Dmal012515.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila malerkotliana
Gene Symbol
pax6a
Assembly
GCA_018153235.1
Location
JAECXV010000067.1:9713897-9723924[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.9 5.9e+03 -3.0 0.1 8 20 96 108 94 110 0.88
2 2 8.3e-35 1.6e-31 108.6 0.0 23 125 136 233 129 233 0.95

Sequence Information

Coding Sequence
ATGGAAACCTCGACAACGCCAGGCCCCGCAAGGACAACCAACAAGCTCAGCACAGCATCACCGGCCACCTCTGCCACGTCGCCGGGATCCCCGGCAGCCATCATGCCCATGGCGGTGCCGATGCCGTCGCATCTGCAACTTTTGGGCAGCTCGGCGGGAAGTGTCGGTCAGCCGACGGCAATGTCACCCATTTCACCCACGGCGGCTCCCACAGTTCATGCCCCAGCGCACAGTCTAAGCCCCTCCACGCCCATTCTGGCCCAGGGAACGCCACCTGCCCCAGCGTTGGGCGGACTGTTTTGTGGAGGCAGCCCTGCTCCAAGTGGAATGGGAGGAGTAGGAGCAGGAGCAGCGCCCGGGTCAGCAGCTGCTGCTGCAGCCACAAATCTCAACGCCCTGGCCTCCCAGCACAGACTACTAGAGTTGTCCCGGTTTGGACTGAGAGGATACGACCTGGCCCAGCACATGCTATCCCAGCAAGGAGCAGTGTCCAAGCTGCTAGGCACTCTGAGACCTCCTGGCTTAATAGGAGGCTCCAAGCCCAAAGTGGCCACCCCAACAGTAGTCTCCAAAATCGAGCAGTACAAGCGCGAGAACCCGACCATCTTCGCGTGGGAAATCCGGGAGCGACTGATCACTGAAGGTGTATGCACCAATGCCACTGCTCCCTCCGTAAGCAGCATAAATAGAATCCTACGGAATCGAGCGGCGGAACGGGCGGCGGCGGAGTTTGCCCGAGCAGCCAGCTACGGCTACGCCATGCATCCCACCCACCCGCATCCGTACACTAGTTTCCCCACCTGGCCAACGCATCATCCGCTGTGGAGTGCCGTGCCCCTGCCCGCCGGAACGGGATCTCCGGGCGCGGGGGTAGGTGGCCTGCCGCCTGGAAGCAGCAGTGGCTATGGCAGCGAAGGAAACGTCAGCTCGAATCCCAACAGTAACGGCAACAACAACACCAACAGCGGTAGCGCCTGCGGGGACAGCAGTGCGGGCAGTGGACGGTTCTCCTTGCCGGCCCTCTCTCCCGACTCCGGAAGCAGGGACAGTCGATCGCCGGATGGGGAAGCAAACAGGATGATAGACATCGAGGGCGAGGACAGCGAGTCGCAGGACAGCGATCAGCCAAAGTTCCGGCGGAACAGGACTACCTTCAGCCCGGAGCAGCTGGACGAGCTGGAGAAGGAGTTCGAGAAGTCGCACTATCCGTGCGTCAGCACCCGCGAGAAGCTGGCCGGCAGGACCGCCCTGAGCGAGGCGAGGGTTCAGGTTTGGTTTTCCAACAGACGAGCGAAATGGCGGCGCCATCAGCGGGTCAACTTGCTCAAGCAGCGCGACTCGCCCTCGACCTCGAGCTCACCCACGCCGGCTTTCGGCGGGGCTCAAGCGGCCAGCAAGGCTCCGGCTCCGGCTCAAGCCCAGGCTCCGGAATCTGGCCAGCACCCACTCCAGGCGATCAGTTCCCAGTTTACCAATCCAGGGGCCTACTACCACACCAGCAGTTCCACCTGTCCCCCAGCCACTATGCCAGCCTGCAACAGTCGCGCGGAAGAGCCCCAGGCATCAGCCCAGCCACCGCCGGTGACTCCACCAACAGCAGCACCCCTGGCAGCGGCCCTGCTGCCTGCCTCAACCACAGCATCAGCTCCATTATCAATGGGCGGTGAGAACAGCGCCTTCCGCAGCCTGCCCATGCCCATGTCGATGTCCATGCCTCCCGCCTCGGCGGCGGCCTTCGCTCTGACCTTTGCCCGCCAGTACATAGCCAAGTACATGGCCACGCCCATGAATCTGGGTGGACGGGTGAACCCGGAGGAGCACTCCGAGGACGAACCGGTGGACGAAGAGGACGAGGTCATAAACGTGGAGCACGACGCCGAGTGA
Protein Sequence
METSTTPGPARTTNKLSTASPATSATSPGSPAAIMPMAVPMPSHLQLLGSSAGSVGQPTAMSPISPTAAPTVHAPAHSLSPSTPILAQGTPPAPALGGLFCGGSPAPSGMGGVGAGAAPGSAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRILRNRAAERAAAEFARAASYGYAMHPTHPHPYTSFPTWPTHHPLWSAVPLPAGTGSPGAGVGGLPPGSSSGYGSEGNVSSNPNSNGNNNTNSGSACGDSSAGSGRFSLPALSPDSGSRDSRSPDGEANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFEKSHYPCVSTREKLAGRTALSEARVQVWFSNRRAKWRRHQRVNLLKQRDSPSTSSSPTPAFGGAQAASKAPAPAQAQAPESGQHPLQAISSQFTNPGAYYHTSSSTCPPATMPACNSRAEEPQASAQPPPVTPPTAAPLAAALLPASTTASAPLSMGGENSAFRSLPMPMSMSMPPASAAAFALTFARQYIAKYMATPMNLGGRVNPEEHSEDEPVDEEDEVINVEHDAE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00481493;
90% Identity
iTF_00538789; iTF_00477289; iTF_00475884; iTF_00477172; iTF_00475770; iTF_00481493; iTF_00481378; iTF_00579929; iTF_00579814; iTF_00550204; iTF_00550085;
80% Identity
iTF_00538789;