Dmim011674.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila mimetica
Gene Symbol
Mef2
Assembly
GCA_037075245.1
Location
JBAMCH010000014.1:12756810-12761980[-]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.7e-28 3.3e-24 84.2 0.4 1 48 10 57 10 57 0.99

Sequence Information

Coding Sequence
ATGGGTcgcaaaaaaattcaaatatcacGCATCACCGATGAACGCAATCGGCAGGTGACCTTCAACAAGCGCAAGTTCGGCGTGATGAAGAAGGCCTACGAGCTCTCGGTGCTCTGCGACTGCGAGATCGCCCTGATCATCTTCTCGTCGAGCAACAAGCTGTACCAGTACGCCAGCACCGACATGGATCGCGTCCTGCTCAAGTACACCGAGTACAACGAGCCCCACGAGTCCCTCACCAACAAGAACATCATCGAGAAGGAGAACAAGAACGGCGTGATGTCGCCGGACTCCCCCGAAGCCGAAACGGACTACACACTCACGCCGCGCACGGAGGCCAAGTACAACAAGATCGACGAGGAGTTCCAGAACATGATGCAGCGCAACCAGATGGCCATCGGCGGGGCGGGGGCGCCTCGCCAGCTGCCCAACAGCAGCTACACGCTGCCCGTGTCCGTGCCGGTGCCCGGCTCCTACGGGGACAACCTGCTGCAGGCCAGCCCCCAGATGTCGCACACCAACATCAGCCCACGTCCATCGAGTTCGGAGACGGATTCAGGTGGGATGTCCCTGATAATCTATCCATCGGGTTCCATGCTGGAGATGTCGAACGGCTATCCGCATTCACACTCGCCGCTTGTGGGATCACCGAGTCCGGGTCCCAGTCCTGGCATAGCCCACCACTTGTCCATCAAGCAGCAGTCGCCGGGCAGCCAGAACGGACGCGCTTCCAACTTGAGGGTGGTCATACCGCCCACCATAGCCCCCATACCGCCCAACATGTCCGCGCCGGACGACGTGGCCTATGCAGATCAACGACAGAGTCAGACTTCGCTGAACACGCCGGTGGTCACGCTGCAGACGCCCATTCCCGCCCTCACGAGCTACTCCTTCGGGGCGCAGGACTTCTCCTCCTCGGGCGTGATGAACAGCGCGGACATCATGAGCCTCAACACCTGGCATCAGGGCCTGGTGCCGCACTCTAGTCTCTCGCACCTGGCTGTCTCGAATAGCACGCCGCCGCCCGCCACCTCACCCGTCTCCATCAAGGTCAAGGCCGAGCCGCAGTCACCGCCGCGAGATCTCTCCGCCAGCGGCCATCAGCAGAACAGCAACGGGTCGACGGGCAGCGGCGggtccagcagcagcacgagcAGCAATGccagcggcggcggaggaggaggcggtggtggAGGCGTCAGCGCAGCCAATGTCATCACGCACTTGAACAACGTCAGTGTCCTGGCAGGGGGTCCTTCGGGGCCAGGAGGAGGTGGTGCCGGAGGAGGCGGCAGCAACGGGAACGTCGAGCAGGCCACCAATCTGAGCGTGCTGAGCCACGCGCAGCAGCACCACCTGGTCATGCCCAACTCGCGGCCCTCGTCCACGGGCCACATTACACCCACTCCAGGGCATGATAAGTATGAAGGATATCCGTACCGCGCGCTAATGGGACATAATCCTAGATGGAATTTTGCCGACTTCATTATCCTTAATGCAGGTGCGCCGAGCAGCGACCAGGATGTGCGTCTGGCCGCCGTCGccgtgcagcagcaacagcagcagcagcaacaccagcagcagcagctgggcgACTACGACGCCCCCAACCACAAGCGACCGAGAATATCGGGCGGATGGGGTACATAG
Protein Sequence
MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRVLLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEAKYNKIDEEFQNMMQRNQMAIGGAGAPRQLPNSSYTLPVSVPVPGSYGDNLLQASPQMSHTNISPRPSSSETDSGGMSLIIYPSGSMLEMSNGYPHSHSPLVGSPSPGPSPGIAHHLSIKQQSPGSQNGRASNLRVVIPPTIAPIPPNMSAPDDVAYADQRQSQTSLNTPVVTLQTPIPALTSYSFGAQDFSSSGVMNSADIMSLNTWHQGLVPHSSLSHLAVSNSTPPPATSPVSIKVKAEPQSPPRDLSASGHQQNSNGSTGSGGSSSSTSSNASGGGGGGGGGGVSAANVITHLNNVSVLAGGPSGPGGGGAGGGGSNGNVEQATNLSVLSHAQQHHLVMPNSRPSSTGHITPTPGHDKYEGYPYRALMGHNPRWNFADFIILNAGAPSSDQDVRLAAVAVQQQQQQQQHQQQQLGDYDAPNHKRPRISGGWGT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00517665; iTF_00593793; iTF_00612769; iTF_00515554; iTF_00538914; iTF_00580674; iTF_00485092; iTF_00533060; iTF_00603300; iTF_00565332; iTF_00486524; iTF_00492189; iTF_00617599; iTF_00535999; iTF_00580673; iTF_00580671; iTF_00504645; iTF_00619108; iTF_00591657; iTF_00607753; iTF_00505359; iTF_00536724; iTF_00596604; iTF_00592348; iTF_00539616; iTF_00494342; iTF_00529524; iTF_00594503; iTF_00543083; iTF_00611307; iTF_00601012; iTF_00574767; iTF_00514845; iTF_00491468; iTF_00488621; iTF_00541029; iTF_00477975; iTF_00571854; iTF_00609128; iTF_00602542; iTF_00604799; iTF_00477296; iTF_00550211; iTF_00475891; iTF_00615520; iTF_00503948; iTF_00545923; iTF_00614865; iTF_00525839; iTF_00484400; iTF_00471569; iTF_00480818; iTF_00561714; iTF_00507571; iTF_00563859; iTF_00590195; iTF_00524372; iTF_00581492; iTF_00489333; iTF_00566037; iTF_00487955; iTF_00487254; iTF_00606263; iTF_00482936; iTF_00480121; iTF_00804345; iTF_00613466; iTF_00490034; iTF_00531611; iTF_00605531; iTF_00481500; iTF_01319711; iTF_00527264; iTF_00580672;
90% Identity
iTF_00515554; iTF_00494342; iTF_00607753; iTF_00491468; iTF_00503948; iTF_00545923; iTF_00614865; iTF_00602542; iTF_00561714; iTF_00507571; iTF_00529524; iTF_00536724; iTF_00565332; iTF_00581492; iTF_00504645; iTF_00606263; iTF_00605531; iTF_00481500; iTF_00550211; iTF_00591657; iTF_00619108; iTF_00505359; iTF_00477296; iTF_00475891; iTF_00566037; iTF_00538914; iTF_00487955; iTF_00596604; iTF_00592348; iTF_00539616; iTF_00486524; iTF_00604799; iTF_00578496; iTF_00615520;
80% Identity
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