Dmel005701.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila melanocephala
Gene Symbol
RREB1
Assembly
GCA_037043625.1
Location
JBAMBD010000523.1:643735-650629[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.036 2.4 8.7 0.8 1 21 275 295 275 297 0.93
2 13 0.00033 0.022 15.1 0.2 1 23 307 329 307 329 0.98
3 13 0.00025 0.016 15.5 7.2 1 23 335 357 335 357 0.98
4 13 0.24 16 6.2 1.7 2 20 587 605 587 607 0.93
5 13 0.016 1 9.9 0.2 1 23 757 779 757 779 0.97
6 13 1.2e-05 0.00081 19.6 0.7 1 23 789 811 789 811 0.99
7 13 0.00083 0.055 13.9 2.0 1 23 817 840 817 840 0.97
8 13 0.003 0.2 12.1 2.0 1 23 1103 1126 1103 1126 0.95
9 13 8.6e-05 0.0057 17.0 0.3 2 23 1522 1543 1521 1543 0.97
10 13 0.14 9.6 6.8 6.3 1 23 1549 1572 1549 1572 0.97
11 13 9.4 6.2e+02 1.1 3.4 1 23 1688 1711 1688 1711 0.78
12 13 0.0084 0.56 10.7 0.5 3 23 1773 1793 1771 1793 0.96
13 13 0.0013 0.088 13.2 4.8 1 23 1799 1821 1799 1821 0.99

Sequence Information

Coding Sequence
ATGCTcgccacacagcagcagcagcaacagcagcagcagcaacaacaacagcaacaatcgcaCACAGcatctgcaactgcagcagcagcagcagcaacacatgAGGATGCTCGGGATTTGGGGTTAATGGAGACGCGACAGCGTCGCGATTCGAGCACATCAGAATCCTCGCTGGAGCATTTGGATTTGGGTCGCACGCCCAAaaagttgagcagcagcagcggcgcacCGCAGCCGACGTCGACGCCACACGACACAGCAGTGACAGCGACGTCGCGCAAGCGCAAACTGCGacagcaacaccaccagcagcagcagcagcagcaacagttgccactcTCCGatgaggagcaacagcagcaacagcaacagcagctgttggaCTCATCAGCGCTGCGGCCGCGTCACAAGCAGCGACGCAGCgccgttgctgccgctgccagcgCCAGCATCGTTGTCGACTACAGCGCCAGCGGCGACGCCAGCTCGCTGCGCAAAAAGTTTCGACTGAAtcgcagcagcgccagcagcaatgCCGCCAACGGTGATTTATCCGAGTCGGGTTTCGTTGATGGCAGCGCCCTCAGTGGCTATCTGcttggcagcaacagcaacaacaacaacaacaataataataacaacaacaacaacaacaatatcagtaatagtagcagcagcagcagcgcagtcgctcagtcagcagcagcagcagcagcgtcggcAGCGCAGCATGCGTCAAGCGTTAGCAGCTCGGGCGGCTCCTCGCCACAGGGCCTCTCGAGCGCCGAGTCGGGCATCGGTGCCGGCGATGAGCACATGAAATATCTGTGCCCCATTTGCGAGGTCGTCTCGGCCACGCCCCACGAATTCACCAATCACATTCGCTGCCACAACTACGCCAACGGCGACACCGAGAACTTCACCTGCCGCATCTGCTCCAAGGTGCTCTCGTCGGCATCCTCGCTGGACCGGCATGTCCTGGTGCACACTGGAGAGCGTCCGTTCAACTGTCGCTATTGCCACTTGAACTTCACAACCAATGGGAACATGCACCGACACATGCGCACCCACAAGCAACATCAggcgtcgcagcagcagcagcagcaacagcagcagcactcgcaacagcagcaatccacacaacagcagcaacaggcacagtcgcagtcgcagcaacaacaacagcgacgccAGCAACATGCGGGTGGAGCTGGAGCAACTGGCTCGGTATCGGGATCGGCACAGTTGTTGACGACGCGAGCGGAGAGCTATGAGAGCGATGCCAGCTGCTCGACGGATGTGTCCAGTGAGCTGAAcagtcacagcagcaacagcaatcagtccaaccacaacaacaacaacaacaacaatagccacaaaacgaacaacaataacaacaacaacaacaatgaggaTGAGCTCGAGCTGGAGGATGAGCAGCTGGTGCTGAGCAGCAAACAGCGACGCCACAAGGCAGccctgaacaacaacaatataattaGGGATGAGGAGCACGAGAATCGGCCGGATGATGATTCGGATGTGGACAGTGCTGATAGCGTTGCCCAGGTGATAACAAGCACACCGGATGTGGCCACGCTGCTCGCTTCGGGCGGCACCTCGCCCACCCACTCGCATTCGGAATCGCATTCACCgcccctgctgctgcagagctGCCCGGCCTGCAATTCGGGTGAATTTGAATCTGTGCCAGCGTTGTGCGCCCATCTGGATGCCGAGCATGCGGACATACCGGCCAAGTGTCGCGAATGCGAGGTGATCTTTGCCACACATCGACAGCTGCAGGCGCACAGCTGTCGAGGATTGCCGCCGCTGCTTGGTGTGAGCTCATCGCCACTGCACAAGCAGGAGGAGAGCGAACTGGaggagcagcaccagcaccagcagcagcagcacgaggaggaggaccacgaacagcagcagcacaagcaggaggaacaggagcaggctGAGCAGCGCGAATGCGAAGATTTCTTCCAGCAGCTGTATCTGAAGAATAAATCGTCAGCAACGCTGCTTCCCTCACCGATCAAACATGAGCCGGCGGACCAGCGACAGGATCTGGCCGACATTCAAAGCATACTCAATATGACCAGTTCCAGCTGCACCTCGAGTTTCCTGCGCAATTTCGAGCAGTCGGTGAACACGCCCTGCTCCAGCCAATATAGCGTCGATGGACGCGATGGCGAGGAGGAGGCCCAGGATGCCTTCACCAATGAATTCCGGCGAATGAAACTGCGCGGTGAGTTCCCCTGCAAGCTGTGCACCGCCGTCTTTCCCAATCTGCGTGCGCTCAAGGGCCACAATCGCTACCATCTGTCGGAGGTGGGCGCCGCTGGTCCATTCCGTTGCAACATGTGTCCCTATGCCGTCTGCGACAAGGCGGCGCTCGTCCGGCACATGCGCACCCACAACGGCGATCGGCCTTACGAGTGCGCCGTTTGCAACTATGCGTTCACCACCAAGGCGAACTGTGAGCGGCATCTGCGCAATCGACATGGCAAGACCAGTCGCGAGGATGTGAAACGTGCGATTGTCTATCATCCGGCCGAGGATGCCAGCTGCGAGGAGAACAAATCGCGGACCGAAGCCGATATCCTAACGGAGCTGAGCGGCTATCGTTGTGCAACGCCCACGGAGCACAGCCCTCGGCCAGCTCCTCtagcagcagcagcagcagcagcagcaacaacatcgctGCCACAACAACCGCTCAAGATTCAGGTGAAGAGCTTGGATCAGCTGGTGGATAAGCCACTGCCAGCACTCGATCTCAGCATGGATGCGCTCGACCTGAGCAAGAAGCCCGCCCAGCTGCTGGCCGAGCAACGGGAGCAAAGGGAGCAGCTCGAAAGACACGAATtggtgctgcagcagcagcagcagcagcagcagcaacaacaacagcagcagcaacaacaacagctgcagcagcagcagcaacaaatgtttgGGGCTGGCGATGCAGCTGCTCAGTATATGCAACAGCTGTTGCGCAGCTTCATGCTCCAGCAATCACCCGGTTTTCCTTTCTTTGGGTTTATGGCGCCACCGCCaccaacagcggcagcagcagcagcagccgcagcaacagcagcagacaaatcaatgacaacaaatccagcagcagcagcagcagcagccggcgcaacagcagcaacaattgctgcaatGCCACTGTCGCTGCCTGTGCCACTGCCCGCTGGTGGTCCGGTCAAGATGGTCATCAAGAATGGCGTCCTGATGcccaagcagaagcagcgccGCTATCGCACCGAGCGTCCCTTTGCCTGCGAGCATTGCTCGGCCCGCTTCACCCTGCGCTCCAACATGGAGCGCCAtgtgaagcagcagcatccacagtTCTATGCGCAGCGCCAGCGACACCGCAGCGGTCATCATGTGATGCGTGAACGGGCTGCATCATCGAGTGCTGTCCAAGCGGCAGCCGCTGCAcaggcagcggcggcagcagcagccgccgccgccgcagcaatGAGTAAtctcagccagcagcaacagttgcagcactCGCATTCACATCATGTCCATGCGCCAATCTCGGAGCAGGTGAAATATGCAATATTGGCGCAGCAATTGAAGGCGCGCAAGGATACCGATTTGTTGCAACAGGCACTGGCACATGGCTCCAGCAGTGTTGTCGCCAATCCGCTGTTGCATTttagctacaacaacaacaacaacaacagcagcagcaacagcatcagcaacaagcagcagcaacaacagttgagCAACAACACTGGCAACTCTTTGGTGCTGGACGACGATGAGCCGCCCAAGCTGATCATTGACGAGGATGACGAGGATGTGGATGGCGaggacgatgaggatgaggaggaggagcaggattttgatgttgatgaggaggagcaggaggatgAAGAGATGGACTTGGACGatgagcatcagcagcagctgcacgaggaggatgatgatgatgatattgatgatgacgatgcagcagcaacagcagcaacagcagcagcagccgcagctgcagcagaggcatcgcagcaacaattgcagccaaCCAAGGACAAGCTGCAAACCAAGCCAATTGAGGCGGCCAAAAAGGTAGCGGAAACCATATTGGAGCAGGCAATCAAGGAGCGCGAGGAGAAAGCCGCCGAGAAGCAGCCGCATCCTCAATCGGAGTCCGTGGGCGGGAATAAGCCGGCGACGCCGACAACAATGAAAACGATGATTGCACAAGCGGAATCGGTGGCCAAGTCCTTGAAGGAGGTGGCCAGTTCACCGTTCAAGGATGAATCTCAGGATCTGGTGCCGGTGGCCAAACTGGTGGACAATGCGACCAGCAATCAGGTGTCGTTCAACAGCTATTTCCGTCCCAGCGACGTCGCCAATCACATGGAGCAGAGCGACGAGGAGGGTCTCGTTGCCAGCGGCAGCGCCAGCGAGAGCAACAATTCCGGCACCGAGGAtgtgaccagcagcagcagcagctgcggcaatGACACCAAAAAGAAGTCCGCCTACAGCCTGGCACCGAATCGTGTCAGCTGCCCGTATTGCCAGCGCATGTTCCCCTGGAGCAGCTCGCTGCGTCGCCACATCCTGACGCACACCGGCCAGAAGCCGTTCAAGTGCTCCCACTGCCCGCTGCTGTTCACCACGAAGAGCAACTGCGATCGCCATCTGTTGCGCAAGCATGGCAACGTTGAGTCCGCCATGTCCGTCTATGTGCCCACCGAGGATGTCAGCGAACCGATACCCGTGCCCAAGTCCGTCGAGGAGATTGAGCTCGAGGAGCAGCGACGTCGCCAGGCGGCCGAAGCCGAACAGGCCGAGCGTGAGCAGCGCGAGCGCCAAAAGGAGCGCGAACGTGAACTGGAAttggaacgggaacgggaacgggaacacCAACAGTTGATACAACAGTTGCGCCAACAAATGGCCGCTGCCGCAGCGGCTGCTGTCGCCGCCGTTGCTGCGCCAACGCATCCACCACCGCCAGCCCAATCGCCACCGGGCCTGGAGGCGAGCAGTGATCTGCCCTACAAATGCCATCTGTGCGAGTTCTCATTCGGCGAGCGGCTGCAGTGCCTCGAGCACATCAAGCAGCTGCACGCACACGAGTTCggcctgctgctggccaagggGGCCATCGAAACGGATGCACAGCtccagcaccaacagcagcagcagcaacaattgccagCGGCTGGCGGTGCTCCACATTCGGATGATGACGCTGCCGCTGTCGGCACCAGATCGGGCAAATATCCCGACTATAGCAATCGCAAAGTGATTTGCGCATTTTGCGTGCGTCGCTTCTGGTCAACGGAGGATCTGCGGCGACATATGCGCACCCATTCCGGGGAGCGTCCGTTCCAGTGCGAGATCTGCTTGAGGAAGTTCACATTGAAGCACAGCATGCTGCGACACATGAAGAAGCACAGTGGACGCAGTCACAATGGTGGCGAGCTCGATCATCAGTCCGATTGCTCCGACGATGAGCAGATGTTGCCCTGCTCCCCACCCTCGACGCCAACGcccactaacaacaacaacaacaacaacaacacttgccagaacaacaacaacaacagcaataacaataacaacaacaacaacagcaacggcaagcAGGTGCTGCGCGAGCTGCTGGGCAAGGCGAACGAGTGGCGAGTGAGTCGCCTGGGCGAGCACAAGGAGAACATTGccgaggcaacaacaacaccctcagcagcaacagcagcagcggcagcaacagctgcagcagcggcagcagcagcagctgtggccaGTGGCGATCTAATTGGTAATCTGTTGGGGATCAGTGATCAGGGCATACTAAACAAGCTGCTCTCCTCACCAGACGAAGCTGCCAAGCTGCTGGGAGTGGAGAAGTAA
Protein Sequence
MLATQQQQQQQQQQQQQQQSHTASATAAAAAATHEDARDLGLMETRQRRDSSTSESSLEHLDLGRTPKKLSSSSGAPQPTSTPHDTAVTATSRKRKLRQQHHQQQQQQQQLPLSDEEQQQQQQQQLLDSSALRPRHKQRRSAVAAAASASIVVDYSASGDASSLRKKFRLNRSSASSNAANGDLSESGFVDGSALSGYLLGSNSNNNNNNNNNNNNNNNISNSSSSSSAVAQSAAAAAASAAQHASSVSSSGGSSPQGLSSAESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLNFTTNGNMHRHMRTHKQHQASQQQQQQQQQHSQQQQSTQQQQQAQSQSQQQQQRRQQHAGGAGATGSVSGSAQLLTTRAESYESDASCSTDVSSELNSHSSNSNQSNHNNNNNNNSHKTNNNNNNNNNEDELELEDEQLVLSSKQRRHKAALNNNNIIRDEEHENRPDDDSDVDSADSVAQVITSTPDVATLLASGGTSPTHSHSESHSPPLLLQSCPACNSGEFESVPALCAHLDAEHADIPAKCRECEVIFATHRQLQAHSCRGLPPLLGVSSSPLHKQEESELEEQHQHQQQQHEEEDHEQQQHKQEEQEQAEQRECEDFFQQLYLKNKSSATLLPSPIKHEPADQRQDLADIQSILNMTSSSCTSSFLRNFEQSVNTPCSSQYSVDGRDGEEEAQDAFTNEFRRMKLRGEFPCKLCTAVFPNLRALKGHNRYHLSEVGAAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSREDVKRAIVYHPAEDASCEENKSRTEADILTELSGYRCATPTEHSPRPAPLAAAAAAAATTSLPQQPLKIQVKSLDQLVDKPLPALDLSMDALDLSKKPAQLLAEQREQREQLERHELVLQQQQQQQQQQQQQQQQQQLQQQQQQMFGAGDAAAQYMQQLLRSFMLQQSPGFPFFGFMAPPPPTAAAAAAAAATAADKSMTTNPAAAAAAAGATAATIAAMPLSLPVPLPAGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRHRSGHHVMRERAASSSAVQAAAAAQAAAAAAAAAAAAMSNLSQQQQLQHSHSHHVHAPISEQVKYAILAQQLKARKDTDLLQQALAHGSSSVVANPLLHFSYNNNNNNSSSNSISNKQQQQQLSNNTGNSLVLDDDEPPKLIIDEDDEDVDGEDDEDEEEEQDFDVDEEEQEDEEMDLDDEHQQQLHEEDDDDDIDDDDAAATAATAAAAAAAAEASQQQLQPTKDKLQTKPIEAAKKVAETILEQAIKEREEKAAEKQPHPQSESVGGNKPATPTTMKTMIAQAESVAKSLKEVASSPFKDESQDLVPVAKLVDNATSNQVSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSSCGNDTKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQAAEAEQAEREQRERQKERERELELEREREREHQQLIQQLRQQMAAAAAAAVAAVAAPTHPPPPAQSPPGLEASSDLPYKCHLCEFSFGERLQCLEHIKQLHAHEFGLLLAKGAIETDAQLQHQQQQQQQLPAAGGAPHSDDDAAAVGTRSGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRSHNGGELDHQSDCSDDEQMLPCSPPSTPTPTNNNNNNNNTCQNNNNNSNNNNNNNNSNGKQVLRELLGKANEWRVSRLGEHKENIAEATTTPSAATAAAAATAAAAAAAAAVASGDLIGNLLGISDQGILNKLLSSPDEAAKLLGVEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00535518;
90% Identity
iTF_00525357;
80% Identity
-