGGCCGCACCCTCTCCAATCACCGCCACTCGCACAGCACCACGTCGCCGGGCAAACTATTTCCCTGCCATGAGTGCGGCAAGACCTTCGGTTCACGCAGCTCGCAGCAGATACACGTGCGGATCCATACGGGCGAGCGACCGTATGGCTGTCGCTACTGCTGGAAGGCGTTCGCCGATGGCGGCACACTGCGCAAACACGAACGCATCCACACTGGCGAGAAGCCCTACGCCTGTTCCGTGTGCACGCGAGCCTTCAATCAGCGCGTGGTGCTCCGCGAACACATACGCTCCCATCACTCGGGCCTGGACGCGGTGCGCGGCACCTACCACTGCACCGTTTGCACTGCCGATTTGTCCTCATCCAATGAGCTCATCCAGCATCTCATCCAGCACAGCGACACGAACACGGCCAAACAGCGGCAGCCCATTACTGGGCCACGCAAGTACAAGCGCCGAAGGAAACTGCAGCCACATGAGATTGCGCACATGCGTGCGGGCAACAAGGATGGCGAGGATTATGCCAGCGACATTGAATATTGCGATTTAGATGTGGAGAATGTCGACGATCTCCTCGACCGCGCCGAGCCCGTGCCCGTGAAAAAGGAGAAGCGCAAGCGAACTGCGACCAATGGCGCCGCAGCGCCAGCACAGAACACCTCGGATTCGGTTaagttggccaacagcagctcgGACCGTCTGTGGGATGAGAAGTTCATGCAGAtgaatggcaacggcaacgtcgCCACTGATGATGCCTACAAGAGCTTCTTTCAGATTGACTCTCTGGTGGTGGTCAACGACACCACCCTGCCGGCTGTTAGCTCCTCGAGCAATGCGGCAGGTGGCGCCAAGTCGCGGCGCAGCGGCAAGCAGGCGCAGCCAGCGGGTAGCAGCGACAAGgtggcggcagctgctggcgaGGAGTCGGGCAAGTCTGGAGTCGcgagcagtcgcagcagcaaaaggaaATCGAGCAAAGCGGCCAAGAATGCAGCTGGAGCAACAgtgacagctgcagctgcagccaccgCCAGCAGTTCGCGTCCCCGCATGATACACACGGAAAAGTCGCGGGTGCCGGCGGAGAGTGCGCCAAAGAGGTCGCGGGGTCGCAGCTACGCCACGCGCACCAGCACCAGCGAGAGCAGCCAGCTGGGTCTGGTCAAGGCGAGCAGTGTTGCCAGCTCGCGCATTGTCGATGATTACGAGATTATATCACCTGCCACACAGCCGCCCAATCAGATCAGCTCCAGTCCGCTGCACATcaagcaggagcaggagcaactgcagcaacaccaccagcaccaccagcagcagcagcagcgcgtgcAGCTCATGTACGACGATACGCATCTGCTGATTGATGCGACCCTGTTGCGCGAGAAGACCTTTGAGAAGTTTAATCCGAGCATTGTCAACGATCTCGAGGAGATACTGCGCAGTCCGCTCAAGCACGATCGGAATGCGCGGCTCCGCTTTACCAGCGAATCGTCGAACACGCCCCAGTTTCTGCCCGAAGAGGAGCAGAATCTTATTAAAATCGAGCCCACGTCGCCGGATCTGCGGGAAATGGTGGAGAGCCAGCAGCGTGTAACTGCCACGGGACAtcaggccacgcccacatcatcttcatcgtcatcgtcggcGGCGCGCACTTCTCGCCATCTGCGACAGCTTACCGCTAACTTGGGCACTCGGGCGGCCGCTAAGCGGAACATTAGCAAGACGACCTCCGCGTCCGGCTCCAAGAAGTCATCGTCAGACTCAACTGTTGCAGTCAGCAAAGCGAACTCCTCCTACCTCAGCTATGGCGTCGACTCGTACACTGTGAGTGTGGCGGCCAGCGCCAACTCCTCAGATGTCAGTTCCGGTTTCTTTTCCATCTCTGAGGTGGTGTCTGCTGCGGATGCCGCCGATgcggcagccaaagcggcggcggccagcaAAACGGAGCGCAGGACGCGCTGCTTTGAGTGTGAAATGTGCTCATCCATATTTCCCGATCGTTCCCAGCTGCTGgaacacatgcatatacacatCTGA
Protein Sequence: MNNQEYGGIQWIQQHASAVDSETDILESGAADGEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANETSGGTVFIRDNGTVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGGRFSRRAELISHFKAHADAQVAADAEAAAAAAAAAIKFEPQQQQRQIDDHFYEQWPLYQDQDQDQDQEQEQEQEEDQVQSHAQAQQLVQQHQTVPQASYPAVSAVAAPTAARGRISRLKPKEESTQYIMIAEKQAASEVDNMPQYMDCEELPLAGSTSIGESGQVADTAQPLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEPDQLYGDFYCSECGISFHRQDLLRRHAKQQHKDAEGGDHAEAGENAKDAPHSCHTCGKAFPSALELNTHVEIHARFPPFKCVLCGVSFYEEEAIKRHLKTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCTRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCTADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAGNKDGEDYASDIEYCDLDVENVDDLLDRAEPVPVKKEKRKRTATNGAAAPAQNTSDSVKLANSSSDRLWDEKFMQMNGNGNVATDDAYKSFFQIDSLVVVNDTTLPAVSSSSNAAGGAKSRRSGKQAQPAGSSDKVAAAAGEESGKSGVASSRSSKRKSSKAAKNAAGATVTAAAAATASSSRPRMIHTEKSRVPAESAPKRSRGRSYATRTSTSESSQLGLVKASSVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQLQQHHQHHQQQQQRVQLMYDDTHLLIDATLLREKTFEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSNTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTATGHQATPTSSSSSSSAARTSRHLRQLTANLGTRAAAKRNISKTTSASGSKKSSSDSTVAVSKANSSYLSYGVDSYTVSVAASANSSDVSSGFFSISEVVSAADAADAAAKAAAASKTERRTRCFECEMCSSIFPDRSQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00567672;
80% Identity: -