Dmel006409.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila melanogaster
Gene Symbol
Rfx2
Assembly
GCA_000001215.4
Location
JANZWZ010000288.1:504098-508136[+]

Transcription Factor Domain

TF Family
RFX
Domain
RFX domain
PFAM
PF02257
TF Group
Basic Domians group
Description
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.8e-38 5.3e-34 117.0 0.1 3 78 277 352 275 353 0.97

Sequence Information

Coding Sequence
ATGCATTCGCGGTACGGCTTTGACTGCCAGACGCGCCATTACCAACAACACCAGCAGACGCACCACCAGCACCACCACCACCACCACCCAAATCCACCGTGTAGCATTCCATTGGAGTCGCCACCGACGCCGCCAGTGATCAGCCCCAGCGCCGCTGCTGCCGTGGCCTACTCGAATCTCCTGGAGAAGTGCCGCTGCAAGCAATCCGTGGCCGCCAATCCCGTTCCAGCACCACCCGCCCAGCTTCAACTACAGTTGCACCACCATCATCATCACCATCACCACCAGACCTTCGTTGCCAGCGCCAGTGCAACCAGCTACAGCAACTGCTCCGCGCTTGGATTGGGTTCGAGAACGGGATCGGGATCGGGATCGGGGAAGTGGAACCGGATCCACTCCATCCACTTCCTCCAACTCAAGCCAGACGCAAATGACGTATCCGTTCTGCCCAGTGGGGACTACCAGGGCAACGGCCAGACGGCGTACTACTCGACCACGGGTCAGTACGGAACCACCTCGTCGGCCGGAGGCTCCTCGAACGGAGCTCACTCCACGACGCTGCCGTACCTGGTGCCCGTGGAGGAGGGCATCCTCCTCAATGGTTCCGCAcactcgctgtcgcagtcgcagtcacaatcgcaTGGACGCGATTCGCCGCACAGCCTGACGGAGGTCGCGTACATCCAGGAGGCGCAGAGCACGCCCCAGACGCCCACCTCGACGACCACGACCCATTCGGCTAGCGGCGGCAGCCTGGGAACGGGCGGTGGAGGCGCCTCCCCGGATTCCGACCAGAGTGCGCTCGGCAGCAGCAACAAGATTGCCTCGGCAACGATCAAGTGGCTGTCGCGCAACTACGAAACGGCGGATGGTGTGAGCCTGCCCAGGAGCACGCTGTACAACCATTACATGCAGCACTGCAGCGAGCACAAGCTAGAGCCCGTGAATGCGGCCAGTTTCGGCAAGCTGATACGTTCCGTGTTCTCCGGACTGCGCACACGTCGCCTGGGCACGCGCGGCAACTCCAAGTACCACTACTATGGTATCCGCATTAAGCCCGGCTCGTTGCTGAACAGCCAGGCGATGGACGACAAGCAGATGCTGGCCGCCGGCTACGGACCATCCTCGGACGGAACCGGCGGACCAGGCAGCGGACCGATGGTCAGCGTCACCAGCAGCACCGCCGGACAGCTGACCGGATCCAATGGATTGGGCGGTGGCCATGGCCAGCGGCACAGCAACGGCACCAAGAAGCACACCTTCAAGCCGGAGACCTACGAGGCGTGCATTCAGTACATCGGCGATGGAACCAGTGCCCTGCCCTCGTTTCCGCCCATCGAGCTGAACCACAGCTTCAACAGCGAACTGACCCTGGAGGACGTGGACACCTTCCGGGGCCTGTATCGGGAGCATTGCGAGTCCTTCCTGGACGCCGTGCTCAATCTGGAGTTCAACACCGTGGAGTTCCTGCTGCGCGACTTCTGGCGGGCCAGCGACAACAATAATCTGGACGAGTGCGAGGAGGAGAAGTACTTGAGCAAGACGAAGCTGTATCTGTTGTGCCACTGCGCAGAAGTGCAGAAGTTCGTGCGAGAGGTGGACTACCAATTCTACCAGAACACCGTCGATGTCATCATACCGGATGTGCTCCGCTCCATACCAAACGCCCTGACCCAGGCCATCAGAAACTTCGCCAAGAACCTGGAGATCTGGCTATGTGAGAGCATGCTGGGCGTGCCGGAGCAGCTTGCCCAGATCAAGACCAGTGCCGTCTCGGCATTCTGCCAAACGCTGAGGCGCTACACCTCGCTGAATCACCTGGCGCAGGCGGCTCGAGCAGTGCTCCAGAATGGTGCACAGATCTCCCAGATGCTAAGCGATCTCAATCGTGTCGATTTCCACAATGTTCAGGAGCAAGCTGCCTGGGTGAGTCAATGTGCGCCCGCCGTGGTCCAGCGCTTGGAGAGCGATTTCAAGGCCGCTCTGCAGCAGCAGAGCTCCCTGGAACAGTGGGCCAGCTGGCTGCAACTGGTGGTGGAATCGGCCATGGAGGAGTACAACGGGAAGCCGACTTATGCTAGAGCCGCCCGCCAGTTTCTGCTAAAGTGGAGCTTCTACAGCTCTATGATCATTCGTGACCTGACGCTGAGATCCGCCTCCAGCTTCGGGAGCTTCCACCTAATTCGCTTGCTGTTCGATGAGTACATGTTCTACCTGGTGGAGCACAAAATCGCCGAGGCACAAGACAAAACAGCCATTGCGGTCATTTGCGAAAGAATGAAAAAGGACATGGACTTTGAGTTCGAGTGCCAGTTCGCCTACATTACCAGCGACACGGAGCACCAGACGACTCCGAGCTCGGCCAGCAGTGGAGGCGACGTGGGCAACGAGGCCAAGCGACTGAAGCAGGAATGA
Protein Sequence
MHSRYGFDCQTRHYQQHQQTHHQHHHHHHPNPPCSIPLESPPTPPVISPSAAAAVAYSNLLEKCRCKQSVAANPVPAPPAQLQLQLHHHHHHHHHQTFVASASATSYSNCSALGLGSRTGSGSGSGKWNRIHSIHFLQLKPDANDVSVLPSGDYQGNGQTAYYSTTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPHSLTEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICERMKKDMDFEFECQFAYITSDTEHQTTPSSASSGGDVGNEAKRLKQE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00605316;
90% Identity
iTF_00596398;
80% Identity
-