Dmel002929.1
Basic Information
- Insect
- Drosophila melanogaster
- Gene Symbol
- ibtk
- Assembly
- GCA_000001215.4
- Location
- JANZWZ010000252.1:946518-949517[-]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 1.9e-07 8e-05 23.1 0.1 3 79 522 594 520 641 0.86 2 3 1.4e-14 6.1e-12 46.0 0.3 7 107 661 764 653 767 0.84 3 3 0.071 31 5.1 0.3 62 109 753 798 744 799 0.84
Sequence Information
- Coding Sequence
- ATGTCAGCCGCCAGGACGCAGGAATACGATTGCACCGCCAAGTGCAGACTCCGCCAGCATGGAAACGCCATCACCGCCGCGCTGACAAAGCGCTCCATTGACAACCAGAAGCTGGCGGCTTTTATTTTCAAGACTTGCGGAAACTTCGCCAATATTTTAGACGATCTGGGCCGCTCGGCGGTGCACATGTCCGCCTCCACGGCCAGGTACGAGATTTTGGAGTGGCTGCTGAACCACGGAGCCTACATCAATGGCCAGGACTACGAATCGGGAAGCAGTCCGTTACACAGAGCCCTCTACTACGGCTCTATAGATTGCGCCGTACTGCTGCTTCGTTACGGGGCCAGTTTGGAACTGCTGGACGAGGACACAAGGTGTCCACTGCAGGCAATCTGCCGGAAGTGCGATGACGATGACCTCGCCACGGATTCACAAAACGATGTCCTAGTGTGGGGCTCGAACAAAAACTACAATCTGGGCATTGGCAACGAGCAGAACACCAATACTCCGCAGGCGGTGGACTTCTTTCGAAAGTCTAACCTTTGGCTGGAACAGGTGGCACTTGGAGCTTACCACAGTCTGTTCTGCGACAAGAAAGGCCACCTGTATGCTGTGGGTCATGGAAAAGGCGGTCGCCTGGGCATTGGATTGGAAAACAGTCTTCCTGCACCCAAGAGAGTTAAGGTTTCGTCCAAGCTGAGCGGCGACTCCATTCAGTGCATCAGCGTGTCCCGCCAGCACTCACTGGTGCTCACGCATCAATCGCTGGTTTTCGCCTGCGGCCTTAACACAGACCATCAATTGGGCGTGCGTGATGCCGCCGAGCAGCTCACGCAGTTTAAGGAAGTGGTCGCGTTGCGTGACAAAGCACTCTATCGCCTACGGCAGCAGGTGTGTCTACGTCTGGGGGCCAACCAGGGCCAGTTTGGCATCAATTCCAACACGCCATCCATCACGGTGCCCACATTGATCAAGCTTCCTGCGAAAACTACAATACGCTTTGTAGAAGCCAACAATGCAGCCACGGTAATTTACAACGAGGAAAAGATCATTACCCTTTGCTATGCAGACAAAACTAGATACATAAAGACCCCCAACTACGAAGATCTCAAGAGCATTTCGGTGATGGGCGGCAACCTTAAGAACTCCACGAAGGGCTCCGCGGCAGCTCTCAAGCTGTTGATGCTCACTGAAACTAACGTGGTGTATTTATGGTACGAGAACACTCAACAATTTTACAGATGTAATTTTTCACCGATTCGTCTGCACCAGATAAAGAAAATACTCTACAAGTGCAATCAGGTTATGGTGCTTTCCGAGGATGGCTGCGTTTATCGAGGAAAGTGCAATCAGATCGCCTTGCCATCCTCAGCACTGCAGGAAAAGTCTCGGGGCAGCCTGGACAACTGGCAGGACAACGATCAAAACAAAACGGAAATCTCCCGGGAACATGTTATCCGGATCGAGCTGCAGCGAGTTCCGAACATCGACCGAGTCACACACCAAGTACTTTCGGAAGCCATCACTGCCACGCAGGAGCACAGCTTCAAGAAGCTGCTGCACGAGACTAGCGACTGTGATGCTGTCCACGATGTGGTTTTCCATGTGGACGGAGAGAAGTTCGCGGCCCACAAGTTTATCATTTACAGTCGAGCGCCAGGTCTCAGAGACCTTATTCGTTGTTATCTGGACAAGGATATTTATTTAAATTTTGATCATTTGACGGGAAAGATGTTTGAATTGATATTGAATCATATCTACTCGAGCTACTGGCCAACAGAGGATGATATTGACTGTATACAGCAAAGTTTGGGACCTGCGAATCCTCAACAGCGAACTCGCACCTGCGAGATGTTCCTACCTCACCTGGAGAAGTTTCAACTAGTCGAGCTGACCAAGTACGTACAGAGCTACGTGCGTGACCATCAATTTCCACTGCCCAATGCCCGAAAACTTTTCAATCGCTTGTATCGCTCCGATCATCCAGAGTTGTACGATGTGAGAATTGTCTGCAAGGACGGAAAAGTACTAGGGGCTCATAAATGTATGTTAGTGGCACGTTTGGAGTACTTTGAGATGATGTTTATGCACTTGTGGGCGGAACGCTCGTCTGTCACCATGGAAGGTGTACCCGCGGAGTATATGGAGCCGGTTCTCGATTACCTGTACAGTCTGGATAACGAGGCTTTTTGCAAGCAGGGTTATCTGGAGACATTCCTCTACAATATGATAACCATTTGTGACCAGTACTTTATTGAGTCGCTGCAGAATGTGTGCGAGTCTCTAATCCTGGATAAAATCAGCATAAGGAAGTGCGGCGAAATGCTCGAGTTTGCCGCCATGTACAACTGCAAAATACTACAGAAGGGCTGTATGGATTTCATTTGCCAAAACTTGTCCCGCGTGCTTTGCTATCGCAGCATTGAACAATGTGATGGAGAGACTCTAAAATGCCTAAATGATCACTATCGAAAGATGTTCAAAAGGGTGTTCGACTACAGACAAATAACTCCATTCTCAGAGGCTATAGAAGATGAGCTGCTGCTCAGCTTTGTGGACAGGGTGTGA
- Protein Sequence
- MSAARTQEYDCTAKCRLRQHGNAITAALTKRSIDNQKLAAFIFKTCGNFANILDDLGRSAVHMSASTARYEILEWLLNHGAYINGQDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRCPLQAICRKCDDDDLATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGLENSLPAPKRVKVSSKLSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKALYRLRQQVCLRLGANQGQFGINSNTPSITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGSLDNWQDNDQNKTEISREHVIRIELQRVPNIDRVTHQVLSEAITATQEHSFKKLLHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDKDIYLNFDHLTGKMFELILNHIYSSYWPTEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQLVELTKYVQSYVRDHQFPLPNARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFMHLWAERSSVTMEGVPAEYMEPVLDYLYSLDNEAFCKQGYLETFLYNMITICDQYFIESLQNVCESLILDKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLKCLNDHYRKMFKRVFDYRQITPFSEAIEDELLLSFVDRV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00607859;
- 90% Identity
- iTF_00607859;
- 80% Identity
- -