Basic Information

Insect: Drosophila melanocephala
Gene Symbol: Hr39
Assembly: GCA_037043625.1
Location: JBAMBD010000600.1:1291356-1294819[+]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.87 4.9e+03 -3.5 8.0 41 96 41 96 20 212 0.60

2 3 3 1.7e+04 -5.4 15.8 30 157 215 344 203 361 0.35

3 3 2.5e-99 1.4e-95 321.0 9.2 1 408 495 870 495 870 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.87	4.9e+03	-3.5	8.0	41	96	41	96	20	212	0.60
2	3	3	1.7e+04	-5.4	15.8	30	157	215	344	203	361	0.35
3	3	2.5e-99	1.4e-95	321.0	9.2	1	408	495	870	495	870	0.84

Sequence Information

Coding Sequence: ATGCCAAATATGTCGAGCATTAAGACGGAGCAGAGTGTTTCACCCGGTGCCAGTGGCAGCTATCAGCTGCCCGTTAACATGTCGACGGCGACAGTGACACCagcgtcgcagcagcagcagcagcaacagcagcagcaacagcagcagcagcaccagcgcCACAATGTCTCCGTGACGAATATCAAATGTGAACTGGACGAGCTGGCGACGCCAACGAATGGCAACCTGGTGCCGGTCATAGCCAactataataatcataatcacaatcacaatcacaatcacagcGGCAGCTTGCGCATACCCCTCGGCGGCAATGGGGATGAGTCCGATTCGGATGCGGAGCTGGCCAACATTGAGAATCTGAAGGTGCGACGACGTGCGTCAGACAAGAATGGTCCGCGTCCCATGTCCTGGGAGGGTGAGCTGAGCGAGAACGAAACGAATGGCGGCGCCGTCGGCGATGAGGAGGAGCTCATGGAAACGGAAACGGTGATCAAGAGCGAgCAGTCAAGTGAACGCCATGTTGCAGCCCATCAAAACCGAACTGGAGAACATAGCCGGCgagatgcaacagcagcagcaacaacagcagcaacaacagcagcagcagcaacaacaacagcagcagcagcaacaacagcagcagcagcagcaacagcagcagcagcaacaacccagctgcaacaacaacaacaacaacaattgctgccaCTGAAGCAACAGAGCTATGCACCGAACAACAAGCTGAAATTGGCGCCGACGCAAAGTGATCccatcaatttgaaatatgagccgacgacaacgacaacatcgtCGCTGCTCTGCGACAGGAGCAAGTCGAATAGTGGCGGCcatttgccgctgctgcccgCCAATCCCAGTCCCGATTCTGCCATACATTCCGTCTATACGCACAGCAGCCCCTCCCAATCGCCGCTGACGTCCCGCCACGCCCCCTATACGCCCTCGCTGAGCAGGAACAACAGCGACGCGTCGCACAGTAGttgctacagctacagctccGAATTCAGTCCCACCCACTCACCCATTCAGGCGCGTCATGCGCCACTCGCCGGCGTCGCTGCCTTGTTCACGGGCAATGCAAATGGCGGTGCACTGCATCATCACAGTGTGCTCTATCGGCCACTCAACGTGGATGCCGCACAGGAGGCACAAAATCTGAGCATGGACGCGGGTGGTGCATCATTGGATGCCAGCGCCACGTTGGCTGCCTCGCCGGCGGGCATCTCGCGCCAGCAGCTAATCAATTCGCCGTGTCCGATTTGTGGGGATAAGATCAGTGGCTTCCACTATGGCATCTTCTCGTGCGAGTCGTGCAAGGGCTTCTTCAAGCGCACCGTCCAGAATCGCAAGAACTATGTGTGTGTCCGAGGCGGTCCCTGCCAGGTGAGCATCTCGACGCGCAAAAAGTGCCCCGCCTGCCGTTTCGAGAAGTGCCTGCAGAAGGGCATGAAATTGGAGGCGATACGCGAGGATCGCACCCGTGGCGGTCGCTCCACCTATCAATGCTCCTACACGCTGCCCAATTCGATGCTCAGTCCGCTGCTCAGTCCCGATCAGGCGGCGGCCgctgcagccgccgccgccgttcaccagcagcagcaacaacaacagcaacatcagcagcagcagcagcaacatggtCCACTCAATGGCTTTGGTGGCGGTGGCTCCAATTCGCTGCCAGCGAGTCCCAGTCTCGGCGGGGCATCCATCAAGACGGAGCAATCGGAGCAGCTAAATCATCATACGTCACCATCAACGCGAGCCTCAAGCATTCCAGCCCTGCTGCAGGAAATCATGGATGTTGAACATCTCTGGCAATATACCGATGCGGAATTGGCACGCATTAATCAGCCGCTGTCCTCGTTTGCAACGGGTGGCTCATCGTCGAGCAGCACGGGCGGTTCAAGTTCCGCCGGACAGCATACGGGCAATGCACAACAGATGACCAATCCACTGCTGGCCAGTGCTGGTCTCGCATCCAACGGCGAGAACGCCAATCCCGATCTGATTGCACACCTCTGCAACGTGGCCGATCATCGCCTCTACAAGATCGTCAAATGGTGCAAGAGTTTGCCGCTCTTCAAGAACATCTCGATCGACGATCAGATCTGCCTGCTCATCAACTCGTGGTGCGAACTGTTGCTCTTCTCCTGCTGTTTTCGTTCCGTCGACACGCCCGGCGAGATCAAGATGTCACAGGGCAGAAAGATTACGCTGGCACAGGCTAAAACCAATGGCTTGCAGGCGTGCATCGAGCGCATGTTGAATCTGACCGATCATTTGCGTCGCCTGCGCGTTGATCGCTACGAATATGTTGCCATGAAGGTAATCGTGCTGCTGCAGTCCGACACAACGGAACTGCACGAGGCAGTCAAGGTGCGCGAGTGCCAGGAGAAGGCGCTGCAGGGTTTGCAGGCCTACACGCTGGCCCATTACCCCGAGACGCCGTCCAAGTTTGGTGAGCTGCTCCTGCGCATACCCGATCTGCAGCGCACGTGTCAGCTGGGCAAGGAAATGCTGACGATCAAAACGCGCGACGGTGCAGACTTTAATTTGCTAATGGAACTGCTGCGCGGAGAACATTGA
Protein Sequence: MPNMSSIKTEQSVSPGASGSYQLPVNMSTATVTPASQQQQQQQQQQQQQQHQRHNVSVTNIKCELDELATPTNGNLVPVIANYNNHNHNHNHNHSGSLRIPLGGNGDESDSDAELANIENLKVRRRASDKNGPRPMSWEGELSENETNGGAVGDEEELMETETVIKSEQSSERHVAAHQNRTGEHSRRDATAAATTAATTAAAATTTAAAATTAAAAATAAAATTQLQQQQQQQLLPLKQQSYAPNNKLKLAPTQSDPINLKYEPTTTTTSSLLCDRSKSNSGGHLPLLPANPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPLAGVAALFTGNANGGALHHHSVLYRPLNVDAAQEAQNLSMDAGGASLDASATLAASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAAAAAAVHQQQQQQQQHQQQQQQHGPLNGFGGGGSNSLPASPSLGGASIKTEQSEQLNHHTSPSTRASSIPALLQEIMDVEHLWQYTDAELARINQPLSSFATGGSSSSSTGGSSSAGQHTGNAQQMTNPLLASAGLASNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSVDTPGEIKMSQGRKITLAQAKTNGLQACIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELHEAVKVRECQEKALQGLQAYTLAHYPETPSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADFNLLMELLRGEH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00575636;
90% Identity: iTF_00595983;
80% Identity: iTF_00542488;