Basic Information

Insect: Drosophila melanocephala
Gene Symbol: -
Assembly: GCA_037043625.1
Location: JBAMBD010000743.1:252027-256167[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 9.5e-05 0.0063 16.8 0.1 1 23 149 172 149 172 0.96

2 14 0.0015 0.099 13.1 2.9 2 23 221 243 217 243 0.89

3 14 0.013 0.85 10.1 0.9 1 23 362 385 362 385 0.93

4 14 0.16 11 6.7 5.5 2 23 434 456 433 457 0.95

5 14 0.0034 0.22 12.0 0.5 1 23 520 543 520 543 0.88

6 14 7.8 5.2e+02 1.4 0.0 2 13 562 573 561 578 0.81

7 14 0.00072 0.047 14.1 3.3 2 23 594 616 594 616 0.96

8 14 0.00082 0.054 13.9 0.1 1 23 725 748 725 748 0.95

9 14 9.3e-05 0.0061 16.9 0.2 1 23 797 820 797 820 0.94

10 14 0.0012 0.08 13.4 2.2 2 23 870 892 869 892 0.97

11 14 0.0025 0.17 12.4 1.4 1 23 979 1002 979 1002 0.91

12 14 0.05 3.3 8.3 2.3 1 21 1054 1074 1054 1075 0.95

13 14 0.032 2.1 8.9 0.6 3 23 1115 1138 1114 1138 0.96

14 14 6.2 4.1e+02 1.7 0.4 1 20 1156 1177 1156 1180 0.61

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	9.5e-05	0.0063	16.8	0.1	1	23	149	172	149	172	0.96
2	14	0.0015	0.099	13.1	2.9	2	23	221	243	217	243	0.89
3	14	0.013	0.85	10.1	0.9	1	23	362	385	362	385	0.93
4	14	0.16	11	6.7	5.5	2	23	434	456	433	457	0.95
5	14	0.0034	0.22	12.0	0.5	1	23	520	543	520	543	0.88
6	14	7.8	5.2e+02	1.4	0.0	2	13	562	573	561	578	0.81
7	14	0.00072	0.047	14.1	3.3	2	23	594	616	594	616	0.96
8	14	0.00082	0.054	13.9	0.1	1	23	725	748	725	748	0.95
9	14	9.3e-05	0.0061	16.9	0.2	1	23	797	820	797	820	0.94
10	14	0.0012	0.08	13.4	2.2	2	23	870	892	869	892	0.97
11	14	0.0025	0.17	12.4	1.4	1	23	979	1002	979	1002	0.91
12	14	0.05	3.3	8.3	2.3	1	21	1054	1074	1054	1075	0.95
13	14	0.032	2.1	8.9	0.6	3	23	1115	1138	1114	1138	0.96
14	14	6.2	4.1e+02	1.7	0.4	1	20	1156	1177	1156	1180	0.61

Sequence Information

Coding Sequence: ATGGAAGGTATGGATCTGTGGACGTCCATGTTTTCGGCTGACTTTGAAGAGGCTGATGCTGGGCCAAAGAGTCACAGTTATGCAGACGAGTTTATGGGCGATGAGGATGCGGATGAGCAGGAgactgctgatgatgatgttgatgctggGAAAGGACCTGAGCCAGATGACGATgccatatttgattttgaactGGAGCCAATTGTTAGCATTGCGGAACCCGAACCAGCACCCAGACCAACTGTCCGATTGGCGCCACCAATGCCGGTTGCTCCGCCCGTTCGGCCCCAGCAGCATCATCTTCAGTCAACGGTTAGCTCCACTTCCTCCTCCATGATGGGAGGTCGCGGTGGTGCTGCCGCGCCACCCACACGACCTACAACATCGCAAATCAATGCCACAGACGAGAATGGAGTGCCCATTAACTATGAACTGGGCGTCATCTATATATGCCCGGCTTGTGGTGCCGAGTTCCGGCAACAGGATATGTGGAAGCGTCACATGAACCAGATGCATCAGTATAACACTCGCCGTGGTCTCAACTTTGTTGGAATTGATAAACTGTATCATCGGTGCCTGGAGTGCAACAAGCGGATTGCCATGCACAGCCGGGAGAATCTGCTCAAGCACAAGTTCACCCATTTGCCATATCGTTGCACCAAGTGCTACATCTGCAAACGCGAGTACAAGTACAGACAAGACCTGATGGTGCATCTGCGCATGGTACACTGTGACGAGGTGGTTGCCATGATGCGTGCCGGTGATGCCAGTGCTGGGCGCAAGACGCGAGTCCGTGAGCCGCGCGTCGAGCAGCGTGCTCATGGTGCGTCTCGGTTCGGGCCGATCAGCCATGGACCGGTTCgtgacgatgatgatggtaTCGAGGTCAAGAATGAGCTGATGGACACGGAAGCAACGGCTGCAACGGCTGCCGATGACGTGGTTGACGAGCAGAATCGCAGCTTCAACCAAGCAAAGAAGAAGCGTATTAATCAGTCGGCCGGCTCTGCAAACGCTGGCAAAGCCGACAACGACAGTGGCAGTGGCGGCGGCGCTTCGGATATCTGCGAAGATTACATACACTACATGTGTCCCGATTGCGGCACCGACTGCGACACGCACGCTCAGTGGAGCCAGCACATTGAATTCGTGCACGACTATGTCAGCCGGCGGGGACTCAATTTTCGTTGCGTGGACATGCAGATGCAGTGCCTCGAATGCAAGGAGTTTGTCATCCCAAACACAATCAAGACACTGCGCGCACACAAATTCAGTCATTTGGCTCAGCCGGATTGGATGCGTTGCAAGCTGTGCTATCGGGGTTATACGGATCATCATGAGCTGGTCACGCACCTGCTCAAGCAGCATCATCTGGAGACATTAATGCCCGaagaggagcaggagcagcaaacGGTCAGTGCCAGTGCCGTCGATGATGCTGAGGATAACTCTGGCATCGGCAATGGCTGCGATGATGAATCCCTGTTGCAATTTGAGGATGTGCCCCGTCGTGGCGGTCGCATTGGCGGCGATGATATGTATGAGCCGCACATTGATTATCTGTGCCCGCAGTGCGGCCGCGAGTTCATTGAGAAGAAGCACTGGCGCACGCATGTTGTCCAGGTGCATGGCATGAACGATCTGGCCAAGCTGAACTTTGAGGTCATCAACGATCGTCAGCTGAAATGCACAGAATGCGAGAAGATCATCACGAATGCCTACGGCATTCAGAATGCGCAACAACACCGGATTACTCATCTGCCCTACAAGGCATATGCGCGCTGTCGCAAATGCCACAAATCGTATACGGATCGCAAGGGTCTGGTTAAGCACTTGGCCACATACCATTGCGTCGGCTATGAACCGCGCAATTCCGGAGCTGGAGGAGCGGCAGTCGGTGCAGGACAGAGCCAGGTCAAGTCGCAAACGCCGCGCAAACAAATTGTTACTGTTGCCAATGAAACGTATGAGATTATCTATTTGGATGACGAGCAATCACCgccaaataacaataatattaatgaggAAAATGATTTTGGCGAGCAGATGCAAGCGGATGATGATGACTATGCCACAGGCTGCACAAGCACACGCCAGTTGCCACCAGCtactgcggctgcggctgctgctgctgtcgccaCAACTTCTGCGTCCAATCAAAATGCGAATCGTTATAAATGCGTTGATTGCGGCTCCCTGTTTGCCACGCAGGCGGCGCTCAAGACGCACATTAGCGAGGAGCATGATTTTATGGACACGCAGTATAGCGCTAAAAAGTTTGATAATGCCGAACATGCAGAGGAGACGACGCCAGCGGCAGCGTCCGTGGCGGCCACTTCGCCTCCCAAAATCTTTTCTGGCGGCTCGACAATCGAacagaattatatatatttgtgcccCTCCTGTGGCAAGCCATATAAGACGCAATTCGAGTGGCGTCGCCACATCAACGAGGAGCACAATTTTGATAAGCggcaatatttgaatatgcgCCAGCTGGACAAGTATCGTTATCAGTGCACTCAGTGCAAGGACATTGTGAGCAATTCGAAGCTAAAGGGACTGCAGGATCATCACTTCAGACACTTGCCCTATAGGCTCTACTTAAAGTGCCTCGTTTGCGGCACCTGCTACAATCACAAGCCCAACATTGCCGCCCATCTGCGTACGCGCCACAACATCTTTGAGCGTGACACGCCCTGGCGTGAAATGCAGCCGAAGCCTCAGAATGGCTATGACACCATCAAATATAAAGATAAGGATATGCCAGTCATGTCCGCCACGACGTCAGACTCGCCGACgcctggcagcagcagtaacagtgCTCGCTCACTGAAACCGCAGCCCGGTTTGCTGCCCATGCGACCCGCTGGCCTAAACACACTGGAGGATAGCATCTCCTATCACAATGCTGTCGATCTGGACTTTATTACCTACTTCTGCCCCGAGTGCAATAAGAACTTTGATTCGCACGCTTTCTGGCGCAAACACATTGTCGAGCAGCACAACTTCAACAGCCGGCAAGGCTTGAACTTTCGCCAGATCGACAATCATCACTATCTGTGCCTGGAGTGCTACAAGCGGGTGACAGTTACCCACACCAAGGGCGCCATTGGGCAGCTGCAGTCGCACAAGTTCCGACATCTTCCATATCGCTCATTTAAGTGCTTGACCTGCAACGGCAAATTTGTGCGaaagcaaatgtttttcaaGCATTTGAATCGTGACACAAATCGCTGCGATAGCGGAGATCATAGTAACGAGGAACACATCTCCGAGCAGCCGGAGGAGAGATCTTCGTCCGCAAACGATGCATCTGATGCCGCCTCGTATCGCTTGCTGTGCCCGCAGTGCGGCGATAACTTCAGCACCAGCACCAAGTCCCTCTGGCGTAAGCATATTAACACTCAACATGGTCTGAGCAAGCTGGAGGTGCTGCACATGTCCAAGCTGGGCGACGAGCTCTATCGCTGCGTGGACTGTGATGAGCAGCTGGAAACGAAACAGCTGCGTGTGCTGCAACAGCATCGCTTCCGCCATTTACCCTATGCCGCATACATACGTTGCCAGCTGtgcgagcaacagcagccggatGAACTGGGCCATGGTCCCGTTGCAGCCGGGATGCACAGCATGTGTGAGCTGCAGCAACACATGCGCGACGAGCATCCCTCGTTTGTAGAGAACGATGAGCAAATGCAGTTGCTCGTCGATGTGGACGACGAGGAGAGCCACACGATGGCGGTGGCAAGCAATGAGGCATCTGACAATGGGTCATATATGCCGATGCCGCTGCAAATGCTCCTCGACggcgatgaggatgaggacaGCCAAACGGCGGCAGCTAACAATGAGACGTCCGACAATGGACCATATATGCCCCTGCCGCCGCATTTACTGGAGGAGGACGTAGACGACTTGGAGTTCGAAGATCAATATCTACTGAGCTAA
Protein Sequence: MEGMDLWTSMFSADFEEADAGPKSHSYADEFMGDEDADEQETADDDVDAGKGPEPDDDAIFDFELEPIVSIAEPEPAPRPTVRLAPPMPVAPPVRPQQHHLQSTVSSTSSSMMGGRGGAAAPPTRPTTSQINATDENGVPINYELGVIYICPACGAEFRQQDMWKRHMNQMHQYNTRRGLNFVGIDKLYHRCLECNKRIAMHSRENLLKHKFTHLPYRCTKCYICKREYKYRQDLMVHLRMVHCDEVVAMMRAGDASAGRKTRVREPRVEQRAHGASRFGPISHGPVRDDDDGIEVKNELMDTEATAATAADDVVDEQNRSFNQAKKKRINQSAGSANAGKADNDSGSGGGASDICEDYIHYMCPDCGTDCDTHAQWSQHIEFVHDYVSRRGLNFRCVDMQMQCLECKEFVIPNTIKTLRAHKFSHLAQPDWMRCKLCYRGYTDHHELVTHLLKQHHLETLMPEEEQEQQTVSASAVDDAEDNSGIGNGCDDESLLQFEDVPRRGGRIGGDDMYEPHIDYLCPQCGREFIEKKHWRTHVVQVHGMNDLAKLNFEVINDRQLKCTECEKIITNAYGIQNAQQHRITHLPYKAYARCRKCHKSYTDRKGLVKHLATYHCVGYEPRNSGAGGAAVGAGQSQVKSQTPRKQIVTVANETYEIIYLDDEQSPPNNNNINEENDFGEQMQADDDDYATGCTSTRQLPPATAAAAAAAVATTSASNQNANRYKCVDCGSLFATQAALKTHISEEHDFMDTQYSAKKFDNAEHAEETTPAAASVAATSPPKIFSGGSTIEQNYIYLCPSCGKPYKTQFEWRRHINEEHNFDKRQYLNMRQLDKYRYQCTQCKDIVSNSKLKGLQDHHFRHLPYRLYLKCLVCGTCYNHKPNIAAHLRTRHNIFERDTPWREMQPKPQNGYDTIKYKDKDMPVMSATTSDSPTPGSSSNSARSLKPQPGLLPMRPAGLNTLEDSISYHNAVDLDFITYFCPECNKNFDSHAFWRKHIVEQHNFNSRQGLNFRQIDNHHYLCLECYKRVTVTHTKGAIGQLQSHKFRHLPYRSFKCLTCNGKFVRKQMFFKHLNRDTNRCDSGDHSNEEHISEQPEERSSSANDASDAASYRLLCPQCGDNFSTSTKSLWRKHINTQHGLSKLEVLHMSKLGDELYRCVDCDEQLETKQLRVLQQHRFRHLPYAAYIRCQLCEQQQPDELGHGPVAAGMHSMCELQQHMRDEHPSFVENDEQMQLLVDVDDEESHTMAVASNEASDNGSYMPMPLQMLLDGDEDEDSQTAAANNETSDNGPYMPLPPHLLEEDVDDLEFEDQYLLS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00517225;
90% Identity: iTF_00577291;
80% Identity: -