Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 9.6e-35 2.4e-32 111.4 0.7 2 109 144 249 143 250 0.97

2 2 9.6 2.4e+03 -1.3 0.0 80 109 252 281 248 282 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	9.6e-35	2.4e-32	111.4	0.7	2	109	144	249	143	250	0.97
2	2	9.6	2.4e+03	-1.3	0.0	80	109	252	281	248	282	0.82

Coding Sequence: ATGGGTGAGGTACTCAAATCGTCCACATTCTCAGCCGGTGCTAATGACAAACTAAAATGGTGTTTACGGGTGAATCCCAAGGGTCTAGATGAGGAGAGCAAGGATTACTTATCATTATATTTACTGTTAGTTTCGTGTAACAAATCTGAAGTCAGAGCCAAGTTCAAATTCTCCATACTAAATGCAAAACGTGAGGAAACCAAAGCAATGGAATCCCAGCGAGCTTACCGTTTCGTGCAGGGCAAAGATTGGGGCTTTAAGAAGTTCATACGCCGTGATTTCCTCTTGGACGAGGCCAACGGTCTCCTGCCCGAGGATAAGCTGACCATATTCTGTGAAGTCAGCGTCGTTGCGGACAGCGTGAACATCTCCGGACAATCCAATATTGTGCAGTTCAAAGTGCCCGAGTGCAAACTATCCGAGGATCTCGGCAATCTCTTTGACAACGAGAAATTCAGCGATGTAACGCTCTCGGTCGGTGGCCGTGAGTTTCAGGCGCACAAGGCCATTTTGGCAGCGCGCAGTGATGTCTTTGCGGCCATGTTTGAGCACGAGATGGAGGAGCGTAAGCTGAATCGTGTCGCCATAACCGATGTGGATCATGAGGTTCTCAAAGAGATGCTCCGATTCATATATACGGGCAAGGCGTCTAACCTAGAAAAAATGGCTGATGATCTCTTAGCGGCTGCTGATAAGTACGCACTCGAAAAGCTGAAAGTGATGTGCGAGGAGGCGCTGTGCGTCAATCTCTCTGTTGAAACAGCAGCCGAAACGTTAATATTAGCTGATCTCCACAGTGCGGATCAATTGAAAGCACAAACGATAGATTTCATTAATACTCATGCCACCGATGTGATGGAAACCTCTGGCTGGCAAAATATGATCAcaacacattcacatttgatAGCGGAGGCATTTCGTGCGCTCGCAACACAACAAATCCCACCAATTGGACCACCAAGGAAACGCGTGAAAATGAGCTGA
Protein Sequence: MGEVLKSSTFSAGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPEDKLTIFCEVSVVADSVNISGQSNIVQFKVPECKLSEDLGNLFDNEKFSDVTLSVGGREFQAHKAILAARSDVFAAMFEHEMEERKLNRVAITDVDHEVLKEMLRFIYTGKASNLEKMADDLLAAADKYALEKLKVMCEEALCVNLSVETAAETLILADLHSADQLKAQTIDFINTHATDVMETSGWQNMITTHSHLIAEAFRALATQQIPPIGPPRKRVKMS

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00337596;
90% Identity: iTF_00107051;
80% Identity: iTF_00473123; iTF_00516325; iTF_00549608; iTF_00544553; iTF_00476684; iTF_00540428; iTF_00493710; iTF_00586736; iTF_00532433; iTF_00509874; iTF_00572659; iTF_00545304; iTF_00568312; iTF_00559547; iTF_00551646; iTF_00832228; iTF_00500366; iTF_00498933; iTF_00616253; iTF_01556181; iTF_00599648;