Dnig003292.1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Drosophila nigromelanica
Gene Symbol
PAX6_4
Assembly
GCA_004149445.1
Location
SCDR01000165.1:22315-28402[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5e-35 1.5e-31 109.5 0.0 23 125 73 170 66 170 0.95

Sequence Information

Coding Sequence
ATGAGGCTGCAACAAATTGTCGCTACCATCTACCTGAATTTAATTAGCACGGCTAGCAACGTGGCTGCGGATCGTTGGGCTCTTACGCACAACCACTGCCCGTCTACGCCGCCCGCTCCCACGTTGGCCCTGTTCGGCGGCGCGGGCAGCGCAGCCCAGGGCagcacatcagcagcagcaacggcggcggccACAAATCTGAGCGCGCTGGCCTCCCAGCATCGGCTACTGGAACTGTCACGCTTCGGGCTGCGGGGCTACGATTTGGCCCAGCACATGCTGTCGCAGCAGGGCGCTGTCTCCAAGCTGCTCGGCACCCTGCGACCGCCGGGGCTCATTGGCGGCTCCAAGCCGAAGGTGGCCACGCCGACAGTTGTCTCCAAGATCGAGCAGTACAAACGCGAAAACCCAACGATATTCGCGTGGGAAATACGCGAGAGACTGATTAGCGAAGGTGTCTGCACGAACGCCACCGCCCCCTCGGTGAGCAGCATTAATCGCATCCTGCGCAACCGCGCCGCCGAGAGGGCCGCTGCGGAGTTCGCGCGTGCGGCCAGCTACGGGTATGCCTTGCATCCgacgcatccgcatccgcaccCGTACACGAGCTTTCCCACCTGGCCGGCGACGTTGCCCGGCCACCATCCGCTGTGGGGCGCGGTGCCGCTGGCCGCGAGCGGCGCCCtgcccggcagcagcagctacaacagcgACGGCAACTCCAATTcgaataccaacaacaacagcaccagcgccggcggcggcagcagcgcggGCAGCGGACGCCTGTCGCTGCCGGCACTGTCGCCGGAGTCGGGCAGCCGGGACAGCCGTTCGCCGGACATGGATGCCAATCGCATGATAGATATCGAGGGCGAGGACAGCGACTCGGAGGACAGTGATCAGCCGAAGTTTCGGCGCAATCGCACAACGTTCAGTGCCGAGCAGCTGGACGAGCTGGAGAAGGAGTTCGAGAAGTCGCACTATCCCTGCGTGGGCACACGCGAGAAGCTGGCGGCGCGCACGGCGCTCAGCGAGGCGCGGGTCCAGGTTTGGTTTTCCAACAGACGAGCGAAATGGCGGCGCCACCAACGGGTCAATCTGCTGAAACAGCGCGACTCGGCTTCACCCACGCCAGCGCAAACCCAACCGGCTACATTGGGTCCACGGCCGGAGTCGAGCCTGCAATATGTCACCCGTTCCAGCGGCTACCACACCCAGCCGCAGCCGGACGAGGacagcaccaccaccatcagctgcagcagcagcatccacacCAGCACAAGCCATATGGGCCCAAGCCGCGAcccagcgacagcaacagcgccgCCTGCCTCACTCACAGCATCAGTTCCATTATTAATGGGCGGTGAGCACAGCGCCTTCCGTGCCGCTCTGCCCTCCCCCTCCGCCACCGCTACCGcttcggcgtcggcgtcagcgtcagcgtcggcaTCGGCGGCCGCATTTGCGCTCAACTTTGCCCGCCAATATATCTGGCGACACATGGCGGGGCCGCAGAAGACCGCGGAACTGGAGGAGGATGTCAATGTGGATGCCGAGACGGAAACGGAGTCGGAGGCTAACTGA
Protein Sequence
MRLQQIVATIYLNLISTASNVAADRWALTHNHCPSTPPAPTLALFGGAGSAAQGSTSAAATAAATNLSALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERAAAEFARAASYGYALHPTHPHPHPYTSFPTWPATLPGHHPLWGAVPLAASGALPGSSSYNSDGNSNSNTNNNSTSAGGGSSAGSGRLSLPALSPESGSRDSRSPDMDANRMIDIEGEDSDSEDSDQPKFRRNRTTFSAEQLDELEKEFEKSHYPCVGTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLLKQRDSASPTPAQTQPATLGPRPESSLQYVTRSSGYHTQPQPDEDSTTTISCSSSIHTSTSHMGPSRDPATATAPPASLTASVPLLMGGEHSAFRAALPSPSATATASASASASASASAAAFALNFARQYIWRHMAGPQKTAELEEDVNVDAETETESEAN