Basic Information

Insect: Drosophila mettleri
Gene Symbol: Trerf1
Assembly: GCA_035047625.1
Location: JAWNPI010000035.1:20556701-20567369[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00013 0.0091 16.4 0.2 2 23 317 338 316 338 0.97

2 6 4.2e-06 0.00028 21.1 1.3 1 23 344 366 344 366 0.98

3 6 0.0004 0.027 14.9 2.5 1 23 372 396 372 397 0.94

4 6 0.00069 0.047 14.1 0.8 2 23 676 697 675 697 0.97

5 6 0.0019 0.13 12.7 0.1 1 23 1818 1842 1818 1842 0.98

6 6 9.3e-05 0.0063 16.9 0.8 1 23 1989 2011 1989 2011 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00013	0.0091	16.4	0.2	2	23	317	338	316	338	0.97
2	6	4.2e-06	0.00028	21.1	1.3	1	23	344	366	344	366	0.98
3	6	0.0004	0.027	14.9	2.5	1	23	372	396	372	397	0.94
4	6	0.00069	0.047	14.1	0.8	2	23	676	697	675	697	0.97
5	6	0.0019	0.13	12.7	0.1	1	23	1818	1842	1818	1842	0.98
6	6	9.3e-05	0.0063	16.9	0.8	1	23	1989	2011	1989	2011	0.98

Sequence Information

Coding Sequence: ATGTGCAACGCGTCTGTGGGCAACGAGGGTTCCGTAACACTGCAACTAAGAGATGCGAATGCCTTGGAGGCAGCCGCGagcagcacaacaacagcaacaacagcaacatcagcagcaacatcgtCATCAGGCCAAGCAAGTGCGTCAGGACTAACGTCAGCATTAGAGAATGCGCTAACTATCGGCTATCCGGATCCGGACATGTTAGCAGATGTCTTGGGCACCATACAGACGGCCTCACTTAAGAACAAacaaatcagcaacagcagcaacaacaacaacaaaagaaacatCAATGGTAGCACCGGTCGAAGTAGCGGCACTACTGCGCCAACAATTCTGAACAACTCGATAGCAGCAACGAGCTCTGGAATTCGTCTGAACAGTCCCAATAGGATAACGATAACGCGACGCAGTGCTAGCAATAAGATTAGCGTACAGACTGTGACCGCCTCAACGAATACAACGATTAGCAGCATTGGTGGCAGCAAGACCAACTACATTAAGAACTGTCTaatacgcagcagcagctgcagcaacacgGCCACCAATGTCACGACGCTGGCACAGATtatgagcaacagcagcaccagcagcgccGCCAGTTTACTCAGTCAGcacaacaataatagcaactgcagcaacagcagcaacttcaGCAACGCCTCGTCCGtgggcagcagcatcagcataaGCAGTactaccagcagcagcaccacaagCAGCCACAGTAGCAGTCACAGCATCAGTAATAGtaacagcaacgacagcaacagcagcagcggccacagCCTAAGTTTCAAGAGCAACGGCCGACATGTCGCTGGCatagtagcaacagcagcatccacGAACACCACTGCAACTGGCATTGGCATTATCACTGTCGACCACGCTCCCCGAAAGAGTCGACCTAAATTATCGTCGCCCACACGCCACGGCCCCCAGCAGTGTCAGATTTGTAGCAAGATCTTTGGAAATGCCTCGGCATTAGCCAAGCACAAACTGACGCACAGCGACGAACGGAAATATATTTGTGCGCTCTGCTCGAAGGCATTCAAGCGGCAAGATCACTTAAACGGACACATGATGACGCATCGGAACAAGAAGCCTTACGAGTGTAAGGCGGAAGGCTGCGGCAAATCCTATTGTGATGCTCGCTCCCTTCGCCGTCATTCGGAGAATCACCATGGTGGTGTGGCAACTCCGAATAACAACTCACTCTCGCCAACCAGTAGCACCAACTGCGGCAGCGtgagcagtggcagcagtagcagcagcagcagcagtgtgggcgtggccaccAACTCGCTTAGCCTATCGCCGGCTACGGCGAGCGGAGATGCCAGCTCACCAGACGGTGCCACCTGCATTCGCACCTACATTTCCACCGGCAGCACAGTGGTTGACGCAGCCACTGGCATTGCGCTGTCCGACGAGCAAATCAAGGCCATGAATTTGCCCATCAAAACTGGCGTTACACTGTTGTCGCCCACCACTTCGACATCGTCGAATGCATCGTCTACAGCATCTTCGTCATGTTCCACATCGGGCAGCAGTACCAACAACAGCactaacaacagcaacaaaaacagcaacagcaacagcaacggcaaaggcaatggcaatggaaatTCCACTGTCACCAGCTCACCGACAATTACGCTTAGCGATGGCACTACGCTCGAGGGCGACGGGCTGACTCGCGAGCAGCTCGATCTCATAAGCAAGATCATGCAGCAGACGAAGCAGACCAGTGCTCAGGTGACGGTCTCCTCTCCCACCAGCGTAAGCTCCTATAAAATCAATACAGAGACGGCGCAAGTGTCTTCGCGTCCACGCACCTGGAACATGCAGTTGCTCAATAATTCGCAAAATGTGACGGTAACTGTGGAGGATGGCACAGAGGTGGCAGGATCGACGGGATCATCAGCTGATGAGGTCAAGGAGGATGAAGTGAACCAGCAGCTGGTGGCCGCCATCAATCCCCATCTGCTCAACATTGTGAAGATCGACAAGCCAGTCGAGTGCAATCTATGTCATCGTAAATTTAAGAACATACCCGCCCTTAATGGGCACATGCGTCTGCACGGCGGATACTTCAAAAAGGATCCGGAAACGAAACGCAGCGAGAAAAAGGACTTGAACGCACCTCCGTTGCAGACTGCCAGCATAGGAGTGCGAGCCCTCATCGAGGAGAAAATCATAAGCAAGCGCAAGGATATAAATAAGGGCGCCTTCGTAGTGCCTGCTCCACCGAGCACCACGTGCAACAGCGTTAGCGtctgcagcaccagcagcaacacactAAGACGCTCGATAAGCGACCTGGAGAGCTTTCTCAATCCGAAATGCAGCACCACCAGCCTGAGTCAAGCACTatccaccagcagcagcaccaccacagCGGTGCTGCCGGCGGCAACCACGATCAAGAGCAGCAATGGGCTCAGTATACAGCAGATTGGACTGCCGCAGAGCATCGAGATCTTCAGCGGAGGTCACAGGCAGCCAAAAACTCTCAGTTTGGGCAGTGGTGCCAACACTATAACCATAACCACCAACAATGTGCCTACCACAACCACCATGAGCGCCCTTACGGCACTGAAGGGTGGCGGCACCATCAATGGCATCTCCACCAATGTGGATCCCAAGGATTCGACACTGATTGAGCTGCTTAAGCGTGGAACGCGCATTGCCGTCGCTTCGAAGAAGACCCACATGCAAGCCCAGAGCAGTACAAACCTGTTGCTGAGCAATGTGACGGGCACGGAGCTCACAGCTATAGGCAGCAGTGTCCAGGCAGCCGGACGCCAGATAATCACCAACAACAATCGCACCGTCATCATACCCTCAGATGTGCATGTGGTGTCCACAAAGAGCAAACTCATCTCGAGCCAAGCCATCAcagccaacgacaacaacaatagtagcaacagcagcaacaacgcacCGTCTTCTGCGAGTAGCATCTCATTGCCGGACGGCACTCCGCTCTCAGTGGCCATTGCGAATGGCCAGGAGAGTCTAGGCGCCAGTGAAGCGAGCGGCATTacaggcggcggcggtggtgttTATACGGTGACATACACCAGCGATGCTGACGCCTCGGACCTCTTCGACGATACAGAGGTCTACAATGTGTCGGATACGGAAATGCTGCTCCAAACGGTGGATACCATGGAATTGCTCAATGATGACGAGGATGAGGTGCAAAAGAGCGAACATTCCGAGGACTTCTCGCTGCTCAACGAAGCCGGCGAAACTGGTCATACCCAACTAGTCAAAATGGAGCCAGACCTATCACCATCATCAgccaacaccagcaacaagaCAACGCCATTGCCCACCTTCCAGCAGTTCCATTCCAAAGAGATCATCATGCAGAACAGCTCACAAATTCAGGCCATTGCCAACATGCGCGGCGGGGGCAGTCTAGGCGTACTCGCCTCACCCCTACATTCGCCAATAGCCTATCCGACGCCGCCGTCCAGCCACGAGAACATGGCTCAGTCGTCGCCTTTCATAGAGGATGCGGCGGCGCAGTTTGTGGACGCCAGTCACACATTCTTTGGCGACAAGACAGACTTCTCGCATGTTTATTTCAAAACAGACGAAAGCGACTCCATGCAGGAGCTCACGGAGAACGACAACGAGAAGATACTCAAGTTGAAGACGGTGCTCGAGGAGAGCAGCTTCGGTCCCTCTATCAAAGTGGAAGATCTGTTAAGCGGCACCGAAGATGATGCTGAGTGCGATTTGCGTGAGTTTGCTGAGACTAATCTCTCGTTCCTGGATGAGGATCAGGAATTCCTGAATGATTCGCGAAATGCCACCTCTCCGCTGTCAGAGTCTTTCTTCACCAGCGGCATTGGCTCGGCCGAGGATGTTAAGCAAGTGCTGCGTGAGGTGCTGCCCGAGGAAAATATCCAATTACAgctgagcagcgagcagcaggGCGAGAACATTATAGATCTGTACTACTTGCCGGGTCTTGGCCTCCAATCCCAGATGATGCCCAACTCCGACGATCCGCTTTTGTCGTCTTCGCCTCGAGAATTTGGCCAGCAGCGCCAGGTTGTGCACACAACTGCAGCGTCAACTGCGACCGTGCAACCTATCGAGCAGTTGCAGTCTACGACTGTGCTTTATGATcagcaccaacaacatcagcagcagcagcaattacaaatgcaattgcaaatgcATGCCCAGCAACATCAATCGGAACAGCAGCCACCACAAgatgagcaacagcagcagccgcaccaacaacaactaggAACTCAGCAGCAACACATGCAATTGCCACAGCTACCTGTTACTCACAGTGAGCAatcccaacagcagcaacaagcagaCTTCATGCTCACCAACTTTACGCCCGTGAGCTGTCAAGCCCAGTACATAGATGCCAATCAGCAACCGATGATGTTGCAGCCGTTGAATAGTCTGCTGCAGCCCGTGCtctatggcagcagcagcgctgccaacAATAAGCCCGCATTTGGCTCGCTGCTCAGCTCCAATACGGCTCAGGCAACTGCACTCGATGCGAGCCTGCTCTTTGCCTGCGATGACTCTAAAAATAACTGCAACAAGTCGATGCTGGCCGCTTTACCCGCGGCGATTCCGACGCCCGTAGTCACTGCTACACCAAGTGTTGCAAATCTTCAGCCGTTGTCCAATCAAACAAATTCCATACTGAAGCGTCGACTGCGGTCCAATGGGCCGCAGGATGTGCACAAGTTCTCGAAATTCCATACACTTTCGCCGCATCGCTCAAAGCTGCGCAAGCCATCACGGACCCACTACACCCCTGCCCCGATACTCAATCCGGATCGCAAGGGCACCGGGCTCTACTGCAATGTGCGCAAGCAGCTTGGTCAGGGAATGTTCGACGTGTTCGACGATGACTTTGGCGATCCTGTAGGCTTGGTGGACTTCTGCGACGAGTCCAAGGTGAATCTGGGCTCCACTTATCAAGCGCAGATCCCAGCCTGCAAGGCATCAGAGGAATCTAGCAAGGAACCCATGTGCGCCGACCTAATGTGGGACCCCAGCGTCCAGTTAGACGACAAGATATTAATGCGTTACATAGATCTCAGCAAATCATCGGCCGTACCCATGGGCAGCCATTCCGAGGAAGTAGCCTTGCAAACGCTGCTCGACGCAAAGGGCAACTCAGCGGCTGCGGTGCTTACTCTACTCCAGATGCAGTCCAGCGCATTCCAAATGAAGTGGACTGCCTATGAGCTAGAACAGTTTCTGCGCGGCCTCGAAAAATACGGCAAAGACTTTGGCAAAATCGCCAGCGAGCTTCACACCAAGACTTCGGGCGAATGCGTGCAAATGTATTATTTCTGGAAGAAACTATGCGTGGACTACAAGGTATCGCACCTCAAAATGGAGCCAGTTCCCGCAAGCATCCCAATGGTAGAGCAGAAGCCCTACGTCTGCGAAATAGCTGACTGCTCAGCGAGCTTCAGCTCGAAGGCGGCGCTGCATGGTCATGTCCGCATACACGCTTATGGTAGAaatgccagcaacaataatagcaacaacagcaacaacaacaacaaccagcatGCAACGGCAACtagtgccaacaacaacaacaacaacagcagcaacagcaacaacacccaTAGCAGCAACGCATGCACACCCCTGACTAGCAGCAGTCAACAGactagcaacagcaacaatgcaacagcaaccatAACGCACACTAATGGCAATAGCAACACCACCgcgaacaacaataataatatgagcaacaacagcagcatcgcTGGCATTTGCACAAACTCAGCGCAGATGCTCTCAATAGCAACAAAGACACTAGCAACCggtgcggctgcagcagcagccacggctgcagcagcagcagcatcatcatcttcGACAGCAACGAAAgacagtagcaacagcagcaattccAATATGCCCAAGGACAGTGAATTTCCCTGCAAGGTGTGCGGCAAAGTCTTCAATAAGGTGAAAAGTCGCAGCGCCCACATGAAAACGCACCGAGTACAAGAGGCAGAACAATCAGCCAATTCCAAGCAGCAATCATCCAcacttgttgttgccgtcgcatcagcagcagcaacgtcagcagcagcaacatccgcctcagcagtagcagcaacagcaatggccaCAGCAACTTCGTAG
Protein Sequence: MCNASVGNEGSVTLQLRDANALEAAASSTTTATTATSAATSSSGQASASGLTSALENALTIGYPDPDMLADVLGTIQTASLKNKQISNSSNNNNKRNINGSTGRSSGTTAPTILNNSIAATSSGIRLNSPNRITITRRSASNKISVQTVTASTNTTISSIGGSKTNYIKNCLIRSSSCSNTATNVTTLAQIMSNSSTSSAASLLSQHNNNSNCSNSSNFSNASSVGSSISISSTTSSSTTSSHSSSHSISNSNSNDSNSSSGHSLSFKSNGRHVAGIVATAASTNTTATGIGIITVDHAPRKSRPKLSSPTRHGPQQCQICSKIFGNASALAKHKLTHSDERKYICALCSKAFKRQDHLNGHMMTHRNKKPYECKAEGCGKSYCDARSLRRHSENHHGGVATPNNNSLSPTSSTNCGSVSSGSSSSSSSSVGVATNSLSLSPATASGDASSPDGATCIRTYISTGSTVVDAATGIALSDEQIKAMNLPIKTGVTLLSPTTSTSSNASSTASSSCSTSGSSTNNSTNNSNKNSNSNSNGKGNGNGNSTVTSSPTITLSDGTTLEGDGLTREQLDLISKIMQQTKQTSAQVTVSSPTSVSSYKINTETAQVSSRPRTWNMQLLNNSQNVTVTVEDGTEVAGSTGSSADEVKEDEVNQQLVAAINPHLLNIVKIDKPVECNLCHRKFKNIPALNGHMRLHGGYFKKDPETKRSEKKDLNAPPLQTASIGVRALIEEKIISKRKDINKGAFVVPAPPSTTCNSVSVCSTSSNTLRRSISDLESFLNPKCSTTSLSQALSTSSSTTTAVLPAATTIKSSNGLSIQQIGLPQSIEIFSGGHRQPKTLSLGSGANTITITTNNVPTTTTMSALTALKGGGTINGISTNVDPKDSTLIELLKRGTRIAVASKKTHMQAQSSTNLLLSNVTGTELTAIGSSVQAAGRQIITNNNRTVIIPSDVHVVSTKSKLISSQAITANDNNNSSNSSNNAPSSASSISLPDGTPLSVAIANGQESLGASEASGITGGGGGVYTVTYTSDADASDLFDDTEVYNVSDTEMLLQTVDTMELLNDDEDEVQKSEHSEDFSLLNEAGETGHTQLVKMEPDLSPSSANTSNKTTPLPTFQQFHSKEIIMQNSSQIQAIANMRGGGSLGVLASPLHSPIAYPTPPSSHENMAQSSPFIEDAAAQFVDASHTFFGDKTDFSHVYFKTDESDSMQELTENDNEKILKLKTVLEESSFGPSIKVEDLLSGTEDDAECDLREFAETNLSFLDEDQEFLNDSRNATSPLSESFFTSGIGSAEDVKQVLREVLPEENIQLQLSSEQQGENIIDLYYLPGLGLQSQMMPNSDDPLLSSSPREFGQQRQVVHTTAASTATVQPIEQLQSTTVLYDQHQQHQQQQQLQMQLQMHAQQHQSEQQPPQDEQQQQPHQQQLGTQQQHMQLPQLPVTHSEQSQQQQQADFMLTNFTPVSCQAQYIDANQQPMMLQPLNSLLQPVLYGSSSAANNKPAFGSLLSSNTAQATALDASLLFACDDSKNNCNKSMLAALPAAIPTPVVTATPSVANLQPLSNQTNSILKRRLRSNGPQDVHKFSKFHTLSPHRSKLRKPSRTHYTPAPILNPDRKGTGLYCNVRKQLGQGMFDVFDDDFGDPVGLVDFCDESKVNLGSTYQAQIPACKASEESSKEPMCADLMWDPSVQLDDKILMRYIDLSKSSAVPMGSHSEEVALQTLLDAKGNSAAAVLTLLQMQSSAFQMKWTAYELEQFLRGLEKYGKDFGKIASELHTKTSGECVQMYYFWKKLCVDYKVSHLKMEPVPASIPMVEQKPYVCEIADCSASFSSKAALHGHVRIHAYGRNASNNNSNNSNNNNNQHATATSANNNNNNSSNSNNTHSSNACTPLTSSSQQTSNSNNATATITHTNGNSNTTANNNNNMSNNSSIAGICTNSAQMLSIATKTLATGAAAAAATAAAAAASSSSTATKDSSNSSNSNMPKDSEFPCKVCGKVFNKVKSRSAHMKTHRVQEAEQSANSKQQSSTLVVAVASAAATSAAATSASAVAATAMATATS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00573254;
90% Identity: iTF_00546585;
80% Identity: iTF_00546585;