Basic Information

Insect: Drosophila mulleri
Gene Symbol: zfh1
Assembly: GCA_035047565.1
Location: JAWNPK010000048.1:608604-612743[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 4.5e-05 0.0034 17.8 1.7 1 23 150 172 150 172 0.97

2 15 0.00083 0.064 13.9 1.2 3 23 180 200 178 200 0.94

3 15 9e-05 0.0069 16.9 0.1 1 23 367 389 367 389 0.98

4 15 0.015 1.1 9.9 0.7 1 23 395 417 395 417 0.98

5 15 1.5e-05 0.0012 19.3 2.1 1 23 448 471 448 471 0.96

6 15 0.00056 0.043 14.4 1.9 1 23 495 517 495 517 0.95

7 15 0.018 1.4 9.7 1.3 1 23 523 546 523 546 0.97

8 15 0.026 2 9.1 0.5 3 19 555 571 554 572 0.95

9 15 0.00016 0.012 16.1 5.6 1 23 581 603 581 603 0.97

10 15 0.041 3.1 8.5 1.2 2 23 609 630 608 630 0.96

11 15 9.1e-06 0.00071 20.0 1.0 1 23 639 661 639 661 0.98

12 15 0.00022 0.017 15.7 0.5 3 23 669 689 667 689 0.97

13 15 5.6e-05 0.0043 17.5 0.5 1 23 695 717 695 718 0.95

14 15 0.053 4.1 8.2 0.4 1 23 728 750 728 750 0.97

15 15 0.00056 0.043 14.4 0.5 1 23 1279 1301 1279 1301 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	4.5e-05	0.0034	17.8	1.7	1	23	150	172	150	172	0.97
2	15	0.00083	0.064	13.9	1.2	3	23	180	200	178	200	0.94
3	15	9e-05	0.0069	16.9	0.1	1	23	367	389	367	389	0.98
4	15	0.015	1.1	9.9	0.7	1	23	395	417	395	417	0.98
5	15	1.5e-05	0.0012	19.3	2.1	1	23	448	471	448	471	0.96
6	15	0.00056	0.043	14.4	1.9	1	23	495	517	495	517	0.95
7	15	0.018	1.4	9.7	1.3	1	23	523	546	523	546	0.97
8	15	0.026	2	9.1	0.5	3	19	555	571	554	572	0.95
9	15	0.00016	0.012	16.1	5.6	1	23	581	603	581	603	0.97
10	15	0.041	3.1	8.5	1.2	2	23	609	630	608	630	0.96
11	15	9.1e-06	0.00071	20.0	1.0	1	23	639	661	639	661	0.98
12	15	0.00022	0.017	15.7	0.5	3	23	669	689	667	689	0.97
13	15	5.6e-05	0.0043	17.5	0.5	1	23	695	717	695	718	0.95
14	15	0.053	4.1	8.2	0.4	1	23	728	750	728	750	0.97
15	15	0.00056	0.043	14.4	0.5	1	23	1279	1301	1279	1301	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCCGCGGTGGACTCTGAGACCGACCTACTGGAAAACGGCGCTGGCGACAGCGAGGTAACGTCCGCCTACTTGGTCAATGGCAATGCAACCGATGAGGATCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCGCGTGATGGTCAGCTGAGCGAGATAATTGCTGCCAACGAGAGCGGCGGCAGCACAGTCTTAATTACGGATAGCGGAACTGTTTCCTATGCCGCGGCATTTGACGAAGATGCCCAGGTGGTCACTGAAGAGATCATCACGGATGACTGGGTGCAGCATCAGGGCGCCGAGCGCGTGGAAATTGCTGCGGAACAAATCGCGGGCAACAACAGCTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTATACGGCATTGCGACCCTATCCCTGTGACTTCTGCAGCCGGCGTTTCCGCAAGAAGACCAGCCTGAACAATCACATGCTGGCGCATCAGAATGATCGTCCGCATCTGTGTAAATTGTGCGGCGCTCGGTTCTCGCGACGGGCCGAGCTCATTAGTCACTTCAAGGCGCACGCCGAGGCACAGGATGCAGCCGATGCGGCGGCAGCAATTAAATTCGAgccgccacagcaacaacagcgccaaATGGACGACCATTTCTATGAGCACGAATGGTCACTGTACCAGGAACAGGAAGACGATCAAGTGCAACAAGATCTGCAGCAAATGGAGCAAGACCAGCAGGATCAGCAtgaacagcaagagcagcagcagcaacagcagctcgtgCTGCCGCAGGCCAGCTATGCAGCAATCAGTGATGTACCCGCCCCCATAGCCACGCGAGGTCGCATCAGCCGCCTGAAGCCCAAAGAGGAGAGCACTCAGTACATTGTGATTGCCGAGAAGCAGACAACGGACGACTTGCAGCCGTACATGGAATGCGAGGAGCTGCCGCCCGCGTTGACGAGCAGCACGTCAATCGAAACGACGACAGTGACTGCCAGCGCGCCCGACAGTGAAGAGACGGCGGCGGCTCCGCGCTTTCCGGTGATAGATGAAAGCAAACCGTTCGTGTGCCAGCAATGCGGCTTGGCATTTGCCCGCGAAAAGGCGCTGGTCTCGCACATTAAGAATCATCGCGTCGACTCTCCGTTCGAATGCAATCAATGCCAGGATATGTTCTGGGACAACTACAGCCTGCAGGAGCATCTGAAGACGCACCAGTTCGAGGAGAGCAATTCGGAGTATGATCCGGCCTCGGCGGGCGACGACAGCGCCAGCGAGTCTGAGCCGGAACAGTTATACGGCGACTTCTACTGCAGCGAGTGcggcatttcatttcacagGCAGGACCTGCTGCGCCGCCACGCCaggcagcagcacaagcagctGGCCACGGATGTGGAGGGCGGCGCTGGTGATGCGGATGCCGAGAGTGCCAAAGATGCGCAGCATTGTTGTCACACGTGCGGCAAATCGTTTCCCAGCGCCTTGGAGCTGCTCGCCCATGCCGAAGTGCACGCGCGCTTCCCGCCCTTCAAATGCGTTCTATGCGGCGTTAGCTTCTATGAGGAGCAGGCCATCAAGCGGCATTTACACACGCGCCATCCGCATGAGCTGAGACCCAACTCGTGCGTGCTGTGCGGCAAGGAGTGTCGCGATCGCAAGGCACTGATGAAGCACGCCTGGGATCACTCGCGGGAGAAGTGCCACTCGTGCTCAAAGTGCGGCAAGAACTTTCACAACAAGGCGCGACTGAAGCGACACATGGCCTCGCATCGGGACAAGTCGGTGGTGTGCGAGGTGTGCCACGAGGAGTTCCCCGACGGGCGAACACTGTCCAACCATCGACATTCGCACAGCACCACCTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGCGGCAAGACCTTCGGTTCGCGCAGCTCCCAGCAGATCCATGTGCGCATCCATACGGGAGAGCGACCGTATGGCTGCCACTATTGCTGGAAAGCGTTCGCAGATGGCGGCACGCTGCGCAAGCACGAACGCATTCACACGGGCGAGAAGCCCTACGCGTGCTCCGTGTGTCCACGTGCCTTCAATCAGCGCGTCGTACTGCGCGAGCACATACGCTCGCACCACTCGGGCCTGGATGCTGTGCGAGGGACATATCACTGCACCGTCTGCTCGGCCGATCTGTCCTCGTCCAATGAGCTCATACAGCATCTCATCCAGCACAGCGACACGAACACCGCCAAGCAGCGACAGCCCATCACTGGTCCACGAAAGTATAAGCGGCGCAGGAAACTGCAGCCACATGAGATCGCGCACATGCGTGCGGAGCATAAGGAGGGCGAGGATTATGCCAGCGACATGGAGTTCTGTGACCTGGATGTGGAGAATGTGGACGAGCTACTGGAAGGGGCAGACACGTTGCCAATCAAAAAGGAGAAGCGCAAGCGTTCAGCTGCCAATCCGGCCAAGTCCGTGAGCAATGGGGGCGCTAGTAGCAATGCCTCTGCGTCGGTCAAGTCCGCCAATAGCAGCTGGGATGAGAAGTTCCTGCAGACAAATAGCAATGGCAACGCCGGCAACACTGATGAGAGCTTCTACCACATCGATTCACTCGTGGTGGTCAATGACACCACATTGCCGGCCGTCAGCTCATCCAGCAATGCACAAGGTGTTCCCAAGTCGCGTCGAGGCGGGTGCAAACAGGCCGAGAATAGCGATAAGTCCGGAGGAGGAgctggcacagcagcagcaacagccgcggCGACTAGCGCGGAATCGAGCAAATCCCACGTCGctagcagtcgcagcagcagccgaaagAAGTCCAGTAAGTCGACCAAGAGTGCTGCTACAGCATCAtccgcaccagcagcagcatccaccaCGGCGAGCAGCTCGCGTCCTCGCATGATACACACGGAAAAGTCGCGTGTGCCGGCGGAGAATGCATCGAAGAAGTCGCGTGGAGGCCGCAGCTACATAACGCGCACCAGCACCAGCGAGACCAGCAGCCAGTTGACCAGCCAGCTGGTCAAGTCGAGCGGCGTGTCCAGCTCGCGAATTGTGGATGACTACGAGATCATATCACCTGCCACCCAGCCGCCCAATCAGATCAGCTCCAGTCCGCTGCACAtcaagcaggagcaggagcagcagcagcagcgcatccAGTTCATGTTCGATGACACCCAATTGATCAACACAGCCATGTTGCGGGAGAAGCCCTACGACAAGTTCAATCCAAGCATTGTCAATGATCTCGAGGAGATATTGCGCAGTCCGCTCAAGCATGATCGGAATGCGCGGCAGCGCTTCACCAGCGAATCGTCTACAACGCTACAGTTCCTGCCCGAGTTGGAGCCAAACCTCATCAAGATTGAGCCCACATCGCCGGATCTGCGTGATATGGTGGAGACCCAACAGCGTGTCAATGCCACTGCTGGACaagcggccacgcccacatcgtCATCCTCGTCGTCGGCGGCGCGCACATCGCGCCACCTGCGACAGCTGACGGCCAATGGATCCAGCAGTCGCGCGACGTCCAAGCGAAGCGCTGGCAAATCTTCAACTGCCGCCGGCTCCAGCACTTCGAagcccagcagcaacacatcCTCAACGGAGGCTGTCAGCAAGTCCTACCTCAGCTATGGTGTGGACTCCTacaatgtgggcgtggcagcgagTGCCAGCTCGTCGGATGTCAGCTCCGGCTTCTTCTCCATCTCCGAGGTGGTATCCGCTGCCCATGCAGCCGATGCGGCCAAGGCCGCAGCAGCGAGCAAAACGGAGCGCCGGACCCGCTGCTTCGAGTGCGAGATGTGCTCATCCATATTTTCGGATCGggcgcagctgctggagcacatgcacatacacatctaA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDLLENGAGDSEVTSAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGSTVLITDSGTVSYAAAFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKTSLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAAAAIKFEPPQQQQRQMDDHFYEHEWSLYQEQEDDQVQQDLQQMEQDQQDQHEQQEQQQQQQLVLPQASYAAISDVPAPIATRGRISRLKPKEESTQYIVIAEKQTTDDLQPYMECEELPPALTSSTSIETTTVTASAPDSEETAAAPRFPVIDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQDMFWDNYSLQEHLKTHQFEESNSEYDPASAGDDSASESEPEQLYGDFYCSECGISFHRQDLLRRHARQQHKQLATDVEGGAGDADAESAKDAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELRPNSCVLCGKECRDRKALMKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCHYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKEGEDYASDMEFCDLDVENVDELLEGADTLPIKKEKRKRSAANPAKSVSNGGASSNASASVKSANSSWDEKFLQTNSNGNAGNTDESFYHIDSLVVVNDTTLPAVSSSSNAQGVPKSRRGGCKQAENSDKSGGGAGTAAATAAATSAESSKSHVASSRSSSRKKSSKSTKSAATASSAPAAASTTASSSRPRMIHTEKSRVPAENASKKSRGGRSYITRTSTSETSSQLTSQLVKSSGVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRIQFMFDDTQLINTAMLREKPYDKFNPSIVNDLEEILRSPLKHDRNARQRFTSESSTTLQFLPELEPNLIKIEPTSPDLRDMVETQQRVNATAGQAATPTSSSSSSAARTSRHLRQLTANGSSSRATSKRSAGKSSTAAGSSTSKPSSNTSSTEAVSKSYLSYGVDSYNVGVAASASSSDVSSGFFSISEVVSAAHAADAAKAAAASKTERRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00473204;
80% Identity: -