Dmet005182.1
Basic Information
- Insect
- Drosophila mettleri
- Gene Symbol
- -
- Assembly
- GCA_035047625.1
- Location
- JAWNPI010000056.1:2839483-2845529[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 13 0.049 3.3 8.3 0.2 1 23 1375 1398 1375 1398 0.94 2 13 7.9 5.4e+02 1.3 0.2 1 23 1562 1584 1562 1584 0.91 3 13 0.00018 0.012 16.0 2.7 2 23 1587 1608 1587 1608 0.97 4 13 3.9e-05 0.0026 18.1 0.2 3 23 1616 1636 1614 1636 0.98 5 13 5.7e-07 3.9e-05 23.8 4.1 2 23 1643 1664 1642 1664 0.97 6 13 5.4 3.7e+02 1.9 0.4 5 23 1677 1695 1675 1695 0.96 7 13 1.3 91 3.8 5.4 3 23 1702 1723 1700 1723 0.93 8 13 0.14 9.7 6.8 0.2 2 23 1734 1754 1733 1754 0.96 9 13 5.5e-05 0.0037 17.6 0.4 1 19 1760 1778 1760 1782 0.95 10 13 1.6e-05 0.0011 19.3 0.5 1 23 1790 1812 1790 1812 0.98 11 13 0.0001 0.007 16.7 7.6 1 23 1818 1840 1818 1841 0.96 12 13 0.0002 0.014 15.8 5.9 1 23 1846 1868 1846 1868 0.98 13 13 0.028 1.9 9.1 8.2 1 23 1874 1896 1874 1897 0.95
Sequence Information
- Coding Sequence
- ATGGTGGACAGTGTGCAGTGTCCCGTGTGCACGCTCTACCTGCACGCGGGTATGAATCTCTCCGATCATTTGGAGACACATCCCAAGGAACAGGTCATTAAGGCTCTGGTGCAAATGACCATCGTCAGTAACAATGGCATGGGCAGCGCCCTGGCGGCGGCTTTGCTCTCTGGTGATAGCGCCACTACTTCCACCTCATTGTCATCCACAAGTGCGGTTGATGTCAAGCCAGTTGTACCAGCATCttcaccaccaccaccaccactaccaccaccaacaacaacaacagcaacgccaacagcagctgcagtggcagtggcaacggcagcaactaAATCAACAGCACCAAAAGCTGCGTTGCCCAGCGGCAACAgtagcaacagtagcagcaacagcagcagcagcggtagcaacagtagcaacagcagctgtggcaacaacaacaacaaattgagcaATCCACCGATAAAGGCAGTAAAAAGCGCGCCACCCACGACTGAGGCGCCAGCCAACACATCAAATACACCCACCACAAGCAGCGTGAACGCCATCTATTCCGACTATCGCTACGACCAGCAGTCCCAGCAGGTGACGGCCACAGCCACAACTGCGGTGCATGGCTTTGCACGTGGTGCCACCACTTTGGTGATACCACAAGCACCACatcaccagcaacagcagcagcagcagcagcatcagtatCTGGcctcacagcagcagcaggctgcACATTTTGCCCAccttcagcaacaacagcagcagcagcagcagccggccaTGAAGTACACCTAtgcagcagcgctgccaccaccgccaccgctgCAGCTCTTTGCGCAGCAGGCGACAGCGACGCAATCACATCAGAAGCCACCACCCGCATATGGCGCCGCCATCAGTCAAATTCGATCTCAGCACAACCAaaataaacagcaacagcagcagcagcaacaacaacagcaacagcagcagcagcatcaacaacaacaacaaaccatAAACTTGCAACATAACGTTAACCTTGCACCACCGAGTGTCAAACATAGTAAAATTCACACGGATATCTTCCTGAatccaccgccaccaccaccgccacagCTCACAATTCCGTCAGCATTGTCGACTGCCTCATTAAGACTGCAATATccgcaacagcatcagcaatcCCTTGCAGCCAGCAATAGCACCagtagcaccagcagcagcagcaacagcaacagtagtaATTATGCCGCAGCCAGTTGCGCCGCCGTTAGCTCCTCTGCCACGCTGATGTCATCCATGTCCGTTGGACGCGCAAGCAGCAGTCGCCAGACAACCAATTCCCCGTTCGGTGCGCTACTGAATGCTGCAGCCCAAGCTGCCTGCGCCTCACCCGCCTCATCCAGCGCGTCTGTGCTGCGCTATGCCGAATCGCCAGTGGCCCACTATCTGGAGCGGGACAATGGCGACTTCATAGTCCAGGAGACCCCGAAGCACATTGTCGAATGCGTTGAGAAGGAAGACGGCGAGTTCTCAGTGATTGAGCGCATCTATCAGTCACCGCCCAGCGTGCTGCACATACACGACGATGACGAAGACGACGAAGAGGAAGATGAGGAGGACGATGGCAAGGGttgggCCAACAGCGACGTTGAGGAGCACATGAAAATGGAAGATCATGTGGAGGATGGCGACGATGAGCACGAGGACAGCCGCAGCAGAGCTTCACACaaagcaacaaccacaaagaAGTCAcgcaaagcaaaggcaaatggTAGAAAGCACAAACGCGTCAACAAGCAACCGCCAGAGGATGAGGATGACTTTATGAGCataggcagcagctgcgccgAGAGCGAGCaccagctggagcagcagcagcatcaggcGCAGCAAACGCATGTGCCACAGGTGCCGTCGCCCACGCCAGGCCAATTGTCCACAGCGCCCTCAACGAGCAGTggagcagccgctgctgccgccgtcgccTCGTGCAGCACCAACTCGAACAAGTCCAAAAAGAATCGCGTAACCGTGCTCAGCGATGTGCCGCTCAACATGAACGAGTACTTGGATCTGGTGGGTAACATTGTGGCATCCAGTCGCATTGGCGCCACACGTCCGTTCGCTGCTGTGGCGCCCATACCGTTGGTCAAGGTGGAGAAGGAGGAGCCCATCGATGAGTACGATGCGGTGCGCGATGAGATGCAAACGATGGAGCAGAAGCACAGCCTGGAGAATCCGAgtggtggcagcagcaacagcagcagcaatagtgGCCACGGCACCACAAGTGTCATACGCAtggccagcaccagcagcagcgccgccgCAAATGTTGCCAACGACGATCTCACACAGCCGCCGCCAATGAAGGTGGAGGTGGAGCCAAcggtgctgctgccgcaacGCTTCTCAGCGCCAGCGCAGCACCGCGGACCCAAGAAGTTAGTCATAAAACCAAAGGCCACTGCGACggcgccggcagcagcagcagcagcagcaacgactaAAAAGACTGATAACaacgctgccagcagcagcagcagcagcagcggcagcggcagcaactgcgCCGAAACACACAGCATATCATCATCAAAGGCAGTCACAGAGCCGTTGCAGATCAAGAGCGAGAACATGGAGAATGTGACCACAAACGGCAGCATTTTGGAGAAGCATCTGACCAACAGCTACGCCGTGCAGCAGGCACGCAAACACTCTGCGGTCAATGACGACGATGCACGCGTGCTGCTCGAGTTTGCCAACTcgaagcagcagccgccggcGGGCAACAGCAATCAGACGACGTTTGTGGTAAATGCGGCCAGTTTCGCTTCGGCGGGCTCTGTGTTTGcgagtggcagcagcggcaacagcagcagcagcaccgttCAGAAGCCAGCGAAGCCAGGCGATGAGTACATTCTGCCAGATAATAATCTAGAGGTGGATGAAATTGTGATATCCTCCTCGTCTTCCTATGCCTCCGACTCGCAGCAcgaacagttgctgctgcgtaagcagcatcaacagcatcagcaacatcagcagcatcagcagcagcagtcgcagcagtcacagcagcaacagcagcagccgctggcgCAGCAGCCGTCCTCCTTTACAGACTTCAATTTCCTATATCATCAGCATGGAACAACaactgtggcagcagcagcagcagcagcagcaacggtgGCAGCAACGACAACTGCCTCAACCTTTTCGCCATTCGGCATGCAGCAACCGCAGGTGCTGCAACATCCACAACACGGCTCGAGCGAAGCCACCAATGCCGCCACGCTGGCCTCCTCCTCCAGTAACTCATCTGTCTTAGATCAGGATTGCTCCATGAATGCGACGTTTCGCGTGGCCAAACAACAATCCGCAATGGGTGCGTGGTATCAGctacagccgcagcaacagccacagcccgGCACTTCACATGGCTCCAGTGTGGAGCAGTCGAGCAATTTCATTGCCGCCCTTGCGGCTGTTGAGTGCTGCAGCGTTGCGGCCGTCGATAGCGATGTGAGCGAAGCCAAGTACTTGGATCTGGATACGTGTAAGCGCGAACAgttgagcaacagcagcagccatttgCCCTCGGCCTCTGCGTCCACGACGTCGTCATCATTTGCGGCCGCGGCCACAGAGAGCAGTCTGGTTGGTGGCCTGGGTCTGAACATACGCACTGATGAGAAGATGCCCGCCAAGGGCGAGATTTCCGAGCAAGAGAGCAACTGTGACATTGAAAACTCCTGGAGTCAATCGATGTACGGCGACTTGTCGCAGCGTTACTTTAGGAATCAGTTCACGGATGGCTATAGTCAGCAGCTGGCCGATTGGCGCCACGATTACTATCCGGCGCAGGATCTcagtggccagcagcagccggagcgTGAGCAAAAGCGCTTTGATTTCAATGCGGTCGCTGCGGAGTATCCGCACCCGGGTCAGCTGGATGCCTCTGCAGGCTCGactagaaataataatttgatggATGCACAGCCCACcacatcgtcgtcgtcgtcagctTTGCTGGCTGGTCCACCAATAGCCTCGACATCGCGTGCAGCTGCCGAAGCGGAGGCCGTGGCCGCAGCGCTGGCGCAACGGAAGCCACCGCGTCGCAAGATCTACAAGTGTCCGCACTGTGTGGCCATCTTCGAGAAGCTGAAGGAGCGCAATGCGCACATGATTGGCGAACACAACTATGTGCGCCAGAACAGACGTCTCATCTGCACACAGGCTTTGGTCAGTACCCCATTGGCAGATCCGCAACAGGCGCaaggacaacagcagcagcagcagcatcaattgCTGCAGACTGCGGGGCATAGCAATAGTGACGTTATGCATGAGGATTCCAAGGATGGCATTATAAAGATAAAGCAGGAACACTGCCATGATAAACAGGATGCTTCTGATCAACTACTTGGCCATTCAGAGTTGCCCGACGTGAAGGATTCTGGCCTGCTCAATGCTAGCGATGAGAACGTTCGCGATGCGGACATGAAGCCGCCAGCCGGCGTGACAGACTTGGACGAGAAGCCGACCATACAGCCCTTGGCAATGACTACACCGGCTGCCAAGCTAGCTGCTCTGTATCGCATGCTCATTGCGTACAATGAGTCCAAGCTGGGCCAGGAGCGAAATAATCTGAGCGAACTGGAGCAAAAGGCCATGGAAAAATCGATATTTCTATGTTACGTATGCCGCACTGATTTCCCCTCTGTAAAGCTGTACGATGCTCATCTGACTGAGCATCCCGCCGAGTGCTTCACCTGCGGCAAGAAATTTTATCGCTGGAAGAACTTTTCGCTGCATTTGAAGCGCCATTTGGGCTGGAAGGAGTTTGGTTGTTACATCTGCGACAAGAAGTTCGTGGTGCGCAGCGCTCTGGTGGAGCACATGCGCATGCACACGGGCCAGACACCGCTCAAGTGTAAGATATGCGGCAAGAAGTTCAAGCGCTACTCGAACTTGACGCAGCATCGAAAGCGTCACACCAAGATCTTGGTGCGTAAGAAGGAGTATGTGTGCCATTGCGGCGAGGTGTTGCCGTCTAAGGCACGCTTCTTGTGGCACAAGGAAACGCACGACTTGAAGCCCAAGTGCTGTCCCTATTGCTGCGATCGTTTTGTGCACGCCAATTCACTGCGCCGACACATTCGATTGGCCCATTCGGATAAGTTTGACTACGCTGAGCCCATGGAGTGCCCCATGTGCAAGCAGATCTTTGCCAAAACCTCAATCAAGGCGCATATGGCCACGCATTCGACAGATCCGCAATACGATTGCGCCATATGCAACAAGAGCTTCTCCACCAAATGGAATCTTAAGATACATTCGTGGGTGCATGCGAATCGCACCGCCAAACCGTTCAAGTGCGAGTACTGCCCCAAGGCGTTTGTGCGCGAGCTGGACTTTAAGAATCACATGAATGCGCACAAACAGATCAAGCCATACACTTGCGAGTACTGCGGCTGCAAGTTCATACGTAAATACAACTATATGCGTCATCGGCGGGAGCATCATGGCAACAAGAAGTTCACCTGCGACCAGTGCGACAAGTCTTTCCATCGGCATTATTATCTGATTGAGCATCGGCGGATCCATACGGGCGAGCGTCCGTTCCATTGTACCATCTGTGGCAAGAGCTCGACGACAAAGACCAATCATAATAAGCATCTGAAGATACATCATTCACGGGACCCATTCACCGTGGAGGTCTAA
- Protein Sequence
- MVDSVQCPVCTLYLHAGMNLSDHLETHPKEQVIKALVQMTIVSNNGMGSALAAALLSGDSATTSTSLSSTSAVDVKPVVPASSPPPPPLPPPTTTTATPTAAAVAVATAATKSTAPKAALPSGNSSNSSSNSSSSGSNSSNSSCGNNNNKLSNPPIKAVKSAPPTTEAPANTSNTPTTSSVNAIYSDYRYDQQSQQVTATATTAVHGFARGATTLVIPQAPHHQQQQQQQQHQYLASQQQQAAHFAHLQQQQQQQQQPAMKYTYAAALPPPPPLQLFAQQATATQSHQKPPPAYGAAISQIRSQHNQNKQQQQQQQQQQQQQQQHQQQQQTINLQHNVNLAPPSVKHSKIHTDIFLNPPPPPPPQLTIPSALSTASLRLQYPQQHQQSLAASNSTSSTSSSSNSNSSNYAAASCAAVSSSATLMSSMSVGRASSSRQTTNSPFGALLNAAAQAACASPASSSASVLRYAESPVAHYLERDNGDFIVQETPKHIVECVEKEDGEFSVIERIYQSPPSVLHIHDDDEDDEEEDEEDDGKGWANSDVEEHMKMEDHVEDGDDEHEDSRSRASHKATTTKKSRKAKANGRKHKRVNKQPPEDEDDFMSIGSSCAESEHQLEQQQHQAQQTHVPQVPSPTPGQLSTAPSTSSGAAAAAAVASCSTNSNKSKKNRVTVLSDVPLNMNEYLDLVGNIVASSRIGATRPFAAVAPIPLVKVEKEEPIDEYDAVRDEMQTMEQKHSLENPSGGSSNSSSNSGHGTTSVIRMASTSSSAAANVANDDLTQPPPMKVEVEPTVLLPQRFSAPAQHRGPKKLVIKPKATATAPAAAAAAATTKKTDNNAASSSSSSSGSGSNCAETHSISSSKAVTEPLQIKSENMENVTTNGSILEKHLTNSYAVQQARKHSAVNDDDARVLLEFANSKQQPPAGNSNQTTFVVNAASFASAGSVFASGSSGNSSSSTVQKPAKPGDEYILPDNNLEVDEIVISSSSSYASDSQHEQLLLRKQHQQHQQHQQHQQQQSQQSQQQQQQPLAQQPSSFTDFNFLYHQHGTTTVAAAAAAAATVAATTTASTFSPFGMQQPQVLQHPQHGSSEATNAATLASSSSNSSVLDQDCSMNATFRVAKQQSAMGAWYQLQPQQQPQPGTSHGSSVEQSSNFIAALAAVECCSVAAVDSDVSEAKYLDLDTCKREQLSNSSSHLPSASASTTSSSFAAAATESSLVGGLGLNIRTDEKMPAKGEISEQESNCDIENSWSQSMYGDLSQRYFRNQFTDGYSQQLADWRHDYYPAQDLSGQQQPEREQKRFDFNAVAAEYPHPGQLDASAGSTRNNNLMDAQPTTSSSSSALLAGPPIASTSRAAAEAEAVAAALAQRKPPRRKIYKCPHCVAIFEKLKERNAHMIGEHNYVRQNRRLICTQALVSTPLADPQQAQGQQQQQQHQLLQTAGHSNSDVMHEDSKDGIIKIKQEHCHDKQDASDQLLGHSELPDVKDSGLLNASDENVRDADMKPPAGVTDLDEKPTIQPLAMTTPAAKLAALYRMLIAYNESKLGQERNNLSELEQKAMEKSIFLCYVCRTDFPSVKLYDAHLTEHPAECFTCGKKFYRWKNFSLHLKRHLGWKEFGCYICDKKFVVRSALVEHMRMHTGQTPLKCKICGKKFKRYSNLTQHRKRHTKILVRKKEYVCHCGEVLPSKARFLWHKETHDLKPKCCPYCCDRFVHANSLRRHIRLAHSDKFDYAEPMECPMCKQIFAKTSIKAHMATHSTDPQYDCAICNKSFSTKWNLKIHSWVHANRTAKPFKCEYCPKAFVRELDFKNHMNAHKQIKPYTCEYCGCKFIRKYNYMRHRREHHGNKKFTCDQCDKSFHRHYYLIEHRRIHTGERPFHCTICGKSSTTKTNHNKHLKIHHSRDPFTVEV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00516419;
- 90% Identity
- -
- 80% Identity
- -