Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 2.1e-14 3.9e-12 46.2 0.0 3 54 34 83 32 88 0.83

2 4 9.5e-05 0.018 15.2 0.1 75 109 82 116 80 117 0.89

3 4 3.1 5.8e+02 0.6 0.1 90 109 129 148 118 157 0.58

4 4 3.2 5.9e+02 0.6 0.2 85 101 136 152 127 191 0.60

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	2.1e-14	3.9e-12	46.2	0.0	3	54	34	83	32	88	0.83
2	4	9.5e-05	0.018	15.2	0.1	75	109	82	116	80	117	0.89
3	4	3.1	5.8e+02	0.6	0.1	90	109	129	148	118	157	0.58
4	4	3.2	5.9e+02	0.6	0.2	85	101	136	152	127	191	0.60

Coding Sequence: ATGTCGTCAACATCGAAGATGGCGGAGAATAGGATAGAGTCTTTGTCGAGAGATTCCAGTGTGGGCAGCCATGCAGACTCCTTATTGAAGCGAATGCACCACTTTGTGGAGAGCCAGCAGCTGTGCGATGTGGTCCTCATCGCTGGGATCGACGGCAGGCGGGTGTCCGCTCATCGCTTGGTGCTAGCAGCTGCGAGTGAATATTTCTCAGCAATGTTTACCGGATCACTGCGCGAGAGCGAGGAGCATGAGCTGCACAAGGACACTGTCGAGTCGCTGCTGGCCACCGCCAACCTGCTGCAGCTGATCCCTGTGGTGACGAAATGCTGCAATTTTCTCGCTCGCCAGCTGCACCCATCCAATTGTATTGGACTCGCATTATTGGCGGAGCAGCTGAACTGCACAGAGCTTCTGCAAGTGGCACAGGCGTTCATCTGCCATCACTTTATGGAGCTGTATCAGGATCAGGAGTTCTTTCAACTAAATGCAATCCAGCTGGGCAAACTGCTGTCCAGCGCTGAACTCAATGTGCCAATGCAGCCAGATGTCTTCCACACGATTTTGTCGTGGATCAAGTGGATTACCACCATTGAGAGCTACTGTCCGCAGCTGAACAAGTGGACGACTTGGGAGCACACGATCGATGGACGTGAGGAGTTTGGAGCCGCTGTCATGACCTAA
Protein Sequence: MSSTSKMAENRIESLSRDSSVGSHADSLLKRMHHFVESQQLCDVVLIAGIDGRRVSAHRLVLAAASEYFSAMFTGSLRESEEHELHKDTVESLLATANLLQLIPVVTKCCNFLARQLHPSNCIGLALLAEQLNCTELLQVAQAFICHHFMELYQDQEFFQLNAIQLGKLLSSAELNVPMQPDVFHTILSWIKWITTIESYCPQLNKWTTWEHTIDGREEFGAAVMT

Sequence clustering based on sequence similarity using MMseqs2