Basic Information

Insect: Drosophila meridiana
Gene Symbol: KLHL17
Assembly: GCA_035045185.1
Location: JAWNPF010000154.1:7080657-7085410[+]

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.2e-31 3.2e-29 101.5 0.0 2 109 63 168 62 169 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.2e-31	3.2e-29	101.5	0.0	2	109	63	168	62	169	0.97

Sequence Information

Coding Sequence: ATGTTTCTGCCTGTCAAATCGAATCACACCGCCGAGTCGAGTGGCAACAACGAGGATGtcaccaccaccagcaacaATTCAACACAGACGCCCAGCGATCTGAGCCCACCGGGCCCCAATGAGGAGGTGCTGCCACAGGCGCATCATCAAAATCCGGGACACTGCATCGCCTCCTTTGCGGCCATCAATCAGATGAGAAATAATGCACAGCTGTGCGATGTGCGCCTCGAGGTGGGCGGGGATACCATCAATGCGCATCGCGTGGTGTTGGCTTCCGTCTCGCCTTACTTCTATGCTATGTTTAATGATGACATGCTCGAGCGTACACAGGGCTTGGTGCGTCTGCATGACGTGGATAGCTCGGCGTTGCGGCAGCTGATCGACTACACCTACACAGGTGAGATAACCATAACGGAGCAGAATGTCCAGGTGCTGCTGCCTGCATCGGGTCTGCTGCAGATGCACTCGGTGCGCGACGCGTGCTGCAAGTTTCTGCTCCGGCAGCTGCATCCATCCAACTGCCTGGGCATACGCAGCTTCGCCGATGCCCACTCCTGCAAGGAGCTGCATACGCGCTCCCACAAATATGCGCTGCAGAACTTCCAACAGGAGGTCAAGGAGCTGATATCGAACAGTCAGCTGAACATTAGCTCCGAAGAGAAAGTGTTTATGGGCGTGCTCAGCTGGGTAAAACACGATCTTGGCCAGCGACGCCTGCACATTGCCGAGCTAATGTCACACGTGAGATTGCCGCTGGTCAGTCGGGATTTCCTGATGAGCTGCGTCGAGGCGGAGACTCTGATGCGTGACGATTCCGAGTGCAAGGAACTGCTGCTGGAGGCCATGAAGTATCACCTGCTGCCCGAGCAGCGCAGCCTGATGGGCAGCCAGCGCACCCAGGAGCGACGACCCGAGGGCATGAGACCCTACATCTTTGCCGTGGGCGGCGGCAGTCTCTTCGCCATACACAACGAGTGCGAGGTCTACAATCCGCGCTGCAACAGCTGGTCTCCAGTGGCGCCCATGCTGTGGCGTCGCTCCCGCTCCGGCGTCACGTCGCTGCACAAGCAGCTCTACGTGGTGGGCGGATATGATGGCGTCAGTGATCTGGCCACTGCCGAGTGCTACAATCCGCTGACCAACAAGTGGAGCAACATCACCCCGATGGGCACGAAGCGTAGCTGCCTGGGCATCTGCGCCTACGATGGCCTGATTTTTGTCTGCGGCGGCTACGATGGCGCCTCCTGCCTGAGCAGCATGGAGCGCTACGATCCATTGACTGGCATCTGGAGCTCCTGCCCGGCCATGAGCACGCGGCGTCGCTACTGCCGCCTGGCCGTGCTCGAGAATCAAATTTATAGCCTCGGCGGCTTCGATTCCACCAACTATCAGTCGAGCGTGGAACGCTTCGATCCACGCGTGGGCCGCTGGCAGCCCGTGCCCAGCATGACGGccaggcgcagcagctgcggcgtCGCCTCCACCGATGGCCACCTGTACTGCATTGGCGGCAACGATGGCACCATGTGCATGTCCAGCGGCGAGCGATTCAACTTGCGGCGCAACTGCTGGGAGCCCATAGCAGCGATGCACTCGCGCAGATCCACTCATGAGGTGGTGGAGGTGGAGGGCGTCTTGTTTGCCTTGGGCGGCAATGATGGCAGCTCCTCGCTGAATTCCGTGGAGCGCTATGATCCGCGCCTGAACAAATGGAGCGTGGTGAATGCAATGGTGGCGCGTCGCAGCTCCGTCGGAGCAGCAGTGCTGGAGTGCTTCCATTTGGAGCGCGGACTGGTGCAGACGACGAACTTATGA
Protein Sequence: MFLPVKSNHTAESSGNNEDVTTTSNNSTQTPSDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQEVKELISNSQLNISSEEKVFMGVLSWVKHDLGQRRLHIAELMSHVRLPLVSRDFLMSCVEAETLMRDDSECKELLLEAMKYHLLPEQRSLMGSQRTQERRPEGMRPYIFAVGGGSLFAIHNECEVYNPRCNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAECYNPLTNKWSNITPMGTKRSCLGICAYDGLIFVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENQIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMTARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFNLRRNCWEPIAAMHSRRSTHEVVEVEGVLFALGGNDGSSSLNSVERYDPRLNKWSVVNAMVARRSSVGAAVLECFHLERGLVQTTNL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00082225;
90% Identity: iTF_00598984; iTF_01327233; iTF_00514289; iTF_00579345; iTF_00576413; iTF_00536106; iTF_00506177; iTF_00536833; iTF_00541825; iTF_00548129; iTF_00574881; iTF_00596001; iTF_01559105; iTF_00335970; iTF_00471682; iTF_00474562; iTF_00481602; iTF_00487362; iTF_00546722; iTF_00559554; iTF_00565442; iTF_00577122; iTF_00592450; iTF_00602658; iTF_00613570; iTF_00500387; iTF_00574115; iTF_00583747; iTF_00604163; iTF_00605635; iTF_00917283; iTF_00483044; iTF_00512068; iTF_00575652; iTF_00485925; iTF_00527365; iTF_00551653; iTF_00584485; iTF_00599653; iTF_01549637; iTF_00537574; iTF_00539718; iTF_00543814; iTF_00547430; iTF_00548870; iTF_00550310; iTF_00563238; iTF_00616262; iTF_00802918; iTF_00805254; iTF_00904806; iTF_01550342; iTF_00498215; iTF_00518503; iTF_00528871; iTF_01321255; iTF_01325735; iTF_01356199; iTF_00472424; iTF_00480232; iTF_00495176; iTF_00525192; iTF_00531016; iTF_00531720; iTF_00555912; iTF_00562536; iTF_00563976; iTF_00616968; iTF_01552520; iTF_00338409; iTF_00514953; iTF_00523017; iTF_00542505; iTF_00566857; iTF_00580041; iTF_00589609; iTF_00619209; iTF_00473130; iTF_00573386; iTF_00593898; iTF_00832234; iTF_00478795; iTF_00492299; iTF_00516331; iTF_00533867; iTF_00550955; iTF_00566155; iTF_00615627; iTF_00804459; iTF_00918219; iTF_01321995; iTF_00601868; iTF_00612140; iTF_00517773; iTF_00558733; iTF_00578605; iTF_00587469; iTF_00612877; iTF_00618477; iTF_00501870; iTF_00509166; iTF_00546030; iTF_00549614; iTF_00553102; iTF_00586030; iTF_00596718; iTF_00604910; iTF_00609230; iTF_00890190; iTF_00483759; iTF_00497455; iTF_00504751; iTF_00521423; iTF_00554447; iTF_00561103; iTF_00564719; iTF_00591759; iTF_00614255; iTF_00891951; iTF_01326479; iTF_01554031; iTF_00336816; iTF_00475280; iTF_00508400; iTF_00519984; iTF_00555152; iTF_00556592; iTF_00585264; iTF_00595312; iTF_00603408; iTF_00606384; iTF_00806032; iTF_00914576; iTF_00494449; iTF_00511345; iTF_00541137; iTF_00582321; iTF_00588209; iTF_00593169; iTF_00598225; iTF_00606385; iTF_00617713; iTF_00567602; iTF_00569746; iTF_00583026; iTF_00916306; iTF_01553298; iTF_01559826; iTF_00476691; iTF_00477395; iTF_00523763; iTF_00525939; iTF_00540435; iTF_00569043; iTF_00588915; iTF_00594611; iTF_00803667; iTF_00473844; iTF_00510612; iTF_00528116; iTF_00539028; iTF_00484501; iTF_00488085; iTF_00493717; iTF_00512789; iTF_00526645; iTF_01551797; iTF_00495926; iTF_00504054; iTF_00534646; iTF_00535382; iTF_00538294; iTF_00597430; iTF_00611414; iTF_00915414; iTF_01320534; iTF_01555478; iTF_00485207; iTF_00491575; iTF_00501111; iTF_00506935; iTF_00513527; iTF_00586743; iTF_00614967; iTF_01327959; iTF_00532440; iTF_00571224; iTF_00577848; iTF_00919128; iTF_01319096; iTF_00475993; iTF_00505465; iTF_00529625; iTF_00552377; iTF_00571961; iTF_00572665; iTF_00591033; iTF_01551065; iTF_00496666; iTF_00509882; iTF_00607130; iTF_01570298; iTF_00470939; iTF_00480923; iTF_00489435; iTF_00490843; iTF_00520699; iTF_01557627; iTF_00339228; iTF_00493020; iTF_00519228; iTF_00530332; iTF_00590300; iTF_00608508; iTF_01548924; iTF_01558364; iTF_00482301; iTF_00488733; iTF_00517053; iTF_00522237; iTF_00557277; iTF_00560349; iTF_00478078; iTF_00498942; iTF_00499646; iTF_00502590; iTF_00545310; iTF_00557982; iTF_00570462; iTF_00601118; iTF_00609950; iTF_00619902; iTF_01323454; iTF_01556190; iTF_00490143; iTF_00568319; iTF_00600383; iTF_00610719; iTF_00486624; iTF_00580800; iTF_00581600; iTF_01322720; iTF_01364007; iTF_01195340; iTF_01556907; iTF_00919884; iTF_00607855; iTF_00251414; iTF_01319826; iTF_01196053; iTF_01324204; iTF_01324977; iTF_01554772;
80% Identity: -