Dmay005248.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila mayri
Gene Symbol
topi
Assembly
GCA_008042485.1
Location
VNJN01005247.1:68124-70871[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 8.6 6e+02 1.1 0.3 2 19 148 164 147 167 0.78
2 11 7.9e-06 0.00056 20.1 2.9 1 23 250 272 250 272 0.97
3 11 0.24 17 6.0 0.3 2 15 298 311 297 319 0.77
4 11 0.1 7.3 7.1 0.0 2 23 382 403 381 403 0.96
5 11 0.0015 0.1 12.9 3.2 1 23 450 473 450 474 0.97
6 11 5 3.5e+02 1.8 0.1 2 17 489 504 488 511 0.83
7 11 4.7e-07 3.3e-05 23.9 1.9 1 23 533 555 533 555 0.95
8 11 0.00019 0.013 15.8 1.0 1 23 561 586 561 586 0.97
9 11 0.57 40 4.8 1.8 1 23 592 614 592 614 0.88
10 11 3.5e-08 2.4e-06 27.5 0.4 1 23 620 642 620 642 0.99
11 11 0.0013 0.088 13.2 2.5 1 23 648 671 648 671 0.96

Sequence Information

Coding Sequence
ATGGATCCCGAAAATTTTGCGAACCTTCAGGAAGGTGAGCAGCAGGCCGGGGAATATACACTGGCCGAGATCGAAGTTGATATGGAGTCGCAGCTGACTCCCAATGACCTGGATCCCGGTGCTACGGTGTTGCTCTCCATTGAGGGAGAGGGAGACGGAGAGCGCGTTATGAGCCACGAAGAGTGGTCCAGGTGGTTTTTAGTAGAGCCGACCCCAAGCCCGGCACCGATGCCCACAGATGTGGTGGTGCAGCGTACCCTGGAAGACCCTGCTCTCAAGCAGATTCTCCAGGAAGCCGACGGCAAGCCAGATTTTGATCCTGAGGCCGAGCAGATGAAGATTCGCAGCTTTTTGGCAGGTTTTACCCACAACAAGATGACCACAGAGCAGTCTGTATTTCAAGGATACCGCTCGAACGCAACTGGCTTTGGCAACCGGATCAAGTGCCCCGATTGTCTAGGCAGTTTCGAACCGTCTTCAATCCAGAATCACTCCTGCATATTTGAGGGCGAACGGAAGTCTAAGCCCAATCCGAAGCCCGTCAACGAAACTGATAAACAGGCGCCAGCTGCGGGAGTTGCCAGTGCTGCTGAGCCTCCCGCTTCCCCTTCCCCAAGCAAACCGAACAGCGTGCGCGTGATCGCGGAGAACCAGATCCGCCTGCGTCGCTTTATGAATGATGAGTTAAAGTACGACATAATCACAGGTGTTGATGGCTCGCGCAGCCGTAAGCCCGGCAAGGGGCTTCACGAGTGCAGCAAGTGTGATCGCAAATTCGTTCATGCCTCCGGGCTGGTGCGCCACATGGAGAAGCACGCCCTGGATCTGATCCCCTCGCAGAGTAACCCACAGCCGGCCGCTTCTCTTTCGGCCGGACTCACCTCCGTAGTAAAGTGTAACTTTTGTGGGCGCATCTTTTACGACCCTCAGGTAGCGTTAGAACATGGCCATGTTCACTTCGATGAACAGCAAGGTTACCAGCCGGAATCTGCAACCAAGAGTGTCGCCAATATAGATTTAAATGAGCTTATAAATGATAGCGGATTGCTGCTGAGCGAGAATTGCTCGGAATCGAAGAAGCTGGAGAAGCCGAATAGCCTGGAAGACCATTTGTTTAGCACCCTTGTGCTGGGTAGCGTTTTGCAATGCGAGTTCTGTGAATACCTGTTTGCTGACATCACGGAGCTGCTCGCCCATTCGGCCACTCACCCGGTTAAACGGCGTTTCGAGTGCACCGCCTGTGACATTAAGATGGATACTGCCAAGGAGGCCAGACTCCATTTCGAGACGGACTGCATCTTCATGCGCGAGGCGGTGAAGTCGCTGAGCGTTTCGATCAGTCGCTATTTCGTGTGCAATGTTTGCGAGCTGAAGTTCGGCAACTCTGAGCTGCTGCAGGATCATCGCTGCACCTACCATCACTACTTTCCGCGGCTCAGTCCGCATGGGACTCGCCTGCTGCTGCCCTGTGATTTCTGCGAGGTAATGTTCGAGTCCGCCAGCGAGGTTCAGCCGCACAACGAGGAGAAACATCTAAGCAAAAAGAAGCGAGAAAAGGAGACACGTAGCAGCATGGCCAGCGGGCGCCAGCGCCAGTATCTTTGCGACATCTGCGGCAAGTCCTACACCCAGTCGAGTCACCTGTGGCAGCACCTGCGCTTCCACCAGGGCGTGAAGCCTTTCGTCTGTCCGGAGGAGAAATGCGACCGCAAATTCACCATCCGACCGGACCTTAACGATCACATCCGCAAGTGCCACACGGGAGAGAGACCGTTTCACTGTCTGGTGTGCGGCAAGCGTTTCCTCACAGGCTCCGTGTTCTACCAGCATCGCCTTATACATCGTGGCGAGCGGCGATACGAGTGCGAAGAGTGTGGTAAGCGATTCTATCGCGCCGATGCACTTAAGAACCATCAGCGCATCCACACCGGAGAGAAGCCGTTTAGCTGCCTCTTCTGCACAAAAACATTTCGCCAGCGTGGCGATCGCGACAAACACATGAGGGCCCGTCACTCGCACCTTGATGCCAACTCGCGCCTCATGATGCAGATGCAGAAGTTCCAGTTGGAGTCGGCCGCAGCCGCCAAGGCCAAGGGCAAAAAAACTCCGCCCGGAGTCGCTGTGGCTGCTTGTGGTAGTCCCCCAGCTGCAGATGGTTTGGAACCTGGAGAGGTAATGTCTTCAGAAGAGCACCTACAAAATCCTGAACCGAACGAGGAAGAGCCGAACTACTTTATAGTGGAGCAGTACATGCAGCCTGGGGAGGATGGCCAGAACGGTTTCAATATGCGGGAAGGAACCTGCACCCTAGAGCAGGGCTGCAccatggaggaggaggagcaacaAATAATTCTGTACGAGACACAGCCACGACGAGATGTAATGGATTTGGGAGACAGCCAGCAATCGAGTCAGGATTTGATCACTTTTGACTATAAGCAGCCGAATGAGCAGCCCATGCAAGACGGAAGCTACGCTCAAATGCTGCAGGGCGACGATAATGCCAGAGTTGTGGTTGTGCAGAATAATCCAACACATCCTTTGTTTTCCAATTCCTACATGTAA
Protein Sequence
MDPENFANLQEGEQQAGEYTLAEIEVDMESQLTPNDLDPGATVLLSIEGEGDGERVMSHEEWSRWFLVEPTPSPAPMPTDVVVQRTLEDPALKQILQEADGKPDFDPEAEQMKIRSFLAGFTHNKMTTEQSVFQGYRSNATGFGNRIKCPDCLGSFEPSSIQNHSCIFEGERKSKPNPKPVNETDKQAPAAGVASAAEPPASPSPSKPNSVRVIAENQIRLRRFMNDELKYDIITGVDGSRSRKPGKGLHECSKCDRKFVHASGLVRHMEKHALDLIPSQSNPQPAASLSAGLTSVVKCNFCGRIFYDPQVALEHGHVHFDEQQGYQPESATKSVANIDLNELINDSGLLLSENCSESKKLEKPNSLEDHLFSTLVLGSVLQCEFCEYLFADITELLAHSATHPVKRRFECTACDIKMDTAKEARLHFETDCIFMREAVKSLSVSISRYFVCNVCELKFGNSELLQDHRCTYHHYFPRLSPHGTRLLLPCDFCEVMFESASEVQPHNEEKHLSKKKREKETRSSMASGRQRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEEKCDRKFTIRPDLNDHIRKCHTGERPFHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFSCLFCTKTFRQRGDRDKHMRARHSHLDANSRLMMQMQKFQLESAAAAKAKGKKTPPGVAVAACGSPPAADGLEPGEVMSSEEHLQNPEPNEEEPNYFIVEQYMQPGEDGQNGFNMREGTCTLEQGCTMEEEEQQIILYETQPRRDVMDLGDSQQSSQDLITFDYKQPNEQPMQDGSYAQMLQGDDNARVVVVQNNPTHPLFSNSYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00489551;
90% Identity
iTF_00478201;
80% Identity
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