Dmet014028.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila mettleri
Gene Symbol
hang
Assembly
GCA_035047625.1
Location
JAWNPI010000109.1:4794110-4804578[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.36 24 5.6 1.0 3 23 464 485 463 485 0.93
2 18 1 70 4.1 3.2 3 22 592 611 590 611 0.89
3 18 0.00077 0.052 14.0 3.3 1 22 713 734 713 736 0.90
4 18 0.089 6 7.5 0.1 2 21 748 767 747 768 0.93
5 18 0.00089 0.061 13.8 0.2 2 23 890 912 889 912 0.95
6 18 0.0026 0.17 12.3 0.1 1 23 920 943 920 943 0.96
7 18 0.00019 0.013 15.9 0.1 2 23 1030 1051 1029 1051 0.97
8 18 0.00037 0.025 15.0 2.9 2 23 1145 1167 1144 1167 0.97
9 18 0.029 2 9.0 0.2 2 23 1176 1198 1175 1198 0.95
10 18 0.0015 0.1 13.0 0.1 1 23 1211 1234 1211 1234 0.97
11 18 0.00016 0.011 16.1 1.1 1 23 1280 1302 1280 1302 0.99
12 18 0.0025 0.17 12.4 0.9 1 23 1310 1333 1310 1333 0.96
13 18 0.087 5.9 7.5 0.4 2 19 1341 1358 1341 1359 0.94
14 18 3.4e-05 0.0023 18.3 0.4 3 23 1452 1472 1451 1472 0.98
15 18 0.0065 0.44 11.1 0.1 1 23 1507 1529 1507 1529 0.97
16 18 0.00076 0.052 14.0 0.6 2 23 1623 1645 1622 1645 0.93
17 18 0.0084 0.57 10.7 0.4 3 23 1701 1721 1701 1721 0.98
18 18 4.9e-05 0.0033 17.8 2.3 1 23 2209 2231 2209 2231 0.99

Sequence Information

Coding Sequence
ATGtgcggtggcagcggcggcatgatCACACCATTGGATCGTCTATCGCTGCATATTTGCCATGCCTGCATCAGCTATTTGAACTCTTGGCAGAGCTTTAAGAATCGCTGCCTCAGCTCACAGACcaagcaatggcaatggctggACAGCGATAAAAACAAGCAGCAGACGCTTCTGGGATATTTGGATTTGAACAAAACGGAGAATGGCAGCTCCattgaacagcagcagcagcagcacgaatCTAATATCGATTCGGCAACGATTGCGGCCGAAAAGGCGTCCGCCAACATTTTGGATGGCATACCTTCGTTGAAGAAACGCAAATCGTTAACAGTTTATGTGAGTCCAAAGCAACAgcttcaacagcaacaacaacagcaacagctacaacagcagcagcatcaacaacaacaacaacaacagcagcagctgcagcagccgggGCAGAatgcagcaagagcagcaaccAGCGCAGCGGCGGAATCACAGCAAACGCTGCAGTCCCTTTTATTGCAGGTGCCCTCGGCAGCAGCATTGGCAACGACGTcaacacaacagcagcagcagcaacagcgcaaatatcaacagcagcagcaacaccgtgtcaagcaacaacattaccaccagcaacatcaacaacagcagcatcagcgctTGAGTCGTATTCGTCAGCCAAGACGCCAGCAACAAGCGACAATGTCGGCCCAACGTATGGTCAAATTTAAGCCGAAATTGTATTTGCCATTGGATATATCggtgccgccgctgccaccaCTGTTGCCGCCACCGTCGCAGTCGCAACAGACGGacactgttgctgctggtgctaaGTTGGcgccgttgcctttgccgttgccgttgccgttgccgctgccgctgccacttgACTTTAGCCAGAGTCAGTGTCAGCATCCGAATCCAAATCAGAATCCTAATCAGCAGAAACATGGCAGcgtgttgccgttgccactgCTGCCGTCGCAGCAGACGCCACtattgccgccgctgccagtTGCGACAATGACCAGcaacgccgctgccgctgcctctggctctggctctggctctgccacTGTCTCTGCTACAtccgcagccgcagtcacGACTCCTCTGCTAATGCCGCCGCTGCCAGCCGTGCCGATCAAGGACGAGCCCATTGACGATACAGACGATGACTTTCAAATGAAGTGCATCGATGAATCCGACGATATGATGGATCCCACAATGTTCCTAGAGCGCTCCGAACATGAGGGCGATGTGCCACTAATGACCTCCGACTATGATTACACGGCGCAACACGGCGTGACGGCGGTTGTGGCGGCGGCATCGCTGCCCGCCAGCGCGGTTGCAAACGTGGCCGCCGCTGGCGACTCAAAGGTGGCCAGCTGTCGGGCCTGCAGTCTGCAGTTTTCGACGCGCGCGAATGCCCGACGCCACGAGCGCAATCTGCATCCGAATCTATTTCAATTGTCGACAGATTCACCAAACAATACGCCCATCACAAAGCCAACGCCGGCCCTGGCCGCCGCACTGGAAATTCAACGTgccgcagcggcggcagcggccacCGCGGAAGCAACCAAAGCCGCAGCCGGTGGCAACATATCAGCGCAAAAGTATCGCCAGGTGGTAATGAATACGTTCATCAAATGCGAAAATGGCGGCTTCGACTACGACAATCCGGAACAGTATCAGCAGCTGCTCACACGCGACAAAGTGGACTTCATACAGGAGAACAATGAGTTTCTGGAGCAATACCAGACGATGACGTGTCGCTGCTGCAATAAATACTTCAACACCTACAAAAATTTCATGGCCCACGTGCGCAAAAAGTATCCAACGCTGCCGCGCAACCTGTGCTTCAACTGCCTCAAAATGAACGACTCGAAGGCGCTGTTCATATCGCATCTGAAGAAGCGCAACTGCATCAATTTGTATCGCGTGCTCAATGCGCTGCGCCTGAAGCAGCCAAATTTTTCGCATGCCAACGCAGCCGGAGTGGCTGTGTCGTCCGATTCCAGTTTGTTGGGTCaacagtcagcagcagcagcggccgccgttgccgtcgcacATGAAACATCAACGGAGCGGCCGGAGAAGCTGCGTGCCAAGGAGCTGTTGGTGAACAAACTGTACGAGTGTAAGCTCTGCCCAAAGGGCTTTCGCACCAAGCACGAGTTCCGCACCCATGTGTATGACAAGCATGCGGATGTGCAGCGCAAGGACAACAATTCGATACAGTGCAGCTTCTGTGGCCTGGACTTTGCCGATCCCGTCGATCGGCGTCGCCACTACAACAACATGGACTGCATTGTCCGCTTGCGCTGCATGACCTGCGATGCGAAACTGGAGACGCATCAGCGCTTCCTCGACCATGTCTATCAGGACCATTTGGGCGGTGTCAGCAGCGATAATGCGTCCACGGCCAACAGCGGCATGGATCATTCACCGGGCAAACGCAGCCTGCTGGGCGCCTTGGGCATCGGCGTGAGTCAATCATCGAACGATGAGTCACGCAGCAGTGcgcataacaataacaatgccgTGGAATCGGCCTTCACCTCAACGCCGAAACcaggtggtggtggtgcagcGGCCAGTGGTGGCTCCACGTCGGGCAGTCGCGATGCGCCCAAATCGCAGTATTTCTCCCGCATGCCACAGGTGTGCCCCATATGCGGGCAACAGTACAATAACTACAACAACGTGCTGCGCCACATGGAATCGAAGCATCCCAATAAACTGCCCGAGACATACAAGTGTGTGCGGTGCGGCCTCGGCTATCCGCGAATCTCATATCTGCGCGAGCACATGATCAATGTGCATGGCGTGGACAAGAATCGGCATTCGGGCGGCTTTGAGTATATTGTGAATGCGGACGCAGTCAAATTGGCGGACGGCAGCACGCCCAATGTCTATACGGGCCGATATGATTATGTGATGAAGGATCTGATGTCAATAACAAATGGTGGGACACTcgATGACGATGAGGAGGAGAGCGGCAGCGTTGCCAAGAAGATGCGACTCgatgacagcagcaacaacagcagcagcatcaacatgAGCCTGGCCAACCAGCAGAAGGAGTGCGTCATCTGCAATGCGGTgttcagcaacaacattggCCTCTCCAATCACATGCGCTCGCATTACACTGCCTCGACGGCGACCAATGCTGCGCTGGCGGCCGCCAATCGCATGACACCCAAATCTTTGACAATTACCGCAACGCCGCCATTGGACACGACGGCGGCAACGTCCACGAGCgtcgcggcggcggcggcggcggcaacagtGGCGACGCCAGCCACGACAACGgctggcggcggtggtggtttACCCCCAGCAATGGTGCATCAGACGCCGCAGGAGCAGGCCGTGTTCCGGCGCAGCCTGGACCAGGCGGCCGATCGACGCTTTCGCCGCATGCGCTGTCGCATCTGCCAGCGCAGGTTCAGCTCGAAGAAATCGTATCGCTATCACATGCTCACCGACCATCAGGTGCAGAACGTGCAGTTCATCAAGTGCAAGCTGTGCAATGCTGAGTTCGCCTACGAGAAGGGGCTCAAGGTGCATCTGTTCAAGGTGCACGGGCGGGCCATCAAGGACGAGATGATAATCAAGCAGTTCGAGTGCGATATCTGTTCGATTGTGTACAGctcggagctggagctgcagcagcacaagcGCAGCGTACACAAGTCCCAAATGGGCGGCGGCAACGATGCCTCCAAGTCAACATCAACGAAATCATCTACCGCTACCTCAGCCTCAGTCTCAGCCGAGCTGGCCGACACATCCGGCACGGCTGCGGCCGCCCTGCCGCTCTATTGGTACCAGTGCAAGTATTGCCCCTCCAACTTCAATACCAACAAGAAGCTGGCCATTCACATCAATTCGCACGACGAGTTCGACTCGAACGATTACTCGTGCAAGGATTGCGGCAATGTCTACAGTGGGCGCAAGAGCCTCTGGgTGCATCGCTATAAGAAGCATCCGCAGGTGCCGGATCCGGCCGAGTGTACGCTGTGCCGCAAGATGTTCTTTGACCGGCAGATGCTGGAGAATCATACGCCCACCTGCAATCGAAAGCCGATCACAGCCACCGGCGCACACCAGCAGgatcagcagcaccaccaccaccagcagcagcagcagcagcaacaacatcgcGCCATATTCAAGCACAAGACGggcgatgatgacgatgaggaGGACGATGATCAGCTAATGATGCTGGACGAtggcaacggcggcggcagcgacagcaatgGCGCCACCGTAATCCATGTGCCGGCCACAAGCAGCGCCAATGCGAGCACACTGAAGATACGCATACCGGAGGTGGCGTGCACGATTTGTGGGGCACGTTTCACCGACCAGGAGATGTTCACCAAGCACATACAGAAGCACGAACAGGATCTGTATGTGGACAATCCGCTGGCGGCGATGTTCGATGATGGCCCAGCCGATGCTGGCCAATTTCAGGTGGAGCGCCAGAACGAGAATGGGGAATACGCGTGCGATTTGTGCGCCAAGACGTTCCCCCAGGTGATTGCGCTCAAGGTGCATCGCAAGTGGCATTTCAGAGGTGATAGCAAGCAGAATCCCATCATCGACGGCGAAGCGACAACGctgaacaacagcagcaacagcagcagcaacaacaacaacaacaacaacaattcactGAGCTCATCGTCGATGCTGCGCGAACTGCATGCTGTGGGCCTGATGcccaaccagcagcagcagcagaagcaactgcaacagcagctgcagcagcaacagcaacatcagcatcagcaacgcAACAACACGTCGAGCGGCTCGAGCAAGTCGATGAAGCGAAAGCGTGAACTTAAATGCGAATACTGCGCCTCCACATtcataagcaacaacaacctgCGTCGCCACATGTACGAGCTGCACAAGCACGAGGTCAGCAATCTGCCGGAGCCGCCGGTCATTGTGGTGGATGAGCCGCTGACGTGCCGTCGCTGCGGCGACCTACGCTTCGACACCAAAGAGCTGTGGATCGAGCACAAGCTGGCGGACGCCAAAATCGTGCGTCCCTTCTGTCCATTCCAATGGGGCTGTGACCTGTGCGGCGAGTATCTGTCGCGCAAAGAGAAGCTCATGAATCACATTAATAATCACCTCAAGGAGGATGTGATAGTGccggtggcagcggcggcagcagtcGCCAGCAAGGCGACGCCACCAGTTGCCAGCAAGAATGCAGCAGCCAAGacaacagccgcaacaacggcaacagcagcagcaacaacaacgacaacaacaaccggAGTTGGAGCCAAGGCGGGCATTGTTAGAGCGGCGGCACCAGCGGGCGGCAGCAGAGTTAATAAGAATAAGCAACTGGAGGAGCAGCTGACAATGAAGGCGGcaaccaagcagcagcagcggcagacgTCGAATGCTGAGCACGATGaggtggaggaggaggagagcgATTTggaggatgatgatgatagcGGCGATAGTGGCGATGGGGATAGCACGAGCGCggacgatgatgacgacgatgacgatgatgaggaTGAAGAGGGCGACgttgacgacgatgatgatgaggacgACGTTGTCgaacaacaattgctgcaacagaaacaacaacaacagcagcagcagcagcaacagcagccacaagcGCAGCCTCTcattagcaacagcaacagcaacagcgaggTGGCacacgacgatgacgacgatcTCATTGAGGAAGTCATTGAGGAGGATGGCATTGTCGAGGAGTtggacgacgatgatgacgacgacgaggacgatGAGGATGGCAATACGACCGATGAGCACCATCAGCTGGCAGCCGaggcaaagcagcagcagcagtcgagaCAGTCGCGGCTCAACTTTGACTACGCGCGCTCCTCGGACAGCGCCAAGCTGAACGGCAATGGGAAACAGacaccgcagcagcagctggccaagtCGAAGGGTGGCCAGCAGGCGGTGCTGGTCATGCATAGCTCCGAGgaggatgatgatgaggatgtCCATGATGGTGATGTCGTTGGTCATGTCAATGACGatgacgaggaggaggaggaggaggatgatgatgatgatgatgatgaggaggaggaggtggTGGGCGTGGGTGAAGCCATGAACATTGATGATATTATTGAGGAGGATGATGGAGAGGATGATGAGGATGTGGTTGGTGTCGGTGGCGGTGTTGTTGAGgaggatgatgatgttgaGGAAGATATGGATGAGGACGATgtggatgatgatgatgatgatgatgatggtgatgatgatgatgacgacgacgttGAAGACattgacgacgatgacgacgacgatgtcgaagtcgaagtcaaTATGGGCAGTAGgaatcatcatcgtcgtcgcgACGGTGCTGTGATGGTCAGCGGCATCAGCATTGGCGACGGTGAGGCTGATGATGGTGTTGCTGATGGTGATGTGGATGGTGATGTGGACGCTGAGGCTACATCATCATCGGAGAGCGAgtcgacaacgacaacatcgCATTCAATTGGTGAGCGGCGTAAAAAATCAGTAGTTAAGTCAGCGGCACATGGCGCTGCCGCTGACCAGTCTAATTCCAGCTATACGTGTGATCTATGTCAACTTTGTTTCGATTCTCAGGAGCAACTGCAGTCACATATTAAAAGCCATTTTCTCAATGGGCCGTCGGCgggtggcagcggcggcagcagcagcaccagcaacaacagcggcaattGCAGAAGAATCGGTGCTatcgctggcagcagcagcagcaacagcaacggcagcagcagcagcaggaccaacaacaacaacaacaacaacaataataataataacaataacaataacaataaaaataataataataataataataacaacagcagcaagagcaaaacCAAAAAGTCTGGCTTGGATGCAACGAAAGGCGAcggcgctgcggctgcggctgctgctgctgctgcagcagcaacgacagcagcgacaagagcaacggcaacgacaacgacaacagcaacagttgccgccGAGACAGCTGCAGATGCAGCAAACAGCTTGAACTGA
Protein Sequence
MCGGSGGMITPLDRLSLHICHACISYLNSWQSFKNRCLSSQTKQWQWLDSDKNKQQTLLGYLDLNKTENGSSIEQQQQQHESNIDSATIAAEKASANILDGIPSLKKRKSLTVYVSPKQQLQQQQQQQQLQQQQHQQQQQQQQQLQQPGQNAARAATSAAAESQQTLQSLLLQVPSAAALATTSTQQQQQQQRKYQQQQQHRVKQQHYHQQHQQQQHQRLSRIRQPRRQQQATMSAQRMVKFKPKLYLPLDISVPPLPPLLPPPSQSQQTDTVAAGAKLAPLPLPLPLPLPLPLPLDFSQSQCQHPNPNQNPNQQKHGSVLPLPLLPSQQTPLLPPLPVATMTSNAAAAASGSGSGSATVSATSAAAVTTPLLMPPLPAVPIKDEPIDDTDDDFQMKCIDESDDMMDPTMFLERSEHEGDVPLMTSDYDYTAQHGVTAVVAAASLPASAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPNNTPITKPTPALAAALEIQRAAAAAAATAEATKAAAGGNISAQKYRQVVMNTFIKCENGGFDYDNPEQYQQLLTRDKVDFIQENNEFLEQYQTMTCRCCNKYFNTYKNFMAHVRKKYPTLPRNLCFNCLKMNDSKALFISHLKKRNCINLYRVLNALRLKQPNFSHANAAGVAVSSDSSLLGQQSAAAAAAVAVAHETSTERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVSSDNASTANSGMDHSPGKRSLLGALGIGVSQSSNDESRSSAHNNNNAVESAFTSTPKPGGGGAAASGGSTSGSRDAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDDEEESGSVAKKMRLDDSSNNSSSINMSLANQQKECVICNAVFSNNIGLSNHMRSHYTASTATNAALAAANRMTPKSLTITATPPLDTTAATSTSVAAAAAAATVATPATTTAGGGGGLPPAMVHQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGRAIKDEMIIKQFECDICSIVYSSELELQQHKRSVHKSQMGGGNDASKSTSTKSSTATSASVSAELADTSGTAAAALPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPDPAECTLCRKMFFDRQMLENHTPTCNRKPITATGAHQQDQQHHHHQQQQQQQQHRAIFKHKTGDDDDEEDDDQLMMLDDGNGGGSDSNGATVIHVPATSSANASTLKIRIPEVACTICGARFTDQEMFTKHIQKHEQDLYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIIDGEATTLNNSSNSSSNNNNNNNNSLSSSSMLRELHAVGLMPNQQQQQKQLQQQLQQQQQHQHQQRNNTSSGSSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDEPLTCRRCGDLRFDTKELWIEHKLADAKIVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHLKEDVIVPVAAAAAVASKATPPVASKNAAAKTTAATTATAAATTTTTTTGVGAKAGIVRAAAPAGGSRVNKNKQLEEQLTMKAATKQQQRQTSNAEHDEVEEEESDLEDDDDSGDSGDGDSTSADDDDDDDDDEDEEGDVDDDDDEDDVVEQQLLQQKQQQQQQQQQQQPQAQPLISNSNSNSEVAHDDDDDLIEEVIEEDGIVEELDDDDDDDEDDEDGNTTDEHHQLAAEAKQQQQSRQSRLNFDYARSSDSAKLNGNGKQTPQQQLAKSKGGQQAVLVMHSSEEDDDEDVHDGDVVGHVNDDDEEEEEEDDDDDDDEEEEVVGVGEAMNIDDIIEEDDGEDDEDVVGVGGGVVEEDDDVEEDMDEDDVDDDDDDDDGDDDDDDDVEDIDDDDDDDVEVEVNMGSRNHHRRRDGAVMVSGISIGDGEADDGVADGDVDGDVDAEATSSSESESTTTTSHSIGERRKKSVVKSAAHGAAADQSNSSYTCDLCQLCFDSQEQLQSHIKSHFLNGPSAGGSGGSSSTSNNSGNCRRIGAIAGSSSSNSNGSSSSRTNNNNNNNNNNNNNNNNNKNNNNNNNNNSSKSKTKKSGLDATKGDGAAAAAAAAAAAATTAATRATATTTTTATVAAETAADAANSLN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00476771;
90% Identity
-
80% Identity
-