Basic Information

Insect: Drosophila melanogaster
Gene Symbol: egg
Assembly: GCA_000001215.4
Location: JANZWZ010000712.1:125791-130005[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.5e-16 8.5e-13 48.0 0.0 5 75 749 812 746 814 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.5e-16	8.5e-13	48.0	0.0	5	75	749	812	746	814	0.91

Sequence Information

Coding Sequence: ATGTCTGGGCAGTCAACAGCCGTGGACTGCTTAGAGAGCAGTGGAAGCACAGTGGAGGATGTCCAAGAAACACCGGCGTCGAGGGAAAAAAGTTACGGGTTGCCGGTGCGCAAAGGAGAAAATAGCTTGGAGTCTCCTGCAGAACAAGCCGCAAAAGATGTGGAAATTGAGGAACTGACACACAGCCCTGATGAACCTGGAAAGTTGGCCGACGAATCGGAGGACCGCAAGGGAGAGAACACGAAAGCCATTGCAAGCAGCCCGGTTTTGGTAGCTGTGGATTCGGACAGCAGTGTTGAGCTAATAGAGAGTCCTGTCAAATTCTCCTCCGCCAACGAAAGTGAGAAAGATCCGCCAAAACCAGATGCTGTCAATGAAGCTGCGGCTAAAGAGGCCGAGGAAATGACTGATAGCAGCATCAGCAGTCCCACATCCGAAAGTTTTCCTGAAAAAGATGAAAAGACCAATAAGGAAAATGAGCAAGAACCTCCTGGCATGGAGGTAGATCAGGACGTCGAGGAGTCAATAAGTCGACCAGCAGAAGAATACAAAATTGAGAATACATTAAAAGACGATGTCCTAGAGGTGGAGCTTGAAAAGGGCACTGCTCCGAAAGCTGCAGAAGACGAGAAGCTGAACGCTTTGTTATCAGATGGAGATGTCTTCTACGACAAGGAATGTGTCAACTGCAATTGCACAAAGCTTCATAAACAGTACCAGTTCCTCTGCATGGGATGCCATGACACAGCAATGGACTTGTATGAGGAGTATGCTGGACAACTAATGGTCAAGCAGCCGCTGCTGCTAAAGGATTTCCATCAGGATCACGCCGACTTTGTGGCTCTGGACAGCAGCGATGAGGAGGAAGAGGAGAAGCAGCCAGAAAAATCGGACTTTTCGAAAAACAAGCTGCAGCTCATCGAAGATGAACTCGATGATGCCATCAAAAATGTACTTAACAAGGTGGATTTTACGGCTCAGCTGTCCTGGTCAAAAACTATTCTCCAGGCGAAAGCAGACCACTTGGAGCGACAATTCGCACTGGCAGATGTGGAACTCGAAAAAGTTCAGACCACCGCTGACAAAATGCACTGCGCTTTGTATAACTCGTGTCCGGTGGCACACAAACATCTGCCCACCCTGGACATTGAACCCAGTGACTATGTGCATGAAGTTCCACCTCCTGGCGAAATCGTGCGTCCTCCAATACAGTTGGGAGAGACATACTACGCTGTTAAGAACAAGGCTATTGCCAGCTGGGTGTCCATAAAGGTAATCGAGTTTACAGAGAGCACCGCCATCAACGGAAACACGATGAAGAGCTACAAGATTAGGTACCTCAACACTCCGTACCAGATGATCAAGACAGTGACGGCCAAGCACATTGCCTACTTCGAACCACCGCCAGTGCGACTGACCATTGGTACCCGCGTGATTGCGTACTTCGATGGCACCACTTTGTCGCGGGGCAAGGATAAGGGCGTGCAGGCCAATCGCTACCGCTACCTAATATTCTACGACGATGGGTACACTCAGTACGTTCCGCACCGCGATGTCCGTCTAGTTTGCCAGGCTTCCGAGAAAGTGTGGGAGGACGTACACGCCGCATCGCGCGATTTCATACAGAAGTACGTGGAGAAGTACTCCGTGGATCGTCCAATGGTGCAATGCACCCGGGGACAAAGTATGACCACTGAATCGAACGGGACCTGGCTGTACGCGCGCGTCATTGACATCGACTGCAGCTTGGTGTTGATGCAGTTTGAGGGCGACAAAAACCATACGGAGTGGATATACAGGGGTTCATTGCGCTTGGGTCCTGTCTTCAGGGAAACCCAGAACAATATGAACAGTTCAAGCGCACAGCAGCTGCGTGTCCCAAGACGCACGGAGCCCTTTATTCGGTACACCAAGGAGATGGAGTCCAGCAGCAAGGTGAACCAGCAGATGCGTGCCTTTGCCCGCAAGAGCAGCGCCTCCGCCCAAAATAACGCATTAGCGGCTGCATCTTCGGCAGCAACCCCAGCCGGAGGACGCACCAATGCAGGAGGTGTCAGCACCAGTAATAGCGCAAGTGCTGTGCGACACCTAAACAACTCGACAATCTACGTGGACGACGAGAACAGGCCCAAGGGCCATGTAGTCTACTTTACAGCCAAGCGGAATCTGCCTCCCAAAATGTACAAGTGCCACGAGTGCAGCCCGAACTGCCTCTTTAAGATCGTTCACCGTCTGGACAGCTACAGTCCGTTAGCGAAGCCTCTGCTTTCTGGCTGGGAACGTCTTGTCATGCGGCAGAAGACCAAGAAGTCCGTGGTATACAAGGGACCTTGTGGCAAAAGCTTGCGCAGCCTGGCCGAAGTTCACAGGTACCTTCGAGCTACTGAAAATGTGTTGAACGTAGACAATTTTGACTTTACGCCCGACCTCAAGTGTCTGGCCGAGTACTCCATTGATCCCTCGATCGTGAAGGACACGGACATTTCAAAGGGGCAGGAGAAGATGGCGATTCCGCTGGTAAACTACTACGACAACACCCTGCCGCCCCCATGCACCTACGCGAAGCAGCGCATCCCTACCGAGGGTGTTCATCTGAATCTGGACGAGGAGTTCCTCTTGTGCTGCGACTGCGAGGACGACTGCTCGGACAAGTCAAAGTGCGCCTGTTGGCAGCTAACGGTGGCGGGCGTGCGGTACTGTAACCCGAAGAAACCCATCGAGGAGATAGGCTACCAGTACAAGCGGCTCCACGAGCACGTGCCCACCGGCATCTACGAGTGCAACTCGCGCTGCAAGTGCAAGAAGAATTGCCTGAACCGGGTGGTGCAGTTCTCCCTAGAGATGAAACTGCAGGTTTTCAAGACCTCAAATCGTGGATGGGGCTTGCGCTGCGTTAACGACATCCCCAAGGGTGCTTTCATCTGTATTTACGCCGGCCATCTGCTCACGGAGACGATGGCCAACGAAGGCGGACAGGACGCCGGCGACGAGTATTTCGCGGACTTAGATTACATAGAGGTCGCTGAACAGTTAAAAGAGGGATACGAGTCGGAGGTGGACCACTCGGACCCGGACGCCGAGGAGGACAACGGGGGACCCGATGCCGAGGACGATGACGACTTCCGGCCAAACTATCACTACCAGCGCAAAATCAAGCGCTCTTCCAGAAGCGGCTCCACGCAGAACAGCTCCACTCAGAGCAGCGAGTTGGACTCGCAGGAGCGTGCGGTGATCAACTTTAACCCAAATGCTGATCTGGACGAGACGGTGCGGGAGAACtcggtgcggaggcttttcggcaaggacgaggcgccctacatcatggacgccaagacaacgggcaaccttggacgctatttcaaccactcgtgcagccccaatctcttcgtgcagaacgtgttcgtggatactcacgacctgcgtttcccctgggttgccttcttctcggccgcgcacatccgctccggcaccgagctgacttggaactacaattacgaggtgggcgtggtgcccggcaaggtgttgtactgccagtgcggggcccccaattgccgccttcgtctgctctaa
Protein Sequence: MSGQSTAVDCLESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQAAKDVEIEELTHSPDEPGKLADESEDRKGENTKAIASSPVLVAVDSDSSVELIESPVKFSSANESEKDPPKPDAVNEAAAKEAEEMTDSSISSPTSESFPEKDEKTNKENEQEPPGMEVDQDVEESISRPAEEYKIENTLKDDVLEVELEKGTAPKAAEDEKLNALLSDGDVFYDKECVNCNCTKLHKQYQFLCMGCHDTAMDLYEEYAGQLMVKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTTADKMHCALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDKGVQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00588140;
90% Identity: -
80% Identity: -