Basic Information

Insect: Drosophila melanica
Gene Symbol: zfh1
Assembly: GCA_004143765.1
Location: SCDT01002355.1:7698-13196[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.1e-05 0.0021 18.6 1.0 1 23 150 172 150 172 0.97

2 15 0.0027 0.27 11.9 1.2 3 23 180 200 178 200 0.94

3 15 7.2e-05 0.0072 16.9 0.1 1 23 361 383 361 383 0.98

4 15 0.00025 0.025 15.2 0.9 1 23 389 411 389 411 0.98

5 15 2.7e-05 0.0027 18.2 2.2 1 23 442 465 442 465 0.95

6 15 8.2e-05 0.0082 16.7 0.8 1 23 485 507 485 507 0.96

7 15 0.0014 0.14 12.8 0.4 1 23 513 536 513 536 0.98

8 15 0.021 2.1 9.1 0.4 3 19 545 561 544 562 0.95

9 15 0.00012 0.012 16.1 5.6 1 23 571 593 571 593 0.97

10 15 0.032 3.2 8.5 1.2 2 23 599 620 598 620 0.96

11 15 7.3e-06 0.00073 20.0 1.0 1 23 629 651 629 651 0.98

12 15 0.00083 0.083 13.6 0.1 3 23 659 679 657 679 0.97

13 15 0.00012 0.012 16.3 0.9 1 23 685 707 685 708 0.95

14 15 0.041 4.1 8.2 0.4 1 23 718 740 718 740 0.97

15 15 0.00038 0.038 14.6 0.5 1 23 1266 1288 1266 1288 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.1e-05	0.0021	18.6	1.0	1	23	150	172	150	172	0.97
2	15	0.0027	0.27	11.9	1.2	3	23	180	200	178	200	0.94
3	15	7.2e-05	0.0072	16.9	0.1	1	23	361	383	361	383	0.98
4	15	0.00025	0.025	15.2	0.9	1	23	389	411	389	411	0.98
5	15	2.7e-05	0.0027	18.2	2.2	1	23	442	465	442	465	0.95
6	15	8.2e-05	0.0082	16.7	0.8	1	23	485	507	485	507	0.96
7	15	0.0014	0.14	12.8	0.4	1	23	513	536	513	536	0.98
8	15	0.021	2.1	9.1	0.4	3	19	545	561	544	562	0.95
9	15	0.00012	0.012	16.1	5.6	1	23	571	593	571	593	0.97
10	15	0.032	3.2	8.5	1.2	2	23	599	620	598	620	0.96
11	15	7.3e-06	0.00073	20.0	1.0	1	23	629	651	629	651	0.98
12	15	0.00083	0.083	13.6	0.1	3	23	659	679	657	679	0.97
13	15	0.00012	0.012	16.3	0.9	1	23	685	707	685	708	0.95
14	15	0.041	4.1	8.2	0.4	1	23	718	740	718	740	0.97
15	15	0.00038	0.038	14.6	0.5	1	23	1266	1288	1266	1288	0.98

Sequence Information

Coding Sequence: ATGAACAACCAGGAATATGGCGGCATCCAGTGGATACAACAGCACGCCTCGGCGGTTGACTCCGAAACGGATATACTGGAAAGCGGCGCCGCCGACGGCGAGGTGACCGCCGCCTATCTGGTGAACGGGAATGCCACAGACGAGGATCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCGCGCGATGGTCAGCTGAGCGAGATCATTGCCGCCAACGAAACGGGCGGCGGCACCGTGTTAATTACGGACAACGGCACCGTTGCCTACGCCGAGTCCTTTGACGATGATGCCCAGGTGGTGACCGAGGAGATTATTACCGATGACTGGGTGCAGCATCAAGGCGCTGAGCGCGTGGAAATCGCGGCCGAGCAGATTGCGGGCAACAACAGCTCGCAGGAGCTGCTGGACATGGAGCAAGATGAGTACACGGCACTGCGGCCGTATCCTTGTGATTTCTGCAGCCGGCGCTTTCGCAAGAAGGCCAGCCTCAACAATCACATGTTGGCGCATCAAAACGATCGCCCGCATTTATGCAAGCTGTGCGGCGGACGTTTTTCGCGACGCGCCGAGTTGATTAGCCACTTCAAGGCGCACGCTGAGGCACAGGTGGCGGCGGATGCCGAGGTCgcggctgccgcagcagcggctgcaattaaattcgaaccgcagcagcagcaacgacaaatCGATGATCATTTTTACGAACAATGGCCGTTTTATCAGGACCAGGatcaggagcaggagcaggaagAGGACCAGGTGCAGCAACAGGCGCAGACACAGGAACTGGTGCAACAGCACCAAACTGTGCCCCAGGCCAGCTATCCAGCGGTCAGTGCTGTGGCAGCGCCAACAGCCGCACGCGGTCGCATTAGTCGCCTCAAGCCGAAGGAGGAGAGCACCCAGTACATTGTGATTGCCGATAAGCAGGCGACATCTGAAGTCGATAATCTGCCTCAGGACATGGACTGTGAAGAGCTGCCGCTGGCGGGCAACACGCCGATCGGGGAAAGCAGCCAAGTCGCTGATGCAGCGCAGCCGCTGCGCTTTCCGGTGCTGGACGAGAGCAAGCCCTTCGTGTGCCAGCAGTGCGGCTTGGCGTTTGCGCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGAGTCGCCCTTCGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGCCTGCAGGAGCATCAGAAGACACATCAGTTCGAGGAAAGCAACTCGGAGTATGATCCGGCATCGGCGGGCGAGGATAGCGCCAGCGAATCGGAACAGGATCAGCTATACGGCGACTTCTACTGCAGCGAGTGCGGCATTTCATTTCACAGGCAGGATCTGCTGCGGCGCcatgccaagcagcagcacaagGATACGGATGGCGGCGACAATGCTGAAGCTGGCGAAAATGCCAAAGATGCGCCACACAGTTGTCACACGTGCGGCAAAGCTTTTCCCAGCGCTCTGGAGCTGAACACCCATGTCGAAATTCATGCCCGTTTCCCGCCTTTCAAATGCGTCCTGTGCGGTGTTAGCTTTTACGAGGAGGAGGCCATCAAGCGGCATTTGAAGACGCGCCATCCGCACGAGCTGAAGCCCAACTCGTGCGTGCTGTGCGGCAAGGAGTGCCGTGATCGGAAGGCGCTGATCAAGCACGCCTGGGACCATTCGCGCGAGAAGTGCCATTCGTGCTCCAAGTGCGGAAAGAATTTCCACAACAAGGCGCGACTGAAGCGGCACATGGCCTCCCATCGCGACAAGTCGGTGGTGTGCGAGGTGTGCCACGAGGAGTTCCCCGATGGCCGCACCCTCTCCAATCATCGCCACTCGCACAGCACCACGTCGCCGGGAAAACTGTTCCCCTGCCATGAGTGCGGCAAGACCTTCGGATCGCGCAGCTCTCAGCAGATACACGTGCGCATCCATACGGGCGAACGACCGTATGGCTGTCGCTACTGCTGGAAGGCGTTCGCCGATGGCGGCACACTGCGCAAACACGAACGCATCCACACCGGCGAGAAGCCCTATGCCTGCTCCGTGTGCACGCGTGCCTTCAATCAGCGCGTGGTGCTCCGCGAGCACATACGCTCCCATCACTCGGGTCTGGACGCGGTGCGCGGCACCTACCACTGCACCGTTTGCACTGCCGATTTGTCCTCTTCCAATGAGCTCATCCAGCATCTCATCCAGCACAGCGACACGAACACGGCCAAACAGCGCCAGCCCATTACCGGGCCACGCAAGTACAAGCGCCGTCGGAAACTGCAGCCACATGAGATTGCTCACATGCGTGCGGGCAACAAGGATGGCGAGGACTATGTCAGCGACATTGAATATTGCGATTTAGATGTGGAGAATGTCGACGATCTCCTCGACCGAGCCGAACCCGTCAAAAAGGAGAAGCGCAAGCGAACTGCGACCAATGGCGCCGCTGCGCCAGCACAGAACACTTCGGATTCGGTTAAATcggccaacagcagctcgGACCGACTGTGGGATGAGAAGTTCATGCAGAtgaatggcaacggcaacgtcgCCTCTGATGAAGCCTACAAGAGCTTCTTTCAGATTGACTCTCTGGTGGTTGTCAACGACACCACCCTGCCGGCTGTTAGCTCCTCGAGCAATGCGACAGGTGGCGCCAAGTCGCGGCGTAGCGGTAAGCAGGCGCAGGCAGCGGGGAGCAGCGACAgggtggcggcagcagctggcgaGGAGTCGGGCAAATCCGGCGGCGcgagcagtcgcagcagcaaaaggaaaTCGAGCAAAGCGGCCAAGAATGCAGCTggagcaacagcgacagctgcagctgcagctgcagccaccgCCAGCAGTTCGCGTCCCCGCATGATCCACACGGAAAAGTCGCGGGTGCCGGCGGAGAATGCGCCAAAGAGAACGCGGGGTCGGAGCTACGCCACGCGCACTACCACAAGCGAGAGCAGCCAGCTGGGTCTGGTCAAGGCGAGCAGTGTTGCCAGCTCGCGCATTGTCGATGATTACGAGATTATATCACCTGCCACACAGCCGCCCAATCAGATCAGCTCCAGTCCGCTGCACATCAAGCAGGAAcaggagcaactgcagcagcaccaccaccagcaacagcagcagcagcagcgcgtgCAGCTCATGTACGACGACACGCATCTGCTGATTGATGCGACACTGTTGCGCGAGAAGACCTTCGAGAAGTTCAATCCGAGCATTGTCAACGATCTCGAGGAGATTCTGCGCAGTCCGCTCAAGCACGATCGGAATGCGCGGCTCCGCTTCACCAGCGAATCGTCGAACACGCCCCAGTTTCTGCCCGAGGAGGAGCAGAATCTTATTAAAATCGAGCCCACGTCGCCGGATCTGCGGGATATGGTGGAGAGCCAGCAGCGTGTCACTGCCACGGGAcacacggccacgcccacatcatcatcgtcgtcgtcgtcggcggcGCGCACTTCGCGCCATCTGCGACAGCTGACCGCCAACTTGGGCACGCGGGCGGCCGCTAGGCGGAACATTAGCAAAACAGCCTCTGCGTCCAGCTCCAAGAAGTCATCGTCGGACTCAACTGTTGCAGTCAGCAAAGCGAACTCCTCCTACCTCAGCTATGGCGTGGACTCGTACACTGTGAGTGTTGCGGCCAGCGCCAACTCCTCAGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTGGTGTCCGCTGCGGATGCCGCCGATGCGGCAGCCAAAGCGGCGGCGGCCAGCAAAACGGAGCGCAGGACGCGCTGCTTTGAGTGTGAAATGTGCTCATCCATATTTCCCGATCGCTCCCAGCTGCTGgaacacatgcatatacacatCTGA
Protein Sequence: MNNQEYGGIQWIQQHASAVDSETDILESGAADGEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANETGGGTVLITDNGTVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGGRFSRRAELISHFKAHAEAQVAADAEVAAAAAAAAIKFEPQQQQRQIDDHFYEQWPFYQDQDQEQEQEEDQVQQQAQTQELVQQHQTVPQASYPAVSAVAAPTAARGRISRLKPKEESTQYIVIADKQATSEVDNLPQDMDCEELPLAGNTPIGESSQVADAAQPLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVESPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEQDQLYGDFYCSECGISFHRQDLLRRHAKQQHKDTDGGDNAEAGENAKDAPHSCHTCGKAFPSALELNTHVEIHARFPPFKCVLCGVSFYEEEAIKRHLKTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCTRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCTADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAGNKDGEDYVSDIEYCDLDVENVDDLLDRAEPVKKEKRKRTATNGAAAPAQNTSDSVKSANSSSDRLWDEKFMQMNGNGNVASDEAYKSFFQIDSLVVVNDTTLPAVSSSSNATGGAKSRRSGKQAQAAGSSDRVAAAAGEESGKSGGASSRSSKRKSSKAAKNAAGATATAAAAAAATASSSRPRMIHTEKSRVPAENAPKRTRGRSYATRTTTSESSQLGLVKASSVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQLQQHHHQQQQQQQRVQLMYDDTHLLIDATLLREKTFEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSNTPQFLPEEEQNLIKIEPTSPDLRDMVESQQRVTATGHTATPTSSSSSSSAARTSRHLRQLTANLGTRAAARRNISKTASASSSKKSSSDSTVAVSKANSSYLSYGVDSYTVSVAASANSSDVSSGFFSISEVVSAADAADAAAKAAAASKTERRTRCFECEMCSSIFPDRSQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: -
80% Identity: -