Dano002201.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila anomelani
Gene Symbol
topi
Assembly
GCA_035045905.1
Location
JAWNOO010000007.1:17044452-17047196[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 9.3 8.2e+02 1.1 0.3 2 19 148 164 147 167 0.78
2 11 8.5e-06 0.00076 20.1 2.9 1 23 251 273 251 273 0.97
3 11 0.088 7.8 7.5 0.4 2 22 299 319 298 320 0.79
4 11 0.12 10 7.1 0.1 2 23 380 401 379 401 0.96
5 11 0.0015 0.14 13.0 3.2 1 23 448 471 448 472 0.97
6 11 5.4 4.8e+02 1.8 0.1 2 17 487 502 486 509 0.83
7 11 5e-07 4.5e-05 24.0 1.9 1 23 531 553 531 553 0.95
8 11 0.0002 0.018 15.8 1.0 1 23 559 584 559 584 0.97
9 11 0.61 54 4.8 1.8 1 23 590 612 590 612 0.88
10 11 3.7e-08 3.3e-06 27.5 0.4 1 23 618 640 618 640 0.99
11 11 0.0013 0.12 13.2 2.5 1 23 646 669 646 669 0.96

Sequence Information

Coding Sequence
ATGGATCCCGAAAATTTTGCGAACCTTCAGGAAGGTGAGCAGCAGGCGGGGGAATACACACTGGCCGAGATCGAAGTTGATATGGAGTCGCAGCTGACTCCCAATGACCTGGACCCCGGTGCTACGGTGCTGCTCTCCATTGAGGGAGAGGGAGATGGAGAGCGCATTATGAGCCACGAAGAGTTGTCCAGGTGGTTTTTGGTAGAGCCGACCCCAAGCCCGGCACCGATGCCCACAGATGTGGTGGTGCAGCGTACCCTGGAAGATCCTGCTCTGAAGCAGATTCTCCAGGAGGCCGACGGCAAGCCGGATTTTGATCCTGAGGCCGAGCAGATGAAGATTCGCAGCTTTCTGGCAGGCTTTACCCACAACAAGATGACCACAGAGCAGTCTGTATTTCAAGGATACCGCTCGAACGCAACTGGCTTTGGCAACCGGATCAAGTGCCCCGATTGCCTAGGCAGTTTCGAACCGTCTTCAATCCAGAATCACTCTTGCATCTTTGAGGGCGAACGGAAGTCTAAGCCCAATCTGAAGCCCGTCGACGAAGCTGATAAACAGGCGGCAGCTGCAGGAGTTGCCAGTGCTGCACCTGAGCCTCCCGCTTCCCCTTCCCCAAGCAAAGCGAACAGCGTTCGCGTGATTGCGGAGAACCAGATCCGCCTGCGTCGCTTTATGAATGATGAGTTGAAGTACGACATAACCACAGGCGTTGAAGGCTCGCGCAGCCGTAAGCCCGGCAAGGGGCTTCACGAGTGCAGCAAGTGTGATCGCAAATTCGTTCATGCCTCCGGCCTGGTGCGCCACATGGAAAAGCACGCCCTAGACCTGATCCCCTCGCAGAGTAACCCACAGCCGGCCGCTTCTCTTTCGGCCGGACTCACCGCCGTAGTAAAGTGTAACGTTTGTGGGCGCATCTTTTATGATCCTCATGTAGCGTTAGAGCATGGCCACGTTCACTTCGATGTACAGCAAAGTTACCAGCCGGAAACTGCGACCAAGTATGCCGCCAATATAGATTTAAATGAGCTTATAAATGACAGCGGATCGCTGCTGAGCGAGAATTGCTCGGAATCGGAAAAGCCGAATAGCCTGGAAGACCATTTGTTTAGCACCCTGGTGCTGGGTAGCGTTTTGCAATGCGAGTTTTGCGAATACCTGTTTGTCGACATCACGGAGCTGCTCGCCCATTCGGCCACTCACCCGGTAAAGCGGCGTTTCGAGTGCACCGCCTGTGACATTAAGATGGATACTGCCAAGGAGGCCAGACTCCATTTCGAGACGGACTGCATCTTCATGCGCGAGGCGCTGAAGTCGCTGAGCGTTTCGGTCAGCCGCTATTTCGTGTGCAATGTATGCGAGCTGAAGTTCGGCAACTCGGAGCTGCTGCAGGAGCATCGCTGCACCTACCATCACTACTTTCCGCGGCTCAGTCCGCATGGAACTCGCCTGCTGCTGCCCTGTGATTTTTGTGAGGTAATGTTCGAGTCCGCCAGCGAGGTTCAGCCGCACAACGAAGAAAAACACCTGAGCAAGAAAAAGCGAGAGAAGGAGACACGTAGCACCATGGCCAGCGGACGCCAGCGCCAGTATCTCTGTGACATCTGCGGCAAGTCCTACACCCAGTCAAGTCACCTGTGGCAGCACCTGCGCTTCCACCAGGGCGTGAAGCCGTTCGTCTGCCCGGAGGAGAAATGCGACCGCAAGTTCACCATCCGACCGGACCTTAACGATCACATCCGTAAGTGCCACACGGGAGAGAGACCGTTTCACTGTCTGGTGTGCGGCAAGCGTTTCCTCACAGGCTCCGTGTTCTACCAGCATCGCCTCATCCATCGTGGCGAGCGGCGATATGAGTGCGAAGAGTGTGGTAAGCGATTCTATCGCGCCGATGCACTTAAGAACCATCAGCGCATCCACACCGGAGAGAAGCCGTTCAGCTGCCTCTTCTGCACAAAAACATTTCGCCAGCGTGGCGATCGCGACAAGCACATGAGGGCCCGTCACGCGCACCTTGATGCCAACTCGCGCCTCATGATGCAGATGCAAAAGTTCCAGCTGGAGTCGGCCGCAGCCGCCAAGGCCAAGGGCAAAAAAACCCCTCCCGGAGTCGCTGTGGCTGCTTGTGGTAGTCCCCCCGCTGCAGAGGGTTCGGAACCCGGAGAGGTAATGTCTTCAGAAGAGCACCTACACAATCCCGAAGCGAACGAGGAAGAGTCCAACTATTTTATTGTGGAGCAGTACATGCAGCCTGGGGAGGATGGCCAGAACGGTTTCAATATGCGGGAGGGAGCCTGCACCCTAGAGGAGCAGGGCTGCAccatggaggaggaggagcagcagatAATTCTGTACGAGACACAGCCAGGACGGGATATGGTGAATTTGGGAGACGGCCAGCAATCGAGTCGGGATTTGATCACTTTTGACTATAAGCAGCCGAATGAGCAGCCCATGCAGGACGGAAGCTACGTTCAAATGCTGCAGGGCGACGATAATGCCAGAGTTGTGGTTGTGCAGAACAACCCAACACATCCTATGTTTTCCAATTCCTACATGTAA
Protein Sequence
MDPENFANLQEGEQQAGEYTLAEIEVDMESQLTPNDLDPGATVLLSIEGEGDGERIMSHEELSRWFLVEPTPSPAPMPTDVVVQRTLEDPALKQILQEADGKPDFDPEAEQMKIRSFLAGFTHNKMTTEQSVFQGYRSNATGFGNRIKCPDCLGSFEPSSIQNHSCIFEGERKSKPNLKPVDEADKQAAAAGVASAAPEPPASPSPSKANSVRVIAENQIRLRRFMNDELKYDITTGVEGSRSRKPGKGLHECSKCDRKFVHASGLVRHMEKHALDLIPSQSNPQPAASLSAGLTAVVKCNVCGRIFYDPHVALEHGHVHFDVQQSYQPETATKYAANIDLNELINDSGSLLSENCSESEKPNSLEDHLFSTLVLGSVLQCEFCEYLFVDITELLAHSATHPVKRRFECTACDIKMDTAKEARLHFETDCIFMREALKSLSVSVSRYFVCNVCELKFGNSELLQEHRCTYHHYFPRLSPHGTRLLLPCDFCEVMFESASEVQPHNEEKHLSKKKREKETRSTMASGRQRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEEKCDRKFTIRPDLNDHIRKCHTGERPFHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFSCLFCTKTFRQRGDRDKHMRARHAHLDANSRLMMQMQKFQLESAAAAKAKGKKTPPGVAVAACGSPPAAEGSEPGEVMSSEEHLHNPEANEEESNYFIVEQYMQPGEDGQNGFNMREGACTLEEQGCTMEEEEQQIILYETQPGRDMVNLGDGQQSSRDLITFDYKQPNEQPMQDGSYVQMLQGDDNARVVVVQNNPTHPMFSNSYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00489551;
90% Identity
iTF_00541264; iTF_00488859;
80% Identity
-