Basic Information

Insect: Drosophila lutescens
Gene Symbol: ey
Assembly: GCA_037075285.1
Location: JBAMCF010000584.1:100260-127809[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.4e-72 3.1e-69 231.0 0.9 2 125 87 210 86 210 0.99

2 2 2.4 5.3e+03 -2.4 0.0 56 80 351 376 350 383 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.4e-72	3.1e-69	231.0	0.9	2	125	87	210	86	210	0.99
2	2	2.4	5.3e+03	-2.4	0.0	56	80	351	376	350	383	0.77

Sequence Information

Coding Sequence: ATGGGCACCGTAGTTCCTCCCTGGTCAGCGGGAACATTGAACATTCTACCGTCCTTAGAGGACATGGCTCACAAGGACAATGTGATTGCAATGAGAAATTTACCCTGTTTGGGTGCCGCTGGTGGGAGCGGACTAGGCGGTATTGCTGGAAAGCCTTCCCCTACAATGGAAGCCGTGGAGGCCAGCACTGCGTCACAGCCCCATTCGACATCGTCTTACTTCGCCACAACTTACTACCATTTAACTGATGATGAATGTCACAGTGGAGTAAATCAGTTGGGTGGCGTTTTCGTTGGTGGAAGACCTTTGCCGGACTCAACGCGGCAGAAAATTGTCGAGCTGGCCCATTCCGGAGCACGACCATGTGATATTTCCCGGATTCTACAAGTTTCCAATGGATGTGTGAGCAAAATTCTCGGAAGGTACTATGAGACAGGGAGTATAAGACCACGTGCTATTGGTGGATCCAAGCCTCGTGTGGCCACAGCCGAAGTGGTTAGCAAAATTTCACAGTATAAGCGCGAGTGCCCGAGTATCTTTGCCTGGGAAATTCGGGATAGATTACTCCAGGAGAACGTTTGTACCAACGATAACATTCCTAGTGTGTCCTCAATTAACCGTGTGTTAAGAAACCTGGCGGCccagaaggagcagcagggCCCGGGAACTAGCAGTTCCAGCACCGGCAACTCGAGCGGCGCAAAAGTGGCCGCCAATGGCAGCGGCAACCTCAGCAACGGCTCGAACGGAACGCGGACCACGTTGACCTCCTCCACTGATCTCATGCAGACGGCCACGCCATTGAACTCCTCGGAGAGCGGCGGCGCGAGCAACTCCGGCGAGGGGAGCGAGCAGGAGTCCATCTACGAGAAGCTCCGGCTCCTGAACACCCAGCACGCGGCAGGATCGGGATCGCTGGACCCAGCCATAGCAGCCCCGCTGGTGGGCCATGCGCCCAGCCACTTCGGACCCCACTCCAGCCACCCACTCAACCAGCTGGTGCACGGCAACCAGCAGActctccagcagcagcagcagagctgGCCGCCCCGCCACTACTCCTCTGGGTCCTGGTACCCCTCCTCACTAGGTGCCAGTGAAATCCCCATCTCGTCGGCTCCGAACATCGCGTCAGTGTCGGCGTATGCCTCGGGTCCTCCGCTCGCCCAGCCCTTGAGTCCGCCGAACGACCTCGCCAGCCTGGGCAGTGGCGGTCACCTGAGAAACTGCCCCGTGACCACGGAGGACATTCATCTGAAGAAGGAACTCGATGGTCATCAGTCGGATGAGACAGGCTCCGGTGAAGGTGAAAACTCCAATGGAGGCGCTTCGAATTTAGGAAACAATGAGGATGATCAAGCTCGTCTTATACTTAAAAGAAAGTTGCAGCGTAATCGAACCTCCTTTACAAACGACCAGATAGATAGTCTTGAAAAAGAGTTTGAACGAACGCACTATCCAGATGTTTTTGCGCGAGAACGATTGGCTGGAAAGATTGGTCTGCCGGAAGCAAGGATTCAGGTTTGGTTCTCGAACCGCCGTGCAAAGTGGCGCCGCGAGGAAAAACTGCGAAACCAGAGGAGAACACCAAATTCCACGGGAGCTAGCGGAACCTCTTCCTCAACATCAGCAACTGCCTCCTTAACAGATAGCCCGAACAGCCTAAGTGCCTGTTCCTCCTTGCTGTCCGGATCAGCAGCGGGCCCTTCAGTCAATACCCTTAATGGTTTATCCTCGCCAAATACATTGTCCACCAGTGCCAGTGCCCCAGCGGTTGGTGCTGGCATCGAGGGTACCGGCAGCCCAACACCAACTCTGCATATTCGACCCGGTTGCACCTCGGACATAGCCGCTGGACGTCACAGTGAAGACTGTAGAAGAGCTTGTTCTCCTTGCCCCCTTGGGATTGGCGGCCAGCCGAATAGCCACCATCACCAGAGCAATGGTCACACCCATGCCCACGCACATGCGCTTGTTCCGGCTATTTCGCCACGACTCAATTTCAACAGCGGCGGGTTCGGGGCGATGTACTCGAACATGCATCACACGGCCTTGTCTATGAGTGATACTTATGGAACGGTAACACCAATTCCAAGCTTTAACCACTCATCCGTCGGATCGTTGGCCCCACCGTCGCCAATATCGCAGCAGGGCGACCTCACGCCACCATCCTTGTACCCGTGCCACATGACTCTGCGACCGCCGCCAATCGCACCTCCACACCACCACATAGTACCGGGTGACGAGGGGAGGCCTGCGGGAGGGATAGGCAATGCCCAATCGGCGAATCTGGGAGCAAACTGCGGTGGCTCGGGATACGAAGTGCTCTCCGCCTACGCGTTGCCCCCGCCCCCGTTGCCATCAAGCAGTGCACCTGCATCGAACTTCGCAACCTCCTCCAGTACTAGTGCGAATGTGACCTCCCATCACACCATGTCCCAAGAACCGTGCCCCTCGCCCTGCAGTTCCAACTCAAACCACCTGGGAGTTGGCCACAGCTCCGTATTCGCGACTGACCCGATTTCTCCGGCTGTATCTTCATATGCACATATGAGCTACAACTACGCTTCGACCGCCAACAACATGTCAGCTTCCTCCCCCGGCGGAGCCGCAGCGCACGTTGCTCCTGGAAAGCAACAGTTCTTCGCCTCATGCTTCTACTCACCTTGGGTCTAA
Protein Sequence: MGTVVPPWSAGTLNILPSLEDMAHKDNVIAMRNLPCLGAAGGSGLGGIAGKPSPTMEAVEASTASQPHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQGPGTSSSSTGNSSGAKVAANGSGNLSNGSNGTRTTLTSSTDLMQTATPLNSSESGGASNSGEGSEQESIYEKLRLLNTQHAAGSGSLDPAIAAPLVGHAPSHFGPHSSHPLNQLVHGNQQTLQQQQQSWPPRHYSSGSWYPSSLGASEIPISSAPNIASVSAYASGPPLAQPLSPPNDLASLGSGGHLRNCPVTTEDIHLKKELDGHQSDETGSGEGENSNGGASNLGNNEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASGTSSSTSATASLTDSPNSLSACSSLLSGSAAGPSVNTLNGLSSPNTLSTSASAPAVGAGIEGTGSPTPTLHIRPGCTSDIAAGRHSEDCRRACSPCPLGIGGQPNSHHHQSNGHTHAHAHALVPAISPRLNFNSGGFGAMYSNMHHTALSMSDTYGTVTPIPSFNHSSVGSLAPPSPISQQGDLTPPSLYPCHMTLRPPPIAPPHHHIVPGDEGRPAGGIGNAQSANLGANCGGSGYEVLSAYALPPPPLPSSSAPASNFATSSSTSANVTSHHTMSQEPCPSPCSSNSNHLGVGHSSVFATDPISPAVSSYAHMSYNYASTANNMSASSPGGAAAHVAPGKQQFFASCFYSPWV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00605519;
90% Identity: iTF_00578371;
80% Identity: iTF_00536605;